Best Large Grants for Nonprofit Organizations in Alabama

Research Grant Program 

Providing research grants to support clinicians and scientists focused on primary immunodeficiency (PI).

Scope and eligibility

• The Immune Deficiency Foundation's Research Grant Program supports patient-centered research focused on improving the treatment, health, disease management, or diagnosis of people with primary immunodeficiency (PI), as well as research that contributes to the broader body of knowledge on PI.
• Awards range from $25,000-50,000. In addition, the Michael Blaese Research Grant Award is bestowed on the highest-scored application each cycle.
• One-year term.

In 2020, GradGuard founded College Life Protected, LLC as a social purpose entity that supports programs, research, professional development, and best practices in higher education that promote greater confidence in the value of higher education as a public good. 

College Life Protected invites the higher education community to apply for grants that are consistent with our mission.

Promoting Financial Literacy

College Life Protected recognizes that that financial literacy is a critical skill for student success, impacting everything from academic persistence to long-term financial well-being. That’s why we are committed to funding programs and initiatives that equip students with the knowledge and resources they need to make informed financial decisions.

By supporting programs that enhance financial education, we aim to empower students to navigate college costs, manage personal finances, and build a strong financial future.

The Urban Indian Health 4-in-1 Program is designed to enhance the health and well-being of urban Native Americans through targeted initiatives in immunization, health promotion, disease prevention, mental health support, and addressing alcohol and substance abuse issues. Funded by the US Dept. of Health & Human Services, this program aims to improve access to essential health services and foster healthier communities among urban Indian populations.

The Kidney Health Equity Community Engagement Award by the National Kidney Foundation aims to enhance health equity in kidney care. This award encourages innovative proposals that address disparities in access to kidney care, education, and treatment. With a funding of $75,000 for one year, it supports healthcare professionals and researchers in implementing community-based solutions to improve outcomes for individuals affected by kidney disease. The initiative seeks to dismantle barriers and foster equitable health practices.

The Chronic Pain Medicine Research Grant, offered by the American Society of Regional Anesthesia (ASRA) and Pain Medicine, aims to enhance research in pain medicine, guiding clinical practice and improving patient care. With a funding limit of $200,000, the grant prioritizes studies in areas such as Regional Anesthesia, Outcomes Research, and Patient Safety, encouraging innovative proposals from North American physician members of ASRA.

National Collegiate Cancer Foundation

The National Collegiate Cancer Foundation (NCCF) is a national 501(c)(3) nonprofit organization dedicated to supporting young adults diagnosed with or impacted by cancer. Its mission is to provide services, resources, and need-based financial assistance that empower survivors and their families to adopt a resilient “Will Win” mindset throughout treatment and beyond. NCCF is one of the few national organizations that provides direct financial support to young adult cancer survivors, primarily through its Survivor and Legacy Scholarships, which assist students pursuing higher education during or after treatment. The Foundation also promotes cancer awareness and prevention within the young adult community. Recognizing that adolescents and young adults (ages 15–39) face unique challenges—including delayed diagnoses, limited access to insurance and clinical trials, fertility concerns, employment disruption, and social isolation—NCCF prioritizes addressing the significant service gaps affecting this underserved population. Operated entirely by volunteers, NCCF remains committed to advancing educational access, financial relief, and hope for young adult cancer survivors nationwide.

NCCF: Legacy Scholarship Program

The National Collegiate Cancer Foundation (NCCF) offers $1,000 competitive scholarships to young adults pursuing higher education who have lost a parent or guardian to cancer. The award is designed to provide financial assistance and encouragement to students continuing their education despite personal loss. Applications are evaluated based on the applicant’s personal journey, sources of encouragement, demonstrated financial need, notable accomplishments, and the quality of recommendations. The scholarship recognizes resilience, perseverance, and academic commitment in the face of cancer-related loss.

National Collegiate Cancer Foundation

The National Collegiate Cancer Foundation (NCCF) is a national 501(c)(3) nonprofit organization dedicated to supporting young adults diagnosed with or impacted by cancer. Its mission is to provide services, resources, and need-based financial assistance that empower survivors and their families to adopt a resilient “Will Win” mindset throughout treatment and beyond. NCCF is one of the few national organizations that provides direct financial support to young adult cancer survivors, primarily through its Survivor and Legacy Scholarships, which assist students pursuing higher education during or after treatment. The Foundation also promotes cancer awareness and prevention within the young adult community. Recognizing that adolescents and young adults (ages 15–39) face unique challenges—including delayed diagnoses, limited access to insurance and clinical trials, fertility concerns, employment disruption, and social isolation—NCCF prioritizes addressing the significant service gaps affecting this underserved population. Operated entirely by volunteers, NCCF remains committed to advancing educational access, financial relief, and hope for young adult cancer survivors nationwide.

