Best Large Grants for Nonprofit Organizations in Wyoming

The Scott R. MacKenzie Foundation offers grants to support innovative genetic research aimed at advancing cures for diseases like cancer, diabetes, lung, and heart diseases. Only U.S.-based tax-exempt organizations with over five years of operation can apply. The Foundation emphasizes collaboration among research entities to enhance genome sequencing and disease detection. By funding these initiatives, they aim to foster awareness and progress in genetic research for future generations.

The ASES Research Grant, provided by the ASES Foundation, offers up to $20,000 for innovative shoulder and elbow research projects. It invites applications from principal investigators who are orthopaedic surgeons working in North America. The funding supports projects lasting between 12 to 24 months and aims to foster advancements in patient care through research. Applications are limited to one per principal investigator per year, promoting focused and impactful research initiatives.

Shaw's Foundation Grants support nonprofit organizations that enhance community well-being, focusing on hunger, youth education, and health. Eligible organizations must be 501(c)(3) certified and serve specific regions like California and Hawaii. An employee sponsor is mandatory for applications in these areas. The grant review process typically takes about eight weeks, and the foundation prioritizes collaborations with local partners to maximize community impact.

The Research Grants on Improving the Use of Research Evidence program aims to enhance the application of research findings for young people aged 5-25 in the U.S. It offers major grants ranging from $100,000 to $1,000,000 over 2-4 years, focusing on impactful studies and capacity-building for researchers. The foundation encourages collaboration among scholars and practitioners to strengthen research practices and evidence use in various settings.

The Sex Worker Giving Circle Grant, launched by the Third Wave Fund, prioritizes funding for grassroots movements led by individuals directly impacted by gender oppression, especially within the sex work community. With a commitment to gender justice, the grant supports organizations that operate with a participatory approach to grantmaking, enabling them to address systemic inequalities. In recent years, the fund has distributed significant resources to empower and sustain these vital movements across the United States.

The Catalyst Award, offered by the American Lung Association, supports innovative research on lung disease and biology. This mentored grant provides $50,000 annually for up to two years, prioritizing novel projects with collaborative training plans. The American Lung Association aims to improve lung health and prevent diseases through research, education, and advocacy, focusing on defeating lung cancer and fostering a tobacco-free future.

The Elevance Health Foundation's Maternal and Child Health Grant supports community-based nonprofit organizations aiming to enhance maternal and infant health outcomes. The foundation prioritizes funding programs that address disparities, improve care access, and promote health throughout the pregnancy journey. Focus areas include reducing pre-term birth rates and severe maternal morbidity. This initiative encourages scalable solutions for measurable impact across various states, ensuring comprehensive support for mothers and infants alike.

The Hadassah Foundation supports organizations enhancing the leadership roles of women and girls in the U.S. Jewish community. Grants of $80,000 are distributed over three years, focusing on program-based or unrestricted support. Eligible applicants must have specific legal statuses and align with the Foundation's gender equity mission. Proposals are accepted until June 11, 2025, through an online system, aiming to address challenges like financial security and mental health while promoting leadership advancement.

The Innovation Award by the American Lung Association offers $75,000 annually for up to two years, aimed at supporting promising investigators in lung disease research. With a legacy of over 120 years, the Association seeks to fund innovative projects that can significantly impact lung health. Eligible candidates must demonstrate prior excellence in their careers and have held a K or R type award within the last three to five years. This initiative fosters groundbreaking advancements in lung disease science.

The McKnight Endowment Fund for Neuroscience offers the Neurobiology of Brain Disorders Award to support innovative research aimed at understanding and treating brain disorders. It provides up to four awards of $100,000 each year for three years, encouraging proposals that explore biological mechanisms and environmental contributions to neurological disorders. The program emphasizes inclusivity and collaboration among researchers to advance the field and improve therapeutic interventions for conditions such as Alzheimer's and Parkinson's disease.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.

The Multiple Sclerosis Clinical Care Physician Fellowship: Pediatric Care, offered by the National Multiple Sclerosis Society, aims to enhance the training of physicians in providing specialized care for pediatric patients with MS. This one-year post-residency program emphasizes direct patient care and multidisciplinary collaboration. Participants will learn under the supervision of MS specialists, gaining essential skills to improve clinical practices and contribute to the MS community, ultimately leading to better outcomes for those affected by this condition.

