Upcoming Webinar
Instrumentl Fall Launch: Grant Work, Leveled Up.
Thu, Oct 29 or Wed, Nov 4 @ 2PM ET

Skip to main content
Main content

Best Operating Grants for Nonprofits in Indiana

Find the perfect Operating grants for nonprofits in Indiana on Instrumentl. 10,000+ Operating grants for nonprofits in Indiana in the United States.

10,000+

Available grants

$2.62B

Total funding

$5K

Median grant

10,000+ grants
$2.62B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,901 Results based on applied filters

AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional) (362945)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.
HIV / AIDS

Richard Beatty Mellon Environmental Stewardship Award

Air & Waste Management Association (A&WMA)
Association/Society
United States
Unspecified amount
The Richard Beatty Mellon Environmental Stewardship Award, established in 1954, honors individuals or organizations for significant contributions to pollution abatement. Eligible candidates demonstrate dedicated efforts in promoting air pollution control and waste management. This prestigious award reflects the legacy of Richard Beatty Mellon, who pioneered research in air quality and environmental protection. The award is open to both members and nonmembers of the Air & Waste Management Association.
Environmental Contamination & Pollution Environmental Stewardship Waste Management

RSLAAIS Leadership Award

American Academy of Allergy, Asthma & Immunology (AAAAI)
Association/Society
United States
Unspecified amount
The RSLAAIS Leadership Award, presented by the American Academy of Allergy, Asthma & Immunology (AAAAI), honors exemplary leaders within state, regional, or local allergy societies. This prestigious award recognizes individuals for their significant contributions to community involvement, clinical education, and the advancement of the AAAAI's mission. Candidates are nominated by the RSLAAIS Board of Governors and must demonstrate a commitment to enhancing their local allergy societies and the broader medical community.
Asthma Vaccines & Immunizations Immune System Diseases

Career Development Award Program RFP- New Application

Melanoma Research Foundation
Private
United States
Up to US $50,000
The Melanoma Career Development Award (CDA) is offered by the Melanoma Research Foundation to support researchers dedicated to melanoma and its prevention. This award is designed for postdoctoral fellows with under five years of experience, research associates, scientists, staff scientists, assistant professors, and those focusing on melanoma prevention. The initiative promotes innovative research to advance understanding and treatment of melanoma, ultimately aiming to reduce its impact.
Cancer / Oncology Pediatric Cancers Skin Diseases & Dermatology

Joseph O. & Geraldine C. Waymire Nursing Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Joseph O. & Geraldine C. Waymire Nursing Scholarship, established by the Waymire family, supports students pursuing nursing careers. It is open to high school seniors from accredited Marion County institutions and those enrolled in nursing programs at various educational levels. Funds can be used for tuition, fees, and other educational expenses. The scholarship aims to foster a diverse nursing workforce, reflecting the mission of the Central Indiana Community Foundation to enhance community opportunities.
Education - High School Academic Scholarship Programs College Success / Persistence +2 more

Moody’s Community Impact Grant Program

Moody’s Investors Service, Inc.
Corporate
Argentina, Brazil +21 more
Unspecified amount
The Moody's Community Impact Grant Program supports organizations with tax-exempt status to foster social and economic equality. Established by Moody's Foundation, it prioritizes initiatives that empower underestimated communities and entrepreneurs, driving innovation and ecological restoration. The foundation focuses on inclusive growth, providing resources for small businesses and community resilience. Eligible organizations must be registered charities under U.S. IRS guidelines, while ineligible entities include individuals and those promoting unlawful discrimination.
Business Development Entrepreneurship Habitat & Ecosystem Restoration

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $600,000
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a funding opportunity for Exploratory Clinical Trials Grants. This program aims to support innovative clinical trials that enhance the understanding and treatment of arthritis and other musculoskeletal and skin conditions. Research proposals should focus on early-stage trials, including first-in-human studies, dose-finding, and biomarker evaluation. The initiative encourages the translation of promising laboratory findings into effective clinical practices, ultimately improving patient outcomes.
Musculoskeletal Diseases Skin Diseases & Dermatology Arthritis

