Best Large Grants for Nonprofit Organizations in District of Columbia

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

The Zuckerman Postdoctoral Scholars Program fosters collaboration between leading scientific institutions in the U.S. and Israel by attracting top postdoctoral researchers. With a focus on STEM leadership, this program offers a unique two-year scholarship, allowing scholars to conduct research at participating Israeli universities and North American institutions. The initiative aims to strengthen academic ties, enhance research capabilities, and support the return of talented Israeli scholars to their home institutions, ultimately enriching the global scientific community.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR) Competitive Grants Program aims to enhance the capacity of state and local government crime laboratories for processing DNA samples. This program focuses on using DNA technology to improve forensic efficiency and implement Rapid DNA in booking stations. It targets jurisdictions with operational challenges, ensuring fair access to funding. Eligible agencies can apply for both competitive and formula CEBR funding.

The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.

The FY 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI) aims to fund U.S. academic teams conducting innovative research to tackle complex challenges for the Department of War. Established in 1985, MURI promotes collaboration among diverse scientific disciplines, enhancing the defense workforce and addressing critical areas of interest through multidisciplinary research efforts at U.S. universities.

Steve Wagner Scholarship

Steve Wagner retired as executive director of the American Council of Engineering Companies of Michigan (ACEC/M) in 2003 after 34 years of service. As a member of the Capitol Club and Michigan Society of Association Executives, Steve was well respected by his peers and colleagues and is known for his honesty and integrity.

Steve and his wife, Lana, were married in 1965 and have two daughters, Shelley and Whitney. Throughout his career, Steve has been a proponent of community service and has given many hours himself to church and community programs. Steve also has been a strong proponent of education. ACEC/M has established this scholarship in honor of Steve Wagner to award engineering and surveying students who, like Steve, are active in the community and find it important and necessary to give something back.

The AHRQ Mentored Clinical Scientist Research Career Development Award (K08) aims to foster a diverse pool of skilled health services researchers. This funding opportunity supports career development for individuals pursuing research that aligns with AHRQ's mission and priorities. Eligible applicants will receive mentorship to enhance their research skills and contributions to the field. Overall, this initiative is crucial for addressing pressing healthcare research needs.

The DOE Quantum Genesis Q Competition aims to accelerate the development of fault-tolerant quantum computing capabilities essential for scientific research. This initiative invites proposals from domestic entities to create viable plans for the Quantum Genesis program, aligning with national scientific goals. The competition serves as a foundational effort to scale quantum technologies and enhance scientific workflows, fostering innovation and collaboration as the nation progresses into a new era of computational power.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Calvin H. & Elizabeth L. Topliff Scholarship

Georgia Mathews, mother to Marion Community Foundation board member, Spencer Mathews, created this endowed scholarship in 2023 in honor of her parents. The scholarship will be awarded to Marion County students who are pursuing a career in either education or engineering, with special consideration for students who will be attending Ohio Northern University, which is where Georgia’s parents met.

Betty Beatty Topliff was born in Pittsburgh but ended up in Marion after meeting Calvin at Ohio Northern and moving to his hometown of Marion. Betty (1928-2022) was a dedicated teacher for 30 years, most recently at Ridgedale High School. Calvin (1924-2009) was an Army veteran who served in Europe during WWII and was awarded the Bronze Star. Calvin retired from the marketing department of Ohio Edison Marion Division after 36 years of service.

Following retirement, Calvin and Betty were Florida snowbirds, but Betty returned to Marion after Calvin’s death to be with her beloved children, grandchildren, and great grandchildren.

The Rea Charitable Trust, established in 2009 by Mrs. Isabel McClintic Rea, prioritizes support for charitable organizations that focus on the arts. Administered by Comerica Bank & Trust, the trust provides funding through structured application periods for organizations based on their names. Eligible applicants must be 501(c)(3) organizations, limited to one application per year. The trust aims to uphold Mrs. Rea's legacy by fostering artistic endeavors within the community.

TechAccess: AI-Ready America is a nationwide initiative aimed at enhancing AI readiness across the U.S. by fostering collaboration and resource sharing. It targets businesses, organizations, and individuals, ensuring widespread access to AI tools and knowledge. The program includes State Coordination Hubs to connect stakeholders, a National Lead for collaboration, and AI-Ready Catalyst Award Competitions to drive innovative solutions. This comprehensive approach seeks to prepare all sectors for an AI-driven economy, benefiting Americans through practical implementation and workforce development.

The RTK Scholars Program, funded by RTK Environmental Group, provides a $1,500 scholarship to support students pursuing careers in science, particularly in environmental studies, biology, and engineering. This initiative aims to cultivate the next generation of experts in environmental testing and technology. Eligible applicants must maintain a GPA of 3.0 or higher and be enrolled in an accredited institution. The application deadline is May 31 each year, promoting academic excellence and dedication to environmental sciences.

