Best Large Grants for Nonprofit Organizations in Connecticut

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Fruit of the Vine Scholarship

The Fruit of the Vine Scholarship Fund benefits graduating Napa County high school seniors and Napa Valley College transfer students who will find the cost of higher education a financial hardship. Consideration is given to applicants who are the first in their family to attend college or are employed (or have a parent or guardian who is employed) in the Napa County wine or grape industry. Recipients of the scholarship will receive funding for up to four years of undergraduate study.

This funding opportunity aims to advance HIV/AIDS research by implementing human new approach methodologies (NAMs) to reduce the reliance on specific pathogen free (SPF) animal models. It emphasizes the integration of NAMs-enabled frameworks for in vitro testing while supporting essential SPF colony resources. The initiative seeks to enhance research rigor and reproducibility through innovative strategies that prioritize human-relevant models, ultimately improving HIV research outcomes and facilitating collaborative development in the field.

QBE Foundation Inc.

The QBE Foundation’s focus is on creating strong, resilient and inclusive communities. We work in partnership with community organizations, working in climate resilience and inclusion – two areas where we believe we can have the greatest impact.

The QBE Foundation is one component that reflects our company’s focus, involvement, and investment in the neighborhoods where we do business, and where our employees live and work. The QBE Foundation also empowers our employees to volunteer with colleagues and community partners to make a difference for those in need. Employees can also coordinate fundraisers that are matched by the foundation.

QBE Foundation Local Grant Program

This program supports high-impact, community-based initiatives aligned to our focus on climate resilience and inclusion.

• Climate Resilience:
  • Helping communities prepare for, adapt to, and recover from climate-related risks, including preparedness, financial resilience, and risk reduction solutions.
• Inclusion:
  • Expanding access to opportunity for underserved communities through economic inclusion, workforce pathways, and removing systemic barriers.

Multiple grants of $30,000 will be awarded across our two focus areas.

The Senator Harold "Potch" Wheeler Memorial Scholarship, managed by the Community Foundation of Whitley County, honors the legacy of a dedicated public servant. This competitive scholarship is available annually to high school seniors from Whitley County who plan to pursue college education in public service or within the Indiana Department of Natural Resources. Recipients are chosen based on their embodiment of the ideals and character traits exemplified by Senator Wheeler.

Generally the Community Foundation's scholarships are awarded to applicants who have high financial need. Applicants with household income exceeding $100,000 are less likely to be awarded, but applying will allow you to be considered for targeted scholarships.

Virginia Valk Fehsenfeld Scholarship

Open to full time undergraduate students who are Kent County residents studying education, dietetics, nutrition, or human services and have a minimum 3.4 GPA.

The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.

The Bob Skiera Memorial Fund Building Bridges Initiative Grant Program supports urban forestry research and collaboration. With a maximum award of $30,000, it aims to enhance communication between arborists, urban foresters, and various professionals. The program welcomes proposals that explore the benefits of urban forests, policy implementation, and ecosystem services. This initiative honors Bob Skiera's legacy, fostering trust and cooperation within the urban planning community for sustainable urban forestry practices.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.

The Moody's Community Impact Grant Program supports organizations with tax-exempt status to foster social and economic equality. Established by Moody's Foundation, it prioritizes initiatives that empower underestimated communities and entrepreneurs, driving innovation and ecological restoration. The foundation focuses on inclusive growth, providing resources for small businesses and community resilience. Eligible organizations must be registered charities under U.S. IRS guidelines, while ineligible entities include individuals and those promoting unlawful discrimination.

The USA Dry Pea and Lentil Council (USADPLC) invites research proposals for pulse crops, focusing on breeding, nutrition, crop management, and product development for the 2023-24 fiscal year. Projects should adopt a transdisciplinary approach to tackle complex challenges, with average awards around $30,000. Researchers are encouraged to leverage industry funding for matching grants. Note that equipment purchases over $10,000 are not eligible. Compliance with specific proposal guidelines is essential.

The Mastercard Strive USA 2025 Innovation Fund aims to enhance the financial health of small businesses across the U.S. by providing up to $250,000 in grants to organizations developing innovative solutions. This initiative focuses on addressing challenges such as limited access to financial resources and vulnerability to economic shocks, ultimately fostering resilience and growth within the small business sector.

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

Lawrence M. Brass, MD Clinical Research Training Scholarship in Stroke

This award aims to recognize the importance of good clinical research and to encourage early career investigators in clinical studies related to stroke, vascular neurology, and neurocritical care.

For the purpose of this scholarship, research is defined as “patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance diagnosis of neurological disease. These areas of research include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health services and outcomes research.” Disease-related studies not directly involving humans or human tissue are also encouraged if the primary goal is the development of therapies, diagnostic tests, or other tools to prevent or mitigate neurological diseases.

This grant opportunity from the US Department of Health and Human Services, specifically the National Institutes of Health, aims to examine the effectiveness of family navigation models that divert non-urgent mental health concerns from emergency departments. The initiative seeks to enhance mental health service engagement, provide necessary resources, and support families in overcoming barriers to help-seeking. Key deadlines for applications range from February 2025 to October 2027.

The 21st Century Museum Professionals (21MP) Program, funded by the Institute of Museum and Library Services, aims to enhance career pathways and professional networks in the museum sector. This initiative focuses on developing current museum staff, recruiting new professionals, and fostering partnerships that promote effective workforce training. By emphasizing peer learning and alternative career pathways, the program seeks to create a robust and diverse museum workforce across the nation.

