Best Large Grants for Nonprofit Organizations in Kentucky

The Life Comes From It Grant, funded by the Tides Foundation, supports grassroots initiatives focused on restorative, transformative, and indigenous justice. It prioritizes projects led by communities of color, emphasizing alternatives to incarceration and community-led solutions. Applicants must be 501c3 organizations based in the United States. This grant fosters a collaborative approach to healing and justice, aiming to shift power dynamics and promote inclusive practices across generations.

The Encompass Health Therapy Grant offers up to $50,000 for research on the effectiveness of therapies in inpatient rehabilitation facilities. This funding aims to enhance understanding of neurological impairments and improve patient outcomes through evidence-based practices. Eligible projects must be conducted in the U.S. or Puerto Rico, require a defined research protocol, and adhere to ethical standards. The grant prioritizes studies on therapy impact, implementation science, and caregiver education, contributing to the advancement of rehabilitation care.

This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.

The American Heart Association is inviting proposals for research on the effects of GLP-1 and GIP agonists in individuals with cardiovascular, kidney, and metabolic diseases. This initiative aims to explore how these medications can alleviate the CKM burden. Researchers with expertise in causal inference, machine learning, and cardiovascular research are encouraged to apply, particularly those working in multidisciplinary teams and leveraging various data sources.

Reader’s Digest Partners for Sight Foundation

The Reader’s Digest Partners for Sight Foundation is a philanthropic organization dedicated to improving the lives of individuals who are blind or visually impaired by fostering independence and self-sufficiency. Its mission is to support programs that help people with vision loss lead independent, productive lives, while its vision is an accessible and inclusive world where individuals have the tools, resources, and opportunities to fully participate in society.

The Foundation’s funding priorities focus on supporting nonprofit organizations and initiatives that provide education, training, and rehabilitation services, assistive technology innovations, vision care and access to aids, and capacity building for professionals serving the visually impaired community. It also invests in programs that enhance employment opportunities, promote independence, and improve service delivery systems for people with vision loss, emphasizing practical, community-based solutions and long-term impact.

Small Discretionary Grants

The Reader’s Digest Partners for Sight Foundation (RDPFS) Track #3 Small Discretionary Grants provide flexible, year-round funding for smaller-scale initiatives that support individuals who are blind or visually impaired. Grant requests are accepted on a rolling basis and awarded at the discretion of the Executive Director. Awards are made until available funds are exhausted, allowing the Foundation to respond to timely or emerging needs.

Greenawalt Foundation

Building Stronger Communities

At The Greenawalt Foundation, we believe that opportunity is the foundation of prosperity. By supporting organizations that educate, train, and empower people in the trades, we’re helping to build a stronger, more sustainable future for all.

Skilled Trades Grant Opportunities

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Eligible Grant Categories

• Skilled Trades Training Support
• Pre-Apprenticeship or Apprenticeship Programs
• Youth Career Exploration Camps

The Reader’s Digest Partners for Sight Foundation offers Single Program Grants to support impactful programs for individuals who are blind or visually impaired. These grants, ranging from $25,000 to $50,000, prioritize initiatives that enhance independence and service delivery. Eligible organizations must be US 501(c)(3) non-profits, and unsolicited proposals are not accepted. The foundation emphasizes community-based solutions and invites qualified applicants to submit a Letter of Inquiry followed by a full proposal.

The AAAAI Distinguished Scientist Award recognizes exceptional contributions in allergy and immunology research, honoring those who have significantly advanced the field and demonstrated leadership. This prestigious award is presented by the American Academy of Allergy, Asthma & Immunology, a leading organization for over 7,000 professionals dedicated to improving patient care and promoting research in allergic diseases. The award highlights the commitment to excellence and innovation within the specialty.

The Cancer Prevention and Control Programs aim to eliminate cancer through collaborative efforts among state, territorial, and tribal organizations. Funded by the CDC, this program supports initiatives such as breast and cervical cancer screening, cancer control planning, and cancer surveillance. By fostering partnerships and community involvement, the program seeks to improve health outcomes and achieve the mission of 'All People Free of Cancer.' This comprehensive approach ensures that resources are effectively coordinated to address the cancer burden in communities.

The Chipotle Cultivate Foundation Grant Program supports 501(c)3 non-profits dedicated to making real food accessible and fostering community growth. Established in 2011, this initiative aligns with Chipotle's mission to cultivate a better world. Eligible organizations can apply through an invitation-only process, focusing on those paving the way for a better future. The foundation also offers mentorship and resources to innovative ventures in the food industry.

The AAAAI Special Recognition Award honors individuals who significantly contribute to the allergy and immunology community. Offered by the American Academy of Allergy, Asthma & Immunology, this prestigious award recognizes outstanding efforts in advancing care and research in the field, promoting optimal patient outcomes. The AAAAI, with over 7,000 members worldwide, is a leading authority in allergy and immunology, dedicated to enhancing the knowledge and practice of these critical health areas.

The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.

