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Best Operating Grants for Nonprofits in South Dakota

Find the perfect Operating grants for nonprofits in South Dakota on Instrumentl. 9,000+ Operating grants for nonprofits in South Dakota in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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9,206 Results based on applied filters

Cheerful Giver Scholarship

Community Foundation of the Central Blue Ridge
Private
United States
Unspecified amount
The Cheerful Giver Scholarship, provided by the Community Foundation of the Central Blue Ridge, offers over $300,000 in financial support to students in the Greater Augusta County area pursuing health care-related education. This need-based scholarship is open to high school seniors, current college students, and adult learners, with a preference for those entering the nursing profession. The foundation aims to enhance community well-being through educational opportunities.
Education - Higher Education Educational Access & Equity Nursing +3 more

Emergency/Medical Workers Behavioral Health Fund

Healthwell Foundation
Private
United States
Up to US $2,000
The Emergency/Medical Workers Behavioral Health Fund aims to support emergency workers facing trauma and anxiety due to their roles. Established by the HealthWell Foundation, it provides financial assistance for treatment-related costs, including copayments for prescription drugs, counseling, and transportation. In 2024, the Foundation awarded over $1.2 billion to underinsured patients, ensuring no one is denied essential healthcare due to financial barriers. This initiative helps address the critical mental health needs of those who serve on the front lines.
Crisis Intervention Emergency Medical Care & Services Public Transportation & Mass Transit Systems +4 more

Arthur N. Rupe Foundation Grant

Arthur N Rupe Foundation
Private
United States
Unspecified amount
The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.
Home Health Care Public Policy Nursing +3 more

Wildlife Annual Grants - Established Investigator ( Avian/Fish/Invertebrates)

Morris Animal Foundation
Private
Afghanistan, Algeria +166 more
Approximately US $100,000
Morris Animal Foundation invites Established Investigators to submit pre-proposals for research focused on reptile and amphibian health. This initiative emphasizes the importance of animal health and welfare while facilitating impactful conservation efforts. Proposals must demonstrate clear animal health needs, collaborative strategies, and potential benefits to wildlife populations. Funding for these projects is anticipated to average around $100,000 over a maximum duration of 36 months, fostering innovative solutions for pressing health challenges in these species.
Herpetology Wildlife Health

Wildlife Health (Reptile and Amphibian) - First Award

Morris Animal Foundation
Private
Afghanistan, Algeria +166 more
Up to US $120,000
The Morris Animal Foundation invites research pre-proposals for the Wildlife Health (Reptile and Amphibian) - First Award, aimed at enhancing the health and welfare of amphibians and reptiles. This initiative focuses on impactful research, particularly in chytrid disease. Eligible applicants include early career researchers with appropriate qualifications and a clear understanding of animal health challenges. Projects should demonstrate collaboration with relevant stakeholders and provide direct benefits to wildlife populations, emphasizing conservation through an animal health perspective.
Herpetology Wildlife Health

Wildlife Health (Reptile and Amphibian) - Pilot Study Awards

Morris Animal Foundation
Private
Afghanistan, Algeria +166 more
Up to US $20,000
The Morris Animal Foundation is offering Pilot Study Awards focused on reptile and amphibian health and welfare, particularly for chytrid research. These awards aim to fund innovative, proof-of-concept studies that demonstrate a clear understanding of animal health issues and collaboration with stakeholders. Proposals must have a direct impact on wildlife populations and adhere to strict health study policies. The maximum funding is $20,000 for a duration of 12 months, ensuring significant contributions to wildlife health advancements.
Herpetology Wildlife Health

Pierce's Disease & Glassy-winged Sharpshooter Board Research & Outreach Grants

California Department of Food & Agriculture
State/Local Government
United States
US $4,300 - US $383,000
The Pierce's Disease and Glassy-winged Sharpshooter Board offers grants to support research and outreach aimed at safeguarding California vineyards from serious pests and diseases. Prior funding has varied from $4,300 to $383,000, with projects typically lasting one to three years. Emphasis is placed on solutions that effectively address pest issues, encouraging multi-disciplinary teams to enhance the impact of their work on winegrape health.
Agricultural Pest Management Entomology Plant Pathology +1 more

Highland Orchestra Scholarship

Legacy Foundation: Lake County's Community Foundation
Private
United States
US $500

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Highland Orchestra Scholarship

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

Symphony / Orchestra Education - Higher Education Education - High School +1 more

Sustainable Forests and Communities Grant

Weyerhaeuser Family Foundation
Private
United States
Up to US $50,000
The Sustainable Forests and Communities Grant aims to foster environmentally and economically sustainable forest communities in the U.S., particularly where the Weyerhaeuser Family has interests. It prioritizes projects enhancing the environment, economy, and community through sustainable practices. Eligible organizations must be 501(c)(3) tax-exempt entities operating in forested areas, focusing on integrated approaches that value forest ecosystem services. This initiative encourages local job creation, sustainable economic activities, and innovative partnerships to achieve sustainability goals.
Forestry Environmental Conservation Ecology +1 more

