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Best Operating Grants for Nonprofits in South Dakota

Find the perfect Operating grants for nonprofits in South Dakota on Instrumentl. 9,000+ Operating grants for nonprofits in South Dakota in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,206 Results based on applied filters

Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) (356611)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $5,500,000
The Blueprint Neurotherapeutics Network (BPN) supports the development of biologic-based therapies for nervous system disorders. This initiative encourages innovative research in biologics, including proteins, antibodies, gene therapies, and cell therapies. The program facilitates collaboration with NIH-funded experts and contract research organizations, ensuring institutions retain IP rights for developed candidates. Key deadlines for grant applications span from January 2025 to July 2027, emphasizing the importance of timely submissions for interested applicants.
Pharmacology Neurological Diseases & Disorders

Lynne Sherwood Scholarship

Grand Haven Area Community Foundation
Private
United States
Unspecified amount
The Lynne Sherwood Scholarship, offered by the Grand Haven Area Community Foundation, aims to support local youth in achieving their educational aspirations. This competitive scholarship considers various factors including financial need and academic achievement. Applicants must reside in West Michigan and submit necessary documents such as transcripts and the Student Aid Report. Lynne Sherwood's legacy as a community leader and educator continues to inspire future generations through this scholarship opportunity.
Education - Higher Education Educational Access & Equity

All Kids Play: Youth Sports Grant - Organization

All Kids Play
Private
United States
Unspecified amount
The All Kids Play: Youth Sports Grant aims to support families and community-based organizations in low-income areas, ensuring access to recreational sports for children in grades K-12. This grant assists those who struggle to afford youth sports, providing essential funding on a first-come, first-served basis. Eligible organizations must demonstrate budget constraints and operate in areas with high low-income student percentages, promoting inclusivity in youth sports participation.
Youth Services Sports & Athletics Education - K through 12

Alice O. Rydell Interior Design Scholarship

Community Foundation Of The Holland Zeeland Area
Private
United States
Unspecified amount

Alice O. Rydell Interior Design Scholarship

Graduating senior or graduating early college student who attends public, private, or home school in the primary service area of the Community Foundation.

Education - Higher Education Design

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) (356925)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.
Integrative & Alternative Health Microbiomes

NAEMT Foundation Scholarships

National Association of Emergency Medical Technicians
Association/Society
United States
Up to US $1,000
The NAEMT Foundation Scholarships provide financial support for individuals pursuing careers in Emergency Medical Services (EMS). Scholarships are available for those seeking certification as Emergency Medical Responders (EMR) or Emergency Medical Technicians (EMT). Recipients must begin their educational programs in the awarded term and maintain good academic standing. Funds are paid directly to educational institutions. The foundation aims to strengthen the EMS profession through education and research funding.
Emergency Medical Care & Services First Responders

Extramural Discovery Science Accelerator Award

American Cancer Society
Association/Society
United States
Up to US $75,000
The Extramural Discovery Science Accelerator Award supports the commercialization of ongoing cancer research projects, focusing on experiments that facilitate technology validation and de-risking. Applications are accepted on a rolling basis, with a budget of up to $75,000 for one year. This award encourages independent investigators at any career stage to advance their technologies, with a strong emphasis on commercial viability and collaboration within a learning community.
Cancer / Oncology Medical Technology, Devices, and Equipment

USF: Youth Learn-to-Swim Grant

Usa Swimming Foundation
Private
United States
Unspecified amount
The USA Swimming Foundation's Youth Learn-to-Swim Grant aims to increase access to swim lessons for children across the nation. By providing funding to swim lesson programs, the foundation ensures that financial barriers do not prevent children from learning this vital life skill. Grants can be used for free or reduced-cost lessons, addressing the needs of underserved communities and promoting safety through swimming education.
Swimming Diversity, Equity & Inclusion