Mastercard Innovation Fund

Mastercard Center for Inclusive Growth
Corporate
United States
US $200,000 - US $250,000
The Mastercard Strive USA 2025 Innovation Fund aims to enhance the financial health of small businesses across the U.S. by providing up to $250,000 in grants to organizations developing innovative solutions. This initiative focuses on addressing challenges such as limited access to financial resources and vulnerability to economic shocks, ultimately fostering resilience and growth within the small business sector.
Entrepreneurship Business Education Business Development +2 more

HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.
Epidemiology & Public Health Addiction & Substance Use Disorders Health Care Access & Delivery +3 more

Friends Foundation for the Aging Grant

Friends Foundation for the Aging
Private
United States
Unspecified amount
The Friends Foundation for the Aging Grant supports innovative and impactful programs aimed at addressing the needs of older adults, particularly within underserved populations. This Quaker foundation prioritizes collaboration and sustainability in its funding efforts. Eligible applicants must be 501(c)(3) public charities focused on enhancing the quality of life for aging individuals. Grants are typically awarded for one year and target organizations that align with the foundation's mission and values.
Aging / Gerontology Senior Services Protestantism +1 more

Senator Harold “Potch” Wheeler Memorial Scholarship

Community Foundation of Whitley County
Association/Society
United States
Unspecified amount
The Senator Harold "Potch" Wheeler Memorial Scholarship, managed by the Community Foundation of Whitley County, honors the legacy of a dedicated public servant. This competitive scholarship is available annually to high school seniors from Whitley County who plan to pursue college education in public service or within the Indiana Department of Natural Resources. Recipients are chosen based on their embodiment of the ideals and character traits exemplified by Senator Wheeler.
Education - Higher Education Education - High School Academic Scholarship Programs +1 more

Jacquelin Goldman Congressional Fellowship

American Psychological Foundation Inc
Private
United States
US $75,000 - US $90,000
The Jacquelin Goldman Congressional Fellowship offers developmental and clinical psychologists a unique opportunity to gain public policy experience while enhancing the application of psychological knowledge in government. Funded by the American Psychological Foundation, this fellowship supports one fellow annually with a stipend of $75,000 to $90,000, along with health insurance reimbursement and professional development funds. Applicants must demonstrate expertise in child psychology and policy issues, and have strong communication skills.
Psychology Children’s Mental Health Health Policy & Advocacy +1 more

Elizabeth Pastor Ashland University Music Education Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Elizabeth Pastor Ashland University Music Education Scholarship supports music students at Ashland University, honoring the legacy of Elizabeth Pastor, a renowned pianist and educator. This scholarship aims to assist students pursuing a music-related career, reflecting Pastor's belief in the transformative power of art. Established through her estate plan, it embodies her commitment to fostering musical talent and enriching the community through education and the arts.
Education - Higher Education Academic Scholarship Programs Music Education +2 more

Bob Zylstra STEM Scholarship

Grand Rapids Community Foundation
Private
United States
US $2,000 - US $5,000
The Bob Zylstra STEM Scholarship, offered by the Grand Rapids Community Foundation, supports undergraduate students who identify as female or as students of color from West Michigan. This scholarship aims to empower students pursuing STEM majors by removing barriers to education and fostering diversity in these fields. Each year, the foundation awards scholarships ranging from $2,000 to $5,000 to help students achieve their academic and career aspirations.
Education - Higher Education College Success / Persistence Educational Access & Equity +3 more

Incyte Healthcare Sponsorships

Incyte Corporation
Corporate
United States
Unspecified amount
Incyte Corporation, a biopharmaceutical leader, offers healthcare sponsorships to support organizations focused on improving patient care and access to healthcare information. Eligible applicants include medical schools, associations, non-profits, advocacy groups, and hospitals. Requests should align with Incyte's commitment to enhancing the lives of patients affected by cancer and other diseases, ensuring compliance with regulatory guidelines. Organizations must enter a written agreement with Incyte to receive funding.
Cancer / Oncology Diseases & Conditions Nursing +2 more

