Best Chattanooga Grants for Nonprofits in Tennessee

Mission

The mission of the Tennessee State Museum is to procure, preserve, exhibit, and interpret objects which relate to the social, political, economic, and cultural history of Tennessee and Tennesseans, and to provide access to educational and cultural programs and exhibitions for the people of the state.

Capital Maintenance and Improvements Grants

For the fiscal year beginning July 1, 2026, the Tennessee General Assembly included a direct appropriation in the amount of $5 million to the Tennessee State Museum “for the sole purpose of providing grants to museums with a 501(c)(3) nonprofit organization or affiliated with a governmental entity for capital maintenance and improvements” (Section 61, Item 21 of the 2026-2027 Appropriations Act). This grant will be facilitated by the State Museum and is open to museums located in Tennessee.

This appropriation is separate from any other funding provided by the State of Tennessee to a museum and must be used for the capital maintenance and improvements as described in the grant application.

The FY26 Neurofibromatosis Research Program's Synergistic Idea Award supports innovative research on neurofibromatosis (NF) through collaborative efforts of two or three Principal Investigators (PIs). By leveraging their unique perspectives, these PIs will tackle significant questions in NF research. Applicants must provide relevant preliminary or published data to support their proposals, ensuring a strong foundation for impactful research outcomes.

The DoW Neurofibromatosis Investigator-Initiated Research Award addresses critical needs in neurofibromatosis research, aiming to enhance patient care through innovative projects. It supports various research phases, excluding clinical trials, and encourages collaboration between scientists and clinicians. The funding mechanism includes two levels based on participation in optional features, such as the Open Science Initiative and collaboration with qualified partners, promoting data sharing and collaborative research efforts.

The FY26 Neurofibromatosis Research Academy – Scholar Award supports early-career independent investigators focusing on neurofibromatosis research. Scholars are required to be within 10 years of their terminal degree and must designate a Career Guide for mentorship, fostering collaboration. This initiative aims to advance impactful research and develop skilled researchers in a supportive environment, addressing critical areas of emphasis in neurofibromatosis research.

The FY26 Neurofibromatosis Research Program's Exploration-Hypothesis Development Award encourages innovative, high-risk research concepts in neurofibromatosis (NF). This award aims to support groundbreaking studies that will pave the way for future scientific inquiries. Proposals should present a well-defined, testable hypothesis grounded in sound scientific rationale. While preliminary data is encouraged, it is not a prerequisite for submission, allowing researchers to explore novel paradigms and perspectives in NF research.

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

The purpose of the Urban & Community Forestry Program is to ensure all Tennesseans experience the numerous benefits of urban and community forests by catalyzing and supporting the growth, management, and sustainability of healthy urban and community forests in all Tennessee communities.This grant provides funding in four key areas:

• Urban and Community Forestry Management: Supports a full range of community forestry activities, from canopy assessment and planning to planting and long-term maintenance.
• Tree Planting: Focuses on projects that address tree equity, reduce urban heat, replace trees lost to storms, and create new greenspaces.
• Program Development or Capacity Building: Helps establish or grow tree boards, nonprofit organizations, and advocacy groups dedicated to urban forestry.
• Workforce Development: Expands opportunities to build a diverse, skilled workforce in the field of urban forestry through outreach and training programs.

The LPRF program is a state funded program that provides grants to eligible local government entities for the purchase of lands for parks, natural areas, greenways, and recreation facilities. The funds may also be used for trail development and capital projects in parks, natural areas, and greenways. At least 60 percent of the funds allocated will go to municipal governments as authorized by TCA 67-4-409. All land associated with the funded projects must be owned by a government entity. LPRF grant require an equal match. The Office of Outdoor Recreation administers the LPRF grants.

Tennessee Housing Development Agency (THDA) will provide HOME funding under its HOME Rental Housing Development Program for the new construction and/or acquisition and rehabilitation of rental housing projects. 

This program comprises state funds which are available as grants to eligible government agencies operating local jails that house Tennessee Department of Correction (TDOC) inmates to support the implementation or enhancement of evidence-based programming to improve offender outcomes.

About Henry L. Hillman Foundation

Henry L. Hillman Foundation inspires, invests in, and leverages great ideas to improve the quality of life in Pittsburgh and southwestern Pennsylvania.

Backup Power When Your Community Needs It

The Powered & Prepared Initiative seeks proposals from nonprofit and municipal organizations in southwestern Pennsylvania for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Southwestern Pennsylvania is increasingly impacted by severe weather events that cause widespread power outages and disruptions. The Powered & Prepared Initiative, supported by Henry L. Hillman Foundation, seeks proposals from nonprofit and municipal organizations for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

The DOW Combat Readiness – Medical Research Program's FY26 Translational Research Award supports innovative research aimed at improving trauma care outcomes. This program emphasizes hypothesis-driven studies that can transition promising technologies into practical solutions for enhancing casualty survivability. Applicants must provide preliminary data and utilize validated animal models, with a focus on projects that meet a minimum technology readiness level of 4, ensuring a mature translational research effort.

The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

State Board Programming Regrants (SBPG)

The Tennessee Historical Records Advisory Board (THRAB) is pleased to provide a grant opportunity for improving the preservation of and access to Tennessee’s historical records, educate and train records custodians, and support archival program development and enhancement.

The grants will be available up to $5,000 per institution and are available to any government entity or not-for-profit organization that holds permanent, historically valuable archival collections. There is no match requirement,

Grant funds are available for the following:

Technology

• This category provides funding for hardware, software, peripherals, and other technology items used to create online digital collections.
• Items requested may not exceed $5,000.

Training

• This category provides funding for registration costs for webinars or workshops related to conservation, digitization, and digital project planning for archivists and museum personnel.

Contracted Services

• This category provides funding to hire a vendor or independent contractor for the purpose of digitization or conservation services.
• You must include a quote for these services from a specific vendor as part of your application.

Contract/Part-Time Archivist

• This category provides funding to hire a contract or part-time archivist for the duration of the grant period to scan documents and create corresponding metadata.
• This person cannot already be employed by or paid by your organization. This cannot be supplemental to an existing salary or hourly employee.

Supplies

• This category provides funding for archival shelving units, acid-free, lignin-free folders and boxes, and other necessary archival supplies or environmental monitoring devices.

Senior Center Capital Grants

The Department of Disability and Aging (DDA) is accepting applications for competitive grant funding for senior centers. The Tennessee General Assembly has provided $5 million to be distributed to senior centers throughout the state. The one-time funding is intended to support senior centers in providing older adults with access to resources, activities and social connection.

Senior centers are invited to apply for grant funding ranging from $5,000 to $50,000. The grant funding is encouraged to fund the following goals:

• Capital Projects, including building improvements and equipment

The Training Opportunities for the Public (TOP) Grant is available for public libraries to be able to provide services for their communities. Grant funds are available for training, hotspots, solar charging tables and Internal Connections.