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Best Operating Grants for Nonprofits in South Dakota

Find the perfect Operating grants for nonprofits in South Dakota on Instrumentl. 9,000+ Operating grants for nonprofits in South Dakota in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,206 Results based on applied filters

Dr. Donald and Ann Gleason Memorial Scholarship

Community Foundation of the North State
Private
United States
Unspecified amount

Community Foundation of the North State

The Community Foundation builds trust through relationship, integrity, and by providing safe places for donors to give their resources.

We are a nonprofit, public charity serving the people of Shasta, Siskiyou and Tehama counties, with a mission to impact the region through the power of giving.

Scholarships

The Community Foundation of the North State manages many scholarship funds that are awarded to graduating high school seniors as well as students already in an undergraduate program. Some scholarships were started by families or individuals; others by businesses or organizations. All scholarships share one important focus: helping young people reach their educational goals.

Dr. Donald and Ann Gleason Memorial Scholarship

Provides scholarships for qualified Shasta County students with financial needs seeking a college education in the medical field.

Dr. and Mrs. Gleason had no heirs but still had a strong desire to help students with a financial need who were seeking a degree in the medical field. The Dr. Donald and Ann Gleason Memorial Scholarship will assist those pursuing an education in mental health, psychiatry, or pre-med studies.

Education - Higher Education Medical Education & Professional Training Psychology

MrBallen Foundation: Rapid Response Grants

Mrballen Foundation Inc
Private
United States
Unspecified amount

Rapid Response Grants 

Emergency funding after mass tragedies.

In the wake of tragic mass events, such as shooting, speed matters. Our Rapid Response Grants provide expedited funding to victims and their families when time is of the essence. These grants ensure that families aren’t left waiting for critical support when they need it most.

  • Awarded swiftly after mass casualty events
  • Designed to provide urgent, compassionate support in crisis situations
Disaster Relief / Humanitarian Aid Family Services Gun Violence Prevention

Pathway to Stop Diabetes Accelerator Award (ACE)

American Diabetes Association Inc
Private
United States
Up to US $325,000
The Pathway to Stop Diabetes Accelerator Award supports innovative early-career researchers tackling diabetes-related challenges. It offers flexible funding up to $325,000 annually for transformative research. Candidates must have independent faculty status and demonstrated productivity in diabetes research. The program aims to inspire groundbreaking discoveries by providing essential resources and mentorship, thereby improving the lives of those affected by diabetes. Nominations focus on translational research that bridges basic science with practical benefits for patients.
Diabetes

Pathway to Stop Diabetes Initiator Award (INI)

American Diabetes Association Inc
Private
United States
Up to US $325,000
The Pathway to Stop Diabetes Initiator Award (INI) aims to support early career researchers in diabetes research by providing funding and mentorship. With a focus on innovative and transformational ideas, this initiative encourages researchers to develop groundbreaking solutions for diabetes prevention and management. The award offers up to $100,000 annually in Phase 1 and $325,000 in Phase 2, fostering a new generation of leaders committed to improving the lives of those affected by diabetes.
Diabetes

Bill Rabbit Legacy Art Scholarship

Cherokee Nation Foundation
Association/Society
United States
Unspecified amount

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Bill Rabbit Legacy Art Scholarship

Applicant must be enrolled in an accredited, four-year, higher education institution pursuing a degree in fine arts or art education with a minimum 3.0 GPA. Accepted focuses include drawing, painting, sculpture, pottery, traditional beadwork and textiles. Three pictures of artwork must be included with application for consideration. This is a one-year scholarship reserved for Cherokee Nation and United Keetoowah Band citizens residing within the Cherokee Nation jurisdictional area.

Education - Higher Education Fine Art Art Education

McKnight Clinical Translational Research Scholarship in Cognitive Aging and Age-Related Memory Loss

American Academy Of Neurology Institute
Private
United States
Up to US $150,000
The McKnight Clinical Translational Research Scholarship supports young investigators focusing on cognitive aging and age-related memory loss. Funded by the McKnight Brain Research Foundation, this scholarship offers $65,000 annually for two years, plus an education stipend. Eligible applicants should have completed their PhD or residency within the last five years and conduct their research in accredited U.S. institutions. The award emphasizes rigorous training and aims to foster careers in human cognitive aging research.
Neurological Diseases & Disorders Cognitive Science Aging / Gerontology