MG Eugene C. Renzi, USA (Ret.) STEM Teachers Scholarship

AFCEA
Association/Society
United States
US $2,500
The MG Eugene C. Renzi, USA (Ret.) STEM Teachers Scholarship, funded by AFCEA and ManTech International, offers $2,500 annually to support U.S. citizens or permanent residents pursuing graduate-level education in STEM teaching for grades K-12. This scholarship honors the legacy of Maj. Gen. Renzi and is aimed at candidates with a minimum GPA of 3.5 who are enrolled in accredited programs. It covers tuition and course-related expenses, fostering future educators in critical STEM fields.
Education - Higher Education Teacher Development & Training STEM / STEAM Education

Preserving Black Churches Grant Program

National Trust for Historic Preservation
Private
United States
US $50,000 - US $500,000
The Preserving Black Churches Grant Program, managed by the National Trust for Historic Preservation, aims to support the preservation of historic Black churches. Grants range from $50,000 to $500,000 and fund various projects, including restoration, capacity building, and community engagement. The program encourages applications from active and non-active congregations, nonprofits, and public agencies, emphasizing the importance of these churches in their communities. This initiative seeks to strengthen heritage and foster cultural connections.
Historic Preservation Black American Culture & Heritage

Louis S. and Nancy L. Rubinsky Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Louis S. and Nancy L. Rubinsky Scholarship

This scholarship has been made possible by the generosity of Nancy L. Rubinsky, who established the Louis S. and Nancy L. Rubinsky Scholarship of the Community Foundation for Muskegon County in honor of Louis. Lifelong residents of Muskegon, Nancy and Louis Rubinsky, had been active members of the Muskegon community. Louis was a fixture on Western Avenue as a salesman at Vets Clothing. Nancy was active at the Muskegon Community College, first, as an instructor of nursing, and, then, as a Board Trustee. Grants from the fund will mirror the Rubinsky's individual passions. In honor of Louis, the fund will support community education projects in the visual and performing arts and Nancy's interests will be expressed by supporting adult/returning students pursuing nursing degrees.

Nursing Adult Education

ASPCA Research Grants: Farm Animal Welfare Research

American Society for the Prevention of Cruelty to Animals (ASPCA)
Private
Canada, United States
Up to US $75,000

ASPCA PRO

ASPCApro.org provides tools and resources for animal welfare professionals, veterinary personnel and volunteers. We take a progressive approach to helping the country's at-risk animals, promoting cutting edge research to advance the field.

ASPCA Research Grants

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) research grants fund high-quality research with a clear potential to benefit animals, either directly or through effecting systems-level change. Proposals to extend existing studies, focused on other disciplines, will also be considered if they can clearly demonstrate substantial potential benefit to animal welfare.

This year we are soliciting proposals in the following six research areas:

  • Access to Veterinary Care (AVC) Research
  • Applied Behavior Research
  • Cruelty Research
  • Farm Animal Welfare Research
  • Psychological Trauma Research
  • Shelter Research

Proposals focused on evaluating the effectiveness of a program or service must demonstrate methodological rigor and a clear plan to produce generalizable scientific knowledge. Please view eligibility information for specific projects from the research area you are interested in. 

Farm Animal Welfare Research

Proposals exploring how farmers’ use of healthier, non-conventional broiler chicken breeds, intersects with the birds’ use of pasture, environmental outcomes, and/or chicken product nutritional content. Research may be conducted by farms or other businesses in addition to academic or research institutions. However, field studies must include an academic partner or follow established field trial protocols for design and data collection.

Livestock & Ranching Animal Welfare - Domestic Animals & Pets

ASPCA Research Grants: Applied Behavior Research

American Society for the Prevention of Cruelty to Animals (ASPCA)
Private
Canada, United States
Up to US $35,000

ASPCA PRO

ASPCApro.org provides tools and resources for animal welfare professionals, veterinary personnel and volunteers. We take a progressive approach to helping the country's at-risk animals, promoting cutting edge research to advance the field.

ASPCA Research Grants

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) research grants fund high-quality research with a clear potential to benefit animals, either directly or through effecting systems-level change. Proposals to extend existing studies, focused on other disciplines, will also be considered if they can clearly demonstrate substantial potential benefit to animal welfare.

