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Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows
Catalyzing Innovation through Partnerships
At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.
About this Challenge
This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).
Award Structure and Funding Level
To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:
For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.
Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease
The Challenge
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease
The Challenge
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
Mary Kay Ash Foundation
Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.
Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.
Mary Kay Ash Foundation: Cancer Research Grant
The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.
Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually.
Interface Health Foundation
Interface Health Foundation is a non-profit, 501c3 tax-exempt organization driven by a collective vision of positive change. In healthcare industry policy, understanding the intricate dynamics of funding and its impact on public access, quality, and cost remains paramount. IHF is dedicated to advancing analysis and research into the crossroads of healthcare industry policy, structural frameworks and affordability.
At IHF, our mission is clear: to empower and support student-led research endeavors that shed light on critical healthcare policy and structural issues affecting the public. Through our initiatives, we seek to foster a deeper understanding of the complex dynamics shaping the healthcare landscape.
Interface Health Foundation: Research Grant
Healthcare administrative grant award opportunities are highly competitive and allow candidates to stand out as they enter the job market. Through this IHF grant award, you will get the opportunity to pull together research and content on topics that aren't fully studied or publicized. Depending on the grant topic, some grantees will also have access to a preceptor who is an executive leader in the healthcare field. The preceptor will serve as a valuable resource to the grantee during the development of the research paper and beyond.
An example of a research topic is the impact of legislated acute care nurse staffing levels on the following: nursing professional job satisfaction, the patient experience, and the standard nursing quality indicators as part of nursing Magnet status accreditation.
Alkermes
At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.
Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.
Pathways APN Research Awards
The Alkermes Pathways Advanced Practice Nurse (APN) Research Awards™ program is designed to empower the advanced practice nursing community by offering funding opportunities that recognize their vital role in evidence-based care and the advancement of mental health research.
The Alkermes Pathways APN Research Awards provide opportunities for individual grants of up to $10,000 per project for licensed psychiatric-mental health nurse practitioners who are actively engaged in clinical, academic, and/or community health settings and are committed to advancing research in schizophrenia or bipolar I disorder.
Alkermes
At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.
Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.
Investigator Sponsored Studies Program
Alkermes seeks to support research designed and conducted by independent clinicians and scientists through our Investigator Sponsored Studies (ISS) program. Alkermes may occasionally announce a Request for Proposals (RFP) for research in clinical areas where gaps in data have been identified.
The ISS research Alkermes supports must be based in the United States and is typically conducted by experienced researchers who have an established history of successfully completing research with independent funding. Alkermes can provide its marketed products to the ISS programs it supports. In addition, there may be financial support available, but please note that study budgets cannot exceed $300,000 (inclusive of overhead).
American Psychiatric Association Foundation
There is no health without mental health. The APA Foundation is working in your community to provide the support and resources we all need to prioritize mental wellbeing where you live, learn, work, worship, and play.
Backed by the medical expertise of the APA and industry-leading strategic partners, we administer community-changing programs, public education campaigns, grants, and awards aimed at increasing mental health literacy, connecting individuals to needed care, and shifting attitudes toward mental health.
Our Mission is to promote the mental health and well-being of individuals and communities. Our Vision is a mentally healthy nation for all – where we live, learn, work, worship, and play.
Diversity Leadership Fellowship
The Diversity Leadership Fellowship identifies and motivates minority psychiatry residents or those interested in minority and vulnerable populations to become well equipped to teach, administer, and provide culturally competent, evidence based mental health and substance abuse services to diverse minority groups and at-risk populations. These populations include—but are not limited to—American Indians/Native Alaskans, Asian Americans/Native Hawaiians/Native Pacific Islanders, Blacks/African Americans, Hispanics/Latinos, LGBTQ, and religious minorities. Program Benefits:
Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.
Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.
Marion Rotary Club’s Karl W. Schell Scholarship
The Marion Rotary Club was chartered in 1922, as club number 1051, with 23 charter members led by Fred Guthery, the first president. The Marion Rotary Club, along with the Marion Rotary Foundation, which was incorporated in 1959, has contributed to many organizations and scholarships over the years.
The Marion Rotary Club Karl W. Schell Scholarship migrated to Marion Community Foundation in 2017. It honors the late Karl Schell and provides financial support for Marion County graduating seniors. Recipients will have been a resident of Marion County for at least two full years and maintain a cumulative grade point average of 2.5 or higher based on a 4.0 scale.
