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Best Large Grants for Nonprofit Organizations in Indiana

Find the perfect Large Grants for Nonprofit Organizations in Indiana on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Indiana in the United States.

10,000+

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$2.62B

Total funding

$5K

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10,000+ grants
$2.62B total
$5K median

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Health & Wellness Agency Grant

Jack And Jill Of America Foundation Inc
Private
United States
Up to US $10,000
The Health & Wellness Agency Grant, offered by the Jack and Jill of America Foundation, aims to empower disadvantaged communities by providing access to heart and mental health education. This grant supports 501(c)(3) organizations that align with the foundation's mission to enhance the well-being of African American children and families. Eligible applicants can receive funding to implement impactful health initiatives, while ineligible expenses include scholarships and operational costs.
Mental Health & Psychiatric Diseases Heart Disease Community Health Education +1 more

Homeless Veterans’ Reintegration Program (HVRP), Incarcerated Veterans’ Transition Program (IVTP), and the Homeless Women Veterans' and Homeless Veterans' with Children Reintegration Grant Program (HWVHVWC) (referred to collectively as HVRP)

US Department of Labor: Veterans' Employment and Training Service (VETS)
Federal Government
Guam, Puerto Rico +2 more
US $150,000 - US $500,000
The Homeless Veterans' Reintegration Program (HVRP) aims to assist veterans experiencing homelessness by providing tailored employment services. This federal initiative focuses on helping veterans transition to stable employment through job training, case management, and connections to local supportive services. HVRP aligns with national priorities to enhance career outcomes for veterans, ensuring they receive the necessary tools and resources for sustainable employment and integration into the workforce.
Military & Veterans Services Homelessness Services Workforce Preparation & Job Readiness +1 more

PNC Foundation: Grow Up Great Grant

PNC Foundation
Private
Accomack County, Virginia, Adams County, Colorado +667 more
Unspecified amount
The PNC Foundation's Grow Up Great Grant is a significant initiative aimed at enhancing educational opportunities for children from birth to age 5. With a commitment of $500 million, this program focuses on improving school readiness through support in vocabulary development, social-emotional learning, and the arts. By partnering with community-based nonprofits, PNC aims to foster stronger, smarter, and healthier communities, ensuring a brighter future for the next generation.
Education - Preschool / Early Learning Teacher Development & Training Parental Involvement in Education +4 more

Presidential Pathology Scholarship

College Of American Pathologists Foundation
Private
United States
US $500 - US $1,500

Who We Are - CAP Foundation

Mission

Our mission is to improve people’s health by:

  • Developing tomorrow’s pathology leaders through awards for advanced training, research, and education.
  • Mobilizing pathologists to expand health equity in medically underserved communities within the US and globally.

Vision

Our vision is that pathologists are equipped to bridge health disparities and enhance outcomes globally.

CAP Foundation History

For over 50 years, the CAP Foundation has granted millions of dollars to support pathology education, research, training, and travel grants, with the purpose to:

  • Enhance the role of the pathologist in the provision of medical care.
  • Advance pathology through the education of the medical community.
  • Encourage the clinical application of research developments.

Our Core Values

  • Advancement: We are committed to pushing the boundaries of pathology and patient care through scholarships, grants, and educational programs.
  • Collaboration: Through effective partnerships, we significantly enhance our capacity to fulfill our mission.
  • Excellence: We are dedicated to achieving the highest standards in pathology education, research, and community service.
  • Service: Service reflects our core mission of improving health equity by providing access to healthcare and pathology expertise, particularly in underserved communities.

Presidential Pathology Scholarship

This scholarship allows the sitting CAP President to personally support educational creativity, expand awareness of pathology, and connect communities through the CAP Foundation’s mission to develop tomorrow’s pathology leaders. This scholarship is established in honor of each sitting CAP President, as a commitment to the CAP Foundation’s efforts to advance the specialty by supporting creative projects that encourage interest in or expand the reach of pathology. Up to two scholarships will be supported each year. Ranging from $500-$1,500 per awardee, to be used toward the selected project(s).

