Best Large Grants for Nonprofit Organizations in District of Columbia

The ASF Family Fund Grant, offered by the Angelman Syndrome Foundation, provides crucial financial assistance to families of individuals with Angelman syndrome. This rare neuro-genetic disorder affects approximately 500,000 people globally. The fund aims to enhance the quality of life for affected individuals, allowing caregivers to apply for up to $5,000 to cover essential needs. Limitations include restrictions on certain expenses and prior grant awards. This initiative aims to support families through education and necessary resources.

The CFF/NIH R01-Unfunded Award, offered by the Cystic Fibrosis Foundation, supports exceptional CF-related research projects that have been submitted to NIH but lack funding. This program aims to bridge the gap for meritorious projects, providing up to $125,000 per year for two years. By facilitating research in cystic fibrosis, the foundation helps ensure that innovative ideas can continue to progress toward improving care and outcomes for individuals affected by this disease.

The CF Foundation/NIH K-Unfunded Award aims to support exceptional research projects in cystic fibrosis (CF) that have been approved by the NIH but lack funding. This award provides temporary financial assistance of up to $80,000 per year for two years to ensure that promising CF research continues without interruption. The initiative focuses on fostering a new generation of researchers dedicated to advancing CF studies while encouraging the NIH to provide long-term support.

The Cystic Fibrosis Foundation's Student Traineeship Award supports students in engaging with cystic fibrosis research through hands-on projects. With a maximum funding of $4,000 for one year, the program aims to inspire students to pursue careers in CF research or care. Eligible applicants must be enrolled in a degree program and collaborate with a faculty mentor on a relevant project. This initiative also emphasizes the importance of maintaining interest in CF-related research among new generations.

The Cystic Fibrosis Foundation offers a Travel Award Supplement aimed at supporting Ph.D. students, postdoctoral fellows, and junior faculty. This funding of up to $3,000 enables trainees to participate in off-site workshops or training programs to enhance their research skills. Eligible applicants must be active researchers in CF projects, with a minimum of one year of experience. The program excludes conference attendance and for-profit entities, ensuring focused support for advancing cystic fibrosis research.

The Harry Shwachman Clinical Investigator Award, offered by the Cystic Fibrosis Foundation, supports clinically trained physicians transitioning to independent researchers in cystic fibrosis. It provides up to $133,000 per year for three years to facilitate research tailored to individual interests. The funding covers personnel costs and supplies, promoting a strong mentorship during this critical stage of their academic careers.

The Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award by the Cystic Fibrosis Foundation supports postdoctoral fellows in advancing their research careers in cystic fibrosis. This program offers up to five years of funding, including 3 years for research training and 2 years for transitioning to an independent faculty position, with a maximum support of $110,000 per year. It aims to foster innovative research that develops new therapies for cystic fibrosis.

The Cystic Fibrosis Foundation offers the Path to a Cure (PTAC) Postdoctoral Research Fellowship Award to support innovative research training in cystic fibrosis (CF). Aimed at enhancing scientific knowledge and facilitating the transition to independent careers, this program funds projects targeting the development of new therapies for CFTR variants. Awards can reach up to $75,000 in the first year and $76,000 in the second year, fostering foundational research that could lead to breakthroughs in CF treatment.

The Pizza Hut Foundation is offering scholarships for students demonstrating financial need and community leadership. Eligible applicants must be U.S. residents aged 17-26, enrolled in accredited post-secondary education for Spring 2026, and maintain a minimum GPA of 2.5. Scholarship amounts range from $500 to $5,000, with distribution to be made in Spring 2026. The application period runs from July 8 to September 5, 2025, with notifications for recipients by November 17, 2025.

Mission

The Mission of the Muskingum County Community Foundation is to improve quality of life in the community by nurturing opportunities and serving needs through collaboration and philanthropy.

Vision

The Envisioned Future of the Muskingum County Community Foundation is that Muskingum County’s quality of life attracts organizations and people to pursue their dreams and practice their passions.

