Best Large Grants for Nonprofit Organizations in District of Columbia

The William L. and Diane C. Wilson Scholarship for Karst Science, established in 2002, honors the legacy of William L. Wilson and aims to support innovative karst scientists. Funded by Diane C. Wilson, it provides a one-time award of $2,500 and recognition at the KWI spring banquet. Eligible candidates must be enrolled in a master's program focused on karst science and its subfields, while PhD students are excluded. This scholarship fosters the growth of new talent in karst research.

The National MS Society offers annual Research Grants for investigator-initiated proposals addressing key research questions from the Pathways to MS Cures Roadmap. These grants support diverse studies, including clinical and nonclinical research aimed at stopping MS disease activity, restoring function, and preventing new cases. Eligible applicants must hold an M.D. or Ph.D. and demonstrate relevance to the Society's research priorities. This funding opportunity promotes collaboration and focuses on underserved MS populations.

Seattle Foundation

Seattle Foundation is an agent of change, igniting powerful, rewarding philanthropy to make Greater Seattle a stronger, more vibrant community for all.

At Seattle Foundation, we believe that community is more than a place. It’s the shared understanding that our joy and well-being are tied to one another. Every day we work with nonprofits, philanthropists, and partners like you to strengthen community by igniting powerful philanthropy and advancing long-term solutions. Because it takes all of us to create a joyful region where every person can thrive.

Patricia Fisher Endowed Scholarship

The Seattle Association of Black Journalists (SABJ) established this scholarship in honor of Patricia Fisher, a Puget Sound native, journalist, educator and role model for her support of young people and her community. Scholarships of $5,000 help students of African descent who are from or attending college in Washington and who are pursuing college careers in communications, such as print, photo, broadcast journalism or multimedia and online journalism. Scholarships are awarded based on scholastic achievement, financial need, community service and a serious interest in communications. Recipient(s) will be matched with a mentor who is a SABJ member.

The MASOT Conney W. Berger Jr. Memorial Graduate Student Award, established in honor of a dedicated toxicologist, supports doctoral students in toxicology/pharmacology. Eligible candidates must present at the MASOT meeting and meet specific criteria, including GPA requirements and MASOT membership. This award, valued at $500, encourages academic excellence and is made possible through the generous support of SafeBridge Consultants, Inc.

The Cultural Capital Fellowship offers $10,000 grants to Native artists and culture bearers dedicated to community outreach and cultural preservation. This fellowship strengthens the Collective Spirit of First Peoples artists, emphasizing the importance of passing on ancestral knowledge and maintaining cultural sharing. Eligible applicants must have strong ties to their Native community and be committed to sustaining cultural practices. The fellowship aims to support those who promote generosity, wisdom, and integrity within their communities.

The Jennifer Easton Community Spirit Award honors Native artists who have dedicated their lives to sharing cultural knowledge and ancestral gifts. With a grant of $50,000, this award supports artists deeply rooted in their communities, fostering healing and resilience. Nominations are open for practicing artists across various mediums, including music, dance, and storytelling, ensuring the continuation of Indigenous traditions and the enrichment of Native culture.

The Native Performing Arts Fellowship (NPA) supports Native artists in enhancing their craft through grants of up to $10,000. This fellowship prioritizes personal artistic development over project-based funding, encouraging applicants to focus on growth through classes, workshops, and professional mentorship. Eligible candidates must be U.S.-based, 18 years or older, and enrolled members of recognized tribes. The program emphasizes Indigenous values in performing arts, fostering resilience and cultural expression.

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a female or female-identified student from a high school in Lackawanna, Luzerne, Pike, Susquehanna, Wayne, or Wyoming county who has 50 or more documented volunteer hours and and who has a GPA of 3.0 or higher.

The Benton Community Foundation will be awarding over $132,330 this year in scholarships to graduating high school seniors from Benton County high schools.

Ruth & Julian Adams Memorial Scholarship

Ruth died in 1983, and Julian died in 2002. Both had a passion for journalism. Ruth’s daughter Shirley McDonald, and her husband Marv McDonald, established the Ruth and Julian Adams Memorial Scholarship Fund as a lasting tribute to Shirley’s parents’ memory. The fund benefits Benton County high school students pursuing careers in journalism.