Special consideration will be given to applicants who intend to pursue an education and career in, or related to, business, management, or the real estate industry.
Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Harris ScholarshipThe Harris Scholarship Fund was created in 2017 by the LaRue United Methodist Church to honor the generosity of the late Everett and Elvida Harris and to support students active with the church.In addition to being a current and active member of the LaRue Methodist Church, recipients of the Harris Scholarship will be a high school senior, graduate, or candidate for graduation from any high school in Marion County with a GPA of 2.0 or greater.
Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.
Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Kaufman Family Memorial ScholarshipThe Kaufman Family Memorial Scholarship Fund was created in 2019 to honor the adventurous spirit of Martin T. Kaufman II.
Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Kannan Family ScholarshipThe Kannan Family Scholarship is open to students from any high school in Marion County, with preference to seniors or graduates of Pleasant High School where the Kannan’s children attended. Their scholarship supports students pursuing a career in a STEM field – science, technology, engineering, or mathematics – or health care and special consideration will be given to those with demonstrated financial need.
Marion Community FoundationMarion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.
Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Tasha Jones Memorial ScholarshipThe Tasha Jones Memorial Scholarship Fund was created in 2020 to honor the young life of Tasha Jones (1985-2020), a long-time and faithful employee of Edgefield Animal Care Center in Marion. The Tasha Jones Memorial Scholarship, created by her colleagues at Edgefield Animal Care Center, supports students pursuing a career in animal science, veterinary medicine, veterinary technician, or veterinary technology, who will be grateful, happy, and hardworking and pursue a goal of making life better for the animals and people they meet every day.
Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Marion Elks Lodge No. 32 ScholarshipThe Benevolent & Protective Order of the Elks is a fraternal service organization with more than 600 members in Marion. The Marion Lodge, the second in Ohio, was instituted in 1885 and recognizes former U.S. President Warren G. Harding as a member.
The Elks Scholarship at Marion Community Foundation was established in 2004 and grows annually with regular contributions from Lodge members. It makes awards to students from Marion and contiguous counties who are in the upper 40th percentile of their graduating class and maintain a GPA of 2.5 or better. Recipients are determined based on an essay which demonstrates their understanding of the ideals and mission of the Benevolent & Protective Order of the Elks and a commitment to the social values embodied by members of the Elks.
Marion Community FoundationMarion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.Mission: To continually improve the Marion Area community through philanthropy, leadership and civic engagement. Dr. Kathy Dixon Memorial ScholarshipThe Dixon Scholarship supports the educational careers of area students wishing to attend Marion Technical College and The Ohio State University at Marion. Applicants can be from any high school in Marion and its six contiguous counties. Special consideration is given to college upperclassmen who are majoring in the fields of science or health care.
Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.
Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.
Clare Cooke Performing Arts Scholarship
Clare Cooke, the namesake of this fund, has worked as a performer, choreographer, and director for the Marion Palace Theatre since 1977, directing Christmas at the Palace and numerous community theater productions and junior musicals for many years, including The Wizard of Oz, The Will Rogers Follies, Annie, Oliver!, The Music Man, Guys and Dolls, Hairspray, and Oklahoma!
The Clare Cooke Performing Arts Scholarship Fund, created in 2012 through gifts from nearly 100 friends and family members, recognizes her outstanding contributions to the performing arts community and quality of life in Marion.
The Cooke Fund awards scholarships to Marion County high school seniors and graduates pursuing an education in the performing arts. Recipients are high school seniors who rank in the top 50th percentile of their graduating class or graduates with a college GPA of at least 2.5.
Kids’ Chance of Nevada
Kids’ Chance of Nevada, in collaboration with Kids’ Chance of America, was established for the purpose of creating, assisting, and supporting programs that provide educational opportunities and scholarships for the children of injured workers in Nevada who have been seriously injured or who have suffered from a fatality as a result of an on-the-job incident.
Kids' Chance of Nevada Scholarship
Kids’ Chance of Nevada scholarships are for children of workers who have been killed, seriously injured, or experienced a debilitating illness in a work-related incident. Scholarships are awarded once a year and students may apply every year for which they are eligible. Current annual scholarships are determined based on the student’s financial need.
Students between the ages of 16-25 whose parent’s on-the-job death or injury resulted in a substantial decline in family income are eligible to apply. The applicant must meet adequate academic standards set by the selection committee. Scholarships may be used to pay for technical school or undergraduate college tuition, books, housing, meals or transportation.
About Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.
Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.