The Stephen Schwartz Musical Theatre Teacher of the Year Award

Ascap Foundation
Private
District of Columbia, Puerto Rico +1 more
US $5,000
The Stephen Schwartz Musical Theatre Teacher of the Year Award, presented by The ASCAP Foundation and the Educational Theatre Association, recognizes outstanding middle and high school musical theatre teachers. Awarded annually, the recipient, selected by a panel of experts, will receive a $5,000 prize and be honored at the EdTA Theatre Education Conference in Minneapolis, MN. This prestigious award highlights the significant impact of dedicated educators in shaping the future of musical theatre.
Music Music Education

Alzheimer's Foundation of America Bi-Annual Grant

Alzheimers Foundation Of America Inc
Private
United States
US $6,000
The Alzheimer’s Foundation of America Bi-Annual Grant aims to support nonprofit organizations in their efforts to enhance the lives of individuals impacted by Alzheimer’s disease and related dementias. Each grant, valued at $6,000, is awarded twice a year, focusing on innovative programs and services. AFA emphasizes partnership and collaboration, enabling grantees to manage their own policies and programs while adhering to specific funding guidelines. This initiative underscores AFA's commitment to compassionate care and ethical standards.
Dementia & Alzheimer’s Disease

RFA: Biology to Prevention Award (CRUK)

American Cancer Society
Association/Society
United Kingdom, United States
Up to US $946,000
The RFA: Biology to Prevention Award (CRUK) aims to foster innovative translational research that enhances understanding of cancer biology, ultimately leading to effective prevention strategies. Joint applications from UK and US research teams are encouraged, with a focus on equal partnerships and complementary expertise. The funding provides up to £600,000 for UK costs and up to $946,000 for US costs, supporting projects of 1 to 5 years duration that address critical research questions in cancer prevention.
Preventative Healthcare Cancer / Oncology

Guinn B. Burton Medical Scholarship

Arizona Community Foundation
Private
United States
Unspecified amount

Arizona Community Foundation

For more than four decades, the Arizona Community Foundation has worked in tandem with generous individuals, families, and organizations to address some of the biggest challenges facing our state.

Scholarships

In partnership with our generous donors, we award millions of dollars annually to help students achieve their educational goals. Through our online system, students complete one application and are matched with available scholarships, based on their eligibility requirements.

Guinn B. Burton Medical Scholarship

Guinn B. Burton established this scholarship fund in her estate trust to provide medical scholarships for disadvantaged students. 

Education - Higher Education Nursing Medical Education & Professional Training

Irv and Irene Boersen Scholarship

Community Foundation Of The Holland Zeeland Area
Private
United States
Unspecified amount
The Irv and Irene Boersen Scholarship supports students from the Regional Synod of the Great Lakes pursuing a Master of Divinity at Western Theological Seminary. Applicants must demonstrate financial need, maintain a GPA of 3.0 or higher, and submit a FAFSA summary page. This renewable scholarship aims to cultivate future pastors and is awarded based on recommendations. It promotes educational access and community involvement, fostering a thriving environment in the Holland/Zeeland area.
Education - Higher Education Educational Access & Equity Religious / Theological Education

William B. and Bonnie Z. Swonger Nursing Scholarship

The Community Foundation of Shelby County
Private
United States
US $1,250

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

William B. and Bonnie Z. Swonger Nursing Scholarship

A Shelby County resident who is a graduate of any high school within Shelby County and is pursuing a Registered Nursing degree. 

Selection based upon:

  • Financial need and academic ability.

Awards

  • Four $1,250 scholarships available
Nursing Career / College Preparation

Clinical Investigator Career Development Award

Lymphoma Research Foundation
Private
Canada, United States
US $375,000
The Clinical Investigator Career Development Award offered by the Lymphoma Research Foundation aims to support early-career physician researchers in developing new lymphoma therapies. With a total funding of $375,000 over three years, the program provides salary support and incidental funds for research supplies and professional development. Eligible candidates must have no more than six years of experience post-training, focusing on clinical research design and implementation to enhance their skills and career trajectory.
Lymphoma

St. Baldrick’s Foundation Fellowship Award

St Baldricks Foundation Inc
Private
United States
Up to US $195,000
The St. Baldrick’s Foundation Fellowship Award supports pediatric oncology training through a two-year fellowship, with a potential third year based on need and achievements. This initiative, powered by community fundraising events, aims to advance research for childhood cancer cures. The award provides a salary capped at $97,500 per year, covering salary and benefits for fellows. This fellowship not only fosters professional growth but also contributes significantly to the fight against childhood cancers.
Pediatric Cancers