Each year the sitting CAP President will select a focus area to support based on at least one of the CAP Foundation’s Five (5) Pillars. CAP Foundation Five Pillars:

  • Global: Expands global pathology access, capacity, training, and equity.
  • Future Leaders: Builds pipeline through learning, leadership, mentorship, and awards.
  • Ethics, Research, Innovation: Advances ethical practice, discovery, innovation, and diagnostic excellence.
  • Advanced Training: Delivers specialized skills through grants, workshops, and roundtables.
  • Community Engagement: Increases visibility and connection with patients, partners, and the public.

Education - K through 12 STEM / STEAM Education Academic Scholarship Programs +2 more

HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $140,000
The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.
Drug Use Disorder Addiction & Substance Use Disorders

PennHOSA Foundation Scholarship

The Foundation for Enhancing Communities
Private
United States
US $2,500
The PennHOSA Foundation Scholarship promotes healthcare careers by providing scholarships to HOSA student members in Pennsylvania. It aims to enhance compassionate care delivery and community needs. Additionally, the Helen Heidelbaugh Aspire Award is given to one student focusing on community service. Eligible applicants must be HOSA members and enrolled in accredited healthcare programs, demonstrating financial need. This scholarship is a one-time award, reinforcing the commitment to future healthcare professionals.
Education - Higher Education Volunteerism & Philanthropy Medical Education & Professional Training +3 more

Agriculture Innovation Center Grant Program (363833)

USDA: Rural Business-Cooperative Service (RB-CS)
Federal Government
American Samoa, Guam +4 more
US $600,000 - US $1,000,000
The Agriculture Innovation Center Grant Program aims to support Agriculture Innovation Centers by providing grants that facilitate technical assistance to agricultural producers. This initiative focuses on enhancing the marketing of value-added agricultural products, ultimately fostering growth in the agricultural sector. Funded by the USDA's Rural Business-Cooperative Service, this program is designed to empower producers and promote innovation in agricultural practices.
Agriculture Entrepreneurship Agricultural Economics +2 more

Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed) (358087)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Central America +6 more
Unspecified amount
This funding opportunity aims to address health disparities in non-communicable and chronic diseases in Latin America. The initiative encourages collaborative research that evaluates public health policies and improves health outcomes among U.S. Hispanics/Latinos. Applications are welcomed from multi-disciplinary teams, with a requirement for collaboration with Latin American institutions. Key deadlines for submission are outlined, with a focus on innovative approaches to tackling critical health issues across the region.
Health Care Access & Delivery Health Policy & Advocacy Health Disparities & Social Determinants of Health +4 more

Pershing Square Lotus Award for Ovarian Cancer Research

Pershing Square Sohn Cancer Research Alliance (PSSCRA)
Association/Society
United States
Up to US $750,000

Pershing Square Lotus Award for Ovarian Cancer Research

The Pershing Square Foundation (PSF) has worked across sectors to catalyze innovative approaches to the most difficult problems. Talented individuals have always been at the center of our approach. We aim to support leaders who transform systems, embrace new paradigms, and have an innate drive to make an impact.

PSF has funded pioneering cancer researchers through the Pershing Square Sohn Cancer Research Alliance for over a decade and supported women’s health initiatives in New York City. Through this Request for Proposals (RFP), PSF aims to combine these two priority areas of women’s health and cancer to shine a light on one of the most understudied and underfunded cancers—ovarian cancer. Ovarian cancer is the deadliest gynecologic cancer, with 80% of women diagnosed at an advanced stage. Only 27% of women diagnosed during an advanced stage survive for five years. Ovarian cancer remains a disease with a poor prognosis due to limited early detection and treatment options.

PSF supports research efforts by 

  • deploying capital quickly, 
  • funding high-risk, high-reward ideas, 
  • bringing new perspectives into a field, 
  • encouraging collaboration, and 
  • leveraging our vast network. We challenge our scientific partners to think creatively and across silos, to spur innovation to fight ovarian cancer.

Through the Pershing Square Lotus Award for Ovarian Cancer Research, PSF is looking for investigators who are either already working on a promising project in ovarian cancer or in another type of cancer that could have an impact on ovarian cancer. Grantees each receive $250,000 a year for three years, totaling $750,000.

Researchers who are not studying ovarian cancer are encouraged to apply and required to find a collaborator with experience in ovarian cancer research.

