Best Large Grants for Nonprofit Organizations in Indiana

The National Cancer Institute (NCI) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing informatics technologies for cancer research. This initiative will support the development of tools that enhance data acquisition, management, and analysis throughout the cancer continuum. By focusing on technologies with proven impact, the NOFO seeks to optimize and sustain resources critical for cancer biology, diagnosis, treatment, and epidemiology.

The H. Lyman Mooney Music Scholarship, offered by the Community Foundation of the Ozarks, provides a $450 scholarship to a graduating senior from Marshfield High School pursuing music studies. Applicants must submit their transcripts, demonstrate financial need through FAFSA-SAI, and provide a letter of recommendation from their music teacher. The scholarship application period will reopen on January 1, 2026, for the 2026–27 academic year, aiming to support students in achieving their educational goals.

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.The Canton Advertising Federation Endowment for Creative Enrichment FundThe Canton Advertising Federation Endowment for Creative Enrichment Fund assists graduating high school seniors or current college students majoring in advertising, graphic design, communication or related fields. Applicants must reside in Stark County.Renewable Scholarship: Yes

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.Adrienne O’Neill Scholarship FundThe Adrienne O’Neill Scholarship Fund was established to assist students who are the first generation in their family to attend college. Applicant must have a cumulative GPA of 2.5, demonstrate financial need and intend to utilize this scholarship as the “last dollars” after all aid/scholarships have been awarded.Renewable Scholarship: Yes

The TFEC Student Emergency Assistance Fund provides crucial financial support for students facing unexpected hardships that threaten their continuation in post-secondary education. Grants of up to $500 per application are available, with a total funding limit of $1,500 for re-applications. This initiative is part of The Foundation for Enhancing Communities' mission to bolster local educational opportunities and foster community resilience, ensuring that students can overcome financial barriers and achieve their academic goals.

The TFEC Aspire to Rise Scholarship Fund, managed by The Foundation for Enhancing Communities, offers financial support to non-traditional students aged 22 and older who have faced challenges in their educational journey. This scholarship is aimed at those pursuing higher education or vocational training, with special consideration for applicants without a post-secondary degree. Additionally, it supports individuals preparing for the GED, fostering opportunities for personal and professional growth in South Central Pennsylvania.

The Bauer Trust Fund Grant supports charitable organizations benefiting blind or handicapped persons. Established by Anthony F. Bauer, it aims to provide lasting support for those in need. To be eligible, organizations must be 501(c)(3) exempt and primarily operate in Connecticut. The fund does not support general operating costs, endowments, individuals, or political activities. This initiative reflects Mr. Bauer's legacy of generosity and commitment to aiding vulnerable communities.

The Leonard-Litz Foundation's LGBTQ+ Advocacy Fund Grant aims to empower LGBTQ+ individuals by funding organizations that advocate for their rights and well-being. With a focus on health, wellness, and racial justice, the fund supports projects that require significant investment for impactful change. Prioritizing partnerships that serve vulnerable communities, including people of color and transgender individuals, this grant fosters equality and addresses systemic inequalities faced by LGBTQ+ people, especially in the northeast U.S.

The Covenant Foundation's Signature & Ignition Grants celebrate excellence in Jewish education by funding innovative projects that enhance educational practices. The Foundation supports diverse institutions across North America, inviting applications for creative programs that can adapt and disseminate effective practices. While Signature Grants may reach up to $150,000 over three years, Ignition Grants focus on untested ideas with funding up to $20,000 for one year. One application per cycle is permitted.

This funding opportunity aims to establish a U.S. network for active surveillance of pediatric acute respiratory illnesses and gastroenteritis. The initiative will focus on respiratory and enteric viruses, assessing the effectiveness of prevention products such as vaccines. Recipients will follow CDC protocols to enroll patients and confirm viral infections, ultimately reducing hospitalizations and enhancing public health strategies for children's healthcare.

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.

The Cole Eriksson Parker Eagle Scout Scholarship Fund

The Cole Eriksson Parker Eagle Scout Scholarship Fund was established to provide scholarships to high school graduates or graduating seniors who are Buckeye Council, Scouting of America, Canton, OH, Eagle Scouts.

Amount:

• Varies. Minimum $500.

Renewable:

• Yes

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.

The Don and Madalyn Sickafoose Educational Trust Fund

The Don and Madalyn Sickafoose Educational Trust Fund was established to assist students residing in southeastern Stark County, northwestern Carroll County and northern Tuscarawas County.

Amount:

• Varies. Minimum $500.

Renewable:

• Yes

The Beistle Company Scholarship, managed by The Foundation for Enhancing Communities, provides financial support for legal dependents of full-time Beistle Company employees. If no eligible dependents apply, it extends to Shippensburg High School graduates and other local students. Applicants must demonstrate academic promise, financial need, and be accepted into an accredited institution. This scholarship aims to enhance educational opportunities for deserving students in the community.

The Teagle Foundation's Knowledge for Freedom initiative aims to empower underserved high school students through transformative experiences in the humanities. Grants ranging from $100,000 to $300,000 over 36 months support programs that foster civic responsibility and personal purpose. Colleges can also apply for planning grants of $10,000 to $25,000 to develop tailored programs. The initiative emphasizes intensive summer seminars led by faculty, with continued support for college applications and civic engagement.