NCCF: Survivor Scholarship Program

The National Collegiate Cancer Foundation (NCCF) Survivor Scholarship Program provides a competitive scholarships to young adults who are cancer survivors or current patients and are pursuing higher education during or after treatment. The program supports students who have demonstrated resilience and continued their educational journey despite the challenges of cancer. Applications are evaluated based on six criteria: demonstration of a strong “Will Win” attitude, quality of essays, financial need, overall cancer survivorship story, commitment to education, and the quality of recommendations. The scholarship recognizes perseverance, hope, and dedication to academic and personal growth.

The Alex O. Santillanes Scholarship, administered by the Community Foundation of NCW, honors the legacy of Alex O. Santillanes, a dedicated youth advocate in the Yakima Valley. This scholarship supports Hispanic high school seniors from the region pursuing higher education in Washington. Eligible applicants must have a minimum GPA of 2.0 and demonstrate resilience against social and economic inequities, particularly those from single-parent families. The scholarship aims to empower the next generation of leaders.

The Youth Regional Treatment Center Aftercare Program aims to support American Indian and Alaska Native youth in maintaining safety, sobriety, and success post-discharge from Youth Regional Treatment Centers. This initiative enhances culturally relevant, community-based aftercare by fostering care coordination, building partnerships, and addressing barriers to improve youth outcomes.

Stark Community Foundation

Since 1963, Stark Community Foundation has been helping individuals, families, businesses and nonprofits like you support the causes you care about.

In addition to personalized donor services, we manage a competitive grantmaking program and award grants to address local needs. Today, the Foundation stewards over 1,000 charitable funds totaling $485 million in assets and has granted more than $300 million to nonprofits in our community and beyond.

Scholarships

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties.

The Manzer-Keener-Wefler Scholarship Fund

The Manzer-Keener-Wefler Scholarship Fund assists applicants with a field of study in or related to photography, visual arts (including graphic design). 

This scholarship is renewable.

About the Program

The Women’s Foundation of Alabama (WFA) created the Advancing Alabama Child Care Accelerator as a critical part of our multi-pronged approach to addressing the child care crisis impacting families nationwide. Through this accelerator, we invest in women business owners, support peer community, and leverage proven business growth strategies to advance sustainable, community-based child care solutions.

Limestone County Child Care Accelerator Program

Launching in April 2026, the Limestone County Advancing Alabama Child Care Accelerator is designed to support center-based and home-based child care providers who are starting or expanding high-quality, thriving child care businesses that meet the needs of working families in Alabama. Businesses accepted into the cohort will join a community of peers and receive high-quality training and coaching from business and child care experts across the state, along with access to tools, resources, and funding opportunities aimed at strengthening operations and increasing the supply of child care seats in Limestone County.

Funding Opportunity

At the conclusion of the training program, participants will be eligible to apply for a grant of up to $25,000 from the Women’s Foundation of Alabama to support the launch or expansion of their child care business. Additional details about the funding application and review process will be shared with individuals selected for the Spring 2026 Limestone County cohort.

Time Commitment

Participants must be able to commit 3–5 hours per week to training and program activities.

The Michael Herman Scholarship, established by the Grand Haven Area Community Foundation, honors a talented young soccer player who passed away tragically at 15. This scholarship is awarded to graduating high school seniors from the Tri-Cities area who have played soccer and wish to continue participating in college-level soccer. Financial need is not a priority, and all eligible students are encouraged to apply for this opportunity to further their education while pursuing their passion for sports.

The Junior Hamilton Memorial Baseball Scholarship, offered by the Community Foundation of North Central Washington, supports graduating seniors from Wenatchee, Eastmont, or Westside High Schools. Eligible applicants must maintain a minimum GPA of 2.85 and have participated in a high school baseball program for at least two years. This scholarship honors Junior Hamilton's legacy, empowering student-athletes and mariachi students to pursue higher education and achieve their dreams.

The GEMSSTAR for Emergency Medicine Supplemental Funding Program provides up to $25,000 over two years to support emergency medicine physicians who have received the NIA GEMSSTAR grant. This program aims to enhance the Professional Development Plan of GEMSSTAR awardees, ensuring they receive the necessary funding for their research endeavors. Eligibility is limited to those who have completed their clinical specialty training and are based at U.S. institutions, with funding contingent upon available resources.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

The Kathryn Lodge Mhatre Creative Writing Scholarship honors the memory of Kathryn Lodge Mhatre, a passionate writer and compassionate individual who tragically lost her battle with mental illness. Established by her parents, this scholarship supports students from Chelan or Douglas County pursuing creative writing. Eligible applicants must have a minimum 3.0 GPA and provide a writing sample, reflecting Kathryn's dedication to learning and her love for storytelling.

Community Foundation of the Endless Mountains

Our mission at the Community Foundation of the Endless Mountains is to improve the region’s quality of life through the power of philanthropy. We do this by offering individuals, families, and businesses the most effective charitable giving tools available in the marketplace today. Founded in 1998, the Community Foundation of the Endless Mountains is honored to work with hundreds of donors, nonprofits, advisors, and civic leaders to achieve dreams for making the Endless Mountains region of Northeastern Pennsylvania an even better place to live for everyone.

