Best Large Grants for Nonprofit Organizations in District of Columbia

The DC Commission on the Arts and Humanities (CAH) is an independent agency in the District of Columbia government. First established in 1968, it evaluates and initiates action on matters relating to the arts and humanities. Additionally, CAH encourages programs and the development of programs that promote progress in the arts and humanities. CAH is the designated state arts agency for the District of Columbia. It is supported primarily through District government funds. Additionally, it receives partial support from the National Endowment for the Arts.

Projects, Events, or Festivals

Projects, Events, or Festivals (PEF) furthers CAH’s mission by encouraging progress in the arts and humanities in the District of Columbia by supporting Individuals and non-profit arts, humanities, arts education, and service organizations who significantly contribute to the District of Columbia as a world-class cultural capital. This grant opportunity program goals:

• Provide access to high-quality arts and humanities experiences for all District of Columbia residents.
• Improve quality of life by supporting vibrant community projects within the arts and humanities.
• Strengthen the creative economy through investments in local individuals and organizations.

PEF is open for projects of all sizes that show District impact and engage District residents and visitors.

CAH encourages community-based projects that share characteristics such as geographic location, common interests, or community impact. Arts and humanities projects may include but are not limited to: concerts; visual arts exhibitions; literary readings; or festivals that feature dance, folk art, film, music, theatre and other art forms. 

The Arts and Humanities Fellowship Program (AHFP) Grant, offered by the DC Commission on the Arts and Humanities, supports individual artists and humanities practitioners in the District of Columbia. This initiative aims to elevate the contributions of various disciplines, including dance, media arts, and visual arts, fostering a vibrant cultural community. Eligible applicants include artists of all career stages, encouraging a diverse range of creative expressions and interdisciplinary practices.

The Equitable Food Access Initiative: Home Delivered Meals, led by the DC Department of Health, aims to enhance food access for District residents. This program invites proposals from qualified community and non-profit organizations to implement effective strategies for delivering meals to those in need. By focusing on evidence-based approaches, the initiative seeks to improve food environments and ensure equitable access to nutritious food options for all residents.

The High-Need Healthcare Career Scholarship Program, offered by the District of Columbia Department of Health, aims to support local residents pursuing careers in high-demand healthcare roles. This initiative addresses critical workforce shortages for positions such as Home Health Aides, Certified Nurse Aides, and Emergency Medical Technicians. Funding is available for training programs that prepare individuals to meet these urgent healthcare needs, enhancing community health services.

The Mid-Atlantic Environmental Justice Fund - Track II focuses on enhancing tree canopy to improve public health and environmental resilience in disadvantaged communities. This initiative aims to address air pollution, stormwater management, and ecological challenges through community-driven tree planting and maintenance projects. Supported by the Chesapeake Bay Trust and various local organizations, this program emphasizes participatory decision-making and requires community recommendations for project proposals, fostering local engagement and sustainability.

The DC Health Community Health Administration is seeking qualified applicants for the Equitable Food Access Initiatives: School Based Nutrition Market. This initiative aims to enhance food access in communities facing food insecurity by implementing evidence-based interventions. Targeting over 10,000 vulnerable residents throughout the year, the program will support families with children by promoting healthier food environments and reducing chronic disease burdens. Applications are encouraged from those ready to improve nutrition and food security for all.

DC Health

The mission of DC Health is to promote and protect the health, safety, and quality of life of  residents, visitors, and those doing business in the District of Columbia. The agency is  responsible for identifying health risks; educating the public; preventing and controlling diseases,  injuries, and exposure to environmental hazards; promoting effective community collaborations;  and optimizing equitable access to community resources.

