Best Foundation Grants for Nonprofits in Indiana

The Indiana CTSI Core Facilities offer Pilot Funding for research projects that utilize advanced technologies and expertise. This funding program encourages proposals that showcase scientific merit and the potential for generating extramural funding or novel intellectual property. Successful projects are expected to lead to new grants or enhance existing ones, thereby contributing to the growth of research and innovation within partner institutions.

About Us

The Indiana Clinical & Translational Sciences Institute (CTSI) has been at the forefront of translational research since 2008. From the lab bench to clinical trials and beyond, we help researchers move their scientific findings through the development pipeline.

Our Mission & Vision

Our mission is to bring together Indiana’s brightest minds to solve the state’s most pressing health challenges. We envision Indiana as one of the nation’s healthiest states.

RFA- Research Project Development Teams: Project Refinement ( first external submissions)

Research Project Development Teams (PDTs) are groups of experienced senior faculty located on each of the Indiana CTSI campuses who will connect you with resources, collaboration opportunities, and small (typically up to $15,000) awards for preliminary or additional data. Each PDT is designed around a common research theme.

There are biostatisticians and regulatory experts on each team, and other experts are added, as needed, to the team to when your application is discussed. You will have access to the expertise and knowledge you need all in one place.

The PDT application process is contingent on the stage of the project. You have selected the application process for pilot funding from the PDTs for a first time external submission. If you are seeking pilot funding prior to an external resubmission please use Research Project Development Teams (PDTs): Project Revision

The Next Generation of the Clinical and Translational Science Awards Program Trial Innovation Network aims to tackle significant challenges in multi-center clinical trials. By enhancing trial efficiency and safety through innovative solutions, the initiative seeks to improve the design and execution of these studies. Key areas of focus include safety monitoring tools, trial leader mentorship, and advancements in digital health technologies. This program invites eligible organizations to apply for funding to promote groundbreaking clinical research.

The BJA FY 2025/2026 Project Safe Neighborhoods Formula Grant Program aims to enhance community safety by funding comprehensive violent crime reduction strategies across the U.S. This initiative, coordinated by U.S. Attorney’s Offices, unites law enforcement, prosecutors, and community partners to tackle issues like drug trafficking and human trafficking. Applications are due by August 27, 2026, emphasizing the DOJ's commitment to empowering communities against ongoing threats and fulfilling its core policy goals.

MissionOur mission is to connect people and resources to address local challenges and opportunities.

Impact AreasThe Community Foundation will prioritize local, mission-aligned grants in impact areas that:

• Address community challenges and opportunities
• Cultivate/maintain community collaboration
• Advance investment in our public spaces and under-resourced neighborhoods
• Maintain a thriving education system from birth through career
• Create a vibrant arts, culture and storytelling environment
• Strive to make Huntington County a more equitable community of choice for all
• Aid in the development of our current and future leaders
• Other impact areas will also be considered.

RequirementsOperational support refers to general organizational expenses such as staffing, administration, and ongoing program delivery, rather than a specific project. 

The U.S. Department of Energy (DOE) plans to issue a Notice of Funding Opportunity (NOFO) titled "Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)." This initiative aims to support financial assistance applications from entities focusing on innovative chemical technologies that enhance supply chain resiliency and reduce costs. The program seeks to advance the production of chemicals from alternative and waste feedstocks, fostering domestic manufacturing and improving environmental safety.

The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

The Mockingbird Nonprofit Incubator Grant Program supports emerging nonprofit founders in creating sustainable growth and impact. The program includes eight live workshops on nonprofit management, fundraising, and access to resources from Givebutter. Selected organizations receive scholarships and the chance to apply for $4,000 in grant funds. Eligibility is limited to 501c3 nonprofits or those under fiscal sponsorship with budgets under $500,000, fostering a community of committed leaders ready to make a difference.