This award aims to 

  • inspire investigators with unique expertise to apply their knowledge to ovarian cancer and 
  • empower ovarian cancer researchers to pursue their boldest, most innovative ideas. Facing a disease where too few have survived to-date, PSF ultimately aims to create a culture around ovarian cancer that offers women hope, akin to the breast cancer community. PSF is passionate about changing outcomes for tens of thousands of women a year and is hopeful that future scientific discoveries will allow for more survivors who can share their stories for years to come.
Cancer / Oncology Reproductive Health Women's Health +1 more

Tick-borne Pathogen Award

Bay Area Lyme Foundation
Private
United States
US $150,000
The Tick-borne Pathogen Award, sponsored by Bay Area Lyme Foundation, offers $150,000 to support innovative research on non-Borrelia tick-borne pathogens. This grant aims to attract scientific talent to explore co-infections with Lyme disease and other related infections. Eligible candidates include researchers from academia or the private sector at the post-doctoral level or higher, with a focus on improving diagnostics and therapies for tick-borne diseases. Applications must present a viable proof-of-concept project.
Microbiology Infectious & Parasitic Diseases Lyme Disease +1 more

Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional) (357817)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The U.S. Department of Health & Human Services, through the NIH, invites applications for the U01 grant aimed at advancing gene-based therapies for ultra-rare neurological and neuromuscular disorders. This initiative focuses on IND-enabling studies and supports the development of innovative therapeutics with proven biological rationale. Applications must include robust data and compelling justification for the proposed clinical candidates, targeting a specific patient population to facilitate IND filing and subsequent clinical trials.
Neurological Diseases & Disorders Rare Diseases Genetics & Genomics +2 more

Native Forward Scholars Fund Internship Assistance Program

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The Native Forward Scholars Fund Internship Assistance Program empowers Native students by providing financial support for internships in non-STEM fields. This initiative breaks down financial barriers, enabling students to gain practical experience in areas like public policy, education, and cultural preservation. Through this program, students enhance their skills while contributing positively to their Tribal communities. The funding covers essential costs such as travel and living expenses, ensuring transparency and accountability in financial assistance.
Public Policy Education - Higher Education Academic Success & Enrichment +4 more

BIE Professional Development Funding for STEM Educators and Students

Native Forward Scholars Fund
Association/Society
United States
Unspecified amount
The BIE Professional Development Funding for STEM Educators and Students, offered by the Native Forward Scholars Fund, supports training opportunities in science, technology, engineering, and mathematics (STEM) for TCU faculty, staff, and students. This funding assists with costs related to professional development including continuing education, conferences, and certifications. Eligible applicants include educators at BIE-funded or controlled schools, as well as those at institutions with significant Native American populations, fostering increased representation and support for Native scholars.
Education - Higher Education Academic Success & Enrichment Native American Services +4 more

Big Bald Dave Adventure Scholarship

Yellowstone Club Community Foundation
Private
United States
Unspecified amount
The Big Bald Dave Adventure Scholarship, provided by the Yellowstone Club Community Foundation, honors Dave Mueller's passion for outdoor adventure. It offers a unique summer trip for Big Sky students in grades 9-11 who demonstrate leadership and a love for the outdoors. Supported by Adventures Cross Country, this scholarship is a wonderful opportunity for students to engage in enriching experiences while giving back to the community. Notably, it is not based on financial need.
Academic Success & Enrichment Education - High School Student Retention & Drop-Out Prevention +2 more

Contractor for Implementation and Evaluation of Healthy Native Babies Project (HNBP) Materials

CDC Foundation
Private
United States
Up to US $100,000

CDC Foundation

The CDC Foundation helps the Centers for Disease Control and Prevention (CDC) and the public health system save and improve lives by unleashing the power of partnerships to protect the health, safety and security of all communities, everywhere. The CDC Foundation is authorized by Congress to mobilize philanthropic partners, corporations, organizations and individuals to support the critical health protection mission of CDC and the public health system.

The CDC Foundation manages hundreds of programs each year aimed at protecting communities across the country from a variety of health threats—from chronic disease conditions including cardiovascular disease and cancer, to infectious diseases like malaria and HIV to emergency responses, such as Ebola and Zika.

