Best Large Grants for Nonprofit Organizations in Guam

The Feasibility Clinical Trials of Mind and Body Interventions (R34) program seeks to support trials focused on complementary health approaches for conditions identified as high-priority by NCCIH. This funding opportunity aims to gather essential data necessary for planning future clinical efficacy studies. Applicants must demonstrate the feasibility of interventions and their potential impact on public health. Contacting NCCIH scientific contacts before submission is encouraged, and a Plan for Enhancing Diverse Perspectives is required.

The National Institute of Environmental Health Sciences (NIEHS) is launching a funding opportunity for research hubs focused on the health impacts of extreme weather. This initiative encourages multidisciplinary teams to engage with community partners on issues such as wildfire smoke and extreme heat. Emphasizing collaboration, the program aims to develop scalable solutions and measurable public health outcomes, leveraging resources and expertise across institutions to address climate-related health challenges effectively.

The NIOSH National Center of Excellence for the Prevention of Childhood Agricultural Injury (U54) aims to enhance the safety and well-being of youth in the agriculture sector. This initiative will conduct vital research, improve data collection, and implement effective interventions to mitigate risks faced by young workers. By collaborating with various stakeholders, the center seeks to translate scientific findings into practical solutions that promote healthier working environments for children in agriculture, forestry, and fishing industries.

The NIH Research Software Engineer (RSE) Award aims to provide salary support for outstanding Research Software Engineers who play a vital role in creating and sharing biomedical, behavioral, or health-related software and tools. This opportunity encourages RSEs to enhance the development of algorithms and support training for prospective users. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the proposal deadline.

The Institute of Education Sciences (IES) offers a grant to support state education agencies in utilizing longitudinal data systems to inform policies and programs for learners with disabilities. This initiative aims to enhance evidence-based decision-making at both state and local levels, ensuring better educational outcomes for at-risk students. The grant encourages collaboration and effective use of data to promote informed policymaking in special education.

The Lewis-Houghton Civics and Democracy Initiative, under the Teaching with Primary Sources program, aims to empower organizations in the U.S. and its territories to create innovative projects that leverage digitized primary sources from the Library of Congress. This initiative, named after Reps. Lewis and Houghton, promotes education in civics, democracy, and history, fostering critical thinking and literacy among students. Grants will be awarded based on the proposal's alignment with these educational goals, enhancing community engagement.

The Rural Health Value Program aims to fund one recipient to provide essential analysis and technical assistance for rural stakeholders. This initiative helps them navigate the value-based care landscape in rural healthcare settings. By supporting rural providers, the program seeks to enhance their participation and success in innovative payment and delivery models that emphasize quality care and value-driven strategies. This funding opportunity ultimately aims to strengthen rural healthcare systems.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The Higher Education Challenge Grants Program, managed by the USDA's National Institute of Food and Agriculture, aims to enhance institutional capacities in food and agricultural sciences education. This initiative focuses on improving curriculum, faculty, and student recruitment for master's and doctoral programs, particularly in veterinary medicine. By strengthening these educational frameworks, the program seeks to ensure the availability of skilled professionals in critical agricultural sectors.

The Disaster Distress Helpline (DDH) offers 24/7 crisis counseling to individuals in the U.S. and its territories facing emotional distress from disasters. Managed by SAMHSA, the helpline aims to enhance and strengthen access to crucial support services year-round, ensuring that those affected by natural or human-caused disasters receive the help they need to mitigate behavioral health impacts.

The National Institute on Deafness and Other Communication Disorders (NIDCD) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) are seeking innovative research applications for non-invasive imaging technologies to study the human olfactory system. This initiative emphasizes the need for advanced multimodal imaging techniques to enhance diagnostic capabilities for olfactory disorders, addressing challenges posed by the system's unique anatomical features. Collaboration among experts is encouraged to foster impactful research developments.

The CTIA Wireless Foundation's Catalyst Grant Program aims to empower social entrepreneurs leveraging 5G technology to tackle critical challenges in American communities. With over $200,000 in unrestricted grants available, the program supports innovative projects that utilize 5G connectivity for social good. As 5G transforms communication and interaction, the Catalyst Grant seeks visionary leaders who can harness this potential to inspire meaningful change and enhance community engagement.

The American Cancer Society (ACS) and the American Society for Radiation Oncology (ASTRO) co-fund the Clinician Scientist Development Grant (CSDG), aimed at advancing the research careers of clinician scientists in radiation oncology. Eligible applicants are full-time faculty members at U.S. institutions with a doctoral degree and an active clinical license. The grant supports research for 3 to 5 years, providing $135,000 annually for direct costs, plus allowable indirect costs, while encouraging diversity in applications.