Incyte: Healthcare-related Charitable Contributions, Sponsorship and Membership Requests

Incyte Corporation
Corporate
United States
Unspecified amount
Incyte Corporation invites organizations to submit membership requests aimed at enhancing healthcare access for patients and advocates. As a biopharmaceutical leader, Incyte supports initiatives that align with its mission to improve patient lives through grants and contributions. Eligible entities include medical schools, associations, non-profits, and advocacy groups. Requests should comply with Incyte's regulatory standards and be submitted at least 60 days prior to the required decision date.
Cancer / Oncology Diseases & Conditions Nursing +2 more

Gary S. Wilmer / RAMI Music Scholarship

Community Foundation of Northern Illinois
Private
United States
Unspecified amount
The Gary S. Wilmer / RAMI Music Scholarship supports local students aged 19 and under who are passionate about music and committed to furthering their education in the arts. Established in memory of Gary Wilmer, founder of RAM Magazine, this scholarship honors his legacy by providing financial assistance to aspiring musicians in Boone, Ogle, or Winnebago County. Applicants are required to submit an audition recording and a reference from a music teacher to demonstrate their dedication to musical excellence.
Music Education - Higher Education Academic Scholarship Programs +2 more

MACC-SIREN Faculty Fellowship in Acute Care Research

Indiana Clinical and Translational Sciences Institute (CTSI)
Association/Society
Cook County, Illinois, Dallas County, Texas +2 more
Unspecified amount
The MACC-SIREN Faculty Fellowship in Acute Care Research, funded by the Indiana Clinical and Translational Sciences Institute, offers junior faculty 20% salary support for a year-long mentored clinical research training program. This NIH-funded initiative aims to develop physician- and surgeon-scientists focusing on high-impact clinical trials in acute care. The fellowship may be renewed once, enhancing opportunities for career development in critical research areas.
Cardiovascular Diseases & Systems Neurological Diseases & Disorders Hematological Systems +1 more

Celine Wyatt Memorial Scholarship

Muskingum County Community Foundation
Corporate
United States
Unspecified amount
The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.
Education - High School Education - Higher Education Women & Girl Services +3 more

ABF Next Generation Research Grants - Stroke

American Brain Foundation
Private
United States
Up to US $150,000

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

Lawrence M. Brass, MD Clinical Research Training Scholarship in Stroke

This award aims to recognize the importance of good clinical research and to encourage early career investigators in clinical studies related to stroke, vascular neurology, and neurocritical care.

For the purpose of this scholarship, research is defined as “patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance diagnosis of neurological disease. These areas of research include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health services and outcomes research.” Disease-related studies not directly involving humans or human tissue are also encouraged if the primary goal is the development of therapies, diagnostic tests, or other tools to prevent or mitigate neurological diseases.

Stroke Neuroscience Neurological Diseases & Disorders

Hays, Karla, Loving Heart, Scholarship

Beatrice Educational Foundation
Association/Society
United States
Up to US $1,000
The Hays, Karla, Loving Heart Scholarship offers financial support to graduating seniors of Beatrice High School, with one to three scholarships available totaling up to $1,000. Administered by the Beatrice Educational Foundation, this initiative aims to assist deserving students in pursuing higher education. The foundation, established in 1987, supports academic achievement and civic involvement in the community. Eligible students must maintain a minimum GPA of 3.0 and demonstrate ethical scholarship application practices.
Education - Higher Education Academic Scholarship Programs Music +2 more

BJA FY 2026 Second Chance Act Community-based Reentry Program

US DOJ: OJP Bureau of Justice Assistance
Federal Government
United States
Up to US $1,000,000
The BJA FY 2026 Second Chance Act Community-based Reentry Program aims to support community organizations and tribal governments in providing essential mentoring and transitional services for individuals returning from correctional facilities. This initiative targets those assessed as moderate to high risk for recidivism, addressing their needs both pre-and post-release. By fostering successful reintegration into society, the program contributes to public safety and reduces recidivism rates, aligning with the mission of the U.S. Department of Justice.
Crime & Justice Reentry Services Employment Services +2 more

Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $700,000
The Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning Resource Allocation Cooperative Agreement aims to enhance the effectiveness of HIV prevention and care planning for RWHAP Parts A and B recipients. Through the provision of training, tools, and technical assistance, this initiative seeks to optimize resource allocation and strengthen the overall system of HIV care and treatment, ultimately improving health outcomes for those affected by HIV.
HIV / AIDS

NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) (352061)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $3,600,000
The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.
Allergies & Allergic Diseases Infectious & Parasitic Diseases Immune System Diseases

Women's Club of Grand Haven Grant

Grand Haven Area Community Foundation
Private
United States
Unspecified amount
The Women's Club of Grand Haven Grant, established in 2001, offers scholarships to non-traditional students from the Tri-Cities seeking further education. Funded through community efforts such as an annual Used Book Sale, this grant prioritizes financial need and is open to applicants residing in Northern Ottawa County or those who graduated from local school districts. Preference is given to female applicants aged 21 and older, supporting educational advancement for those whose academic journeys have been interrupted.
Education - Higher Education Educational Access & Equity Adult Education +3 more

IDNR: State Duck Stamp Funding

Illinois Department of Natural Resources
State/Local Government
Canada, United States
Up to US $500,000
The IDNR: State Duck Stamp Funding program supports the development of waterfowl propagation areas in the Mississippi Flyway. Funded by sales of State Migratory Waterfowl Stamps, it focuses on projects in Canada and the U.S. that enhance waterfowl populations. Eligible applicants include not-for-profit organizations aiming to implement the North American Waterfowl Management Plan. This initiative not only fosters wildlife conservation but also strengthens ecological sustainability in the region.
Habitat & Ecosystem Restoration Land / Habitat Conservation Ornithological Conservation

F26AS00071 Cooperative Endangered Species Conservation Fund: Habitat Conservation Plan Land Acquisition Grants

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $26,000,000
The Cooperative Endangered Species Conservation Fund supports habitat conservation through land acquisition grants. Established in 1997, this program aims to minimize conflicts between listed species conservation and land use. The U.S. Fish and Wildlife Service provides matching grants to state agencies for projects that ensure the long-term protection of habitats. By acquiring land or conservation easements, this initiative facilitates species recovery and helps prevent future listings under the Endangered Species Act, enhancing overall ecosystem health.
Environmental Conservation Habitat & Ecosystem Restoration Land / Habitat Conservation

Operating Grants for Nonprofits in Indiana Highlights

Looking for operating grants for nonprofits in Indiana?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Indiana recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Indiana

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Operating grants for nonprofits in Indiana grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

49 Operating grants for nonprofits in Indiana over $25K in average grant size

37 Operating grants for nonprofits in Indiana over $50K in average grant size

33 Operating grants for nonprofits in Indiana supporting general operating expenses

200+ Operating grants for nonprofits in Indiana supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Art & Culture

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Indiana?

Most grants are due in the second quarter.

Q1
24.6%
Q2
28.1%
Q3
23.6%
Q4
23.7%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Indiana?

Grants are most commonly $14,375.

$375 $375 Min.
$14,375 $14.4 K Median
$429,344 $429.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Indiana?

Grants are most commonly $158,271.

$158,271

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Indiana year over year?

In 2024, funders in Indiana awarded a total of 42,920 grants.

2022 40,294

2023 39,261

2024 42,920

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Indiana given out in Indiana, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Operating Grants for Nonprofits in Indiana changing over time?

Funding has increased by 35.58%.

2022 $4,633,293,808

2023 $4,997,384,462
7.86%

2024 $6,775,520,204
35.58%

Indiana Counties That Receive the Most Funding

How does grant funding vary by county?

Marion County, Monroe County, and Tippecanoe County receive the most funding.

County Total Grant Funding in 2024
Marion County $5,951,081,269
Monroe County $587,464,361
Tippecanoe County $370,158,455
St Joseph County $332,109,828
Allen County $235,684,076