Confluence Program Grants

Conservation Alliance
Private
Canada, United States
US $140,000
The Confluence Grant Program, initiated by the Conservation Alliance in 2021, aims to strengthen partnerships with historically racially excluded groups. It awards four grants of $100,000 over two years to support projects that protect or restore natural places. The program emphasizes building meaningful relationships and sharing resources, ensuring that funded projects center on solutions led by impacted communities. By fostering collaboration and addressing funding gaps, the program enhances the conservation landscape for diverse voices.
Environmental Justice & Advocacy Environmental Conservation Asian / Pacific Island Culture & Heritage +3 more

J.R. Simplot Company Foundation Grant

J R Simplot Company Foundation Inc
Private
Arkansas, California +8 more
Unspecified amount
The J.R. Simplot Company Foundation Grant supports U.S. non-profit organizations focused on art, education, youth, community, and global food and agriculture. Established in 1929, the foundation is committed to enhancing community welfare through creative cultural endeavors, educational initiatives, health services, and youth programs. Applications are reviewed quarterly, ensuring a timely response to organizations dedicated to making a positive impact in their communities.
Performing Arts Visual Arts Education - Higher Education +5 more

Paul L. Busch Award

Water Research Foundation
Private
United States
Up to US $100,000
The Paul L. Busch Award, provided by the Water Research Foundation, honors individuals for innovative research in water quality. This prestigious award supports promising researchers with a $100,000 grant to advance their work. The selection process is inclusive, with no restrictions based on race, gender, or nationality, and encourages applications from diverse candidates. Recipients are expected to collaborate with U.S.-based organizations, fostering practical applications of their research in the water environment.
Sanitation & Clean Drinking Water Water Resource Management Freshwater Conservation

GLS Campus Suicide Prevention (363809)

Substance Abuse and Mental Health Services Adminis
Federal Government
United States
Unspecified amount
The GLS Campus Suicide Prevention program aims to enhance behavioral health services for college students, addressing critical issues such as suicide, depression, and substance use disorders. By fostering a culture of help-seeking and reducing stigma, this initiative ensures that at-risk students receive timely intervention and support. The program represents a vital investment in the mental well-being of students, promoting a healthier campus environment through evidence-based strategies and comprehensive public health approaches.
Mental Health & Psychiatric Diseases Addiction & Substance Use Disorders Health Care Access & Delivery +1 more

Jeanette Zaichkin NRP Nursing Grant for Excellence and Innovation in NRP Education

American Academy Of Pediatrics
Private
Canada, United States
Up to US $10,000
The Jeanette Zaichkin NRP Nursing Grant for Excellence and Innovation in NRP Education supports nurses dedicated to enhancing neonatal resuscitation training. This grant, offered by the American Academy of Pediatrics, provides up to $10,000 for innovative projects addressing key gaps in transitional physiology and evidence-based practices. Eligible applicants must be current NRP Instructors and work in neonatal care settings. The initiative aims to empower nurses in teaching essential skills for successful newborn resuscitation.
Nursing Obstetrics & Neonatal Care Medical Education & Professional Training +1 more

Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $30,000,000
The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.
Infectious & Parasitic Diseases HIV / AIDS Chronic Illnesses

Thoma Foundation Special Project Funding Grant

Carl And Marilynn Thoma Foundation
Private
United States
Unspecified amount
The Carl and Marilynn Thoma Foundation offers Special Project Funding to support innovative initiatives in the arts, particularly in under-resourced areas. This grant encourages collaborative projects that enhance community engagement and education, focusing on art exhibitions and scholarships in the greater Texas Panhandle. By fostering leadership and creativity, the Foundation aims to empower individuals and organizations to make a lasting impact in the fields of art and art history.
Fine Art Visual Arts Art Education +7 more

Rapid Impact Research Award

American Heart Association
Association/Society
United States
Up to US $100,000

Over our more than 100-year history, we've been fighting heart disease and stroke, striving to save and improve lives.

Our Mission

To be a relentless force for a world of longer, healthier lives.

Rapid Impact Research Award

Purpose

The American Heart Association continuously seeks innovative ideas to address the most pressing issues impacting cardiovascular and brain health. To that end, the Association is pleased to announce the Rapid Impact Research Award program, which will support early and mid-career investigators proposing innovative research that aligns with the Association’s mission. Novel basic, clinical and/or population health proposals are invited in the following three priority areas of research.

  • Sudden cardiac arrest/resuscitation science
  • Cardiovascular Kidney Metabolic Syndrome
  • Stroke and/or vascular dementia

Applicants will be asked to indicate alignment of their proposal with one or more of the topic areas listed above. 