The NIH R25 program enhances clinician-scientists' involvement in research by supporting educational activities aimed at recruiting individuals from diverse backgrounds into biomedical, behavioral, and clinical sciences. This initiative promotes the development of research experiences and mentoring networks to foster a robust research workforce. Applications are due by 5:00 PM local time of the applicant's organization, providing an opportunity for engaging with the NIH's mission.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award supports investigator-initiated clinical trials of natural products, including botanicals and dietary supplements. This funding opportunity aims to validate the pharmacokinetics and bioavailability of these products over three years in a phased approach. Successful trials will provide crucial data for further development and clinical application, emphasizing the importance of scientifically driven research in natural product efficacy.

The NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) promotes innovative clinical trials on natural products, such as botanicals and dietary supplements. This funding opportunity supports studies that demonstrate significant scientific rationale and preliminary evidence for efficacy. Applications can explore various delivery methods and combinations with existing treatments to enhance outcomes. Funding is available for up to three years, aimed at bridging basic science discoveries into practical clinical applications.

The Disability Inclusion Fund Grant, managed by Borealis Philanthropy, aims to support organizations advocating for disability inclusion, rights, and justice. As a partner in philanthropy, Borealis facilitates donor collaboratives to maximize impact across various communities and movements. Organizations interested in applying for this grant are encouraged to review the detailed FAQ for further information. This initiative is a vital step towards fostering inclusivity and promoting the rights of individuals with disabilities.

The Frankenthaler Climate Initiative offers implementation grants aimed at enhancing energy efficiency in visual arts museums, addressing climate change through innovative projects. With deadlines extended for those affected by the LA Fires, eligible institutions can apply for funding ranging from $50,000 to $100,000. This initiative supports museums of all sizes, helping them reduce emissions and operational costs while promoting sustainable practices in the arts sector.

The Teiger Foundation Single Project Grant supports innovative visual arts projects at non-profit exhibition spaces with annual budgets exceeding $3 million. Focused on curatorial practices, the grant encourages experimentation and creativity, aiming to drive positive structural change in contemporary art. Eligible expenses include artist fees, publication costs, and coalition-building efforts. The next Call for Proposals opens in Fall 2026, with funding of up to $150,000 available for selected projects.

The U.S. Fish and Wildlife Service's Coastal Program offers vital technical and financial support for projects aimed at protecting and restoring fish and wildlife habitats in priority coastal ecosystems. Collaborating with conservation partners, the program ensures that all projects are scientifically sound and align with the missions of the Department of the Interior. Applicants must contact a local office for guidance before applying, ensuring projects meet strategic conservation goals.

The Rural Housing Preservation Grant (HPG) program, administered by the USDA's Rural Housing Service, offers funding to support very low- and low-income homeowners in rural areas. This program also assists rental property owners and cooperative housing complexes in making necessary repairs and renovations, ensuring that housing remains accessible to those in need. Preapplications must be submitted by September 8, 2026, to comply with regulatory requirements.

The Applied Drug Policy Research Experiences project aims to provide graduate students and recent post-graduates with hands-on research opportunities to support the National Drug Control Strategy. Through rigorous studies and data analyses, this initiative will explore the evolving dynamics of illicit drug supply and usage, assisting public health and safety officials in anticipating drug-related issues and crafting effective responses to safeguard the American public.

The National Cancer Institute (NCI) is seeking applications for studies that explore how bariatric surgery influences cancer risk, emphasizing the need for innovative research in this area. This funding opportunity encourages the participation of researchers who focus on the long-term impacts of bariatric surgery beyond weight loss and diabetes, addressing critical gaps in understanding the disease mechanisms involved. Key deadlines for application submissions span from February 2025 to October 2027.

The Infant-Toddler Court Program State Awards empower states and communities to enhance child welfare practices by integrating courts, social services, and families. This initiative promotes safety, healthy development, and nurturing relationships for young children involved in child welfare. Awardees implement the evidence-based ITC approach, sharing lessons learned with local teams, tracking outcomes, and training to ensure effective program expansion across targeted communities.

The Placement and Coordination Program, administered by the Office of Refugee Resettlement, invites eligible organizations to enhance refugee resettlement services. By diversifying service providers, the program aims to strengthen the national resettlement framework. Key responsibilities include managing the Program of Initial Resettlement and Intensive Case Management for vulnerable refugees, ensuring comprehensive support from arrival through initial resettlement, and addressing barriers to self-sufficiency.

This grant opportunity supports large-scale research projects aimed at combating antibiotic-resistant bacteria (CARB). It focuses on promoting the appropriate use of antibiotics, reducing the transmission of resistant strains, and preventing healthcare-associated infections (HAIs). Funded by the US Department of Health and Human Services' Agency for Healthcare Research and Quality (AHRQ), this initiative encourages innovative approaches to address these critical public health challenges.

This grant opportunity invites applications for Large Health Services Research Demonstration and Dissemination Projects aimed at combating antibiotic-resistant bacteria (CARB). The projects should focus on promoting the appropriate use of antibiotics, minimizing the transmission of resistant bacteria, and preventing healthcare-associated infections (HAIs). Applications must be submitted by 5:00 PM local time of the applicant organization, as specified in the announcement.