This year we are soliciting proposals in the following six research areas:

  • Access to Veterinary Care (AVC) Research
  • Applied Behavior Research
  • Cruelty Research
  • Farm Animal Welfare Research
  • Psychological Trauma Research
  • Shelter Research

Proposals focused on evaluating the effectiveness of a program or service must demonstrate methodological rigor and a clear plan to produce generalizable scientific knowledge. Please view eligibility information for specific projects from the research area you are interested in. 

Applied Behavior Research

Proposals that inform the development, refinement, or validation of evidence-based shelter behavior protocols, or validation of applied shelter behavior research methodology. Proposed research must assess the impact of interventions for common behavior concerns in shelter populations that frequently lead to euthanasia of otherwise adoptable dogs and cats, such as excessive arousal, or validate methodologies to reliably assess behavior and/or welfare in the shelter environment. 

Proposals that include a shelter-researcher partnership aspect are especially encouraged. Examples include, but are not limited to, inclusion of both shelter and academic staff on the study team, the creation of a shelter-facing deliverable, an implementation prospectus that includes a feasibility assessment and identified partner shelter. 

Animal Welfare - Domestic Animals & Pets Animal Behavior (Ethology)

Louise M. Cryderman Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Louise M. Cryderman Scholarship

This scholarship has been made possible by the generosity of Louise M. Cryderman, who established the Louise M. Cryderman Scholarship of the Community Foundation for Muskegon County. Louise Cryderman was Muskegon's first legal assistant and active in many women's groups during her career. She worked for Stephen H. Clink, founder of the Community Foundation for Muskegon County and Landman, Latimer, Clink, and Robb law firm. She realized the importance and effectiveness of making a charitable gift that keeps on giving. Since she had no children and was a widow when she died in 1977, she left the bulk of her estate, including her house, to the Community Foundation. According to her wishes, this scholarship is to help worthy students with the cost of higher education.

Education - Higher Education Career / College Preparation

Leonard and Edna K. Blomdahl Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Leonard and Edna K. Blomdahl Scholarship

This scholarship has been made possible by the generosity of Edna Blomdahl, who established the Leonard and Edna K. Blomdahl Scholarship of the Community Foundation for Muskegon County. Through all their years together, both Leonard and Edna were known for their countless acts of hospitality, citizenship and service. Late in 1998, she established the fund, designating that it be used for scholarships to graduating seniors from the White Lake area of Muskegon County.

Education - Higher Education Career / College Preparation

Lewis and Eloise "Bud" Munz Memorial Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Lewis and Eloise "Bud" Munz Memorial Scholarship

This scholarship has been made possible by the generosity of the family of Lewis and Eloise "Bud" Munz, who established the Lewis and Eloise "Bud" Munz Memorial Scholarship of the Community Foundation for Muskegon County. Daughters Louise Munz Krill and Barbara Munz Peterman started this in their parents' memory to recognize an area student who wants to pursue an education while playing golf or tennis. Both graduates of University of Michigan, their parents, Lewie (an engineer) and Bud (a librarian) were avid golfers and tennis players. In fact, Lewie was the number one tennis player in college and ranked nationally. They were active members of the Muskegon Country Club and devoted to Muskegon.

Education - Higher Education Tennis

Leigh T. Prettyman Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Leigh T. Prettyman Scholarship

This scholarship has been made possible by the generosity of the friends and family of Leigh T. Prettyman, who established the Leigh T. Prettyman Scholarship of the Muskegon County Community Foundation . Leigh Prettyman was a prominent and successful insurance executive at Northwestern Mutual Life Insurance. Scholarships from this fund are awarded to worthy Muskegon students planning to attend a four- year college. This ensures that Leigh Prettyman's dedication to his community and its youth will endure through the lasting gift of education.