HAHSTA Prevention Services

Purpose

This funding announcement is to support a comprehensive approach that identifies and prevents HIV, STI, and HBV/HCV among populations, such African American women, youth (18-24), men who engage in male to male sexual contact (MMSC), biological males who identify as female, biological females who identify as male, African American males, unhoused individuals, and others most at risk for exposure. Applicants should ensure that all people are aware of their health status and of methods to reduce their risk of these diseases. This approach may lead to improved health outcomes, enhanced self-efficacy, improved health literacy, viral suppression, and reduced new infections. The framework fully supports the Ending the HIV Epidemic (EHE) in the District of Columbia (DC).

Applicants who exhibit the capacity to deliver comprehensive HIV prevention activities that include HIV, STI, and HBV/HCV screening and delivery of PrEP/PEP education will be considered for funding. Services are to be fully accessible and well-suited to each population’s behavioral and cultural settings.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The General Operating Support Grant Program offers essential funding to non-profit organizations focused on arts and humanities. Applicants must demonstrate a commitment to diverse artistic expressions and community engagement, aligning with the DC Commission on the Arts and Humanities' goals. The program reviews applications based on three categories: Generalists, Service Organizations, and Capacity Building, ensuring that a significant portion of resources is dedicated to arts and humanities initiatives.

The Comcast NBCUniversal Foundation offers Local Impact Grants to nonprofit organizations in 11 markets, providing $225,000 to support local programs addressing community issues. Eligible organizations must be 501(c)(3) nonprofits with a revenue exceeding $100,000 and must operate in one of the specified television markets. The grants aim to empower youth through education, promote diverse storytelling, and enhance community engagement. This initiative underscores Comcast's commitment to fostering inclusion and equitable opportunities for underserved communities.

The Doris Duke Foundation's Environment Program grants aim to foster a resilient environment through effective conservation efforts. By supporting U.S. nonprofit organizations, the foundation seeks to protect biodiversity, address climate change, and advance equity, particularly for marginalized communities. The program emphasizes land conservation, natural climate solutions, and inclusive practices, ensuring that conservation efforts benefit both wildlife and people. This initiative is pivotal for enhancing the health of ecosystems and communities across the United States.

The Extension Risk Management Education (ERME) Competitive Grants focus on underutilization of crop insurance projects to enhance agricultural producers' economic viability. This initiative, backed by the Northeast ERME Center and others, provides funding to deliver education in various risk management areas. Grants up to $100,000 are available for projects running from April 2026 to September 2027, with plans to support 7-10 new projects based on quality applications and funding availability.

The Roy A. Hunt Foundation's Environment Initiative Grants aim to support projects that enhance ecological health and sustainability. With an annual budget of approximately $3.4 million, the foundation prioritizes initiatives that promote responsible environmental practices, clean energy, and waste reduction. Grants between $25,000 and $75,000 are available for projects at various levels, focusing on innovative solutions that foster community partnerships and address root causes of environmental challenges.

Many Hands Grants has awarded over $2.5 million since 2004 to support local nonprofits focused on women, children, and families in need throughout the Washington, DC area. The organization offers four grants annually, including a $100,000 Impact Grant and three Partner Grants. The funding is unrestricted and aims to enhance the operational capacity of grantees, enabling them to better serve their communities in areas such as economic empowerment, education, health, and housing.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Sigma Xi Grants-in-Aid of Research Program, celebrating 100 years of supporting research, offers financial assistance to undergraduate and graduate students. Members can receive grants ranging from $500 to $5,000, while non-members can apply for up to $1,000. Additionally, there are specific funds available for astronomy and vision-related research. This program fosters collaboration between students and mentors, promoting scientific excellence through hands-on experience.

The Mid-Atlantic Panel on Aquatic Invasive Species Grant Program invites proposals for funding to tackle aquatic invasive species (AIS) challenges. Key priorities include research on AIS management, innovative control methods, and educational outreach. Eligible applicants range from individuals in government agencies to non-profit organizations. The program seeks to support initiatives that align with the Aquatic Nuisance Species Task Force standards and aims to enhance regional AIS management strategies.

