Best Large Grants for Nonprofit Organizations in Connecticut

The KUH U24 Center Coordinating Hub aims to foster collaboration among funded Centers within the NIDDK/KUHN mission. This initiative encourages the development and sharing of vital research resources, including data, reagents, and expertise, with the broader scientific community. By creating a national network, the program enhances research capabilities and promotes innovative solutions in kidney, urology, and hematology diseases.

The NIDDK Multi-Purpose Resource-Related Research Centers Cooperative Agreement (U2C) invites applications to enhance research capabilities in areas such as obesity and diabetes. These centers provide specialized services, including technical support and data coordination, primarily to clients at other institutions lacking necessary expertise. This initiative aims to bolster high-impact research through collaboration and experiential training, addressing critical health challenges aligned with NIDDK's mission.

About

Community Foundation of Greenville bridges philanthropy and purpose in Greenville County, helping people make their charitable giving simpler and more powerful for 70 years. We strategically match diverse needs and opportunities in Greenville County with philanthropic resources.

Vision:

Community Foundation of Greenville will be the leading catalyst for developing assets and unlocking potential to meet the needs of an inclusive and equitable community.

Mission:

Community Foundation of Greenville improves the lives of Greenville County residents through strategic philanthropy, community investment, and collaborative leadership.

Obermier Scholarship Fund in Memory of John N. Obermier, Edith M. Obermier and Mary Belle Obermier

Purpose

Mary Belle Obermier established this scholarship with a gift from her estate in 2012. Her intent was to help academically deserving students who need financial assistance to be able to attend college and to give preference to qualified students who are committed to a career in the United States Navy. The preference for naval students is in recognition of the US Navy careers of her deceased husband, John, and his deceased first wife, Edith, who were both veterans of World War II.

Criteria:

• Applicants must demonstrate financial need (economically disadvantaged).
• Applicants must have a current academic GPA of 3.0 or higher.
• Applicants must be enrolled/accepted to an institution of higher learning prior to applying.
• Applicants must submit one letter of recommendation from a teacher, employer, or clergy.

Preference in the selection process will be given in the following order to qualified students who are:

students who are committed to a career in the United States Navy

residents of Greer, SC

residents of South Carolina and

residents of all other states

The Towsley Foundation Grants support initiatives that enhance community welfare and sustainability, focusing on diverse fields such as education, health, and the arts within Michigan. With a commitment to effective philanthropy, the foundation prioritizes projects that demonstrate creativity and strategic impact. Eligible organizations must operate in Michigan and adhere to specific funding guidelines, fostering financial sustainability. Grants are allocated based on project merit and organizational capacity, reinforcing the foundation's mission to improve lives through thoughtful partnerships.

Pfizer’s Core Values of Social Responsibility and Philanthropy

About

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. It was Charles Pfizer’s vision at the beginning and it holds true today.

Improving Health Outcomes in Patients with ATTR-CM Through the Development of a Shared Decision-Making Tool (Decision Aid)

Overview

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a progressive, lifethreatening condition associated with significant morbidity, mortality, and burden on patients, caregivers, and healthcare systems. The multisystemic disease course is often characterized by diagnostic delays, complex treatment pathways, and evolving therapeutic options, which can create uncertainty and decisional conflict for patients and clinicians alike. Shared decision-making (SDM) has emerged as a critical component of patientcentered care1, particularly in complex and preference-sensitive conditions such as ATTR-CM. Well-designed decision aids can support meaningful dialogue between patients and healthcare professionals by improving understanding of disease trajectory, treatment options, risks and benefits, and alignment of care with individual patient values and goals.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Joseph and Lorraine Finley Scholarship

Purpose of Scholarship

To provide financial support to high school seniors who are residents of the Wayne County town of Walworth and continuing their education at any accredited two-year, four-year, or technical school.

Number and Size of Awards

Four awards of $7,000 each; paid as $1,750 per year for up to four consecutive years of undergraduate study. Award paid in the Fall and divided equally between the Fall and Spring semesters.

