Best Large Grants for Nonprofit Organizations in Indiana

The Laboratory Flexible Funding Model (LFFM) aims to enhance state food testing laboratories' capabilities, supporting an integrated food safety system. By prioritizing sample testing and food defense preparedness in microbiology, chemistry, and radiochemistry, this cooperative agreement facilitates method development and expands testing capacity, ensuring safer food for consumers.

The Cystic Fibrosis Foundation offers Postdoctoral Research Fellowship Awards to support research training in cystic fibrosis. The program provides up to $66,000 in salary support for the first year and $67,000 for the second year, along with $9,000 for research and travel expenses. Applicants focusing on CFTR protein function restoration or gene correction strategies are encouraged to apply. Open to U.S. citizens and residents, preference is given to recent graduates beginning their research careers.

The Pathway to Stop Diabetes Initiator Award (INI) aims to support early career researchers in diabetes research by providing funding and mentorship. With a focus on innovative and transformational ideas, this initiative encourages researchers to develop groundbreaking solutions for diabetes prevention and management. The award offers up to $100,000 annually in Phase 1 and $325,000 in Phase 2, fostering a new generation of leaders committed to improving the lives of those affected by diabetes.

The Samuel Robinson Award is a scholarship for college juniors and seniors attending Presbyterian-related institutions. To qualify, students must memorize the Westminster Shorter Catechism's 107 questions and answers within 18 months. Eligible applicants for 2024 are those graduating in 2024 or 2025. This award encourages academic achievement and religious education among students committed to their faith and educational pursuits.

The Gina M. Finzi Memorial Student Summer Fellowship Program, funded by the Lupus Foundation of America, aims to engage students in lupus research across various disciplines. Six awards of $4,000 each will be granted for projects spanning 10 weeks between May and September 2026. Eligible applicants include undergraduate and graduate/medical students, with specific allocation preferences. This initiative promotes valuable research experiences under the guidance of established faculty at accredited institutions.

The McKnight Clinical Translational Research Scholarship supports young investigators focusing on cognitive aging and age-related memory loss. Funded by the McKnight Brain Research Foundation, this scholarship offers $65,000 annually for two years, plus an education stipend. Eligible applicants should have completed their PhD or residency within the last five years and conduct their research in accredited U.S. institutions. The award emphasizes rigorous training and aims to foster careers in human cognitive aging research.

The Alzheimer’s Foundation of America Bi-Annual Grant aims to support nonprofit organizations in their efforts to enhance the lives of individuals impacted by Alzheimer’s disease and related dementias. Each grant, valued at $6,000, is awarded twice a year, focusing on innovative programs and services. AFA emphasizes partnership and collaboration, enabling grantees to manage their own policies and programs while adhering to specific funding guidelines. This initiative underscores AFA's commitment to compassionate care and ethical standards.

The RFA: Biology to Prevention Award (CRUK) aims to foster innovative translational research that enhances understanding of cancer biology, ultimately leading to effective prevention strategies. Joint applications from UK and US research teams are encouraged, with a focus on equal partnerships and complementary expertise. The funding provides up to £600,000 for UK costs and up to $946,000 for US costs, supporting projects of 1 to 5 years duration that address critical research questions in cancer prevention.

Access Advocate for Clinical Research Participation

Objective:

This program will support implementation and evaluation of a Parkinson’s disease (PD) focused Access Advocate model designed to increase inclusive research participation. Funding will support Access Advocates at clinical sites to build practical, relationship based pathways to improving representative research enrollment and retention.

Funding Details:

• Duration: 24 months 
• Award Amount: $200,000 

The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and its inclusive recruitment strategy has examined what barriers and motivators shape participation (e.g., FIRE-UP PD study3) as well as funded sites to pilot tactics that address those barriers (e.g., Black & African American Connections to Parkinson’s Disease study4). Now we aim to scale and validate approaches that show early promise by investing more deeply and measuring impact across settings.

This program will fund advocates at clinical sites to build practical, relationship-based pathways to improving representative research enrollment and retention. These support staff will help patients and care partners navigate health system complexity and everyday needs that often determine whether research participation is feasible. They will help address barriers such as transportation, caregiving responsibilities, language needs, and insurance and financial strains by connecting people to resources, coordinating logistics and providing consistent follow-up. These advocates also should discuss research participation opportunities with patients and connect them to recruiting studies.

The model is grounded in the idea that research participation is more feasible when (i) foundational practical needs are addressed first and (ii) raised by a trusted health care partner. By helping to reduce practical barriers, advocates are expected to increase screenings, enrollment conversion and retention across key trial milestones.