The TTP Bridge Program aims to enhance the safety and accessibility of bridges in Tribal communities, addressing the urgent need for infrastructure improvements. With aging bridges affecting economic development and children's transportation, this program allows federally recognized Indian Tribes to apply for funding for planning, construction, and rehabilitation of bridges. By focusing on TTP bridges in poor condition, the initiative seeks to strengthen economic foundations and ensure better connectivity with markets, benefiting both families and communities.

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a graduating senior from a high school in Lackawanna, Luzerne, Wayne, or Pike county who plays baseball and plans to continue playing in college.

The Ollie Hinkle Heart Foundation's Technology Grant aims to improve pediatric heart care outcomes through innovative collaborations. By focusing on predictive technologies for early recognition, precision for personalized care, and preventive measures for quality of life, the foundation seeks to transform care for heart children and their families. Their mission emphasizes community support, education, and advocacy to ensure no family faces unmet needs alone, creating a legacy of love and courage in the heart community.

Marshall High School Scholarship

Marshall High School is a cornerstone of the Middletown community — a place where students are challenged to grow, lead, and serve. This scholarship was established to recognize the best of what Marshall students represent: hard work, resilience, and a genuine desire to contribute to something greater than themselves.

Each year, this scholarship is awarded to a graduating senior who embodies the spirit of Marshall — a student who has made the most of their time in school, given back to their community, and is ready to carry those values forward into college and beyond.

The Maternal and Child Health Encounters Networks (MCHEK) program, funded by the US HHS: Health Resources & Services Administration, aims to enhance maternal and infant health by preventing exposure to harmful substances throughout pregnancy. Through a national expert call center, it provides evidence-based guidance on medications, nutrition, and environmental factors. By translating complex scientific data into accessible information, MCHEK empowers families and healthcare providers to make informed choices that improve health outcomes.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

The PCC Rapid Response Grants provide support for cultural initiatives that aim to shape narratives during critical cultural moments. These grants prioritize projects that engage communities of color, immigrants, refugees, and other marginalized groups, focusing on intersectionality, gender justice, and social equity. Eligible projects include pop culture campaigns, research, and public spectacles that respond to urgent political and cultural events, aiming to reach mass audiences and disrupt harmful narratives.

Scholarship amounts vary depending on the scholarship applied for. Applicants are encouraged to apply for as many awards as they are eligible to increase the likelihood of receiving one or more awards.

Scholarships can be used for cost of attendance, direct education expenses, including tuition, books, and/or other school-related fees.

If you receive an award, be sure to complete your scholarship acceptance form (online portal). Scholarship awards are paid directly to the academic institution by the end of August.

Bob Suddeth 4-H Scholarship Fund

The Bob Suddeth 4-H Scholarship supports DeKalb County graduating seniors who have been active in 4-H for at least six years, including their senior year of high school, and who plan to pursue agriculture-related education. Financial need is an important consideration, and students may attend any accredited trade school, college, or university. 

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

The NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22) aims to support researchers from underrepresented backgrounds in transitioning to faculty positions. This award offers funding for three years to assist in establishing independent biomedical careers. Applications are due on specific deadlines, including February 12 and June 12 for standard submissions, and March 12 and July 12 for renewal applications. This initiative promotes diversity in scientific research.

The St. Baldrick’s Foundation Fellowship Award supports pediatric oncology training through a two-year fellowship, with a potential third year based on need and achievements. This initiative, powered by community fundraising events, aims to advance research for childhood cancer cures. The award provides a salary capped at $97,500 per year, covering salary and benefits for fellows. This fellowship not only fosters professional growth but also contributes significantly to the fight against childhood cancers.

The St. Baldrick’s Foundation Research Grant Award supports innovative research aimed at curing childhood cancers. With funding of $100,000 per year for two years, this grant is designed for hypothesis-driven projects that can be laboratory, clinical, or epidemiological in nature. Established through community-driven fundraising events, the foundation empowers volunteers and donors to make a significant impact in the fight against cancer, ensuring a brighter future for young survivors.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

Gregory D. Spring Perseverance Scholarship

Established in memory of Gregory D. Spring, this scholarship is for a graduating senior from Allegany-Limestone Central School, Ellicottville Central School, Franklinville/Ten Broeck Academy, Portville Central School, Hinsdale Central School or Olean High School with a preference for a student who intends to pursue a degree or certification in a trade or technical program. 

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.

Ginger D. Schroder Cattaraugus County Legislative District 2 Scholarship

The Ginger D. Schroder Legislative District 2 Scholarship is given to a graduating high school student residing in Cattaraugus County Legislative District 2 who will pursue a trade degree or 2-or 4-year college degree.