St. Baldrick’s Foundation Research Grant Award

St Baldricks Foundation Inc
Private
United States
Up to US $200,000
The St. Baldrick’s Foundation Research Grant Award supports innovative research aimed at curing childhood cancers. With funding of $100,000 per year for two years, this grant is designed for hypothesis-driven projects that can be laboratory, clinical, or epidemiological in nature. Established through community-driven fundraising events, the foundation empowers volunteers and donors to make a significant impact in the fight against cancer, ensuring a brighter future for young survivors.
Pediatric Cancers

Innovations in Alzheimer’s Caregiving Awards

Family Caregiver Alliance
Private
Alaska, Hawaii +1 more
US $20,000
The Innovations in Alzheimer’s Caregiving Awards, overseen by the Family Caregiver Alliance, recognize organizations that enhance support for family caregivers of individuals with Alzheimer’s disease. These awards highlight innovative approaches in three categories: Creative Expression, Increasing Access and Reducing Stigma, and Public Policy. Each award is valued at $20,000, and applicants must be non-profit organizations, government agencies, or universities operating within the U.S. that focus on the needs of unpaid caregivers.
Dementia & Alzheimer’s Disease

Gina M. Finzi Memorial Student Summer Fellowship Program

Lupus Foundation Of America Inc
Private
Canada, Mexico +1 more
US $4,000
The Gina M. Finzi Memorial Student Summer Fellowship Program, funded by the Lupus Foundation of America, aims to engage students in lupus research across various disciplines. Six awards of $4,000 each will be granted for projects spanning 10 weeks between May and September 2026. Eligible applicants include undergraduate and graduate/medical students, with specific allocation preferences. This initiative promotes valuable research experiences under the guidance of established faculty at accredited institutions.
Lupus

John W. and Yvonne Y. Hsu Edmisten Scholarship

San Luis Obispo County Community Foundation
Private
United States
Up to US $5,000
The John W. and Yvonne Y. Hsu Edmisten Scholarship, offered by the San Luis Obispo County Community Foundation, supports students pursuing Aeronautical Engineering or related fields. This scholarship is open to high school seniors, undergraduates, and returning students, providing essential financial assistance to help them achieve their educational and career aspirations. With a commitment to fostering diversity and inclusion, the foundation aims to empower local students to reach their full potential.
Education - Higher Education Education - High School Academic Scholarship Programs

Cystic Fibrosis Foundation: Postdoctoral Research Fellowship Award

Cystic Fibrosis Foundation
Private
United States
Up to US $151,000
The Cystic Fibrosis Foundation offers Postdoctoral Research Fellowship Awards to support research training in cystic fibrosis. The program provides up to $66,000 in salary support for the first year and $67,000 for the second year, along with $9,000 for research and travel expenses. Applicants focusing on CFTR protein function restoration or gene correction strategies are encouraged to apply. Open to U.S. citizens and residents, preference is given to recent graduates beginning their research careers.
Cystic Fibrosis

Julian Crocker Community Scholarship

San Luis Obispo County Community Foundation
Private
United States
Up to US $5,000

About Us

The Community Foundation San Luis Obispo County is a resource for local charitable giving. Created by and for the people of San Luis Obispo County, The Community Foundation is an enduring source of charitable funds to meet the changing needs and interests of the region. We envision San Luis Obispo County as an inclusive haven where everyone, regardless of background, feels free to fully participate. In collaboration with our community partners and donors, we seek to foster a safe, respectful environment with ample opportunity for all to reach their potential and contribute to the success of our community. We invite you to join us in celebrating diversity, making sure all of our neighbors feel seen, and free from dehumanizing rhetoric and violence, as we shape a future where all residents can flourish. 

2025-2026 Scholarship Applications

Big dreams start here! With support from generous individuals, families, and businesses, the Community Foundation offers scholarships that help San Luis Obispo County students reach new heights in their education and careers.

Julian Crocker Community Scholarship

This scholarship is in memory of Dr. Julian Crocker, former Superintendent of San Luis Obispo County Schools and longtime educator. Scholarship awards support student pursuing community.

