Best Small Grants for Nonprofits in American Samoa

The Disaster Distress Helpline (DDH) offers 24/7 crisis counseling to individuals in the U.S. and its territories facing emotional distress from disasters. Managed by SAMHSA, the helpline aims to enhance and strengthen access to crucial support services year-round, ensuring that those affected by natural or human-caused disasters receive the help they need to mitigate behavioral health impacts.

Amgen is a leading biotechnology company dedicated to advancing medicine through Independent Medical Education (IME). It funds accredited educational programs that empower healthcare providers to enhance patient care. IME funding supports critical areas such as oncology, bone health, cardiovascular education, and more. Amgen's commitment ensures that these educational activities remain unbiased and compliant with applicable guidelines, fostering innovation and improved health outcomes for patients worldwide.

The Assisting Specialty Crop Exports initiative aims to enhance U.S. specialty crop market access by developing low-oxygen storage and packaging systems for tree nuts. By addressing phytosanitary requirements and pest control, the initiative supports producers in maintaining product quality while complying with international standards. This funding opportunity from the Foreign Agricultural Service encourages innovative solutions that can improve export processes and reduce reliance on costly fumigation methods, ultimately benefiting U.S. agribusiness and ensuring competitiveness in global markets.

The AHRQ Health Services Research Demonstration and Dissemination Grants (R18) aim to support innovative health services research that addresses priorities in quality, safety, and effective healthcare delivery. These grants encourage collaboration among various stakeholders, including patients and policymakers, to enhance healthcare practices across diverse settings. Applications are due by 5:00 PM local time of the applicant organization. This initiative fosters improvements in healthcare outcomes and delivery systems.

The AHRQ Small Health Services Research Grant Program (R03) invites applications for health services research focused on enhancing healthcare quality and patient safety. This funding opportunity supports diverse research settings, including hospitals and home healthcare. Projects may involve collaboration with various stakeholders such as patients, clinicians, and policymakers. By addressing AHRQ research priorities, this initiative aims to improve healthcare delivery and practice while promoting effective partnerships across the healthcare spectrum.

The AHRQ Health Services Research Projects (R01) aims to fund innovative health services research that aligns with AHRQ's priorities, such as enhancing healthcare quality and safety. This initiative encourages applications from various healthcare settings including hospitals and home care, promoting collaboration among diverse stakeholders like patients and policymakers. By addressing key areas of healthcare delivery improvement, this funding opportunity seeks to foster advancements in patient care and overall health system performance.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) supports innovative, hypothesis-driven clinical studies with a focus on diseases relevant to NIDDK. This initiative facilitates early peer review and assessment of study designs while providing essential support for operational documents. Applicants are encouraged to consult with NIDDK staff before submission to enhance the chances of success.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

The Japan International Award for Young Agricultural Researchers encourages young talent in agriculture, forestry, and fisheries in developing regions. Since its inception in 2007, this award recognizes up to three researchers under 40 who demonstrate exceptional research and innovation potential. Awardees are invited to Japan for a ceremony and receive $5,000 each. This initiative, supported by the Japan International Research Center for Agricultural Sciences, aims to foster future advancements and motivate emerging leaders in agricultural research.

The Doris Duke Foundation's Environment Program grants aim to foster a resilient environment through effective conservation efforts. By supporting U.S. nonprofit organizations, the foundation seeks to protect biodiversity, address climate change, and advance equity, particularly for marginalized communities. The program emphasizes land conservation, natural climate solutions, and inclusive practices, ensuring that conservation efforts benefit both wildlife and people. This initiative is pivotal for enhancing the health of ecosystems and communities across the United States.

The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) aims to support clinical trials that evaluate interventions for communication disorders. This funding opportunity encourages collaboration between NIDCD Project Scientists and investigators, focusing on trials that require FDA oversight, establish efficacy, or pose risks of harm. By fostering well-designed studies, the NIDCD seeks to advance treatment and prevention strategies in the field of communication disorders.

The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The Roy A. Hunt Foundation's Environment Initiative Grants aim to support projects that enhance ecological health and sustainability. With an annual budget of approximately $3.4 million, the foundation prioritizes initiatives that promote responsible environmental practices, clean energy, and waste reduction. Grants between $25,000 and $75,000 are available for projects at various levels, focusing on innovative solutions that foster community partnerships and address root causes of environmental challenges.

The Sigma Xi Grants-in-Aid of Research Program, celebrating 100 years of supporting research, offers financial assistance to undergraduate and graduate students. Members can receive grants ranging from $500 to $5,000, while non-members can apply for up to $1,000. Additionally, there are specific funds available for astronomy and vision-related research. This program fosters collaboration between students and mentors, promoting scientific excellence through hands-on experience.

The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.

The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.

The FY26 Tick-Borne Disease Research Program (TBDRP) Idea Development Award aims to fund innovative research that enhances understanding and treatment of Lyme disease and other tick-borne diseases. The program encourages creative approaches that challenge existing paradigms and fosters impactful discoveries. A special career development option is available for early-career investigators, offering mentorship and a tailored review process to support significant research advancements.

The DARRP Restoration Implementation Grants aim to enhance marine and coastal habitat restoration through collaboration between NOAA and non-federal partners. These grants address oil spills and hazardous substance releases by supporting restoration activities authorized under various environmental laws. Eligible applicants will implement projects that promote sustainable fisheries, recover endangered species, and boost local economies. Through careful planning and evaluation, recipients will contribute to effective restoration strategies that align with NOAA's mission and the needs of coastal communities.

The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.

The FY26 Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award aims to foster innovative therapeutic and diagnostic research for Lyme disease and other tick-borne conditions. This award supports early-stage drug discovery and evaluation studies, as well as novel diagnostic methods that can be seamlessly implemented in clinical environments, ultimately enhancing patient care and quality of life.

The HEAL Initiative aims to identify new druggable targets for pain within the understudied proteome. This funding opportunity invites applications for pilot projects that generate preliminary data and tools for exploring these targets. The initiative seeks to enhance research on understudied proteins related to pain management, providing essential funding for biochemical and biological work. This NOFO is part of the NIH's broader effort to develop novel medications that address various aspects of opioid addiction and its consequences.

The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.

The HIV Prevention and Alcohol R61/R33 funding opportunity aims to advance innovative HIV prevention strategies through a phased research approach. The R61 phase focuses on developing and pilot testing interventions, addressing key implementation questions for diverse populations. Following successful milestones, the R33 phase expands testing of these interventions and explores their effectiveness and sustainability, particularly in relation to alcohol use and related health issues.

The WaterSMART Cooperative Watershed Management Program offers funding to eligible entities for developing local solutions to water management issues. This initiative supports watershed group development, restoration planning, and project design, promoting stakeholder cooperation and improving water reliability. It aligns with key priorities from the Trump administration, addressing complex water challenges and enhancing federal grant oversight. By facilitating these efforts, the program aims to stretch limited water resources and foster collaborative solutions among diverse stakeholders.

The Matson Foundation, a corporate entity, emphasizes community involvement through charitable donations. They support a diverse range of areas including maritime conservation, education, human services, culture, and civic programs. Eligible organizations must be qualified non-profits, with a primary focus on community support where Matson operates. The foundation prioritizes projects that engage local communities, ensure sustainability, and demonstrate measurable impact, while adhering to specific eligibility and ineligibility criteria for funding.