Marion Academy of Medicine Scholarship
The Marion Academy of Medicine Scholarship was created by physicians of the local medical community in 2008. While the Academy dissolved in 2014, it had existed for decades as an educational organization comprised of physicians in Marion County. Through this fund, its support of future medical students will continue in perpetuity.
Assets from this former organization were donated to create this scholarship at Marion Community Foundation and support the education of local students pursuing degrees and careers in osteopathic medicine. Recipients will be graduates of any high school in Marion County and maintain a college GPA of 3.0 or greater.
About Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.
Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.
Helen & Bob Bintz Scholarship
The Bintz Scholarship, created in 2001, supports Catholic education and makes awards to any Marion County student to attend a Catholic university, especially the University of Dayton, the alma mater of many family members. The fund honors the parents of its creators, Patricia Kelly, Suzanne Burkhart, and MaryJo Balistreri.
Recipients of the Bintz Scholarship rank in the upper 25th percentile of their high school graduating class and/or maintain a college GPA of 3.0 or higher. They must have attended a high school located in Marion County for at least the 18 months prior to their application.
About Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.
Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.
Civitan Club of Marion Scholarship
The Civitan scholarship supports life-long Marion students pursuing or intending to pursue a field of study or career that either involves working with children in education or working with children or adults with disabilities.
About Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.
Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.
American Legion Post 162 Scholarship
Created in 2022 by the membership of Marion’s American Legion Post 162, this fund will support college scholarships for Marion County students who have been local residents for at least two years. Recipients of Post 162’s scholarships will be persons on active duty with any service of the U.S. military, honorably discharged veterans of any U.S. military branch, current or honorably discharged members of the Reserve or National Guard, or relatives (spouse, child, stepchild, grandchild, sibling, first cousin, niece, or nephew) of a person who meets one of these criteria.
About Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.
Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.
Altrusa Club of Marion Scholarship II
Altrusa Club of Marion Scholarship Fund II was created in memory of Ferol Mae Burley. It supports female students from Marion County pursuing a degree in business management.
About Marion Community Foundation
Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.
Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.
Altrusa Club of Marion Scholarship I
The Altrusa Club of Marion Scholarship Fund I was established in memory of Lynda L. Williams, Ruth Kramer, and Clara J Walters. It supports life-long Marion County students pursuing higher education.
Brown County Community Foundation
BCCF operates as a 501 (c)(3) corporation. It professionally manages and distributes income from charitable bequests consistent with the donor’s wishes and interests. In other words, BCCF manages charitable funds, making grants to local, nonprofit organizations based on advice from donors. Donors can specify a specific organization or a general area of concern within the community to which their gift be directed.
Scholarships
The Foundation manages several academic scholarship funds, many established expressly for Brown County High School graduates.
Additionally, through the Foundation’s affiliation with The Lilly Endowment Inc., over forty Brown County residents have received four-year full-tuition scholarships through the Endowment’s Community Scholars Program.
BCCF Scholarships are available to current high school graduates, students currently enrolled in college, past graduates planning to enroll, as well as G.E.D. graduates.
Shaffer Family Scholarship
Purpose
To provide educational scholarships for students who are accepted into and attending accredited two or four year public or private intuitions of higher learning.
Looking for youth sports grants in Guam?
Read more about each grant below or start your 14-day free trial to see all youth sports grants in Guam recommended for your specific programs.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for Youth Sports grants in Guam?
Most grants are due in the first quarter.
What's the typical grant amount funded for Youth Sports Grants in Guam?
Grants are most commonly $362,500.
What's the typical amount funded for Guam?
Grants are most commonly $88,367.
What's the total number of grants in Youth Sports Grants in Guam year over year?
In 2024, funders in Guam awarded a total of 74 grants.
Among all the Youth Sports Grants in Guam given out in Guam, the most popular focus areas that receive funding are Human Services, Arts, Culture & Humanities, and International, Foreign Affairs & National Security.
1. Human Services
2. Arts, Culture & Humanities
3. International, Foreign Affairs & National Security
How is funding for Youth Sports Grants in Guam changing over time?
Funding has increased by 27.20%.
How does grant funding vary by county?
Guam County, Barrigada Municipality, and Mangilau Municipality receive the most funding.
| County | Total Grant Funding in 2024 |
|---|---|
| Guam County | $4,043,021 |
| Barrigada Municipality | $937,699 |
| Mangilau Municipality | $887,000 |
| Hagatna Municipality | $385,107 |