The Just Tech Fellowship, supported by the Social Science Research Council, aims to empower diverse researchers and practitioners to address injustices arising from new technologies. With a two-year award of $100,000 annually, this fellowship fosters collaboration and community engagement, promoting equitable tech futures. It focuses on the intersection of technology and social justice, encouraging insights from historically marginalized groups to inform structural change and create a more just society.

Digital Promise

Digital Promise is a global nonprofit working to expand opportunity for every learner. Working with a wide range of partners and practitioners in the U.S. and around the world, our initiatives have impacted over 4.4 million students and 180,000 teachers across 173 districts and in 27 countries to date.

Digital Promise was authorized by Congress in 2008, signed into law by President George W. Bush, and formally launched by President Barack Obama in September 2011. Startup support came from the U.S. Department of Education, Carnegie Corporation of New York, William and Flora Hewlett Foundation, and Bill & Melinda Gates Foundation. Since then, Digital Promise has grown rapidly with support from both original and new funders.

AIMS EduData Initiative

The Advancing Innovative Math Solutions (AIMS) EduData Initiative, funded by the Gates Foundation, seeks to build sustainable and scalable research infrastructure to advance math learning. AIMS EduData especially encourages applications from graduate students and early career professionals, educators with research roles, such as those working in district research offices, and researchers located at minority serving institutions or Title I school districts. Successful applicants will conduct original research using datasets provided by leading digital learning platforms (DLPs) and participate in a growing community.

RightOn Education and Teachley Math RFP

For education researchers and practitioners

Benefits for successful applicants:

• Opportunity to investigate associations between features of a Digital Learning Platform and mechanisms supporting student learning, engagement, motivation, and instructional practice.
• Opportunity to contribute to the education R&D movement by expanding its capacity and skills, providing feedback to DLPs about the utility of their datasets and insights about their features, and demonstrating the affordances and value of conducting research through DLPs.
• Involvement in a dynamic, supportive community of digital learning providers and researchers
• Two proposals will be funded

This solicitation offers opportunities to run experiments in two DLPs. One enables research with Teachley Math, an intervention that includes interactive digital games and problem-solving modeling tools, lessons and formative assessment data for students in grades K-5. The second enables research with RightOn Education, an online digital learning platform for grades 7-10 that allows teachers to create or select math games, engage students in feedback and reflection on their thinking, and access real-time information about student misconceptions. 

Teachley Math

Teachley Math is particularly interested in research investigating:

• Through what mechanisms does feedback shape outcomes?
• What sequences of tool actions best predict eventual correctness?
• What are common error patterns and do they vary by grade level?
• Do process measures add predictive validity beyond final-answer accuracy?

The Owen-Carr Townships Community Fund Grants aim to enhance the communities of Owen and Carr Townships and Medora, Indiana. Administered by the Community Foundation of Jackson County, this fund accepts various forms of donations to support local projects. Community members have established a permanent endowment to secure funding for future initiatives. The grant proposals are reviewed quarterly, fostering a collaborative effort to improve local infrastructure and support community-driven projects.

Digital Promise

Digital Promise is a global nonprofit working to expand opportunity for every learner. Working with a wide range of partners and practitioners in the U.S. and around the world, our initiatives have impacted over 4.4 million students and 180,000 teachers across 173 districts and in 27 countries to date.

Digital Promise was authorized by Congress in 2008, signed into law by President George W. Bush, and formally launched by President Barack Obama in September 2011. Startup support came from the U.S. Department of Education, Carnegie Corporation of New York, William and Flora Hewlett Foundation, and Bill & Melinda Gates Foundation. Since then, Digital Promise has grown rapidly with support from both original and new funders.

AIMS EduData Initiative

The Advancing Innovative Math Solutions (AIMS) EduData Initiative, funded by the Gates Foundation, seeks to build sustainable and scalable research infrastructure to advance math learning. AIMS EduData especially encourages applications from graduate students and early career professionals, educators with research roles, such as those working in district research offices, and researchers located at minority serving institutions or Title I school districts. Successful applicants will conduct original research using datasets provided by leading digital learning platforms (DLPs) and participate in a growing community.