A. Porter Spirit of ZHS Fund

A long time teacher at Zanesville High School. As a new teacher ZHS embraced her and she embraced the Blue Devils. Annette Porter is a first generation college graduate from a single parent home. While her parents supported her decision to go to college, it was necessary to incur personal debt which was and is common. This scholarship is available to help those students who may need a little financial help to take the first step toward college, and also make the collegiate experience less burdensome.

Becoming a Blue Devil was a process. Annette had a lot of help along the way, from Principals, Asst Principals, teaching peers, friends and family, so in an effort to pay it forward she has created this scholarship. “ Everyone of my students had potential, the most difficult thing was to convince them to work toward achieving it”. This scholarship will be awarded to a Blue Devil, not necessarily the most “spirited” but the Best Blue Devil who demonstrated all of the qualities that make up a Blue Devil.

Robert B. Tonjes Scholarship

Amount

• $1500
• Active
• Renewable

Applicant must be a graduating senior of a Henderson County public high school or the equivalent who is pursuing a four-year degree in nursing or another medical related field. Applicant must demonstrate financial need to attend an institution of higher learning.

William Elliott Frye Memorial Scholarship

Funding Amount:

• $1000
• Active

This scholarship is to assist a student seeking a higher education at an accredited community college or technical school. Students must be a resident of Western North Carolina that include, but not limited to, graduating seniors, current college students, and returning adult education students who are focused on a career and technical education field. Students may be either full-time or seeking a certification to advance their education. Students must demonstrate financial need and meet all requirements of the attending education institution.

The Future Energy Leaders Scholarship, offered by the Delaware Community Foundation, supports graduating seniors from Sussex County high schools pursuing two or four-year degrees. Awardees receive $2,500 annually for four years, contingent on maintaining enrollment and demonstrating financial need. With a record $850,000 awarded to 245 students for the 2024-2025 school year, this scholarship aims to expand educational opportunities and equity within the community.

Ocean State Media Scholarship

The scholarship offers awards to residents of Ocean State Media’s demographic market area who demonstrate promise of a successful career in the fields of journalism and/or media.

Scholarship Award Details

Established by Rhode Island PBS in 2017, the Ocean State Media Scholarship offers awards to residents of the station’s demographic market area who demonstrate promise of a successful career in the fields of journalism and/or media. Awards of up to $15,000 will be awarded annually and are renewable for an additional three years.

The Karl A. Bickel and Madira Bickel Journalistic Scholarship Fund Grant supports journalism students at accredited colleges and universities. Established under Karl A. Bickel's Last Will and Testament, it awards approximately $40,000 annually. Eligible organizations must have journalism programs and qualify as 501(c)(3) exempt entities. While there are no geographical restrictions, preference is given to institutions in Florida. The fund is administered by Wells Fargo Bank, ensuring that deserving students receive necessary financial support.

The Anna B. Glauser Trust Grants provide financial support to organizations aiding physically handicapped individuals, particularly blind residents in Delaware County, PA. Established in memory of Willis K. Glauser, the trust awards 1-2 grants annually, ranging from $2,500 to $5,000. Eligible organizations must be 501(c)(3) certified, while funding for salaries is typically excluded. This initiative reflects Anna Glauser's lifelong commitment to assisting the visually impaired community.

Thomas E. and Marian L. Overby Scholarship

Amount

• $1000
• Active
• Renewable

This scholarship is to provide financial support for an individual pursuing a degree in the field of nursing. The scholarship recipient shall be under the age of 50 seeking education beyond the high school level to become a nurse or certified nursing assistant.

The William C. Risser Charitable Trust Grants support mental health research, particularly in Schizophrenia. This private foundation assists 501(c)(3) nonprofit organizations across the U.S. with grants typically ranging from $25,000 to $55,000. Administered by Wells Fargo, the Trust awards 1-2 grants annually, focusing on program support for scientific and educational research. Eligible organizations must meet IRS exemption requirements.