Education - Higher Education Career / College Preparation

Marie VanderVoort Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Marie VanderVoort Scholarship

This scholarship has been made possible by the generosity of Marie VanderVoort, who established the Marie VanderVoort Scholarship of the Community Foundation for Muskegon County. Marie VanderVoort was born in the Netherlands, came to the United States at age 14 and died in 1997 at the age of 100. Marie attended Hackley School of Nursing, graduating in their second class of students in 1922. She did private duty work at both Hackley and Mercy Hospitals until her retirement. She traveled extensively and loved exploring the diverse areas of the world. Marie enjoyed her family, particularly her nieces and nephews. One of her nieces, Maxine Hooper, as well as several others, encouraged her to leave a bequest to the Community Foundation to provide nursing scholarships in her name. 

Education - Higher Education Nursing

Mona Shores Optimist Club Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Mona Shores Optimist Club Scholarship

This scholarship has been made possible by the generosity of the members of the Mona Shores Optimist Club, who established the Mona Shores Optimist Club Scholarship of the Community Foundation for Muskegon County. The Mona Shores Optimist Club is committed to making a difference in the lives of others with the money that they raise! In 1994 this active service club established the Mona Shores Optimist Club Scholarship to benefit graduating seniors from Fruitport, Holton, Mona Shores, Montague, Muskegon Catholic, Muskegon Heights, Muskegon, North Muskegon, Oakridge, Orchard View, Ravenna, Reeths-Puffer, West Michigan Christian and Whitehall high schools. Three scholarships are awarded each year on a rotating basis between the 14 high schools. The Mona Shores Optimist Club is to be commended for spreading its good works all around Muskegon County. 

Education - Higher Education Career / College Preparation

Mary A. Eyke Nursing Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Mary A. Eyke Nursing Scholarship

This scholarship has been made possible by the generosity of Mary A. Eyke, who established the Mary A. Eyke Nursing Scholarship of the Community Foundation for Muskegon County. Mary A. Eyke has been described as friendly and independent, “a rock,” by her family, but Mary was more than that. She was a dedicated Registered Nurse and Director of Nursing who taught OB/GYN and pediatrics nursing at Mercy School of Nursing at Mercy General Health Partners for 30 years…and she was a philanthropist! At her death, after a life of 92 years, her wish was to establish the Mary A. Eyke Nursing Scholarship. Her passion was helping her students become good nurses. The Mary A. Eyke Nursing Scholarship will provide financial assistance to students who have dedicated themselves to the nursing profession Mary loved so very much.

Education - Higher Education Nursing

Merrie Schmiege 4-H Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Merrie Schmiege 4-H Scholarship

This scholarship has been made possible by the generosity of the family of Merrie Schmiege, who established the Merrie Schmiege Scholarship of the Community Foundation for Muskegon County. This scholarship has been established by Maxine and Don Schmiege in memory of their daughter, Merrie, who died in a tragic automobile accident. Merrie was an active member of 4-H, received many local and state equestrian awards, taught horseback riding, and owned many horses. On account of her enthusiasm for equestrian activities and the programs of 4-H, Mr. and Mrs. Schmiege chose to create a Scholarship that provides financial support to young men and women who actively participate in these excellent programs. To the credit of the Schmiege's, Merrie's zeal and love of life will endure through the lasting gift of education.

Education - Higher Education Youth Development & Leadership

The Andy Warhol Foundation- Arts Writers Grant

Andy Warhol Foundation for the Visual Arts
Private
United States
US $15,000 - US $50,000
The Andy Warhol Foundation's Arts Writers Grant supports writers engaging with contemporary visual art through various formats, including articles, books, and short-form writing. Grants range from $15,000 to $50,000, catering to both emerging and established writers. Eligible applicants must be individuals over 25, U.S. citizens or residents, and published authors. This initiative encourages critical discourse and interdisciplinary approaches in arts writing, particularly related to post-World War II visual art and its diverse contexts.
Performing Arts Visual Arts Art History

John Jurkas Law Enforcement Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

John Jurkas Law Enforcement Scholarship

This scholarship has been made possible by the generosity of the family and friends of John Jurkas, who established the John Jurkas Law Enforcement Scholarship of the Community Foundation for Muskegon County. John Jurkas served the City of Muskegon Police Department for 34 years, during which he established the reputation as a detective with the shrewd ability to solve crime. Mr. Jurkas completed his distinguished career as investigator for the Muskegon County Prosecutor. Following his death in 1991, family and friends established this to assist young people who wish to continue this tradition of excellence in law enforcement. The fund provides awards to Muskegon County students pursuing careers in law enforcement. These scholarships ensure that John Jurkas will continue to promote excellence in the field of law enforcement through the lasting gift of education.

