Best Large Grants for Nonprofit Organizations in Alabama

The Arthritis Foundation's Clinical Fellowship RFP aims to address the rheumatology workforce shortage by inviting applications from institutions with clinical training programs. It encourages innovative training approaches to prepare future rheumatologists for the evolving needs of the arthritis community. Funding includes $150,000 for a two-year adult fellowship, $225,000 for a three-year pediatric fellowship, and $300,000 for a four-year Med-Peds fellowship, all designed to enhance access to specialized care.

The Friends of Reservoirs: Small Grant program offers annual grants of $2,000 to member organizations of Friends of Reservoirs, with additional product donations bringing the total value over $3,500. This initiative, supported by generous sponsors, aims to enhance reservoir fisheries habitats. Applicants should note a $25 application fee, which contributes directly to the grant fund. This program focuses on fostering community engagement and improving aquatic ecosystems.

The ADDF-Harrington Scholar Program aims to transform academic discoveries into effective treatments for Alzheimer’s disease and related dementias. With funding of up to $600,000 annually, this program prioritizes innovative drug targets and supports research from hit-to-lead optimization to IND-enabling studies. Eligible applicants include academic investigators with a strong potential to advance meaningful therapeutics. The program emphasizes collaboration with industry experts, making it a significant opportunity for advancing dementia research.

The Pediatric Cancer Research Foundation (PCRF) is dedicated to funding innovative research aimed at curing childhood cancer. With a focus on collaborative efforts, PCRF has contributed over $51 million since 1982, significantly improving survival rates for childhood cancers. The Translational Research Grant supports cutting-edge clinical trials and therapeutic approaches, enhancing the journey from laboratory discoveries to patient care. This initiative underscores the urgent need for effective treatments, offering hope for children diagnosed with cancer and their families.

The Pediatric Cancer Research Foundation (PCRF) offers the Emerging Investigator Fellowship Grant to support post-doctoral fellowships and clinical investigator training for promising pediatric cancer researchers. This grant aims to accelerate advancements in childhood cancer treatment by funding innovative research ideas. Applicants must have completed a minimum of two years in their fellowship or be within two years of their junior faculty role. This initiative fosters the next generation of researchers dedicated to combating childhood cancer.

The American Heart Association (AHA) is launching the RFP for a Strategically Focused Research Network (SFRN) aimed at enhancing the early detection and delaying the progression of valvular heart disease. This initiative seeks collaborative proposals from researchers to address critical questions and advance understanding in this field. With a maximum budget of $4.4 million and a duration of four years, the AHA plans to award at least three grants based on scientific merit and alignment with its mission.

The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.

This grant aims to enhance applied regulatory science research for the evaluation and treatment of cardiotoxicity associated with oncology therapeutics. The initiative will facilitate collaboration with the FDA to develop effective methodologies and solutions, ensuring that research outcomes are directly relevant to regulatory decision-making. Key activities include regular communication with funded investigators and a focus on improving detection and management of cardiotoxicity, ultimately leading to impactful publications and presentations.

The NEI Postbaccalaureate Opportunities in Vision Science (POVS) Research Education Program aims to enhance the training of a diverse workforce in biomedical research. This NIH-funded initiative focuses on providing intensive, hands-on research experiences for recent college graduates from various backgrounds, preparing them for doctoral programs in biomedical fields. The program encourages participation from individuals without prior research opportunities in vision sciences, fostering a nationally recruited cohort for substantial impact in the field.

The Civic Engagement Microgrant Grant Program, funded by Research!America, aims to enhance public engagement skills among early-career scientists. By providing financial support for innovative projects, this initiative encourages collaborations across various STEM disciplines. Grantees will develop essential skills in communication and policy-making to strengthen community ties and promote science as a national priority. This program addresses the critical need for scientists to connect with local communities and policymakers to ensure the relevance and impact of scientific research.

The Pediatric Cancer Research Foundation (PCRF) offers Donor Designated Grant Programs aimed at funding innovative projects addressing childhood cancer. These grants support researchers dedicated to finding cures, enhancing treatment, and improving care. With an annual commitment to extraordinary researchers, PCRF ensures funds are directed towards promising advances in prevention and treatment. Since 1982, PCRF has raised over $51 million, significantly impacting survival rates and striving to eliminate childhood cancer through collaborative efforts and cutting-edge research.

The Athene Charitable Foundation focuses on corporate social responsibility through community involvement, aiming to create positive social impacts in education, health, human services, and the environment. Their initiatives include partnerships, employee volunteering, and donations aligned with their mission. They prioritize organizations that support diversity and inclusion while ensuring compliance with their non-discrimination policies. Eligible entities must be registered 501(c)(3) organizations or equivalent, enhancing community welfare where Athene employees live and work.