The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.

The Land Trust Bird Conservation Initiative, led by the Cornell Lab of Ornithology, aims to support land trusts in conserving private lands for bird protection. With funding for up to fourteen grants, the initiative encourages capacity building and management projects that enhance bird habitats. Eligible organizations can apply for grants to expand conservation efforts through collaboration and innovative strategies, fostering partnerships that leverage additional funding and community support. This initiative highlights the importance of birds in land stewardship and conservation.

Arizona Community Foundation

For more than four decades, the Arizona Community Foundation has worked in tandem with generous individuals, families, and organizations to address some of the biggest challenges facing our state.

Scholarships

In partnership with our generous donors, we award millions of dollars annually to help students achieve their educational goals. Through our online system, students complete one application and are matched with available scholarships, based on their eligibility requirements.

Guinn B. Burton Medical Scholarship

Guinn B. Burton established this scholarship fund in her estate trust to provide medical scholarships for disadvantaged students. 

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

George F. and Asha W. McMillan Scholarship

This scholarship is to provide financial support to an individual in order for him or her to receive a degree in Christian education or related studies or to advance his or her Christian vocation.

Community Foundation for Mason County, MI

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Scholarships

If you’re a high school or homeschooled senior, current college student, early college senior, or a student pursuing a master’s or doctoral degree, the Community Foundation for Mason County may have a scholarship for you.

Marlene Schoenberger Scholarship

This scholarship has been made possible by the generosity of Tamar Schoenberg, who established the Marlene Schoenberger Scholarship Fund of the Community Foundation for Mason County in memory of her mother, Marlene. This scholarship is presented to Mason County students pursuing Fine Arts and Performing Arts.

Beckley Area Foundation

Beckley Area Foundation was established in January 1985 by ten community-minded citizens. It began with a gift of $1.1 million from the Dr. Thomas Walker Memorial Health Foundation as “seed” money for this Raleigh County project. BAF assets have grown to over $70 million with over 500 different funds managed by our three trustee banks. Today, Beckley Area Foundation is one of West Virginia’s largest community foundations.

Since its inception, BAF has distributed over $23 million to charities and other worthy projects in the fields of education, public recreation, health & human services, the arts, animal services and beautification.

Scholarships

The Beckley Area Foundation proudly manages scholarship funds established by individuals, businesses, and organizations dedicated to helping students pursue higher education. Many of these scholarships are tailored for specific schools, fields of study, or graduates from local high schools, while others offer broader opportunities. No matter the path, our scholarships aim to support students from our region as they work toward achieving their educational goals.

Most of these scholarships must be awarded to students from our geographic area or at least preference given to such students. While the majority of scholarships benefit Raleigh County applicants there are others designated for Fayette, Summers, Webster, and Wyoming students. 

Owen C. Meadows and Brenda J. Meadows Scholarship

Must be resident of Raleigh County; Pursuing an accredited nursing program (including technical, baccalaureate or advanced nursing education programs); Merit and need based.​

This scholarship is not renewable.

Delaware Art & Design Scholarship

Awards:

• One time award of $20,000. Students may reapply each year.

Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Mountz Girls ScholarshipThe Mountz Girls Scholarship Fund was created in 2022 by Patricia Anne Chapman to honor her mother and aunts — Virginia M. Duffey, Glenna L. Rodman, and Jean A. Kibler, and her mother, Rachel F. Chapman. An inheritance from her Aunt Glenna Lou was the seed money to start the scholarship, to be awared to female students — seniors and graduates — of high schools in Marion County pursuing an education in the fine arts, visual arts, commercial art, or art education.

A Little HOPE, Inc. is a charitable foundation that provides grants to organizations offering bereavement support services and grief counseling for children and young adults who have lost a loved one. The grant amounts vary based on project scope and budget. Applications are by invitation only, sent out each October, and interested organizations should submit an email with necessary details for consideration.