Best Large Grants for Nonprofit Organizations in Connecticut

The Elevance Health Foundation's Food as Medicine Grant aims to enhance access to nutritious foods and improve health outcomes for individuals facing diet-related conditions. This initiative invites qualified nonprofits to submit proposals focused on scalable solutions that address food insecurity and promote health equity. The foundation prioritizes programs that demonstrate measurable outcomes and support whole-person health, particularly for populations at high social risk. Grants will be awarded for a term of 1-3 years, with funding based on program needs.

The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for up to four Clinical Trials Network Laboratory Centers (LCs). These LCs will support HIV prevention and treatment strategies by providing necessary laboratory infrastructure and technologies for clinical trials. They will ensure rigorous laboratory testing and oversight, enhance sample integrity, and utilize advanced data management systems to meet evolving demands in HIV research and testing.

The Reader’s Digest Partners for Sight Foundation offers Single Program Grants to support impactful programs for individuals who are blind or visually impaired. These grants, ranging from $25,000 to $50,000, prioritize initiatives that enhance independence and service delivery. Eligible organizations must be US 501(c)(3) non-profits, and unsolicited proposals are not accepted. The foundation emphasizes community-based solutions and invites qualified applicants to submit a Letter of Inquiry followed by a full proposal.

The Lotte Lenya Competition, established in 1998 by the Kurt Weill Foundation for Music, honors the legacy of renowned actress Lotte Lenya. This unique contest blends acting and vocal skills, targeting performers aged 19-32 from diverse backgrounds. Celebrating its 25th anniversary in 2023, the competition has increased its prize offerings, with over $1.6 million awarded to more than 800 singers. It's a prestigious platform that has propelled many winners to successful careers in musical theater and opera.

Gilead Sciences

At Gilead, we are relentlessly committed to advancing transformative therapies for the most serious diseases, delivering an exponentially positive impact on health.

For more than three decades, we have combined scientific rigor with a deep sense of purpose to improve health outcomes and reimagine care. Our work spans more than 35 countries with a focus on three therapeutic areas: virology, oncology, and inflammation, where unmet medical needs remain greatest.

From individual patients to whole populations, we’re committed to delivering healthier futures for people and communities worldwide.

Our Mission: To discover, develop and deliver innovative therapeutics for people with life-threatening diseases.

HIV Prevention NOVA 2026

Program Description

Gilead Sciences invites research proposals that advance the evidence base for innovative and scalable models of delivery for long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the United States.

This Topic of Interest (TOI) is focused on care delivery models implemented in non-traditional settings, defined as clinical and non-clinical environments where PrEP services are not routinely provided. Emphasis is placed on approaches that reflect real-life practice and address gaps in current PrEP delivery infrastructure.

Persistent inequities in PrEP uptake in the U.S. suggest that expanding availability within traditional clinical settings alone is unlikely to reach all populations with unmet PrEP need.1,2 Rigorous implementation studies in non-traditional settings where PrEP services are not routinely provided are needed to evaluate whether these models can reduce access barriers and improve equitable reach among individuals who may benefit from PrEP.2,3,4

The goal of this TOI is to generate practical, decision-relevant evidence that informs how LA PrEP can be implemented, scaled, and sustained in real-life U.S. settings.

The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.

The Little Giraffe Foundation is dedicated to supporting neonatal health through research grants ranging from $5,000 to $10,000. Since 2011, they have provided substantial resources to hospitals and institutions, focusing on both immediate and long-term health challenges faced by premature infants. Eligible applicants include scientists and healthcare professionals from U.S.-based institutions. The foundation aims to advance research in biological processes, genetics, clinical studies, and more, improving outcomes for vulnerable populations.

The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.

The RSLAAIS Leadership Award, presented by the American Academy of Allergy, Asthma & Immunology (AAAAI), honors exemplary leaders within state, regional, or local allergy societies. This prestigious award recognizes individuals for their significant contributions to community involvement, clinical education, and the advancement of the AAAAI's mission. Candidates are nominated by the RSLAAIS Board of Governors and must demonstrate a commitment to enhancing their local allergy societies and the broader medical community.

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We believe accurate, contextual and balanced health care reporting is more important than ever.

People depend on health care stories to make life-altering decisions every day.

AHCJ U.S. Health System Reporting Fellowship

This opportunity is for U.S.-based journalists.

Issues with the U.S. health care system are often obvious — from large swaths of uninsured residents and junk insurance plans, to high maternal mortality rates and preventable medical errors. But what is at the root of issues like these? What could an equitable health care system look like? 

Through the U.S. Health System Reporting Fellowship, supported by The Commonwealth Fund, you can pursue a significant reporting project related to the U.S. health care system at the local, regional and/or national level.

This fellowship allows mid-career journalists to maintain their regular employment while working on a major project over a 12-month calendar year. You’ll pursue the projects with the support of your newsrooms or arranged outlets, which commit to publish or air the work.

We believe that issues of health equity impact every facet of the health care system, which is why we’re specifically interested in projects focused on health equity. This might include racial disparities within a community, gaps in public health inclusion, unstable housing, insurance access, food insecurity, violence as a health issue, how health care institutions or systems are applying a racial equity lens to their policies and practices or otherwise addressing inequities or disparities, or other examinations of systemic problems that have become so apparent over the last few years.

Guidance is provided by AHCJ mentors through customized seminars on health care systems, conference calls and email consultations. The fellowship covers the cost of attending the seminars and the annual AHCJ conference, as well as a $2,500 project allowance to defray the cost of field reporting, health data analysis and other project-related research. In addition, you will receive a $5,000 fellowship award upon the successful completion of the project.

The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.