The Stanley Fahn Junior Faculty Award, offered by the Parkinson's Foundation, supports early-career scientists in Parkinson's research. With $300,000 in funding over three years, it aims to bridge the gap for junior faculty transitioning to independent research. Eligible applicants must hold a PhD or MD and be U.S. or Canadian faculty members. This award promotes innovative research proposals that advance understanding and treatment of Parkinson's disease, fostering the next generation of scientists in this critical field.

The Willis C. Helm Charitable Trust, established in 1954, focuses on supporting organizations that work on juvenile delinquency and the development of boys from broken homes. It provides annual grants averaging between $5,000 and $15,000, with a total giving of around $60,000 for five grants each year. Eligible organizations must be 501(c)(3) exempt and preferably located in Minnesota. Applications are accepted year-round, with a deadline of March 31 for annual review.

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

The NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22) aims to support postdoctoral fellows from underrepresented backgrounds in transitioning to tenure-track positions. This award provides essential funding for salary and research support for three years, enabling candidates to establish independent biomedical careers. Key deadlines for applications range from February 2025 to October 2027, ensuring ample opportunity for eligible researchers to secure funding for their career development.

The Abortion Bridge Collaborative Funds, initiated by the Women Donors Network, aim to enhance abortion access across the U.S. in response to the 2022 Dobbs decision. The fund prioritizes support for 501c3 organizations committed to reproductive justice, focusing on immediate community needs and sustainable solutions. Emphasizing grassroots leadership and innovative approaches, the fund seeks to build a robust infrastructure for reproductive care, ensuring equitable access for all individuals in need.

The B-Fund Grant by the Brem Foundation aims to enhance early detection of breast cancer by funding crucial screening and diagnostic tests for women in need. This initiative supports entities in the DC metro area, providing financial assistance for services like mammograms and ultrasounds, while ensuring equitable access regardless of socio-economic status. However, it excludes costs related to post-diagnosis care, employee salaries, and administrative expenses, promoting targeted and effective use of funds in the fight against breast cancer.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

The Beattie Family Foundation offers educational scholarships aimed primarily at medical and nursing students facing financial challenges. These scholarships, ranging from $2,000 to $5,000, support individuals currently enrolled in accredited institutions who demonstrate strong academic capabilities. Additionally, limited funds are available for vocational or trade school tuition for those aspiring to enter skilled labor professions. The foundation prioritizes applicants based on financial need and academic performance.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The Anna Lalor Burdick Program supports initiatives that enhance women's access to reproductive health care, contraception, and pregnancy termination. It prioritizes funding programs that provide comprehensive sexual and reproductive health education, particularly for disadvantaged women. The program seeks innovative approaches, clear goals, and sustainable models, while emphasizing advocacy efforts. Organizations dedicated to reproductive rights in restrictive environments are encouraged to apply, as the foundation aims to empower women through informed choices.

The Aim High Grant Program offers one-year grants of $20,000 to support out-of-school time programs for middle school youth. Funded by the New York Life Foundation, this initiative aims to enhance students' transition to high school by providing essential skills and guidance. Programs must demonstrate effective engagement strategies and serve low-income communities. This grant represents a vital investment in the future of young people, helping them develop academically, socially, and emotionally.

The Alice M. Ditson Fund supports recording projects that aim to document and promote the music of younger, lesser-known American composers. The fund prioritizes living composers of classical concert music, especially those in the early stages of their careers, while also recognizing established composers who deserve greater visibility. Eligible applicants include organizations with a fiscal sponsor or non-profit status, and projects must involve significant contemporary American music.

The AED Grant Program, run by the Hopey’s Heart Foundation, aims to enhance sports safety by providing life-saving AEDs to eligible schools and recreational centers. Although the program is currently closed, it will reopen for applications in April 2026. The Foundation focuses on preventing Sudden Cardiac Arrest among student athletes through education and medical equipment. Eligible organizations include 501(c)(3) entities and government bodies, ensuring broader access to vital resources for sports safety.

The Arthur F. Burns Fellowship offers journalists from the U.S., Canada, and Germany a unique opportunity to enhance their skills through a two-month exchange program. Participants engage in a structured orientation in Washington, D.C., followed by hands-on training at German media outlets. This fellowship not only enriches careers but also fosters international understanding, with many alumni advancing in prominent media roles globally. With financial support for living and travel expenses, this program significantly enhances the quality of transatlantic news coverage.

LSC’s Basic Field Grants aim to enhance access to civil legal services for low-income individuals across the U.S. and territories. These grants support eligible organizations for up to three years through a competitive application process. The funding is allocated to specific service areas, which change annually, and focuses on providing comprehensive legal assistance. The program includes three types of service areas, ensuring diverse populations, including agricultural and Native American communities, receive necessary legal support.