The GEMSSTAR for Emergency Medicine Supplemental Funding Program provides up to $25,000 over two years to support emergency medicine physicians who have received the NIA GEMSSTAR grant. This program aims to enhance the Professional Development Plan of GEMSSTAR awardees, ensuring they receive the necessary funding for their research endeavors. Eligibility is limited to those who have completed their clinical specialty training and are based at U.S. institutions, with funding contingent upon available resources.

The Sidney R. Baer, Jr. Foundation offers Clinical Research Grants to support advancements in the treatment and understanding of schizophrenia and bipolar disorder. Focused on organizations with IRS tax-exempt status, these grants aim to enhance mental health services and research. By funding initiatives in cognitive and behavioral sciences, the foundation seeks to improve the lives of those affected by serious mental illness, ensuring they receive the support and resources necessary for a better quality of life.

The Cooperative Development Fund Grant supports cooperative development, research, and technical assistance for cooperatives focused on seniors, international development, and affordable housing. Grants, typically ranging from $20,000 to $30,000, are awarded once a year, with a two-stage application process: a concept paper followed by a full proposal for selected applicants. Up to two grants are awarded annually, with decisions announced shortly after the Advisory Board meeting in January.

The American Academy of Audiology offers the Investigator Research Grant to promote essential research in audiology and balance health care. With a funding limit of $20,000 for one-year projects, the grant aims to support innovative research that enhances the evaluation and management of hearing and balance disorders. Eligible applicants must hold a doctoral degree in audiology or hearing science and be affiliated with a non-profit institution in the U.S. or Canada, fostering collaboration between academia and clinical practice.

The OREF/ASES Rockwood Clinical Shoulder Research Grant aims to foster innovative clinical research in shoulder care. By offering seed funding to new investigators, this grant supports promising projects that demonstrate clinical relevance and practical application. Successful completion will position principal investigators to pursue larger NIH or DOD funding opportunities, further advancing shoulder research. This initiative underscores the commitment to nurturing talent and excellence within the field.

The Lois Lenski Covey Foundation offers the Bookmobile Grant to promote literacy among underserved children. Grants range from $500 to $3,000 specifically for purchasing books for youth from preschool to grade 8. Eligible organizations include 501(c)(3) nonprofits and public libraries that operate lending bookmobiles. The Foundation aims to ensure access to quality literature, fostering a love of reading in disadvantaged communities while addressing their limited book budgets.

Conserving Black Modernism Grant Program

The African American Cultural Heritage Action Fund (AACHAF), a program of the National Trust for Historic Preservation, has launched the Conserving Black Modernism grant program through funding from and a partnership with the Getty Foundation’s Keeping it Modern initiative. The Conserving Black Modernism grant program is designed to empower and equip preservationists and stewards with funding and technical support to preserve the material heritage, innovation, and legacy of modern architectural sites designed by Black architects.

Integrated into the Action Fund’s existing National Grant Program, the Conserving Black Modernism grant program will support non-profits and municipalities to steward 16 historic assets of modern architecture through funding, technical assistance, public awareness, and education. The program will support eligible project planning activities and seeks to develop future-looking plans that model and strengthen stewardship, interpretation, and asset management. This program aims to increase recognition of Black architects and their artistic expressions as well as diversify the meaning of American modern architecture and design. The Action Fund invites proposals from a broad pool of applicants who steward these places for public benefit and access.

Grants made from Conserving Black Modernism will total $150,000 each. Funding will be flexible and can support planning activities, limited capital improvements, and indirect costs. Funding ratios will be balanced to support and prioritize comprehensive project planning needs. For example, a $150,000 project planning grant with 10% indirect can be allocated to advance a full-scale building evaluation and preservation plan. The grant period for this type of project will be 12 months.

Conserving Black Modernism grants can also support projects consisting of a mix of project planning and limited capital improvements. Funding ratios will be balanced to prioritize project planning. For example, an applicant may propose a project which allocates $90,000 for planning activities, $45,000 for capital expenses, and $15,000 for indirect expenses. The grant period for this type of project will be 18 months.

Grantees can address the building’s priority needs and experience the full cycle of planning, design, and construction. Additional grantee support will include technical assistance, promotion, and conservation management training.