RightOn Education and Teachley Math RFP

For education researchers and practitioners

Benefits for successful applicants:

• Opportunity to investigate associations between features of a Digital Learning Platform and mechanisms supporting student learning, engagement, motivation, and instructional practice.
• Opportunity to contribute to the education R&D movement by expanding its capacity and skills, providing feedback to DLPs about the utility of their datasets and insights about their features, and demonstrating the affordances and value of conducting research through DLPs.
• Involvement in a dynamic, supportive community of digital learning providers and researchers
• Two proposals will be funded

This solicitation offers opportunities to run experiments in two DLPs. One enables research with Teachley Math, an intervention that includes interactive digital games and problem-solving modeling tools, lessons and formative assessment data for students in grades K-5. The second enables research with RightOn Education, an online digital learning platform for grades 7-10 that allows teachers to create or select math games, engage students in feedback and reflection on their thinking, and access real-time information about student misconceptions. 

RightOn Education

RightOn Education is particularly interested in research investigating questions related to the following areas (illustrative research questions are provided below):

• Student confidence and math self-efficacy: How do patterns of student confidence differ across correct and incorrect responses, and how do they vary by question or Common Core standard?
• Productive struggle, metacognition, and learning from misconceptions: How do different types of reflection prompts (e.g., self-directed vs. peer-directed explanations) affect the likelihood of optional hint submission and the length of student-generated hints?
• Student motivation and engagement: How do different incentive conditions influence student participation in optional activities, and how are they associated with student correctness and confidence?

The SCCF Education Grants Cycle supports projects that enhance education and skill development for all ages in Steuben County. Grants range from $500 to $25,000, aimed at nonprofits with a focus on improving quality of life. Special consideration is given to collaborative initiatives addressing root causes. Eligible applicants include nonprofits serving Steuben County, while individuals and projects primarily funded by government sources are not supported.

The Officers’ Research Grants on Reducing Inequality support studies aimed at understanding and addressing inequalities affecting youth ages 5-25 in the U.S. This initiative funds descriptive, intervention, and measurement development studies focused on academic, social, behavioral, and economic outcomes. The William T. Grant Foundation encourages research that identifies specific inequalities and explores effective programs or policies to mitigate these disparities while addressing systemic issues such as racism and structural inequality.

The Lend A Hand Society offers the Book Mission Grant to assist low-income individuals and families by funding the acquisition of books for educational institutions and libraries. This initiative supports various programs focused on emergency assistance and camperships for children. Non-profit organizations across the United States can apply, with grants aimed at enhancing literacy and education. Grantees must provide reports detailing the use of funds and project progress, ensuring transparency and accountability.

The Dave Dowling Scholarship, offered by the Association of Specialty Cut Flower Growers, supports aspiring students in horticulture or floriculture. With an award of $1,000 each for two promising candidates, this scholarship encourages young individuals to pursue careers in cut flower production. Successful applicants also receive a one-year ASCFG membership, fostering community and educational opportunities. This initiative aims to advance the domestic cut flower industry by nurturing the next generation of growers.

The ACS Local Section Innovative Project Grant Program aims to empower local sections of the American Chemical Society to devise and execute innovative projects that enhance community engagement and chemistry literacy. By fostering collaboration and inclusiveness, this program encourages sections to implement new initiatives inspired by successful practices from other groups. The goal is to strengthen member involvement and promote sustainable activities that contribute positively to the community's scientific culture.

The Philip J. Wyatt Award in Analytical Chemistry, established in 1947 and endowed by the Wyatt Family Foundation in 2026, recognizes outstanding contributions to analytical chemistry. Offered by the American Chemical Society, the award includes a $5,000 prize and a certificate, with up to $2,500 for travel expenses to the award presentation meeting. This award supports diversity and inclusion by being available regardless of race, gender, or background, promoting a global community in the field of chemistry.

