Best Small Grants for Nonprofits in South Dakota

The Older Adults Home Modification Grant Program aims to assist nonprofit organizations, governments, and housing authorities in making essential modifications to homes for low-income seniors. By focusing on safety and accessibility, the program seeks to reduce fall risks, enhance general safety, and improve seniors' ability to live independently. This initiative promotes aging in place, allowing seniors to remain in their homes rather than transition to nursing facilities, thereby fostering a sense of community and well-being.

The Mech SS Carl C. Smith Graduate Student Award, established by the Society of Toxicology, honors Carl C. Smith's commitment to advancing graduate education in toxicology. This prestigious award encourages graduate students to submit outstanding abstracts for the 2026 SOT Annual Meeting. Eligible applicants must be graduate student members of SOT and PhD candidates who have passed their comprehensive exams. The award promotes diversity and inclusiveness in the field while recognizing exceptional contributions to toxicology.

The Family Unification Program (FUP) aims to assist families and youth at risk of homelessness by providing Housing Choice Voucher (HCV) assistance. It targets families facing housing issues that could lead to out-of-home placement for children and youth aged 18-24 who have aged out of foster care. The program offers flexible voucher durations, with extensions available under specific conditions, ensuring support for those in need of stable housing.

The Nick Andros Music Scholarship, established by the family and friends of Nick Andros, honors his passion for music and positive inspiration. This scholarship seeks to support students who demonstrate Nick's spirit through their dedication to the arts. Eligible candidates must be high school seniors from Saginaw County with a minimum GPA of 2.0, pursuing an undergraduate degree. Applicants are required to submit an MP3 of their work, showcasing their musical talents.

The DoW Toxic Exposures Investigator Initiated Research Award aims to fund critical studies addressing diseases linked to military-related toxic exposures. This award supports a wide range of research phases, from basic laboratory investigations to translational research involving both animal models and human subjects. Projects may also explore New Approach Methodologies, enhancing our understanding and treatment options for affected individuals. By facilitating innovative research, this initiative seeks to improve patient care and outcomes.

The FY26 Toxic Exposures Research Program (TERP) Clinical Trial Award supports clinical trials aimed at addressing health issues from military-related toxic exposures. This initiative encourages collaboration through a Partnering Principal Investigator Option, enhancing interdisciplinary research efforts. Projects range from early-phase trials to large-scale studies, focusing on innovative treatments and management strategies for affected populations. The goal is to expedite the translation of research findings into effective clinical applications.

The DoW Toxic Exposures Translational Research Award aims to foster translational research that bridges military-related toxic exposure studies and clinical applications. This program encourages innovative collaborations by allowing for a Partnering Principal Investigator Option, enhancing interdisciplinary partnerships. By integrating basic science with clinical insights, the initiative seeks to expedite the development of impactful health care products and interventions to address toxic exposures faced by military personnel.

The Mech SS Sheldon D. Murphy Student and Postdoctoral Endowment Award, established by the Society of Toxicology, honors the legacy of Dr. Sheldon D. Murphy, a pioneer in toxicology. This award supports PhD candidates and postdoctoral trainees who demonstrate excellence in mechanistic toxicology. Nominees are selected based on the scientific quality of their abstracts, ensuring a focus on impactful research. This initiative fosters the next generation of toxicologists dedicated to advancing human and environmental health.

The Juan Diego Guadiana Legacy Foundation Scholarship supports students from Las Cruces High School or Doña Ana County, especially those affected by cancer treatment or pursuing health-related fields. This scholarship is open to various backgrounds, including BiPOC and LGBTQIA+ communities. The foundation aims to empower students at different educational stages, ensuring they have the resources necessary to thrive in their academic and professional journeys.

About Alex’s Lemonade Stand Foundation

Alex's Lemonade Stand Foundation (ALSF) emerged from the front yard lemonade stand of 4- year-old Alexandra “Alex” Scott, who was fighting cancer and wanted to raise money to find cures for all children with cancer. Her spirit and determination inspired others to support her cause, and when she passed away at the age of 8, she had raised $1 million. Since then, the Foundation bearing her name has evolved into a national fundraising movement. Today, ALSF is one of the leading funders of pediatric cancer research in the U.S. and Canada, funding research projects and providing programs to families affected by childhood cancer. ALSF is one of the only childhood cancer research organizations that has been given the NCI peer-reviewed funder designation for rigorous selection of research grants. The mission of ALSF is to change the lives of children with cancer through funding impactful research, raising awareness, supporting families, and empowering everyone to help cure childhood cancer.