This program will test these hypotheses and further establish training, infrastructure needs and sustainability of such positions.

Program Goal

This program aims to:

• Support establishment of site-based Access Advocates to support potential participants and care partners across multiple active or planned PD studies.
• Evaluate needs and opportunities for onboarding and ongoing training for advocates in PD and clinical research fundamentals as well as site and local resources.
• Recommend repeatable workflows for identifying prospective participants, assessing barriers, connecting them to resources, coordinating logistics and supporting follow-up.
• Collect and report a core set of evaluation metrics across sites (reach, encounters, referrals, screened, enrolled, retained), including barrier tracking and resolution.
• Evaluate the impact of Access Advocates in recruiting and retaining underrepresented community individuals to/in Parkinson’s studies.
• Evaluate the impact of Access Advocates on “health system value” indicators (e.g., appointment adherence/show rates, medication access/adherence proxies) that could support funding sustainability from other sources.
• Establish a cross-site learning community that enables funded sites to share lessons, refine the Access Advocate model and inform broader adoption beyond the funding period.

The National Network of STI Clinical Prevention Training Centers (NNPTC) aims to enhance the education and training of clinicians and disease intervention professionals in STI patient care. This initiative focuses on improving the ability of healthcare providers and systems to effectively diagnose, manage, and counsel individuals at risk for STIs, ultimately reducing morbidity and enhancing public health outcomes on both local and national levels.

The INCLUDE Project aims to enhance the health and quality of life for individuals with Down syndrome by generating comprehensive genomic and multi-omics data. This initiative encourages applicants to submit samples to NIH-supported resources, facilitating the exploration of molecular mechanisms related to health conditions associated with Down syndrome. The data will be shared via the INCLUDE Data Hub, promoting collaboration within the research community, though no direct funding is available to applicants.

Ocean State Media Scholarship

The scholarship offers awards to residents of Ocean State Media’s demographic market area who demonstrate promise of a successful career in the fields of journalism and/or media.

Scholarship Award Details

Established by Rhode Island PBS in 2017, the Ocean State Media Scholarship offers awards to residents of the station’s demographic market area who demonstrate promise of a successful career in the fields of journalism and/or media. Awards of up to $15,000 will be awarded annually and are renewable for an additional three years.

The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.

The Pediatric Cancer Research Foundation (PCRF) offers the Emerging Investigator Fellowship Grant to support post-doctoral fellowships and clinical investigator training for promising pediatric cancer researchers. This grant aims to accelerate advancements in childhood cancer treatment by funding innovative research ideas. Applicants must have completed a minimum of two years in their fellowship or be within two years of their junior faculty role. This initiative fosters the next generation of researchers dedicated to combating childhood cancer.

Casey's Cash for Classrooms Grants support K-12 public and nonprofit private schools through funding for physical improvements, material needs, teacher support, and community engagement. In 2025, $900,000 was awarded across 80 grants, allowing schools to enhance their learning environments. With a commitment to community engagement, Casey's has donated $15 million since 2019, emphasizing their dedication to making life better for communities and guests. Grants range from $3,000 to $50,000, with funds required to be used within 12 months.

The Anna Fuller Fund Grant provides year-round support for organizations dedicated to alleviating suffering caused by cancer. Established in memory of Egbert C. Fuller’s wife, the fund prioritizes applications that focus on cancer research and education initiatives. Eligible applicants must be 501(c)(3) organizations or equivalent charities outside the U.S. Grant funds cannot be used for direct treatment, ensuring that resources are allocated to research and public education.

The Aim High Grant Program offers one-year grants of $20,000 to support out-of-school time programs for middle school youth. Funded by the New York Life Foundation, this initiative aims to enhance students' transition to high school by providing essential skills and guidance. Programs must demonstrate effective engagement strategies and serve low-income communities. This grant represents a vital investment in the future of young people, helping them develop academically, socially, and emotionally.

The Alice M. Ditson Fund supports recording projects that aim to document and promote the music of younger, lesser-known American composers. The fund prioritizes living composers of classical concert music, especially those in the early stages of their careers, while also recognizing established composers who deserve greater visibility. Eligible applicants include organizations with a fiscal sponsor or non-profit status, and projects must involve significant contemporary American music.

College Foundation, Inc.