Dover Grants, offered by Speedway Children's Charities, supports 501(c)(3) nonprofit organizations focused on children's welfare in Delaware and the mid-Atlantic region. The grants prioritize initiatives assisting homeless, foster children, and victims of trafficking. Applicants must complete a two-phase application process, beginning with a Pre-Proposal and followed by a Full Proposal if selected. The organization emphasizes funding for critical, medical, and educational needs to foster a brighter future for children.

The Truancy Reduction Service Grant, offered by the District of Columbia Department of Human Services, focuses on providing essential services to combat truancy among youth aged 10-17 in selected schools. This initiative, aimed at enhancing mental health, mentorship, and family support, emphasizes the importance of culturally competent strategies and outreach. Applicants must demonstrate experience with at-risk youth and ensure services are accessible in Spanish, targeting diverse populations, including those facing housing instability and special needs.

Department of Energy and Environment

The Department of Energy and Environment (DOEE) is the leading authority on energy and environmental issues affecting the District of Columbia. Using a combination of regulations, outreach, education, and incentives, our agency administers programs and services to fulfill our mission. We work collaboratively with other government agencies, residents, businesses, and institutions to promote environmentally responsible behavior that will lead to a more sustainable urban environment.

Clean Water Construction Grant Program

The mission of the District of Columbia’s Clean Water Construction (CWC) program is to fund the design and construction of voluntary projects that provide clean water to District streams and rivers.

Clean Water Construction Treatment Works Projects - Notice Of Funding Availability and Request For Partners (RFP)

DOEE seeks to identify collaborative partners for its fiscal year (FY) 2027 Clean Water Construction (CWC) grant application to the Environmental Protection Agency (EPA). Applications are requested for project partners in three categories of work: (1) Sewage Infrastructure Projects, (2) Stormwater Grey Infrastructure Projects, and (3) Stormwater Green Infrastructure Projects. This RFP is competitive.

Clean Water Construction Grant Program - Stormwater Green Infrastructure Projects

Stormwater Green Infrastructure Projects include techniques and plantings used to reduce stormwater runoff through groundwater infiltration, evapotranspiration, and rainwater harvesting; and projects designed to protect, restore, or construct stream and wetland ecosystems.

Project examples

• Green streets;
• Permeable pavement;
• Bioretention;
• Green roofs;
• Cisterns for harvesting and reuse of stormwater;
• Street tree/urban forestry/tree box expansion;
• Downspout disconnection;
• Wetland restoration;
• Stream restoration and daylighting;
• Sustainable landscaping and site design;
• Other practices that mimic natural hydrology to provide a water quality benefit; and
• Equipment to maintain these practices, such as a vacuum-powered street sweeping of permeable pavers.

Housing Opportunities for People Living with HIV/AIDS

This funding opportunity is to support rental assistance and housing-related supportive services for eligible District and Maryland residents living with HIV through the Housing Opportunities for Persons with AIDS program.

The mission of DC Health is to promote and protect the health, safety, and quality of life of residents, visitors, and those doing business in the District of Columbia. The agency is responsible for identifying health risks; educating the public; preventing and controlling diseases, injuries, and exposure to environmental hazards; promoting effective community collaborations; and optimizing equitable access to community resources.

The mission of HAHSTA is to protect and improve the health of District residents by preventing, diagnosing, treating, and reducing the transmission of HIV, viral hepatitis, sexually transmitted diseases, and tuberculosis, while ensuring access to high-quality, coordinated, and culturally responsive care and support services for individuals and communities most impacted by these conditions.

The mission of the CBHCP Division is to strengthen the HIV service delivery system by expanding access to stable housing, enhancing organizational and workforce capacity, and fostering strategic community partnerships that improve health outcomes, promote service coordination, and address structural barriers impacting people living with HIV in the District of Columbia.

