Upcoming Webinar
How Funders Feel About AI, and What Keeps Them Saying Yes.
Wed, Oct 14 @ 2PM ET

Skip to main content
Main content

Best Foundation Grants for Nonprofits in South Dakota

Find the perfect Foundation grants for nonprofits in South Dakota on Instrumentl. 9,000+ Foundation grants for nonprofits in South Dakota in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,206 Results based on applied filters

Estelle Massey Osborne Scholarship

Nurses Educational Funds Inc.
Private
United States
Unspecified amount
The Estelle Massey Osborne Scholarship supports exceptional African American nurses pursuing master's degrees. Applicants must have at least two semesters remaining in their program, maintain a minimum GPA of 3.6, and hold a current RN license. This scholarship, provided by Nurses Educational Funds Inc., honors Estelle Massey Osborne, the first African American nurse to earn a master's degree in the U.S. It aims to promote nursing leadership through financial assistance for advanced education.
Education - Higher Education Nursing Mental Health & Psychiatric Diseases +2 more

Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant

National Scleroderma Foundation
Private
United States
US $200,000
The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.
Rare Diseases Immune System Diseases Interstitial Lung Disease

Alzheimer’s Association: Center for Dementia Respite Innovation Grant (CDRI)

Alzheimer's Association
Private
United States
US $50,000 - US $100,000
The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.
Dementia & Alzheimer’s Disease Caregiver Support / Respite Care

NMDP Barbara Buchbinder Nurse Research Program Grant

National Marrow Donor Program
Private
United States
US $25,000
The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.
Children’s Health & Pediatrics Hematological Systems Cell Biology +1 more

Jack Feldt Ambucs Memorial Scholarship

Grand Haven Area Community Foundation
Private
United States
Unspecified amount
The Jack Feldt Ambucs Memorial Scholarship, established in 1997, supports students in the Tri-Cities area pursuing a degree in Physical Therapy. Funded by the Grand Haven Area Community Foundation, this scholarship prioritizes applicants demonstrating financial need. It considers college juniors and graduating high schoolers, reflecting the spirit of community and collaboration championed by Ambucs. Eligible candidates need to provide transcripts and additional required documents to complete their application.
Education - Higher Education Educational Access & Equity Physical Therapy +2 more

Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.
Neuroscience Neurological Diseases & Disorders Stroke

NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) (352061)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $3,600,000
The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.
Allergies & Allergic Diseases Infectious & Parasitic Diseases Immune System Diseases

Friends Foundation for the Aging Grant

Friends Foundation for the Aging
Private
United States
Unspecified amount
The Friends Foundation for the Aging Grant supports innovative and impactful programs aimed at addressing the needs of older adults, particularly within underserved populations. This Quaker foundation prioritizes collaboration and sustainability in its funding efforts. Eligible applicants must be 501(c)(3) public charities focused on enhancing the quality of life for aging individuals. Grants are typically awarded for one year and target organizations that align with the foundation's mission and values.
Aging / Gerontology Senior Services Protestantism +1 more

MRF Breakthrough Consortium (MRFBC) Young Investigator Team Award to Advance the Field of Translational Immuno-Oncology

Melanoma Research Foundation
Private
United States
Up to US $150,000
The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.
Cancer / Oncology Skin Diseases & Dermatology Pediatric Cancers

Melanoma: Established Investigator Award

Melanoma Research Foundation
Private
United States
Up to US $125,000
The Melanoma Established Investigator Award offers up to $125,000 annually for two years, aimed at established melanoma researchers or senior researchers transitioning into melanoma research. Eligible applicants include Associate Professors or higher, with both tenured and non-tenured faculty encouraged to apply. U.S. citizenship is not a requirement for this funding opportunity provided by the Melanoma Research Foundation.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

Career Development Award Program RFP- New Application

Melanoma Research Foundation
Private
United States
Up to US $50,000
The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

Encompass Health Therapy Grant

Encompass Health Corporation
Corporate
Puerto Rico, United States
Up to US $75,000
The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.
Medical Rehabilitation Home Health Care Health Care Access & Delivery +3 more