Contractor for Implementation and Evaluation of Healthy Native Babies Project Materials

The CDC Foundation invites proposals from Tribes, Tribal Serving Organizations (TSOs), and Urban Indian Organizations (UIOs) [T/TSOs/UIOs] to implement and evaluate the implementation of the updated Healthy Native Babies Project (HNBP) materials within their service areas. This initiative aims to strengthen culturally relevant infant safe sleep education, increase community awareness and support Native families in reducing sleep related infant deaths. Selected T/TSOs/UIOs will adapt, disseminate and assess the use of HNBP materials in ways that reflect the cultural, linguistic and community-specific needs of the Native populations they serve.

Maternal And Perinatal Health Sleep Community Health Education +2 more

SAF National Awards Program: Cultural and Community Engagement Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The SAF National Awards Program honors individuals in forestry for their innovative contributions to diversity and inclusion. Notably, the Cultural and Community Engagement Award recognizes SAF members who exemplify leadership in these areas. This award not only includes a $500 honorarium but also offers complimentary registration to the SAF convention and additional funds for travel. It highlights the importance of fostering an inclusive culture within the forestry profession.
Forestry Diversity, Equity & Inclusion

NCAA Postgraduate Scholarship - Fall Sports

National Collegiate Athletic Association
Private
Canada, Puerto Rico +2 more
US $7,000
The NCAA Postgraduate Scholarship for Fall Sports offers up to 126 scholarships annually, valued at $10,000 each, to student-athletes who excel academically and athletically. Eligible candidates must be in their final year of intercollegiate competition and maintain a minimum GPA of 3.20. Scholarships are awarded three times a year, with 21 available for men and 21 for women across various sports. This initiative promotes graduate education and recognizes the achievements of outstanding student-athletes.
Sports & Athletics Equestrian Sports Duathlons & Triathlons +2 more

SAF National Awards Program: Student Leadership Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The SAF National Awards Program recognizes exceptional student leaders in forestry. The Student Leadership Award honors an SAF student member demonstrating leadership skills at various levels. Recipients receive a $200 honorarium, complimentary convention registration, and up to $500 for travel expenses. Additionally, the recipient's faculty advisor and SAF Student Chapter benefit from $150 each. This award aims to encourage student engagement and excellence in sustainable forestry and resource management.
Forestry Education - Higher Education

SAF National Awards Program: Carl Alwin Schenck Award

Society of American Foresters (SAF)
Association/Society
United States
More than US $500
The Carl Alwin Schenck Award, presented by the Society of American Foresters, honors exemplary contributions in forestry education. This prestigious award recognizes individuals with at least ten years of professional experience who demonstrate outstanding teaching abilities and commitment to forestry. Awardees receive a $500 honorarium, complimentary registration for the SAF national convention, and up to $500 for travel expenses. This award underlines the importance of effective education in advancing sustainable forestry practices.
Forestry Education - Higher Education

Middle Run Foundation Grant

Middle Run Charitable Foundation
Private
United States
US $5,000 - US $50,000

Home

The Middle Run Foundation is a family-governed foundation based in Newark, Delaware. The Board of the foundation is chaired by Sarah Ives Gore, its founder, and includes her children, grandchildren, and non-family members who bring experience and expertise to our work.

About

Purpose:

The purpose of the foundation is to fund and support non-profit programs which focus on building healthy, self-sufficient families.

Apply

The Middle Run Foundation makes grants up to $500,000 annually with individual grants ranging from $5,000 to $50,000.

Basic Human Needs Homelessness Services Food Access & Hunger +3 more

Ag Health and Safety Grants

CHS Foundation
Corporate
United States
Unspecified amount
The Ag Health and Safety Grants, awarded by CHS and the CHS Foundation, aim to enhance agricultural safety and foster community well-being. These grants focus on educating youth and farmers about agricultural hazards, providing training for rural professionals, and developing essential safety guidelines. With a commitment to improving safety standards, the program has benefitted over 32,000 youth and supported more than 450 communities through safety initiatives and equipment, ensuring a safer future for all involved in agriculture.
Agriculture Agricultural Education Farms & Farming +2 more

Building Hope: Future Forward Schools Prize & Fellowship Program

Building Hope
Private
United States
US $50,000
The Building Hope: Future Forward Schools Prize & Fellowship Program aims to enhance career exploration for middle and high school students. This initiative, launched by Building Hope in partnership with American Student Assistance, recognizes schools that excel in career-connected learning. Awardees receive funding, mentorship, and resources to empower students from diverse backgrounds, ensuring they develop essential skills for future success. With $50,000 available for five schools, this program fosters innovation and prepares students for a changing economy.
Education - Middle School Education - High School Academic Success & Enrichment +1 more