Bio-Therapeutic Impact Award

The Bio-Therapeutic Impact Award accelerates the development of clinical trials for promising biologic approaches to treating childhood cancer. These approaches include, but are not limited to, immunotherapy, gene therapy and small molecules. The award, intended for investigators who are initiating clinical trials, totals the maximum of $1.8 million awarded over three years.

The IEN-WMAN Mini-Grant Program provides crucial financial support to Indigenous communities and grassroots organizations impacted by mining in the U.S. and Canada. With over $200,000 distributed annually in $4,000 grants, the program aims to address mining-related environmental and health issues. Priority is given to proposals that demonstrate a direct impact on affected communities, particularly Indigenous-led initiatives, ensuring that financial assistance is directed where it is most needed.

Samsung Solve For Tomorrow

The Samsung Solve for Tomorrow competition asks students to consider how science, technology, engineering, and math (STEM) can be used to create change in their communities. With the help of their teachers, students compete to win up to $100,000 in prizes for their school, plus the opportunity to work with Samsung employees to develop their innovations. 

Guidelines

Your teacher will apply on behalf of your team by answering these five questions, each in 1,000 characters or less.

• Describe the community challenge or issue you are planning to tackle.
• How will STEM be applied to address this challenge or issue?
• What is the anticipated impact to your local community?
• What activities will you put in place to achieve your goals?
• How will you define and measure success?

Your solution may go through many iterations as you test and refine the idea, but the problem you are solving should remain the same throughout the competition. .

Once your teacher submits your team’s application, the fun begins! Get to work building your solution, gathering data, and iterating as you go. 

Helpful Tips

• Choose a problem that you and your classmates are truly passionate about solving.
• Pick a topic that's manageable for your team and realistic to execute within the bounds of the competition. Feasibility is included in the judges’ scoring rubric.
• Consider the audience you are developing a solution for and get their input as you work.
• Leverage your local community. See if you can connect with your town government or other leaders in your area to get them invested in and excited about your project.
• Remember to back up any claims with facts and statistics.

Reasons to get involved

• Prizes for your school range from $1,000 all the way up to $100,000.
• Community recognition: Samsung Solve for Tomorrow participants and winners are frequently featured in the local news.
• Build crucial skills in areas like public speaking, critical thinking, and entrepreneurship.
• Collaborate with your peers on a project you feel passionate about.
• Help your community become a better place with your innovative thinking.
• Through the Solve for Tomorrow competition, educators can teach Problem-Based Learning (PBL) by challenging students to find solutions in their communities. 

In 2020, GradGuard founded College Life Protected, LLC as a social purpose entity that supports programs, research, professional development, and best practices in higher education that promote greater confidence in the value of higher education as a public good. 

College Life Protected invites the higher education community to apply for grants that are consistent with our mission.

Promoting Financial Literacy

College Life Protected recognizes that that financial literacy is a critical skill for student success, impacting everything from academic persistence to long-term financial well-being. That’s why we are committed to funding programs and initiatives that equip students with the knowledge and resources they need to make informed financial decisions.

By supporting programs that enhance financial education, we aim to empower students to navigate college costs, manage personal finances, and build a strong financial future.

About

Mission, Vision & Values

To enhance our community through philanthropy.

We aspire to co-create diverse, meaningful and innovative charitable giving that yields an exponential positive impact within local communities and beyond.

Coopey Boys’ Memorial Fund

About the fund

The Coopey Boys, Raymond Peter and Lauritz Martin, were born with hemophilia, a genetic disorder that impairs the body’s ability to make blood clots. Sadly, they both died at an early age. The Coopey Boys’ Memorial Fund benefits Corvallis students who suffer from a physical handicap or serious chronic health problem.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The FY26 Kidney Cancer Research Program's Idea Development Award supports innovative research that enhances understanding of kidney cancer, aimed at improving patient outcomes. Proposals should feature a strong hypothesis and a detailed research plan, with team members experienced in kidney cancer research. A unique aspect is the Partnering Principal Investigator option, fostering collaboration between two investigators, ensuring comprehensive project development while allowing for distinct submissions. This award emphasizes impactful partnerships to drive advancements in the field.