The L’Oréal USA For Women in Science Fellowship empowers women postdoctoral scientists by providing annual grants to support their research in STEM fields. This initiative not only recognizes their contributions but also encourages them to serve as role models for future generations. With a long-standing partnership with the AAAS, the program has awarded over $5 million to 105 scientists, demonstrating a strong commitment to advancing women's roles in science and technology.

The Kelley Foundation

The Kelley Foundation was established by Robert and Judy Kelley and their daughter Marla. The Kelleys are native Oklahomans and longtime residents of Southern Oklahoma.

The foundation is primarily focused on humanitarian projects in Oklahoma, with an emphasis on Southern Oklahoma. Our mission is to develop and strengthen our community, state, and nation by providing essential resources to those in need.

The Kelley Foundation Grant

The Kelley Foundation is a private, charitable foundation, incorporated under the laws of the State of Oklahoma and operated exclusively for providing support through its gifts and grants to religious, charitable, scientific, and educational institutions which are qualified under section 501(c)(3) and which are not private foundations within the meaning of section 509(a) of the Internal Revenue Service Code.

The Nature Awards for Inspiring Women in Science, particularly in the Science Outreach category, honors initiatives that empower girls and young women in STEM fields. With a focus on engagement and retention, the awards aim to celebrate projects that encourage participation in natural sciences, technology, engineering, mathematics, and medicine. Winners will receive significant cash prizes and opportunities for mentorship, creating pathways for future generations of women in science.

The Nature Awards for Inspiring Women in Science celebrate outstanding contributions by women in STEM fields. These awards recognize early-career female researchers who demonstrate exceptional achievements, face challenges, and inspire the next generation through outreach. Winners receive prizes totaling $50,000, mentorship opportunities, and invitations to prestigious ceremonies. This initiative promotes inclusivity and aims to enhance the representation of women in science, thereby supporting a diverse and equitable scientific community.

The NIH Director's New Innovator Award supports creative early-stage investigators pursuing innovative research with transformative potential for science relevant to the NIH mission. Applications are encouraged across all NIH-related fields, enhancing support for emerging talent. This award is part of the NIH Common Fund's High-Risk, High-Reward Research Program, which aims to cultivate groundbreaking research and foster the next generation of scientists.

About the Hertz Foundation

Empowering the Nation’s Most EXCEPTIONAL Innovators

The Hertz Foundation identifies and empowers the nation’s most exceptional innovators in science and technology, fueling a lifelong community dedicated to solving our most pressing problems.

Hertz Community

Awards & Recognition

We’ve established several awards to recognize and support Hertz community members who are accelerating solutions to significant real-world challenges, either through their individual careers or volunteering to strengthen the Hertz Foundation’s work. In addition to providing financial and professional support at a critical time, we also hope to generate more awareness within the Hertz community and inspire collaborations that build on the momentum.

Hertz Thesis Prize

The Hertz Thesis Prize recognizes fellows who publish exemplary doctoral theses with applications to real-world problems. Winners receive a $5,000 honorarium.

Exemplary Graduate Work

Since 1981, more than 60 fellows have been recognized with the Hertz Thesis Prize. Much of their work has led to successful patents, the formation of influential companies and contributed solutions to some of our most pressing challenges.

The Foundations of Trusted Systems initiative seeks innovative research to develop secure, resilient, and affordable technologies for Command, Control, Communications, Computers, and Intelligence (C4I) and Cyber systems. This Broad Agency Announcement (BAA) aims to establish trusted foundations for hardware and software, building on previous work to enhance information processing systems. Researchers are encouraged to submit white papers for evaluation and potential funding.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

The NIH R25 program promotes broad participation in the biomedical and behavioral sciences by supporting educational activities. It aims to encourage individuals from diverse and underrepresented backgrounds to engage in research through mentoring networks and research education experiences. This initiative seeks to enhance the workforce by providing opportunities for further study and career advancement in research fields, ultimately contributing to a more inclusive scientific community.

The NSF Core Research in Biological Sciences (BIO Core) program supports innovative research that enhances our understanding of biological systems, from molecular to biome scales. This funding opportunity encourages interdisciplinary proposals and can fund both single and multi-investigator projects. The awards will vary in scope and duration, accommodating exploratory projects and long-term commitments, depending on available funding and alignment with the program's objectives.

The National Science Foundation (NSF) is offering funding through the Engineering (ENG) program, focusing on foundational research in civil, mechanical, and manufacturing innovation. Key areas include advanced manufacturing systems, civil infrastructure, and intelligent dynamic systems. The NSF ENG encourages innovative and transformative proposals that may not require immediate commercial outcomes. Award sizes and durations will vary based on budget availability, aiming to support long-term research advancements.

The ACLS Graduate Internships on the Spiritual Infrastructure of the Future program offers summer opportunities for current PhD students in the humanities and social sciences to engage with organizations addressing the evolving American religious landscape. This initiative aims to cultivate future leaders by providing practical experiences that demonstrate the value of doctoral training beyond academia. Supported by the Templeton Religion Trust, the internships encourage collaboration between fellows and community organizations, fostering a deeper understanding of spiritual infrastructures.