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Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Scholar Awards

Objectives

There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

Award Description

The MGNet Scholar Program provides mentored research training to prepare Scholars for an independent research career in the field of MG. The MGNet Scholar Program is 1 year in duration and selected Scholars receive up to $100,000 to support salary, research costs and didactics with potential for renewal. The program will provide an additional $3,000 to travel to MGNet sites to learn specific skills and/or to scientific meeting(s) to present the results of their research. If available for renewal, the program requires approval after interim report and is contingent on demonstration of adequate progress on the research and career development plan. Indirect costs are not allowed. Scholars are encouraged to transition to NIH (e.g., K award), departmental, or private foundation support for their research and further career development.Research must constitute at least 50% of each Scholar’s professional effort. Each Scholar must form a 2-3-member advisory committee to include a primary mentor, an additional clinician investigator or collaborator, and a MGNet faculty sponsor. The advisory committee will meet with the Scholar at least quarterly to review progress and each Scholar will develop an individual academic career development plan and renew it with the committee at least every 6 months.

The Michael Aurbach Fellowship for Excellence in Visual Art, awarded by the College Art Association, supports artist members with an MFA or equivalent who teach studio classes. This fellowship provides a $7,500 award and conference registration to a qualifying artist, focusing on their artistic work rather than a proposal. It aims to recognize and empower visual arts professionals in academia.

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

• Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
• Late-onset AChR Ab positive MG with a disease bias towards men
• Paraneoplastic thymoma-associated MG
• Muscle specific kinase (MuSK) Ab positive
• AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

• Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
• Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
• Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
• Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Pilot and Feasibility Grants

Objectives

MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

The priorities of the Pilot Grant Program are:

• Identification treatment responsive biomarkers
• Assess clinical measures and improve that enhance clinical trial readiness
• Evaluation of therapeutic interventions for one or more of the five distinct sub-types of MG

Pilot studies must be designed to access the resources of MGNet and focused on clinical and translational research, including fulfilling the definition of clinical and translational research and exclusion of animal studies.

Funding

The MGNet expects to fund up to two grants, each at a level of $75,000 (IDCs will be limited to 10% and included in the $75,000). Projects will be funded for 12 months. Selection among the applications received will be based on the recommendations of a review committee. A grant may be renewed for an additional one year with approval of interim report by the same review process and availability of funds. Demonstration of fulfillment of initial aims and justification for additional funding will be required. The request will be required a minimum of three months prior to the initial funding period completion.

The NewSchools: Teaching Reimagined Grant offers a unique funding opportunity of $150,000 to $250,000 for innovative ideas aimed at reimagining the role of educators and enhancing student outcomes. With a focus on leveraging generative AI, the grant supports early-stage organizations and initiatives that prioritize diverse teaching strategies and community involvement. The application deadline is January 8, 2026, with a priority deadline of December 1, 2025, for updates on eligibility.

The NIDCD Early Career Research (ECR) Award (R21) supports early-stage scientists in establishing independent research careers in areas such as hearing, balance, and language. This grant facilitates small, innovative research projects and aims to generate preliminary data for future R01 applications. It is not intended for thesis work and is designed to enhance research methodologies and technologies in biomedical and behavioral sciences. Applications are due by 5:00 PM local time of the applicant organization.

The Sachs Family Foundation Grant aims to enhance the quality of life for economically and educationally disadvantaged individuals and families. The Foundation supports self-sustaining charitable organizations focusing on economic and educational opportunities, particularly in low-income communities in the U.S. and developing countries. Grants are available for various initiatives, including education, housing, and job training, with a keen interest in programs that demonstrate clear potential for sustainability.

The Association of American Educators Foundation offers classroom grants of up to $500 for full-time educators to support various educational projects and materials. These funds can be used for items such as books, software, and art supplies. Grants must be utilized within one year of approval, and competition is strong due to high application volumes. Note that applicants from specific states will not be eligible for national funding.

The Association of American Educators Foundation offers the National Teacher Scholarship to promote professional excellence among educators. This scholarship provides funding for various professional development opportunities, including conferences and learning materials, with awards up to $500. Available to full-time educators who haven't received AAE funding in the last two years, the scholarship aims to enhance the quality of education across the nation while supporting educators' growth and collaboration.

The Hearst Foundation's Health Grant aims to support nonprofits that enhance healthcare access for underserved populations in the U.S. Focused on improving skills and increasing healthcare practitioners, the grant also emphasizes public health and medical research. With a history of funding significant projects, the foundation prioritizes programs that address the complex needs of low-income, rural, and elderly communities. This commitment ensures a sustainable impact on national health outcomes while supporting innovative healthcare delivery systems.

The Addressing Health Inequities in Clinical Diagnostics initiative invites Small Business Concerns to develop innovative clinical diagnostics that rectify health disparities in diverse patient populations. Applications should identify a specific inequity in current diagnostic practices and propose actionable solutions. This funding opportunity promotes inclusivity in clinical settings, ensuring that diagnostics are effective across varied demographics. All submissions must adhere to the deadline of 5:00 PM local time for the applicant organization.

The Addressing Health Inequities in Clinical Diagnostics program invites Small Business Concerns to develop innovative clinical diagnostics that tackle health disparities. This initiative emphasizes identifying and addressing issues within existing clinical diagnostics that contribute to inequities, ensuring inclusive solutions for diverse patient populations. By fostering advancements in clinical lab assays and point-of-care devices, the program aims to create equitable healthcare opportunities for all.