The DoW Kidney Cancer Early-Career Scholar Award is a unique initiative by the Academy of Kidney Cancer Investigators, established in FY19. It aims to foster innovative kidney cancer research through a mentoring program that pairs early-career scholars with experienced mentors. This program not only enhances research capabilities but also builds a robust network of kidney cancer researchers. By supporting promising scholars, the initiative aspires to advance the field and improve treatment outcomes for kidney cancer patients.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

Angel Post Deployment Test Program

Through a collaborative partnership with UNCF, XYZ Corporation has established a scholarship program to help STEM students get on the fast track to a rewarding career. In addition to direct financial support, Intel-sponsored scholarships offer the benefits of exposure to potential job opportunities, networking with fellow scholars, insight to other Intel scholarships, research, training opportunities, and access to Intel mentors offering support on technical, non-technical, cultural, and dissertation-related needs.

The John and Polly Sparks Early Career Grant, offered by the American Psychological Foundation, supports early career psychologists focused on research and intervention for serious emotional disturbances in children. This grant empowers researchers to develop scientifically-backed treatments that can be implemented broadly across the country, encouraging diverse applicants with a commitment to improving mental health outcomes for affected youth.

The Remsberg-Trout Scholarship Fund supports local students pursuing STEM degrees. One scholarship assists a senior from Williamsport High School, while two additional scholarships are available for graduates from other Washington County public high schools. All applicants must be members of the National Honor Society. This initiative, part of the Community Foundation of Washington County, MD, aims to foster educational opportunities and enhance the community's future.

The Ryan Myers Memorial Scholarship Fund, established by the Community Foundation of Washington County, MD, supports graduating seniors from various educational backgrounds in Washington County. This scholarship honors Ryan Myers' legacy, encouraging students pursuing higher education, trade schools, or apprenticeships. Ideal candidates reflect Ryan's positive spirit and aspirations, aiming to make a meaningful impact in their communities while achieving their academic and career goals.

The Polly W. Roesch Vocal Music Scholarship, established by the Community Foundation for the Land of Lincoln, supports graduating seniors from Sangamon County pursuing degrees in vocal music and performing arts. This scholarship reflects the foundation's commitment to enhancing educational opportunities in the region. Eligible candidates include high school seniors and college students who are direct descendants of U.S. Service Members residing in specific Illinois counties. This initiative aims to foster talent in the arts and provide financial assistance to deserving students.

The Great Lakes Bay Pride Scholarship, offered by the Saginaw Community Foundation, supports Michigan residents dedicated to promoting respect and acceptance across diverse backgrounds. This scholarship is open to high school seniors and college students pursuing undergraduate or Career and Technical Education (CTE) programs, with awards ranging from $500 to $4,000. Eligible applicants must maintain a minimum GPA of 2.5 and demonstrate commitment through volunteer work in the LGBTQ+ community.

The Holland Scholarship, established in honor of Merle Holland Leis Frenzel, aims to support aspiring music students from Saginaw County. Funded by her friends and former students, this scholarship encourages recipients to pursue their musical dreams while honoring the support of her parents, Norton and Virginia Holland. Eligible applicants must maintain a minimum 3.0 GPA, be seniors at Saginaw County public high schools, and be involved in music programs. Awards typically range from $500 to $4,000.

Improving Metastatic Prostate Cancer (mPCa) Care Through Innovative Strategies

The National Comprehensive Cancer Network® and Pfizer Global Medical Grants (Pfizer) are collaborating to offer a new grant opportunity seeking proposals for investigator-initiated research to improve mPCa care. Pfizer (hereafter, “Grantor”) is providing $1 Million in funding to support quality improvement studies to advance health care quality, the delivery of quality care, and improve health care provider performance in mPCa care. The Grantor will serve as the funding organization. Grants are available to all investigators from institutions within the United States. 

Aim

To promote the advancement of scientific knowledge, health care provider performance, and/or health care quality improvement focused on improving mPCa care.

A total of $1 Million is available to fund all projects. The intent is to fund 2-5 studies. There is a funding cap of $250,000 per study. Exceptional studies with budgets above this amount will be considered based on scientific merit and must contain a robust justification. All budgets must include line-item information and robust justification.