The Dr. Alice M. Hudder- Richard T. Molder Post-Secondary Scholarship Fund

Erie Community Foundation
Private
United States
Unspecified amount
The Dr. Alice M. Hudder- Richard T. Molder Post-Secondary Scholarship Fund, established by Richard Molder, supports Erie County high school seniors pursuing post-secondary education. In 2023, the Erie Community Foundation awarded over $800,000 in scholarships to deserving students. Two awards will be granted: one for students focusing on science, math, or business, and another for those studying art or music, emphasizing financial need and a strong work ethic.
Education - Higher Education Career / College Preparation Education - High School +3 more

NBA Foundation Grants

National Basketball Association Foundation
Private
Canada, United States
More than US $25,000
The NBA Foundation Grants aim to empower Black youth by providing economic opportunities through skills training, mentorship, and career advancement programs. Established by all 30 NBA teams, the foundation focuses on organizations aligned with its mission, specifically those serving Black youth in NBA markets. Applications for 2024 grants are now open, with a review process taking 12-14 weeks. This initiative is crucial for promoting sustainable economic and racial justice in communities.
Career / College Preparation Black American Services Youth Services +2 more

Strengthening Collaboration Between Tuberculosis Control Programs and Affiliated Partners in the United States.

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.
Epidemiology & Public Health Infectious & Parasitic Diseases Preventative Healthcare +1 more

DOE Computational Science Graduate Fellowship: Science & Engineering Track

United States Department of Energy (DOE)
Federal Government
United States
Unspecified amount
The DOE Computational Science Graduate Fellowship (CSGF) supports U.S. citizens and permanent residents pursuing Ph.D. degrees in computational sciences. Established in 1991, it provides a $45,000 annual stipend, full tuition, and a $1,000 professional development allowance over a maximum of four years. The program encourages interdisciplinary research, offering fellows practical experience in DOE laboratories, enhancing their careers in high-performance computing and scientific research across various fields.
Physics Biology Bioengineering +11 more

Juliette Low’s Amazing Girls Scholarship

East Texas Communities Foundation
Private
United States
US $1,000
The Juliette Low’s Amazing Girls Scholarship, established in 2011 by the East Texas Communities Foundation, is aimed at female graduating seniors from Smith County who have been active in Girl Scouts. This scholarship supports educational pursuits for students attending any college in the U.S. Applicants must demonstrate financial need and have a minimum GPA of 3.00. The award amount is $1,000, and preference is given to recipients of the Girl Scout Gold Award. Reapplication is encouraged.
Academic Scholarship Programs Educational Access & Equity Education - Higher Education +3 more

Large Grants for Nonprofit Organizations in Indiana Highlights

Looking for large grants for nonprofit organizations in Indiana?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Indiana recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Indiana

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in Indiana grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

49 Large Grants for Nonprofit Organizations in Indiana over $25K in average grant size

37 Large Grants for Nonprofit Organizations in Indiana over $50K in average grant size

33 Large Grants for Nonprofit Organizations in Indiana supporting general operating expenses

200+ Large Grants for Nonprofit Organizations in Indiana supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Indiana?

Most grants are due in the second quarter.

Q1
24.6%
Q2
28.1%
Q3
23.6%
Q4
23.7%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Indiana?

Grants are most commonly $14,375.

$375 $375 Min.
$14,375 $14.4 K Median
$429,344 $429.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Indiana?

Grants are most commonly $158,271.

$158,271

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Indiana year over year?

In 2024, funders in Indiana awarded a total of 42,920 grants.

2022 40,294

2023 39,261

2024 42,920

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Indiana given out in Indiana, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Indiana changing over time?

Funding has increased by 35.58%.

2022 $4,633,293,808

2023 $4,997,384,462
7.86%

2024 $6,775,520,204
35.58%

Indiana Counties That Receive the Most Funding

How does grant funding vary by county?

Marion County, Monroe County, and Tippecanoe County receive the most funding.

County Total Grant Funding in 2024
Marion County $5,951,081,269
Monroe County $587,464,361
Tippecanoe County $370,158,455
St Joseph County $332,109,828
Allen County $235,684,076