Cardiovascular Diseases & Systems Neurological Diseases & Disorders Stroke +1 more

Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation

Ducks Unlimited
Private
North America
Up to C $5,000
The Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation honors the legacy of Dr. Bruce Batt, a leading figure in waterfowl research. This fellowship offers up to $5,000 annually to graduate students at North American universities conducting vital research on waterfowl and wetlands. Renewable for up to two additional years for PhD students, the fellowship promotes the integration of sound science in conservation efforts, supporting the next generation of waterfowl professionals.
Ecology Ornithology Limnology +1 more

Therapeutic Giving: Cardiovascular & Metabolism: Local & Regional Organizations

Johnson & Johnson Innovative Medicine
Corporate
United States
Unspecified amount
The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on supporting nonprofit organizations that enhance patient access to treatment in cardiovascular and metabolic health. Applications are encouraged for initiatives that promote education, empower patients, and address healthcare disparities. Eligible organizations must be IRS 501(c)(3) certified, with a preference for programs demonstrating measurable outcomes. The funding period for local organizations extends from January to October 15th, while national organizations can apply in September.
Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases Health Disparities & Social Determinants of Health +3 more

Therapeutic Giving: Cardiovascular & Metabolism: National Organizations

Johnson & Johnson Innovative Medicine
Corporate
United States
Unspecified amount
The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.
Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases Health Care Access & Delivery +3 more

AAAAI Distinguished Layperson Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Distinguished Layperson Award recognizes non-medical citizens for their significant contributions to the field of allergy, asthma, and immunology. Established by the American Academy of Allergy, Asthma & Immunology (AAAAI), this annual award honors individuals who have promoted public education, supported research, and influenced positive change in legislation related to allergies. This acknowledgment reflects the growing importance of citizen volunteers in advancing the specialty and improving patient care.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

AAAAI Distinguished Clinician Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Distinguished Clinician Award honors individuals with a significant impact on allergy, asthma, and immunology. Recognizing those dedicated to patient care and clinical research, the award emphasizes excellence in diagnosing and treating allergic diseases. Recipients are selected based on their extensive clinical research and contributions to the field, including published works and presentations at national and international meetings. This prestigious recognition reflects the important role of clinicians in advancing allergy and immunology practices.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

AAAAI Allied Health Recognition Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The AAAAI Allied Health Recognition Award honors non-physician members who have significantly contributed to allergy and immunology education or research. As part of the American Academy of Allergy, Asthma & Immunology, this award emphasizes the importance of allied health professionals in advancing patient care. Eligible recipients include AAAAI Allied Health members who demonstrate excellence in their field, ensuring that contributions to the specialty are recognized and celebrated.
Immune System Diseases Asthma Allergies & Allergic Diseases +1 more

ANR Foundation - Postdoctoral Physician Scientist Fellowship

Arthritis National Research Foundation
Private
United States
Up to US $50,000
The ANR Foundation Postdoctoral Fellowship offers financial support to researchers focusing on arthritis and related autoimmune diseases. This initiative aims to cultivate future leaders in the field by providing fellowships that foster innovative research and exceptional training opportunities. Open to various research areas, including osteoarthritis and lupus, the fellowship seeks to empower physicians to advance their work and make impactful contributions to understanding these conditions.
Immune System Diseases Arthritis Musculoskeletal Diseases +1 more

Bay Area Lyme Foundation Grant

Bay Area Lyme Foundation
Private
United States
Unspecified amount
The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.
Acarology Lyme Disease

Foam Recycling Coalition Grant Program

Foam Recycling Coalition
Association/Society
Canada, United States
Unspecified amount

About Foam Recycling

The process to recycle foam is like that of other recyclables. In the case of foam products, a special compactor – called a “densifier” – may be used in the processing of the material. Foam products are over 90% air, so densifying it allows the material to be transported more cost-effectively. To give you an example, a 48-foot truckload of baled foam polystyrene weighs only around 16,000 pounds, whereas a truckload of densified foam polystyrene weighs 40,000 pounds.

Innovative alternatives are being developed and deployed that are categorized as chemical recycling (vs. mechanical recycling). This will take the plastic resin back to its base state – in the case of foam PS, back to a styrene monomer. With chemical recycling, increased organic contamination will only impact the amount of foam for recovery (yield), but will not impact the recyclability of the plastic.

Foam Recycling Coalition Grant Program

Funding Source: Funding for the grant program comes from contributions from members of the Foam Recycling Coalition, a special interest group of the Foodservice Packaging Institute.

Grant Amounts: Funding amounts will be made on a case-by-case basis and will be dependent on equipment needs. The maximum amount per grant is $50,000.

Cash Match: No cash match is required, but additional costs by the grantee may be incurred for related items such as site preparation, provision of conveying system and electrical infrastructure, freight, and other installation costs.

Waste Management Recycling

Operating Grants for Nonprofits in South Dakota Highlights

Looking for operating grants for nonprofits in South Dakota?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in South Dakota recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in South Dakota

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ Operating grants for nonprofits in South Dakota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 Operating grants for nonprofits in South Dakota over $25K in average grant size

23 Operating grants for nonprofits in South Dakota over $50K in average grant size

23 Operating grants for nonprofits in South Dakota supporting general operating expenses

91 Operating grants for nonprofits in South Dakota supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

2,000+ Grants on Instrumentl focused on Community Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in South Dakota?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in South Dakota?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in South Dakota year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in South Dakota given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Operating Grants for Nonprofits in South Dakota changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538