The mission of the Housing Opportunities for Persons with AIDS (HOPWA) program is to provide stable, affordable housing and housing-related supportive services for low-income individuals living with HIV and their households, recognizing housing stability as essential to improved health outcomes, sustained engagement in care, and overall well-being

The District of Columbia Department of Energy and Environment (DOEE) aims to replace diesel vehicles with zero-emission equivalents to enhance community health. The grant supports replacing medium- and heavy-duty vehicles registered in the District, with available funding totaling $2,396,457. Non-governmental organizations, faith-based groups, universities, and private enterprises are encouraged to apply for rebates on vehicle replacement costs, promoting a cleaner environment and reduced NOx emissions.

Chesapeake Watershed Investments for Landscape Defense (WILD) Program

The Chesapeake Watershed Investments for Landscape Defense (WILD) Grants Program delivered in partnership with the U.S. Fish and Wildlife Service supports efforts to improve the condition and connectivity of habitats for at risk and federally listed species.

The National Fish and Wildlife Foundation (NFWF) is committed to operating in full compliance with all applicable laws, regulations, and Executive Orders. We continuously monitor legal and regulatory developments to ensure our policies, procedures, and operations align with current federal directives. We encourage all applicants to do the same.  

The ability and extent to which NFWF is able to make awards is contingent upon receipt of funds from federal agencies and/or other funding partners. Final funding decisions will be made based on the applications received and the level and timing of funding received by NFWF.

The WILD Program Pillars are:

• Pillar 1: Restore, conserve, and connect fish and wildlife habitat
• Pillar 2: Improve water quality for fish, wildlife and people
• Pillar 3: Align the power of nature to adapt to changing landscapes
• Pillar 4: Expand access to nature and outdoor recreation for all Americans
• Pillar 5: Build partnership capacity to collaborate and coordinate actions

The Chesapeake WILD Grants Program has three distinct tracks:

• Collaborative Conservation
  • Grants of up to $200,000 will be awarded for projects that support and enhance the capacity of partnerships, networks, and other collaborative models working collaboratively to advance place-based, landscape-scale, and crossjurisdictional habitat restoration, conservation, and connectivity outcomes.
• Planning and Technical Assistance
• Implementation

The Employees Community Fund (ECF) of The Boeing Company empowers employees to make a significant impact through pooled donations. Established over 60 years ago, this employee-managed fund supports charitable organizations in communities where Boeing operates. The Potomac Region Chapter, formed in 2000, focuses on education, veterans, and low-income communities, with over 130 members contributing to the cause. Grants are available to nonprofits that align with these focus areas, fostering community engagement and support.

The Capacity Building Initiative (CBI) by the Chesapeake Bay Funders Network aims to enhance the organizational capacity of groups working towards community well-being and natural resource management. Funded projects may include strategic planning, staff training, and technology assistance, with funding requests typically capped at $40,000 for nonprofits and $150,000 for local governments. Eligible applicants include nonprofits and local governments operating within the Chesapeake watershed, focusing on water and natural resource goals.

The Diminished Tree Species Grant Program focuses on restoring native tree species crucial for biodiversity and forest health. By funding scientific research, seed orchard development, and land preservation, the program aims to combat climate change through effective tree restoration projects. The Oak Hill Fund, a private entity, encourages project-specific applications, prioritizing organizations that meet eligibility criteria under Section 501(c)(3) of the IRS. This initiative is vital for sustaining healthy ecosystems and mitigating environmental impacts.

Anacostia River Watershed Trash Trap Maintenance RFA

DOEE seeks eligible entities to propose ways to monitor and maintain trash traps, provide environmental workforce development, and educate District residents about pollution that impairs the District’s waterbodies. A successful applicant will propose ways to design and implement a trash trap maintenance program for eight (8) trash traps in the Anacostia Watershed for one (1) year: to collect the trash; to collect data on the amount and types of trash being captured; to recruit, train, and employ District residents to assist; and to coordinate opportunities for volunteers to assist with maintenance and learn about the need for trash reduction in District waters and watersheds The amount available for the 12-month project is $160,000.