The Kiwanis Club of Albuquerque Scholarship Fund, established in 1948, supports graduating seniors from Albuquerque metro area high schools who demonstrate strong academic performance and community service. Annually, one to four scholarships of up to $1,000 are awarded to students pursuing careers in child development and teaching. The fund emphasizes the importance of community involvement and academic excellence, encouraging students to share their career goals and financial needs through an essay as part of their application.

The Ronald Barnes Memorial Grant, offered by The Guild of Carillonneurs in North America, supports North Americans pursuing studies in carillon performance, composition, music history, or instrument design. Established in 1998 to honor Ronald Barnes, a significant figure in carillon music, the grant has awarded over US$140,000 since 2007. For the 2025 cycle, grants of up to US$14,138 are available, depending on the number of successful applicants, promoting education in this unique art form.

Raptor Research Foundation

The Raptor Research Foundation advances the science, conservation, and understanding of birds of prey -RRF Mission Statement

The Raptor Research Foundation (RRF) is the world’s largest professional society for raptor researchers and conservationists. Founded in 1966 as a non-profit organization, our primary goal is the accumulation and dissemination of scientific information about raptors. The Foundation organizes annual scientific conferences and provides competitive grants and awards for researchers and conservationists. The Foundation also provides support and networking opportunities for students and early career raptor researchers.

“Wings to Fly” Travel Grant

The Award: The “Wings to Fly” grant supports travel from outside the U.S. and Canada for four to five raptor researchers or conservationists to present a paper or poster at our annual meeting.

Each grant will include support for airfare, visa fees, and food and lodging, as well as waived conference registration fees and a one-year membership to RRF. 

The MIND Prize, funded by The Pershing Square Foundation, supports innovative research to combat neurodegenerative diseases like Alzheimer's. It empowers early-to-mid-career investigators to explore unconventional approaches and fosters collaboration across disciplines. Each winner receives $250,000 annually for three years, promoting advancements in neuroscience and creating a unique network for researchers. The initiative aims to enhance our understanding of brain health and tackle pressing societal challenges.

The Holloway Family Foundation, established in North Central Texas, aims to enhance community quality of life regardless of race, gender, or religion. Their mission focuses on financial security, creative expression for under-resourced youth, and mentorship for personal development. The foundation supports organizations that provide workforce training, artistic opportunities for children, and guidance for youth in need. By fostering individual growth and economic stability, they empower families and strengthen communities, staying true to the founders' core values and personal experiences.

The Pediatric Visiting Professorship, funded by the Rheumatology Research Foundation, aims to recognize exceptional scientific abstracts from pediatric rheumatology fellows at ACR Convergence. This award facilitates knowledge sharing and promotes advancements in rheumatic disease care. The professorship spans two to three days and includes diverse teaching formats. Selected fellows receive a $1,000 honorarium for virtual visits or $1,500 for in-person engagements, along with reimbursement for travel expenses, enhancing the future of pediatric rheumatology education.

The Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement aims to enhance the effectiveness of HIV prevention and care planning for RWHAP Parts A and B recipients. Through the provision of training, tools, and technical assistance, this initiative seeks to optimize resource allocation and strengthen the overall system of HIV care and treatment, ultimately improving health outcomes for those affected by HIV.

The AIDS Drug Assistance Program (ADAP) Emergency Relief Funds aim to provide essential funding to states and territories. This initiative focuses on preventing, reducing, or eliminating waiting lists for ADAP services, ensuring timely access to necessary medications and support for individuals living with HIV/AIDS. This program addresses critical funding shortfalls, enhancing the healthcare infrastructure and improving health outcomes in affected communities.

The New Mexico Veterans Memorial Scholarship, established in 2024, supports graduating high school seniors in New Mexico who embody the Medal of Honor Core Values: Courage, Sacrifice, Integrity, Commitment, Patriotism, and Citizenship. This scholarship encourages students to explore and reflect on these values through a personal essay and community service. Preference is given to students from Albuquerque High Schools, fostering a commitment to excellence and civic duty among the youth.

The Goodnow Fund is a family foundation that provides approximately $1.5 million in grants annually to nonprofit organizations. Focused on supporting vulnerable children, Alzheimer's research, educational opportunities for low-income students, and environmental improvement, the Fund primarily aids organizations in Fairfield County, Connecticut. It identifies potential grantees directly and does not accept unsolicited proposals. For more information, organizations can contact the Fund's Executive Director.

The American Heart Association is inviting proposals for research on the effects of GLP-1 and GIP agonists in individuals with cardiovascular, kidney, and metabolic diseases. This initiative aims to explore how these medications can alleviate the CKM burden. Researchers with expertise in causal inference, machine learning, and cardiovascular research are encouraged to apply, particularly those working in multidisciplinary teams and leveraging various data sources.

The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.

The Little Giraffe Foundation, a national non-profit based in Chicago, provides NICU Support Grants ranging from $100 to $1,000. Since 2011, they have positively impacted countless families by delivering over 32,000 gift bags and funding essential research. These grants aim to enhance the experience for parents and patients in neonatal intensive care units, supporting initiatives like holiday gift bags and resources for bonding with babies. Applications are welcomed from eligible U.S.-based institutions.

The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.

The Ryan White HIV/AIDS Program Part C Capacity Development Program aims to enhance the capabilities of community-based organizations, focusing on improving health outcomes and decreasing HIV transmission. This initiative supports individuals who have not yet accessed regular HIV care, emphasizing innovative care solutions and infrastructure development to address these critical needs.

RRCU Gives Foundation Grant

Mission Statement:

RRCU Gives strengthens our region by providing meaningful financial support to nonprofits addressing hunger, housing, and financial education. Through our annual grant awards and major funding initiatives, we help local organizations grow, thrive, and create lasting change.

 We award grants annually, with applications in June and awards in August.

Focus Areas

• Hunger
• Housing
• Financial Education