The Institutional Translational Research Training Program (T32) aims to prepare trainees for advancing basic research into clinical applications. This program focuses on developing essential skills in experimental design, statistical analysis, and effective science communication. Participants, including advanced predoctoral students and postdoctoral fellows, will engage in a two-year training program that fosters collaboration among neuroscientists and clinicians, ultimately equipping them to tackle basic research challenges and translate discoveries into viable therapies.

The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.

The NEA Foundation's Student Success Grants support educators in creating innovative learning experiences that foster critical thinking, problem-solving, and cultural understanding among students. This initiative encourages project-based and personalized learning, enabling students to engage with real-world challenges. Applicants must be members of the National Education Association and can use grant funds for educational materials and experiences. The focus is on enhancing academic skills, communication, and collaboration, ultimately promoting joy in learning.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The NEA Envision Equity Grants empower educators to implement innovative projects that foster cultural understanding, anti-racism, and civic engagement among students. With funding of up to $5,000, these grants support diverse educational initiatives over a 12-month period. Eligible applicants include NEA members, and funds can be allocated for resources, materials, and professional development aimed at enhancing student learning experiences. Projects that prioritize critical thinking and collaboration are particularly encouraged.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

The Trail Accelerator Grants aim to enhance mountain bike trail communities by providing essential planning and design services. With funding between $10,000 to $30,000, these grants support local organizations in creating sustainable trail systems. The initiative encourages projects that increase access and promote community engagement, particularly focusing on diversity and inclusion. Applicants must demonstrate the capacity to match funds, ensuring collaborative efforts to improve trail networks and experiences for all riders.

The Mathematical Sciences Postdoctoral Research Fellowships (MSPRF) aim to support emerging leaders in mathematics and statistics. These fellowships enhance participants' research environments, ensuring significant scientific development. Awardees can choose between a Research Fellowship or a Research Instructorship, with funding available for research across various mathematical and statistical disciplines. Proposals are submitted directly to the NSF, and fellows must affiliate with eligible institutions or organizations.

The Mathematical Sciences Research Institutes, supported by the National Science Foundation, serve as critical national resources aimed at advancing research in mathematics and statistics. These institutes facilitate the discovery and dissemination of knowledge while enhancing connections with related fields. Their activities attract top mathematical minds to tackle pressing problems and engage a diverse array of U.S.-based researchers, ultimately bolstering the impact of mathematical sciences across various disciplines.

The Founders Project Fulfillment Grant, offered by the Children's Theatre Foundation of America (CTFA), is dedicated to supporting 501(c)(3) IRS-certified theatres with a strong commitment to artistic excellence for young audiences. Eligible organizations must have a minimum operating budget of $1,000,000 and a proven track record of diversity in leadership, making this grant a vital resource for fostering inclusive theatre experiences for children and families.

The Ash Grove Charitable Foundation Grant supports public charities with 501(c)(3) status, focusing on capital projects that enhance community life in states where Ash Grove operates. With a commitment to environmental sustainability, education, and human services, the Foundation prioritizes funding for renovation and construction projects. Grants typically reach up to $25,000, aiming to foster better living standards and support local initiatives that are vital for community growth and resilience.

The National Cancer Institute (NCI) invites applications for transformative research in cancer biology and oncology through nanotechnology. This funding opportunity aims to address significant challenges by exploring the interactions of nanomaterials with biological systems. Projects should focus on utilizing nanoparticles and devices for targeted cancer therapies and enhancing diagnostic capabilities. Successful proposals will contribute to the foundational knowledge necessary for future nanotechnology-based interventions in cancer treatment.

Bell's Brewery Small Grassroots Grants support projects focusing on water stewardship across the Great Lakes watershed. With grant amounts ranging from $500 to $5,000, eligible organizations can apply for funding to improve ecosystem health, enhance public health through better water resource management, and promote resilience against climate-related water risks. This initiative highlights Bell's commitment to environmental stewardship and community support in all 50 states and DC.

The Pioneering Aerospace Capabilities, Engineering and Research (PACER) program is a 20-year Broad Agency Announcement (BAA) by the US Air Force aimed at advancing innovative aerospace technologies. This initiative encourages white papers and proposals for research and development to enhance technology readiness levels. It is designed to provide the warfighter with a decisive advantage through transformative technology solutions. Multiple awards are anticipated, allowing for a range of project durations and funding values.

The Wild Animal Initiative offers Seed Grants to support innovative projects in wild animal welfare research. These grants aim to facilitate early-career researchers and established scientists in testing new techniques and approaches that incorporate welfare assessments into ecological studies. The program emphasizes cost-effective solutions, focusing on improving the welfare of wild animals. Successful proposals will explore diverse themes such as wild fish welfare and near-term welfare interventions to address urgent animal welfare challenges.

The National Science Foundation (NSF) seeks proposals for Arctic research to enhance understanding of the rapidly changing Arctic environment and its social systems. This initiative encourages innovative research that connects the Arctic region with lower latitudes, aiming to improve projections of future changes. Collaborations with federal and international partners are encouraged for co-reviewing proposals. Proposals that extend beyond the Arctic must clearly articulate their relevance to Arctic knowledge advancement.