The Frymier, Jack R. and Maxine C. Scholars Award Fund, established by the Noble County Community Foundation, offers a one-time $1,500 award to a Central Noble High School senior. Eligible applicants must maintain a minimum GPA of 3.20, demonstrate community involvement, and intend to pursue a career in education. This initiative aims to support local students in their educational endeavors, enhancing their opportunities while contributing positively to the community.

Alger Regional Community FoundationThe Alger Regional Community Foundation (ARCF) is a locally based 501(C)(3) nonprofit corporation dedicated to enhancing the quality of life in Alger County through grants and scholarships.ARCF is a unique institution. It is a permanent, yet flexible, collection of endowment funds contributed by people from all walks of life who want to make a difference in our community.Thelma N. Cotey ScholarshipApplicants must be planning to pursue further education in the areas of medicine, business, or forestry. 

The Gerald & Sybil Cohen Family Foundation Scholarship aims to ease the financial burden of college costs for students pursuing education in STEM fields. Open to U.S. citizens aged 18 and older with a minimum GPA of 3.5, the scholarship is available for public colleges and universities. Preference is given to dependents of former employees of Information Builders, Inc. Awards are not guaranteed and may vary in amount.

The Youth Grant Committee in Clay County aims to enhance youth engagement in community service and leadership. This committee, comprising local high school students, reviews grant applications for youth-led initiatives that address community needs. By prioritizing projects that are sustainable, collaborative, and proactive, the committee fosters a culture of philanthropy and service among the youth. The application process encourages handwritten submissions, ideally authored by youth, ensuring their direct involvement in community upliftment.

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.The Wayne D. Ackerman Scholarship FundThe Wayne D. Ackerman Scholarship Fund assists seniors from Stark County high schools who will graduate in May/June. Applicants must be accepted as full-time students at a four-year college or university, have a GPA of at least 3.0, and have demonstrated outstanding involvement in academics and extracurriculars.Renewable Scholarship: No

The Plant Protection Act Section 7721 PPDMDPP provides funding to safeguard U.S. specialty crops and natural resources from invasive plant pests and diseases. With up to $90 million available in FY 2027, projects will focus on early detection and mitigation strategies across six goal areas, including pest identification and public outreach. This initiative aims to enhance agricultural resilience and support proactive measures against harmful pests, ensuring the protection of vital agricultural systems.

The Central PA Architects Foundation Fund Architecture Scholarship, offered by The Foundation for Enhancing Communities, supports students from select counties in Pennsylvania who are enrolled in architecture degree programs. This scholarship aims to foster educational opportunities for individuals demonstrating financial need and commitment to the field of architecture, ultimately contributing to the growth and development of local communities.

The Bruce Mangione Fund, established by The Foundation for Enhancing Communities, honors Bruce Mangione's legacy through scholarships for students in Harrisburg. This fund supports those attending local schools or dependents of Clearway Energy or Harrisburg Hilton employees. It emphasizes community involvement, work ethic, academic performance, and financial need, thus advancing educational opportunities and fostering local talent in South Central Pennsylvania.

The Warren L. and Florence W. Calvert Memorial Scholarship Fund, established in 1974, supports deserving geological students pursuing graduate studies in Economic Geology. Awarded first in 1978, the fund is sustained by contributions from HGS members and investment returns. Recipients, selected based on academic merit and endorsements from Earth Science professionals, must carry a minimum of 9 credit hours and can renew for subsequent years with satisfactory progress.

The Leonard Litz Foundation supports LGBTQ+ organizations through grants that promote health, wellness, crisis intervention, racial justice, advocacy, and social assistance. Priority is given to organizations in the northeast U.S. and those serving communities of color and transgender individuals. Applications that clearly link funding requests to specific needs will receive stronger consideration. The foundation aims to foster a supportive environment for the LGBTQ+ community to thrive.

Stark Community FoundationStark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds. The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.The Canton Professional Educators' Scholarships FundThe Canton Professional Educators’ Scholarships Fund was established to assist high school graduates enrolled in an academic plan (college/university, 2-year vocational, technical or advanced study). Applicants must be the natural or adopted child of a CPEA member, must have achieved a cumulative high school GPA of 3.0 or above, and college students must be “a student in good standing.”Renewable scholarship: No

The Gordon B. and Josephine Hewlett Memorial Scholarship, established in 1999 by the children of Gordon B. and Josephine Hewlett, supports Franklin County students pursuing nursing degrees. This scholarship primarily targets undergraduate students but may extend to graduates if qualified applicants are scarce. Funded by The Foundation for Enhancing Communities, it emphasizes academic achievement and community service, ensuring that local talent is nurtured in the healthcare sector.

The Teaching Health Center Graduate Medical Education (THCGME) Program aims to equip residents with the skills to deliver exceptional healthcare, especially in rural and underserved areas. By funding the training of residents in HRSA-supported primary care residency programs, it fosters a diverse healthcare workforce capable of meeting the needs of various populations. This initiative not only enhances the quality of care but also strengthens community health systems.