College Foundation, Inc. (CFI), a non-profit corporation serving North Carolina students and families since 1955, administers education loan programs, several major grant and scholarship programs funded by the State of North Carolina for students attending North Carolina colleges and universities, and the tax-advantaged "NC 529" college savings program on behalf of the North Carolina State Education Assistance Authority (NCSEAA).

Teacher Education Assistance for College and Higher Education (TEACH) Grant Program

The TEACH Grant Program provides grants of up to $4,000 a year to students who are completing or plan to complete course work needed to begin a career in teaching. More information may be found at the Federal Student Aid TEACH Grant website.

Repayment Information

As a condition for receiving a TEACH Grant, you must sign a TEACH Grant Agreement to Serve in which you agree to (among other requirements) teach

• in a high-need field;
• at an elementary school, secondary school, or educational service agency that serves students from low-income families; and
• for at least four complete academic years within eight years after completing (or ceasing enrollment in) the course of study for which you received the grant.

The Christine Riggins Shepherd Scholarship Fund, established by the Community Foundation of Central Georgia, aims to support students from Lamar, Pike, Monroe, Upson, or Spalding counties attending Georgia Southern University. With at least one award given annually, the scholarship amount varies. Recipients can renew their scholarships for up to four years if they maintain eligibility. Preference is given to applicants from Lamar County, promoting educational opportunities for local students.

The AWS Welding Workforce Grants aim to enhance welding programs by providing up to $50,000 for essential resources such as new equipment and training. This initiative addresses the growing demand for skilled welders while supporting educational institutions. Eligible applicants include secondary schools, community colleges, and post-secondary programs. Preference is given to proposals that significantly increase welding graduates and address geographic areas with high needs. Note: Applications are currently closed and will reopen in January 2026.

HCLTech Grant Edition II focuses on impactful climate action by investing $5 million over five years to support NGOs in the Americas. This initiative aims to enhance sustainable projects that align with the 17 Sustainable Development Goals (SDGs). With a history of significant contributions in India, HCLTech is committed to achieving net-zero emissions by 2040 and fostering innovative solutions to address pressing climate challenges. The grant encourages collaboration and aims to transform communities through effective climate action.

The AED Grant Program, run by the Hopey’s Heart Foundation, aims to enhance sports safety by providing life-saving AEDs to eligible schools and recreational centers. Although the program is currently closed, it will reopen for applications in April 2026. The Foundation focuses on preventing Sudden Cardiac Arrest among student athletes through education and medical equipment. Eligible organizations include 501(c)(3) entities and government bodies, ensuring broader access to vital resources for sports safety.

Every Battle Creek area resident shall have the resources to access post-secondary education and training.

Your dreams matter — and we want to help you achieve them. Whether you’re a graduating high school senior, an adult returning to school, or a graduate student pursuing advanced education, we’re here to support you by opening doors to opportunity.

Beyond tuition, many funds support total cost of attendance — books, fees, equipment, and in some cases childcare or transportation.

Checks are made payable to the educational institution indicated on the follow-up and mailed directly to the educational institution. Checks are typically mailed in early August.

In God We Trust, Mitchelle T. Savage Memorial Scholarship Fund

The In God We Trust, Mitchelle T. Savage Memorial Scholarship was established to provide educational opportunities beyond high school for Battle Creek area graduates or graduating seniors. Eligible recipients will be graduating seniors from Battle Creek area public and private schools who will be attending a college that is a member of the Council for Christian Colleges and Universities.

The Monticello College Foundation Grant supports projects that promote female education. Eligible applicants include professional educational associations and accredited colleges in the Midwest. The foundation prioritizes innovative proposals that demonstrate significant need. Grants are given for a single fiscal year, with ongoing requests requiring annual re-application. Proposals should be submitted by August 31 for fall consideration and by February 28 for spring review. Funding is not available for direct grants to individuals or capital purposes.

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Bill Rabbit Legacy Art Scholarship

Applicant must be enrolled in an accredited, four-year, higher education institution pursuing a degree in fine arts or art education with a minimum 3.0 GPA. Accepted focuses include drawing, painting, sculpture, pottery, traditional beadwork and textiles. Three pictures of artwork must be included with application for consideration. This is a one-year scholarship reserved for Cherokee Nation and United Keetoowah Band citizens residing within the Cherokee Nation jurisdictional area.

The Dalsemer Interstitial Lung Disease Award, funded by the American Lung Association, provides $50,000 per year for two years to support junior investigators researching interstitial lung disease. This award aims to foster independence in early-career scientists while building on the Association's 120-year legacy of improving lung health through innovative research and advocacy efforts, ultimately enhancing the lives of those affected by lung disease.