Education - Higher Education Education - High School Academic Scholarship Programs

Frederic C. Collin Trust Grant

COLLIN FREDERIC C TUW
Private
United States
US $2,000 - US $3,800
The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.
Tennis Equestrian Sports

Justin McCutcheon Memorial Scholarship

San Luis Obispo County Community Foundation
Private
United States
Up to US $1,000
The Justin McCutcheon Memorial Scholarship, offered by the San Luis Obispo County Community Foundation, honors the memory of Justin McCutcheon by supporting high school seniors who are members of a Central Coast Athletic Association Golf Team. This scholarship aims to empower students in San Luis Obispo County to pursue their educational and career aspirations. Applications for the 2025-2026 scholarship cycle are now open, providing an opportunity for students to achieve their dreams.
Education - Higher Education Education - High School Academic Scholarship Programs

Cloutier-Valenti Legacy Scholarship

Delaware Community Foundation
Private
United States
US $1,000
The Cloutier-Valenti Legacy Scholarship, funded by the Delaware Community Foundation, offers a one-time award of $1,000 to graduating seniors from selected high schools in Delaware. Eligible students must enroll in an accredited institution, demonstrate financial need, and show involvement in community activities. The scholarship aims to support students pursuing degrees in science, contributing to the foundation's mission of enhancing educational opportunities and equity in the community.
Education - Higher Education Educational Access & Equity STEM / STEAM Education

The Anna Fuller Fund Grant

The Anna Fuller Fund
Association/Society
Countries
US $75,000 - US $150,000
The Anna Fuller Fund Grant provides year-round support for organizations dedicated to alleviating suffering caused by cancer. Established in memory of Egbert C. Fuller’s wife, the fund prioritizes applications that focus on cancer research and education initiatives. Eligible applicants must be 501(c)(3) organizations or equivalent charities outside the U.S. Grant funds cannot be used for direct treatment, ensuring that resources are allocated to research and public education.
Cancer / Oncology Preventative Healthcare

Kelly A. McAdams Scholarship

San Luis Obispo County Community Foundation
Private
United States
Up to US $10,000
The Kelly A. McAdams Scholarship, offered by the San Luis Obispo County Community Foundation, supports high school seniors, undergraduates, and returning students in their educational pursuits. Established in memory of Kelly A. McAdams, this scholarship aims to empower local students to achieve their academic and career goals. With a commitment to fostering diversity and inclusivity, the foundation encourages applicants from all backgrounds to apply for this opportunity in the 2025-2026 academic year.
Education - Higher Education Education - High School Academic Scholarship Programs

Lois and Duke Williams Memorial Scholarship

San Luis Obispo County Community Foundation
Private
United States
Up to US $2,500
The Lois and Duke Williams Memorial Scholarship, offered by the San Luis Obispo County Community Foundation, aims to support students who have faced challenges in their lives and wish to pursue post-secondary education. Open to high school seniors, undergraduates, and returning students, this scholarship represents a commitment to fostering educational opportunities for those who strive for success despite obstacles. Apply now to take your first step towards achieving your dreams!
Education - Higher Education Education - High School Academic Scholarship Programs

Manford and Maude Brown Medical Education Scholarship

San Luis Obispo County Community Foundation
Private
United States
Up to US $2,000
The Manford and Maude Brown Medical Education Scholarship, offered by the San Luis Obispo County Community Foundation, supports local residents pursuing degrees in medical or healthcare fields. Open to high school seniors, undergraduates, and returning students, this scholarship aims to empower aspiring healthcare professionals in achieving their educational goals. With a commitment to inclusivity and community support, it fosters a brighter future for students in San Luis Obispo County.
Education - Higher Education Education - High School Academic Scholarship Programs

Operating Grants for Nonprofits in South Dakota Highlights

Looking for operating grants for nonprofits in South Dakota?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in South Dakota recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in South Dakota

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ Operating grants for nonprofits in South Dakota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Operating grants for nonprofits in South Dakota over $25K in average grant size

23 Operating grants for nonprofits in South Dakota over $50K in average grant size

23 Operating grants for nonprofits in South Dakota supporting general operating expenses

91 Operating grants for nonprofits in South Dakota supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

2,000+ Grants on Instrumentl focused on Community Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in South Dakota?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in South Dakota?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in South Dakota year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in South Dakota given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Operating Grants for Nonprofits in South Dakota changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538