Donor Information

This scholarship was established by a couple who believed in education and in helping their community.

The Sean Warner Memorial Endowment Fund, established by Mark and Susan Warner, honors their son by supporting children in need. This grant focuses on emotional support services for children of divorced parents and is awarded every other year through a competitive process. With a value of approximately $500, it aims to assist in general charitable purposes, making a meaningful impact on the lives of affected children.

The Parkinson's Foundation offers Community Grants to support impactful programs for people with Parkinson's disease across the U.S. With over $5 million awarded in the last three years, the Foundation aims to enhance health, wellness, and education. Eligible applicants include local non-profits and healthcare facilities focusing on mental health, care partner support, and exercise programs tailored for PD. This initiative promotes diversity, equity, and inclusion in service delivery.

The OJJDP FY 2026 Opioid Affected Youth Initiative provides funding to support states and localities in combating violent crime and overdose deaths. This initiative aims to enhance prevention, intervention, and treatment strategies for children, youth, and families impacted by substance use disorders. Collaboration among law enforcement, educational institutions, and community organizations is essential to effectively address the needs of at-risk populations and those already involved in the child welfare and justice systems.

The NIJ FY 2026 Research and Evaluation on Human Trafficking funding opportunity aims to support comprehensive research and evaluation projects. It focuses on preventing human trafficking, assessing the impact of federal policies, and enhancing services for victims. This initiative, led by the National Institute of Justice in partnership with the Office for Victims of Crime, seeks to generate insights that can inform better responses to human trafficking in the U.S.

Ethan J. Hazelwood Heart of Gold Memorial Scholarship

The Ethan J. Hazelwood Heart of Gold Memorial Scholarship was established in 2025 by family and friends of Ethan as a lasting tribute to his life and giving spirit.

Those who knew Ethan remember him as a kind, creative, and giving person. He was always helping others and once gave the boots on his feet to a fellow student who had none.

Open to individuals in Whitley and Noble County, the scholarship is for high school seniors as well as non-traditional students, who wish to pursue additional education in the field of agriculture or diesel mechanics.

Arnold Ventures

Arnold Ventures (AV) is a philanthropy dedicated to improving the lives of Americans through evidence-based policy solutions that maximize opportunity and minimize injustice. We focus on improving systems where outcomes are falling short, incentives are misaligned, and the time is right for change. To advance this mission, we invest in rigorous research to strengthen the evidence base on what works to improve outcomes for individuals, families, and communities, and to inform policy and practice at scale.

AV’s Higher Education team seeks to fund rigorous, causal research on programs, policies, and practices that improve student outcomes and deliver stronger returns on investment for students and taxpayers. Our work focuses on strengthening the evidence base on effective student success models and aligning policy and funding incentives to support their adoption and scale.

Causal Research to Improve Outcomes for Part-Time Students

Purpose of the RFP

This RFP seeks to fund rigorous causal research that builds the evidence base on effective programs and policies for part-time students and identifies scalable, cost-effective approaches to improve completion and labor market outcomes. Findings should generate actionable insights to inform institutional practice, system-level decision making, and state policy, with the goal of improving outcomes and maximizing return on investment for students and taxpayers.

Population of Interest

Because enrollment intensity is fluid, proposals do not need to limit eligibility to students who are enrolled part-time at baseline. Instead, studies should focus on interventions that primarily serve or are expected to meaningfully impact students who are more likely to enroll part-time, including:

• Adult learners (age 25+)
• Student parents and caregivers
• Working adults

Interventions may serve mixed-enrollment populations, so long as the proposed study is clearly designed to improve outcomes for these populations.

About The Children’s Heart Foundation

The Children’s Heart Foundation (CHF) is the country’s leading national organization solely dedicated to funding congenital heart defect (CHD) research. The mission of The Children’s Heart Foundation is to fund the most promising research to advance the diagnosis, treatment, and prevention of congenital heart defects. Since its inception, CHF has funded millions of dollars of CHD research across the U.S. and Canada. 