The Law & Science Program, funded by the National Science Foundation, invites interdisciplinary proposals that explore the intersection of law and scientific principles. It focuses on research examining human behavior, legal processes, and the application of technology in legal contexts. Topics include crime, environmental science, and forensic studies. Applications are due on January 15 and August 1 for the years 2021 through 2025, promoting innovative research that enhances understanding of legal systems.

Award

Deborah Jin Award for Outstanding Doctoral Thesis Research in Atomic, Molecular, or Optical Physics

This award recognizes doctoral thesis research of outstanding quality and achievement in atomic, molecular, or optical physics and encourages effective written and oral presentation of research results. The annual award is presented to one individual and consists of a $2,500 stipend and a certificate.

Finalists are invited to present their research at the annual DAMOP Meeting. All finalists will be reimbursed up to $1,000 for travel expenses.

APS Honors recognizes and celebrates the accomplishments of the global physics community. Guided by our core values, APS Honors encourages nominations that reflect the full range of talent, distinction, and experience in our field, and supports broad canvassing for professional achievement across diverse backgrounds, perspectives, and expertise.

Nominees for and holders of APS Honors (prizes, awards, and fellowship) and official leadership positions are expected to meet standards of professional conduct and integrity as described in the APS Ethics Standards. Violations of these standards may disqualify people from consideration or lead to revocation of honors or removal from office.

The PLTW Computer Science program, supported by the Caterpillar Foundation, aims to enhance STEM education in underserved communities. Grants of $20,000 will be awarded to public and charter schools to implement PLTW Computer Science courses over two academic years. This initiative focuses on building workforce readiness and ensuring students gain essential skills in a rapidly evolving job market, thereby creating opportunities for future success.

The Forrest E. Mars, Jr. Chocolate History Grant, offered by the Mars Wrigley Foundation, supports projects that explore and share chocolate's rich cultural history. Launched in 2013, this grant aims to educate the public about chocolate's global significance and its impact on heritage. Projects can include research, immersive experiences, and publications. Awardees must present their findings at Heritage Chocolate Society meetings, emphasizing educational impact, equity, and inclusion in their proposals.

The PLTW Computer Science - Program Expansion grant, funded by the Caterpillar Foundation, aims to enhance STEM education in underserved communities. This initiative focuses on expanding existing PLTW Computer Science programs by adding courses, class periods, and training teachers for the 2025-2026 academic year. The grant prioritizes schools with a significant high-need student population, promoting workforce readiness and equipping students with essential skills for a changing world.

The Hope Goddard Iselin Fellowship in Public Horticulture, established in 2013 by the Hope Goddard Iselin Foundation, honors the legacy of its namesake, a pioneer in enhancing urban landscapes. This fellowship supports graduate students engaged in practical research and training at recognized public gardens or similar institutions across the U.S., providing annual funding of $5000. It aims to foster experiential learning and promote the study of public horticulture, thus connecting people with nature.

The Simons Foundation's Targeted Grants in Mathematics and Physical Sciences (MPS) program invites applications for funding to support research projects. Grants can be awarded for up to five years, with flexible funding levels. Eligible applicants include established educational institutions and research centers, and funding can cover various expenses such as salaries, travel, and equipment. Notably, the program does not allow funding for U.S. national labs. For complete guidelines, refer to the Simons Foundation's website.

The PLTW Computer Science grant, funded by Lockheed Martin, aims to support schools in expanding or establishing PLTW Computer Science courses. This initiative addresses the critical shortage of skilled professionals in STEM fields, enabling students to gain essential knowledge and skills. Since 2007, Lockheed Martin has successfully partnered with PLTW to implement programs across the nation, impacting over 77,000 students. Schools are encouraged to apply for funding to enhance their computer science curriculum.

The Harvard-Yenching Library Travel Grant supports scholars outside Boston in utilizing its extensive collections for research. This program prioritizes non-tenured faculty, dissertation-writing Ph.D. candidates, and independent scholars, especially those from institutions lacking East Asian language resources. Grants are awarded based on merit and must be used by August 31, 2026, to encourage diverse academic engagement and exploration.