Historic Asset Example Archetypes

While this is not an exhaustive list, we are particularly interested in the following 20th-century property archetypes:

• Buildings Located on HBCU Campuses
• Community and Cultural Centers
• Schools
• Libraries
• Houses and Residences
• Spaces Associated with Sports & Recreation
• Green Book Sites
• Sites associated with Women’s History
• Sites associated with LGBTQ+ History

The Mech SS Sheldon D. Murphy Student and Postdoctoral Endowment Award, established by the Society of Toxicology, honors the legacy of Dr. Sheldon D. Murphy, a pioneer in toxicology. This award supports PhD candidates and postdoctoral trainees who demonstrate excellence in mechanistic toxicology. Nominees are selected based on the scientific quality of their abstracts, ensuring a focus on impactful research. This initiative fosters the next generation of toxicologists dedicated to advancing human and environmental health.

The Birth Center Membership Support Grants, offered by the American Association of Birth Centers Foundation, aim to assist birth centers facing financial hardships in paying membership fees. Eligible centers can receive support covering up to 50% of the fees, whether they are applying for membership for the first time or renewing their membership. This initiative emphasizes the importance of maintaining high standards in maternity care and supports centers committed to serving low-income women.

The Parker B. Francis Fellowship for Pulmonary Research offers three years of funding, totaling $225,000, for clinical and basic scientists transitioning to independent research careers in pulmonary and critical care medicine. Eligible candidates include those with relevant doctoral degrees, U.S. or Canadian citizenship, and a track record of research experience. The fellowship encourages diverse research topics, including bioethics in pulmonary medicine, while requiring mentorship and adherence to strict eligibility criteria.

The IEN-WMAN Mini-Grant Program provides crucial financial support to Indigenous communities and grassroots organizations impacted by mining in the U.S. and Canada. With over $200,000 distributed annually in $4,000 grants, the program aims to address mining-related environmental and health issues. Priority is given to proposals that demonstrate a direct impact on affected communities, particularly Indigenous-led initiatives, ensuring that financial assistance is directed where it is most needed.

About Alex’s Lemonade Stand Foundation

Alex's Lemonade Stand Foundation (ALSF) emerged from the front yard lemonade stand of 4- year-old Alexandra “Alex” Scott, who was fighting cancer and wanted to raise money to find cures for all children with cancer. Her spirit and determination inspired others to support her cause, and when she passed away at the age of 8, she had raised $1 million. Since then, the Foundation bearing her name has evolved into a national fundraising movement. Today, ALSF is one of the leading funders of pediatric cancer research in the U.S. and Canada, funding research projects and providing programs to families affected by childhood cancer. ALSF is one of the only childhood cancer research organizations that has been given the NCI peer-reviewed funder designation for rigorous selection of research grants. The mission of ALSF is to change the lives of children with cancer through funding impactful research, raising awareness, supporting families, and empowering everyone to help cure childhood cancer.

Bio-Therapeutic Impact Award

The Bio-Therapeutic Impact Award accelerates the development of clinical trials for promising biologic approaches to treating childhood cancer. These approaches include, but are not limited to, immunotherapy, gene therapy and small molecules. The award, intended for investigators who are initiating clinical trials, totals the maximum of $1.8 million awarded over three years.

We are living in a time of intensified state violence and mass criminalization. The current political climate has doubled down on surveillance, policing, incarceration, and the criminalization of protest, migration, and mutual aid. For directly impacted communities, the trauma is relentless — and those of us committed to resistance are feeling the weight of outrage fatigue.

But we know: the antidote to outrage fatigue is movement response. The expansion of state violence and mass incarceration often forces organizations to respond quickly to unanticipated events despite lacking the necessary resources or capacity.

The Strategic Opportunities Support (SOS) Fund-CJI’s rapid-response fund-is designed to support bold, strategic, and immediate actions by grassroots organizations on the front lines of resistance. The Fund awards grants up to $7,500 and enables organizations to move quickly and collaboratively in response to emerging threats and seize opportunities to advance justice, healing, and systemic transformation.

The Burroughs Wellcome Fund's Next Gen Pregnancy Initiative Grants aim to enhance research on pregnancy outcomes, addressing issues such as preterm birth and maternal health. With an emphasis on fostering diverse scientific collaboration, the initiative supports innovative proposals from researchers across various disciplines. Each grant offers up to $500,000 over four years, encouraging groundbreaking studies that explore the biological and environmental factors affecting pregnancy. This initiative seeks to improve health outcomes through informed research and interdisciplinary partnerships.