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $212,004 - US $2,725,311
This funding opportunity aims to advance HIV/AIDS research by implementing human new approach methodologies (NAMs) to reduce the reliance on specific pathogen free (SPF) animal models. It emphasizes the integration of NAMs-enabled frameworks for in vitro testing while supporting essential SPF colony resources. The initiative seeks to enhance research rigor and reproducibility through innovative strategies that prioritize human-relevant models, ultimately improving HIV research outcomes and facilitating collaborative development in the field.
HIV / AIDS

Neonatal Research Initiative- RFP

Little Giraffe Foundation
Private
United States
US $5,000 - US $10,000
The Little Giraffe Foundation is dedicated to supporting neonatal health through research grants ranging from $5,000 to $10,000. Since 2011, they have provided substantial resources to hospitals and institutions, focusing on both immediate and long-term health challenges faced by premature infants. Eligible applicants include scientists and healthcare professionals from U.S.-based institutions. The foundation aims to advance research in biological processes, genetics, clinical studies, and more, improving outcomes for vulnerable populations.
Obstetrics & Neonatal Care

Little Giraffe Foundation: NICU Support Grants

Little Giraffe Foundation
Private
United States
Up to US $2,000
The Little Giraffe Foundation, a national non-profit based in Chicago, provides NICU Support Grants ranging from $100 to $1,000. Since 2011, they have positively impacted countless families by delivering over 32,000 gift bags and funding essential research. These grants aim to enhance the experience for parents and patients in neonatal intensive care units, supporting initiatives like holiday gift bags and resources for bonding with babies. Applications are welcomed from eligible U.S.-based institutions.
Obstetrics & Neonatal Care

OREF/Musculoskeletal Transplant Foundation Research Grant Prgram

Orthopaedic Research and Education Foundation
Private
United States
US $100,000
The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.
Human Genome & Genetics Cell Biology Synthetic Biology +4 more

The Anne and Tony Hillerman Scholarship

Albuquerque Community Foundation
Private
New Mexico, United States
Unspecified amount
The Anne and Tony Hillerman Scholarship, part of the New Mexico Press Women Scholarship Fund, supports New Mexico students pursuing undergraduate or graduate degrees in journalism or communications. Established in 2023, the fund promotes ethical journalism and offers networking opportunities through the NMPW Annual Conference. Eligible applicants must be enrolled in a relevant program, provide a portfolio of work, and submit a personal essay detailing their interests and career goals. This scholarship fosters the next generation of communicators and advocates for First Amendment rights.
Education - Higher Education Vocational & Trade Education Career / College Preparation +3 more

Kiwanis Club of Albuquerque Scholarship Fund

Albuquerque Community Foundation
Private
United States
Up to US $1,000
The Kiwanis Club of Albuquerque Scholarship Fund, established in 1948, supports graduating seniors from Albuquerque metro area high schools who demonstrate strong academic performance and community service. Annually, one to four scholarships of up to $1,000 are awarded to students pursuing careers in child development and teaching. The fund emphasizes the importance of community involvement and academic excellence, encouraging students to share their career goals and financial needs through an essay as part of their application.
Education - Higher Education Vocational & Trade Education Career / College Preparation +3 more

New Mexico Veterans Memorial Scholarship

Albuquerque Community Foundation
Private
United States
Unspecified amount
The New Mexico Veterans Memorial Scholarship, established in 2024, supports graduating high school seniors in New Mexico who embody the Medal of Honor Core Values: Courage, Sacrifice, Integrity, Commitment, Patriotism, and Citizenship. This scholarship encourages students to explore and reflect on these values through a personal essay and community service. Preference is given to students from Albuquerque High Schools, fostering a commitment to excellence and civic duty among the youth.
Education - Higher Education Vocational & Trade Education Career / College Preparation +3 more

Geoff Richter Performing Arts Award

Foundation For Jewish Philanthropies
Private
United States
US $2,000

Our Mission

Empower donors to fulfill their passions and dreams by establishing charitable vehicles designed to create a positive and enduring impact on Jewish Buffalo, Western New York and the World.

Geoff Richter Performing Arts Award

The Geoff Richter Performing Arts Award Committee announces the availability of an Award up to $2,000! The GRPAA was founded in memory of Geoff Richter, Western New York Musician and Educator of the Arts.