AHA/CHF Congenital Heart Defect Research Awards

The Children’s Heart Foundation partners with the American Heart Association to fund Congenital Heart Defect Research Awards. This collaborative investment of funds provides support for investigators who are actively conducting research directly related to advancing the prevention, diagnosis, and treatment of CHDs, which directly aligns with The Children's Heart Foundation's mission. 

Congenital Heart Defect Funding Opportunities

A multi-year commitment between the American Heart Association (AHA) and Children’s Heart Foundation (CHF) jointly supports Predoctoral Fellowship or Postdoctoral Fellowship investigators actively conducting basic, clinical, population, or translational congenital heart defects research.

Predoctoral Fellowship

Purpose

To enhance the integrated research and clinical training of promising students who are matriculated in pre-doctoral or clinical health professional degree training programs and who intend careers as scientists, physician-scientists or other clinician-scientists, or related careers aimed at improving global cardiovascular, cerebrovascular and brain health.

• AHA research awards are limited to U.S.-based non-profit institutions, including medical, osteopathic, and dental schools, veterinary schools, schools of public health, pharmacy schools, nursing schools, universities and colleges, public and voluntary hospitals and others that can demonstrate the ability to conduct the proposed research.

• Applicants must be AHA Professional Members at the time of proposal submission. The AHA expects all mentors associated with training/mentored research awards to maintain active AHA membership, as well.

• This award is not for individuals of faculty/staff rank.

Applicants are not required to reside in the United States for any period before applying for American Heart Association funding. However, applicants must have one of the following designations at the time of proposal submission – not award start date, depending on career stage and each individual’s situation. An awardee must maintain one of the designations listed below throughout the duration of the award. Please consult with your institution’s grant officer.

• U.S. citizen
• Permanent resident
• Pending permanent resident (must have filed Form I-485 for permanent resident status and obtained an I-797C 3 Notice of Action that the application has been received by USCIS and case is pending)
• E-3 Visa - specialty occupation worker
• F-1 Visa – student (for predoctoral and postdoctoral fellows only)
• G-4 Visa - family member of an international organization employee
• H1-B Visa - temporary worker in a specialty occupation
• J-1 Visa - exchange visitor (pre- and postdoctoral fellowships only; all other awardees must obtain an H-1B or equivalent by the award activation date)
• O-1 Visa - temporary worker with extraordinary abilities in the sciences
• TN Visa - NAFTA Professional
• DACA - Deferred Action for Childhood Arrivals

The Earthwatch Institute's Teach Earth Fellowship connects K-12 teachers with scientists through immersive research expeditions. Celebrating 50 years, this program empowers educators to inspire students with hands-on environmental science experiences. Teachers gain confidence, collaborate with peers, and develop impactful curricula. The fellowship includes workshops, networking opportunities, and resources to enhance environmental education in classrooms. Participants return with renewed purpose, ready to engage their communities in conservation efforts.

The American Epilepsy Society's Junior Investigator Research Awards support early-career researchers in epilepsy. The awards, offering up to $50,000 for one year, aim to enhance the ability of new investigators to secure longer-term funding from sources like the NIH. Proposals are encouraged across a range of epilepsy research, including basic, translational, and clinical studies, as well as health services research. This initiative also includes complimentary membership to the AES Annual Meeting.

The American Epilepsy Society offers Research and Training Fellowships for Clinicians, providing up to $75,000 for one year to support clinical fellows or new faculty aiming to advance in epilepsy research. This fellowship encourages proposals across basic, translational, and clinical research. It also includes $1,000 for travel to the AES Annual Meeting, membership benefits, and complimentary registration, fostering collaboration and knowledge sharing in the epilepsy research community.

About OSAC

The Office of Student Access and Completion (OSAC) is an office of the Higher Education Coordinating Commission (HECC) committed to assisting Oregonians in their pursuit of higher education and a brighter future. Established in 1959 by the Oregon Legislature, OSAC provides innovative funding and programs to Oregon students and families.