The Anne and Tony Hillerman Scholarship, part of the New Mexico Press Women Scholarship Fund, supports New Mexico students pursuing undergraduate or graduate degrees in journalism or communications. Established in 2023, the fund promotes ethical journalism and offers networking opportunities through the NMPW Annual Conference. Eligible applicants must be enrolled in a relevant program, provide a portfolio of work, and submit a personal essay detailing their interests and career goals. This scholarship fosters the next generation of communicators and advocates for First Amendment rights.

The Delaney L. Wykle Nursing Scholarship, managed by the Beckley Area Foundation, aims to support nursing students from Raleigh and Summers counties in West Virginia. Applicants must demonstrate financial need, possess a minimum 3.0 GPA, and be enrolled in an accredited four-year nursing program. This scholarship helps empower students to achieve their educational goals while enhancing community health services in Southern West Virginia.

The Ochylski Family Foundation supports registered 501(c)(3) nonprofit organizations through grants aimed at enhancing their operational capacity. With an application deadline of October 1, organizations must submit a detailed request outlining their initiatives. The foundation's mission aligns with its commitment to foster community development and nonprofit effectiveness in Iowa, ensuring that resources are allocated to impactful projects that serve the public good.

The FY 2027 Service Area Competition (SAC) funding aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive preventive and primary care. This initiative allows for a competitive selection of service areas, ensuring that health centers can effectively deliver high-quality healthcare. Additional service areas may be announced throughout the year to accommodate changes in service availability, supporting continuous care for those in need.

The Alice M. Ditson Fund offers organizational support for summer festivals and conferences focused on contemporary American classical music. This funding opportunity encourages the appreciation of works by younger, relatively unknown American composers. Eligible applicants include performing organizations and institutions that promote artistic excellence. The Fund emphasizes supporting living composers at various career stages, ensuring a broader recognition of their contributions to classical concert music. It is crucial for applicants to align their projects with the Fund's mission of enhancing public knowledge and appreciation.

The AAAAI Distinguished Scientist Award recognizes exceptional contributions in allergy and immunology research, honoring those who have significantly advanced the field and demonstrated leadership. This prestigious award is presented by the American Academy of Allergy, Asthma & Immunology, a leading organization for over 7,000 professionals dedicated to improving patient care and promoting research in allergic diseases. The award highlights the commitment to excellence and innovation within the specialty.

The Juliette P. Doster Scholarship Fund honors the legacy of Mrs. Doster, who dedicated forty years to improving healthcare in Calhoun County. This renewable scholarship supports students pursuing associate's or bachelor's degrees, as well as approved workforce training programs. Awarded yearly for up to four years, recipients must maintain academic standards. Funding varies based on the Community Foundation's annual income, and the award covers tuition, housing, supplies, and other educational expenses.

The Jerry and Martha Taylor Memorial Scholarship, offered by the Quad Cities Community Foundation, supports students from Rock Island County pursuing post-secondary education. With awards of up to $1,000, this scholarship is not renewable and is open to applicants with a minimum GPA of 2.75. Preference is given to students majoring in journalism, theater arts, or special education, or those attending accredited trade schools.

The SAF National Awards Program includes the John A. Beale Memorial Award, recognizing exceptional voluntary service in forestry by SAF members. Established to honor John Beale's legacy, this award is presented at the SAF national convention and includes a $500 honorarium, complimentary registration, and up to $500 for travel expenses. Nominees must demonstrate sustained commitment to the SAF and its mission, showcasing leadership and promotion of forestry principles.

The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.

The National Trappers Foundation (NTF) offers grants to individuals and organizations for projects related to furbearers. Founded in 1988, NTF supports educational and conservation initiatives that promote the management and restoration of furbearers and natural resources. Grants are available for research, habitat development, and educational programs. Contributions to NTF are tax-deductible, reflecting its commitment to conservation and community engagement.

The SAF National Awards Program recognizes exceptional contributions to forestry through its Honorary Membership award. This accolade is presented to individuals whose impact on the field is acknowledged by their peers, highlighting their distinguished service in advancing forestry knowledge and societal awareness. Awardees receive lifetime membership in SAF along with complimentary convention registration. The program seeks to honor those, including non-professional foresters, who have made significant strides in forestry, both domestically and internationally.

Nurses Educational Funds

Nurses Educational Funds, Inc. depends solely on donations to advance our only mission, to promote nursing leadership through annual scholarship support for professional nurses seeking masters and doctoral degrees in nursing education, practice, research, and administration.

NEF’s only purpose is to provide nursing scholarship assistance to make graduate level nursing education possible. NEF is one of the largest, national, private, professionally endorsed source of funds for advanced nursing study with over one hundred years of service to and for professional nursing. NEF is a non-profit organization with 501(c) status.

Rita Reis Wieczorek Scholarship for Maternal-Infant and Pediatric Nursing

Created in 2020, by Rita Reis Wieczorek, EdD, RN, PNP, FAAN, together with NEF. Dr. Wieczorek is an NEF Board Member Emeritus and longtime board member. This scholarship is the first NEF Scholarship to focus on maternal-infant and pediatric nursing. For over four decades Dr. Wieczorek has devoted her career to providing the best maternal-infant and pediatric care to her patients as well as teaching the highest standards of care to master's and doctoral nursing students, motivating them to excel in their care for the well-being of mothers, infants and children.