About Geoff Richter

A native of Eden, New York, Geoff received his Bachelor of Music degree with a Performer’s Certificate in trumpet and a Master’s with a Performers Fellowship, from the Eastman School of Music.

Geoff played trumpet professionally with the Rochester, San Antonio, and Buffalo Philharmonic Orchestras and Niagara Falls, Binghamton, Chautauqua, Orchard Park, Clarence, Cheektowaga, and Amherst Symphony Orchestras. He co-founded the Buffalo Brass Quintet, the Buffalo Niagara Concert Band, and The Frankfurters, an internationally known Bavarian show band. He also acted as the summer/pops conductor of the Erie County Wind Ensemble and the Amherst Symphony Orchestra.

After retiring from a long career at Williamsville North High School, Geoff started working part time as director of the orchestra for musicals at St. Joseph Collegiate Institute. He also worked with the Mount Saint Mary Academy band and recruited and directed the orchestra for the annual school musical.

Performing Arts Education - Higher Education Music +2 more

Allergic Respiratory Diseases Award

American Lung Association
Private
United States
Up to US $150,000
The Allergic Respiratory Diseases Award, supported by the American Lung Association and the American Academy of Allergy, Asthma & Immunology, aims to bolster research in allergic respiratory diseases. Designed for faculty in Clinical Allergy and Immunology at academic medical centers, this award offers $75,000 annually for up to two years. It seeks to empower researchers at pivotal points in their careers, enhancing understanding and treatment of these conditions while promoting lung health.
Respiratory Diseases & Systems Allergies & Allergic Diseases Immune System Diseases

Mentored Quantitative Research Development Award (Parent K25 Independent Basic Experimental Studies with Humans Required) (353711)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Mentored Quantitative Research Development Award (K25) aims to engage skilled professionals in NIH-relevant research, enhancing their expertise in addressing health-related issues. This award supports individuals with backgrounds in quantitative sciences and engineering, providing them with dedicated time for supervised research and study. Key application deadlines span from June 2024 to February 2027, emphasizing the program's commitment to fostering innovative research in health and disease.
Engineering Mathematics Chemistry +8 more

Accelerating Research and Development of Next Generation Malaria Vaccines Against Malaria – A Model for Mosquito-Borne Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAID is focused on advancing the research and development of next-generation malaria vaccines, aiming to leverage innovative vaccine design techniques. This initiative not only aims to enhance malaria prevention but also serves as a model for combating other mosquito-borne diseases. By utilizing cutting-edge methods such as structure-based immunogen design and combination vaccines, the program seeks to significantly reduce both parasite infection rates and the overall disease burden associated with malaria.
Malaria Tropical Diseases

HIV/AIDS Clinical Trials Network Leadership and Operations Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is calling for applications for four Leadership and Operations Centers (LOCs) as part of its HIV/AIDS Clinical Trials Network initiative. These LOCs will guide research on HIV therapeutics, prevention, and treatment strategies across diverse populations. The initiative aims to enhance evidence-based practices and improve health outcomes for individuals affected by HIV, ultimately contributing to the goal of ending the HIV epidemic.
HIV / AIDS

Foundation Grants for Nonprofits in South Dakota Highlights

Looking for foundation grants for nonprofits in South Dakota?


Read more about each grant below or start your 14-day free trial to see all foundation grants for nonprofits in South Dakota recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Foundation Grants for Nonprofits in South Dakota

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ Foundation grants for nonprofits in South Dakota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Foundation grants for nonprofits in South Dakota over $25K in average grant size

23 Foundation grants for nonprofits in South Dakota over $50K in average grant size

23 Foundation grants for nonprofits in South Dakota supporting general operating expenses

91 Foundation grants for nonprofits in South Dakota supporting programs / projects

2,000+ Grants on Instrumentl focused on Community Services

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Foundation grants for Nonprofits in South Dakota?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for Foundation Grants for Nonprofits in South Dakota?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Foundation Grants for Nonprofits in South Dakota year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Foundation Grants for Nonprofits in South Dakota given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Foundation Grants for Nonprofits in South Dakota changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538