OSAC Scholarship Program

The OSAC Scholarship Application provides current and future Oregon students one easy application to apply for multiple scholarships at one time. OSAC awards more than $10 million in scholarships annually through more than 600 scholarships. 

The American Epilepsy Society offers Postdoctoral Research Fellowships to support trainees conducting research on epilepsy's causes, treatment, and consequences. These fellowships provide up to $49,000 for stipend and benefits, $1,000 for travel to the AES annual meeting, and complimentary membership. Proposals can be basic, translational, or clinical research, and the number of awards depends on available funding.

The American Epilepsy Society offers Predoctoral Research Fellowships to support students conducting epilepsy-related dissertation research under expert mentorship. Proposals in basic, translational, or clinical research are encouraged. Each fellowship provides up to $30,000 for stipend and travel to the AES Annual Meeting for one year, along with a one-year AES membership. The number of awards varies annually based on available funding.

The Oregon Barber and Hairdresser Grant Program, administered by the Oregon Higher Education Coordinating Commission, offers one-time financial assistance to low-income students attending eligible barbering and cosmetology schools in Oregon. This grant aims to support students with significant financial need, ensuring they can pursue their education without financial barriers. Limited funding means only those with a demonstrable need receive support, and grant amounts may vary yearly based on fund performance.

The Lung Cancer Discovery Award, offered by the American Lung Association, supports innovative research aimed at improving outcomes for lung cancer patients. With funding of $100,000 per year for up to two years, this award encourages groundbreaking projects that enhance diagnostic and therapeutic strategies, investigate genetic forms of lung cancer, and develop novel screening methods. The initiative is a vital step towards reducing lung cancer morbidity and mortality, ultimately improving patient care and saving lives.

The Hasting Innovation Award for Interstitial Lung Disease, offered by the American Lung Association, provides $75,000 annually for up to two years to support early-career researchers. This award targets investigators with proven excellence and a track record of accomplishment, aiming to advance lung disease science. Successful candidates must have held a K or R type award within the last three to five years, fostering innovation and discovery in lung health.

The Dalsemer Interstitial Lung Disease Award, funded by the American Lung Association, provides $50,000 per year for two years to support junior investigators researching interstitial lung disease. This award aims to foster independence in early-career scientists while building on the Association's 120-year legacy of improving lung health through innovative research and advocacy efforts, ultimately enhancing the lives of those affected by lung disease.

HCLTech Grant Edition II focuses on impactful climate action by investing $5 million over five years to support NGOs in the Americas. This initiative aims to enhance sustainable projects that align with the 17 Sustainable Development Goals (SDGs). With a history of significant contributions in India, HCLTech is committed to achieving net-zero emissions by 2040 and fostering innovative solutions to address pressing climate challenges. The grant encourages collaboration and aims to transform communities through effective climate action.

The Klingenstein Third Generation Foundation's 'Transformation of Mental Health Care Program' seeks innovative research into improving mental health care access for children and adolescents, particularly from under-resourced backgrounds. Applications are invited for studies that build on promising pilot work, focusing on scalable delivery models and technology use. Eligible applicants are academic researchers based in the U.S. who can demonstrate rigorous research capabilities. The foundation plans to award up to two grants of $100,000 each year for two years.

The United Advisory Scholarship Commission Scholarship, established in 1982 by William and Cordula Freese, supports students with visual or physical impairments in Saginaw County. This scholarship aims to aid those who are graduating high school seniors or currently enrolled in college, ensuring they can pursue higher education full-time. Preference may be given to previous recipients, reinforcing the foundation's commitment to supporting the community's unique needs.

The Child Well-Being Grant Program, established by the Doris Duke Foundation, focuses on promoting the healthy development of children and preventing abuse. With a commitment to addressing systemic inequities, the program supports initiatives that strengthen social service systems and foster partnerships to enhance access to services. It prioritizes funding for projects that encourage community-based interventions and the development of future leaders dedicated to improving child welfare, ensuring all children have the opportunity to thrive in safe and supportive environments.