Education - Higher Education Police & Law Enforcement

ASH Medical Student Physician-Scientist Award

American Society of Hematology Inc
Private
Canada, Mexico +1 more
US $42,000
The ASH Medical Student Physician-Scientist Award offers first-, second-, and third-year medical students a unique chance to engage in hematology research under the mentorship of an ASH member. This year-long project requires recipients to dedicate over 80% of their time to research, with funding totaling $42,000 for various expenses. Eligible candidates must be ASH members and actively enrolled in accredited medical programs in the U.S. or Canada, aiming for a career in hematology.
Hematological Systems Medical Education & Professional Training

ASH Graduate Hematology Award

American Society of Hematology Inc
Private
Canada, Mexico +1 more
US $80,000
The ASH Graduate Hematology Award supports graduate students in the U.S. and Canada pursuing research in hematology. Offering a $40,000 annual stipend for two years, it covers tuition, research expenses, and travel to the ASH Annual Meeting. Eligible applicants must be PhD students in their first three years and have a mentor's support. This award aims to foster careers in academic hematology, encouraging innovative research in various hematologic fields.
Hematological Systems Medical Education & Professional Training

ASH Medical Educators Institute Grant Program

American Society of Hematology Inc
Private
Canada, United States
Unspecified amount in in-kind support
The ASH Medical Educators Institute Grant Program aims to cultivate future leaders in hematology education through a comprehensive training initiative. This program includes workshops, webinars, and mentorship, designed for junior faculty and senior fellows in the U.S. and Canada. Participants enhance their teaching skills, develop scholarly projects, and build valuable professional networks. The initiative promotes diversity in medical education and seeks to empower educators dedicated to advancing the field of hematology.
Hematological Systems Medical Education & Professional Training

Darrell H. and Rosaline M. Smith Scholarship

Community Foundation for Muskegon County
Private
United States
Unspecified amount

Community Foundation for Muskegon County

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Scholarships

Our scholarship funds seek to empower and encourage Muskegon County residents to pursue their dreams, hone in their gifts, and give back to our community.

If you’re a high school or homeschooled senior, current college student, early college senior, or adult learner, the Community Foundation for Muskegon County may have a scholarship for you. We manage one of the largest scholarship programs in our area, with over $1 million committed to students in over 500 new and renewed scholarships awarded each year.

Darrell H. and Rosaline M. Smith Scholarship

This scholarship has been made possible by the generosity of Rosaline M. Smith, who established the Darrell H. and Rosaline M. Smith Scholarship of the Community Foundation for Muskegon County. Rosaline a former Treasurer for the City of Muskegon, and Darrell Smith, a longtime employee of the Muskegon Post Office, who cared deeply for each other and shared more than 50 years of marriage. Music was something they loved and had very much in common. The Darrell H. and Rosaline M. Smith scholarship was created to honor Darrell, who is no longer with us, and to provide a helping hand to graduating seniors of any Muskegon County high school who have demonstrated academic achievement and will pursue a music degree.

Education - Higher Education Music Education

Operating Grants for Nonprofits in South Dakota Highlights

Looking for operating grants for nonprofits in South Dakota?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in South Dakota recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in South Dakota

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ Operating grants for nonprofits in South Dakota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Operating grants for nonprofits in South Dakota over $25K in average grant size

23 Operating grants for nonprofits in South Dakota over $50K in average grant size

23 Operating grants for nonprofits in South Dakota supporting general operating expenses

91 Operating grants for nonprofits in South Dakota supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

2,000+ Grants on Instrumentl focused on Community Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in South Dakota?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in South Dakota?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in South Dakota year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in South Dakota given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Operating Grants for Nonprofits in South Dakota changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538