Scholarships

Many generous individuals, families, and businesses have established scholarship funds to provide support to graduates in our region. Scholarships are available to graduating high school seniors.

Cody Albert Memorial Scholarship

Established by Dale and Linda Albert in memory of their son Cody to provide a college scholarship to students from Susquehanna County who will major in the Visual Arts, Psychology, or Physical Therapy and who have overcome anxiety, depression, or other adversity.

Community Foundation of the Endless Mountains

Our mission at the Community Foundation of the Endless Mountains is to improve the region’s quality of life through the power of philanthropy. We do this by offering individuals, families, and businesses the most effective charitable giving tools available in the marketplace today. Founded in 1998, the Community Foundation of the Endless Mountains is honored to work with hundreds of donors, nonprofits, advisors, and civic leaders to achieve dreams for making the Endless Mountains region of Northeastern Pennsylvania an even better place to live for everyone.

Scholarships

Many generous individuals, families, and businesses have established scholarship funds to provide support to graduates in our region. Scholarships are available to graduating high school seniors.

Lawrence & Phyllis DeWolfe Scholarship

Established by the family and friends of Mr. and Mrs. Lawrence DeWolfe to provide college scholarships to graduating seniors from Blue Ridge, Lackawanna Trail, and Mountain View school districts who will major in agriculture, education, a STEM field or law enforcement.

The JADE Learning Electrical Technologies Scholarship supports students enrolled in North Carolina technical or occupational schools focused on electrical systems technologies. Eligible candidates include undergraduates, graduates, and apprentices who demonstrate financial need and strong academic performance. The scholarship application requires careful attention to specific donor-defined eligibility criteria. Applications open on December 16, 2025, and close on March 3, 2026, with preference given to those pursuing a two-year associate’s degree.

The AISES Burlington Northern Santa Fe Foundation Scholarship supports Native students pursuing degrees in STEM fields. This scholarship aims to empower Indigenous students by providing financial aid and fostering diversity within the STEM community. Applicants must be full-time students and either enrolled citizens or descendants of recognized Native American or Indigenous groups. The program is part of BNSF’s commitment to enhancing educational opportunities for underrepresented communities in the transportation sector.

The American Indian College Fund Scholarship supports high school students who are enrolled members of federally recognized tribes, or their descendants, pursuing higher education. Applications open annually on February 1st, with a priority deadline of May 31st. This merit-based scholarship provides an opportunity for students to receive awards averaging between $2,000 and $3,000 to help fund their college education. Eligible students should apply during their last semester of high school.

The American Indian College Fund offers scholarships to American Indian and Alaska Native students enrolled at Tribal Colleges and Universities (TCUs). Applications open annually on February 1st, with a priority deadline of May 31st. Eligible students can apply for various merit-based scholarships, with awards averaging between $2,000 and $3,000. The College Fund encourages applications by the priority deadline for a better chance of funding.

The Katie Moore Memorial Nursing Scholarship, administered by the Community Foundation of North Central Washington, supports students pursuing a Bachelor of Science degree in nursing. Preference is given to those specializing in pediatric nursing and with relevant experience. Eligible candidates must have completed two years of college with a minimum GPA of 3.5 or be enrolled in an RN to BSN program. This scholarship honors Katie Moore's legacy and aims to foster compassionate care for children.

The Growing Convergence Research (GCR) initiative by the National Science Foundation (NSF) promotes innovative solutions to complex societal and scientific challenges through multidisciplinary collaboration. By integrating diverse expertise, GCR aims to address specific problems and foster new research paradigms. Proposals must outline a five-year plan, divided into two phases, with budgets not exceeding $1.2 million for Phase I and $2.4 million for Phase II. Successful projects are expected to lead to transformative advances in science and technology.

The American Indian College Fund offers scholarships for non-Tribal college students, providing financial support for American Indian and Alaska Native students pursuing higher education at accredited institutions. Applications open annually on February 1st, with a priority deadline of May 31st. Award amounts typically range from $2,000 to $3,000. Students are encouraged to apply early to ensure priority review for available scholarships, fostering educational opportunities and success for Indigenous youth.

The Aim High Grant Program, funded by the New York Life Foundation, offers 15 two-year grants of $100,000 each to support out-of-school time programs that assist middle school students in their transition to high school. This initiative addresses chronic absenteeism and promotes educational attainment in low-income communities, enhancing the cognitive, social, and emotional development of youth. By fostering skills necessary for academic success, the program aims to create brighter futures for participants.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a Notice of Funding Opportunity (NOFO) under the NIH HEAL initiative to enhance research on joint health and pain. This initiative aims to refine the understanding of joint tissues and pain mechanisms, expand clinical phenotyping, and support preclinical testing of novel therapies. Collaborations among experts in neurobiology, pain science, and rheumatic diseases are encouraged to foster innovative solutions for joint pain management.