The BJA FY 2026 Second Chance Act Community-based Reentry Program aims to support community organizations and tribal governments in providing essential mentoring and transitional services for individuals returning from correctional facilities. This initiative targets those assessed as moderate to high risk for recidivism, addressing their needs both pre-and post-release. By fostering successful reintegration into society, the program contributes to public safety and reduces recidivism rates, aligning with the mission of the U.S. Department of Justice.

The Implementing Zero Suicide in Health Systems program aims to enhance suicide prevention efforts for adults within health systems. Funded by the US HHS's Substance Abuse and Mental Health Services Administration (SAMHSA), this initiative employs a comprehensive approach that incorporates all seven elements of the Zero Suicide framework: Lead, Train, Identify, Engage, Treat, Transition, and Improve. This program seeks to create safer health environments and reduce suicide rates effectively.

The Instrument Donations Program by Music Movement supports children and young adults with Autism and learning differences by providing funding for musical instruments. This initiative fosters self-expression, personal growth, and emotional well-being through music. Grants typically range from $500 to $1,500 and are available to applicants within the United States. The program encourages artistic development and enhances social skills, making a significant impact on the lives of those facing developmental challenges.

The SAF National Awards Program recognizes outstanding contributions to forestry through various awards, including the Employer Leadership Award. This award honors employers who significantly support SAF members' professional engagement. Recipients receive a $500 honorarium, complimentary convention registration, and travel expense support. The program aims to celebrate the achievements of individuals and organizations in promoting sustainable forestry practices and enhancing professional development, ultimately driving excellence in natural resource management.

The SAF National Awards Program celebrates outstanding contributions to forestry through various awards, including the Outstanding Local Unit Achievement Award. This award recognizes local units for their sustained leadership or special projects that benefit the Society of American Foresters and the forestry profession. Each awarded unit receives a $500 honorarium, complimentary convention registration, and funding for travel expenses, ensuring recognition and support for their impactful efforts in forestry.

The NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3) invites applications for the execution of investigator-initiated, interventional clinical trials across various phases. This program supports researchers in finalizing preparations necessary for trial initiation, including IRB establishment and staffing. Successful UG3 projects may transition to the UH3 phase, emphasizing the need for hypothesis-driven studies with significant clinical impact within NIAMS's research mission.

The Store-Based Giving Program by Ross Stores Foundation supports socioeconomically disadvantaged youth by providing gift cards for school or professional clothing. Organizations must be federal tax-exempt and serve at least 60% low-income youth. Eligible programs include academic achievement and life skills initiatives. Award amounts typically range from $300 to $500, depending on budget and mission alignment. Applications are not accepted from organizations that have received donations within the past 12 months.

The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.

The Gifford Pinchot Medal, awarded by the Society of American Foresters, honors exceptional contributions by forestry professionals in North America. Recognizing achievements in administration and practice, this medal is presented every odd-numbered year at the SAF national convention. Recipients receive a $500 honorarium, complimentary registration, and up to $500 for travel expenses. This prestigious award highlights the importance of leadership and innovation in the forestry profession.

The SAF National Awards Program recognizes exceptional contributions to forestry through its Honorary Membership award. This accolade is presented to individuals whose impact on the field is acknowledged by their peers, highlighting their distinguished service in advancing forestry knowledge and societal awareness. Awardees receive lifetime membership in SAF along with complimentary convention registration. The program seeks to honor those, including non-professional foresters, who have made significant strides in forestry, both domestically and internationally.

The SAF National Awards Program includes the John A. Beale Memorial Award, recognizing exceptional voluntary service in forestry by SAF members. Established to honor John Beale's legacy, this award is presented at the SAF national convention and includes a $500 honorarium, complimentary registration, and up to $500 for travel expenses. Nominees must demonstrate sustained commitment to the SAF and its mission, showcasing leadership and promotion of forestry principles.

The Young Forester Leadership Award, presented by the Society of American Foresters (SAF), recognizes exceptional leadership from young forestry professionals under 40 years old. This award highlights contributions to forestry through innovative projects and sustained leadership roles. Recipients receive a $500 honorarium, complimentary registration for the SAF national convention, and support for travel expenses up to $500. This prestigious accolade aims to encourage the next generation of forestry leaders to excel in their professional endeavors.

Music Movement's Independent Living Initiatives grant supports individuals with Autism and developmental differences in the U.S. Grants, typically ranging from $1,500 to $5,000, aid in various areas including independent living, camps, and continued education. Applicants must be legal guardians of eligible individuals aged 18 and older. The grant portal will reopen for submissions on March 28, 2026, encouraging early review of guidelines to ensure complete applications.

The Hays, Karla, Loving Heart Scholarship offers financial support to graduating seniors of Beatrice High School, with one to three scholarships available totaling up to $1,000. Administered by the Beatrice Educational Foundation, this initiative aims to assist deserving students in pursuing higher education. The foundation, established in 1987, supports academic achievement and civic involvement in the community. Eligible students must maintain a minimum GPA of 3.0 and demonstrate ethical scholarship application practices.

The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.