Best Large Grants for Nonprofit Organizations in Kentucky

The Clarence W. Winter Charitable Trust, established from Mr. Winter's Will, provides annual grants of $3,000 to $5,000 to support tax-exempt organizations focused on charitable, religious, scientific, literary, or educational purposes. While there are no geographic restrictions, the Trust prioritizes organizations in Bucks County, PA. With a commitment to community betterment, Mr. Winter's legacy continues to support impactful initiatives for years to come.

The ISF Impact Campaign Grant supports completed short or feature-length films that aim to create a positive societal impact through outreach and community engagement. This grant is available to all filmmakers, focusing on projects that depict American Muslim narratives. Recipients will receive funding along with mentorship to enhance their impact campaigns, which must include a comprehensive proposal detailing goals and success metrics.

The National Institute on Minority Health and Health Disparities (NIMHD) is offering funding for innovative research aimed at improving health outcomes for Native Hawaiian and Pacific Islander populations. This grant will support preparatory and pilot activities that focus on understanding health disparities, testing interventions for chronic diseases, and promoting health behavior changes in collaboration with community partners. Projects should address critical health issues such as cancer, diabetes, and maternal health.

The Holthouse Foundation for Kids supports organizations that empower at-risk youth through character education, life skills, and entrepreneurship. They provide grants to non-profit entities recognized under Section 501(c)(3) of the Internal Revenue Code, focusing on community enrichment in Houston and beyond. While inquiry letters are accepted year-round, they do not guarantee funding, and applicants must understand that proposals are not a promise of financial support.

The Herbert Family Foundation Grant focuses on philanthropic efforts that promote healing and fight hunger. Founded by Jim and Judi Herbert, both Distinguished Alumni of the University of Tennessee, the foundation supports health and food charities. It aims to advance medical research, education, and hunger relief initiatives, emphasizing sustainable practices and nutritional assistance. The foundation's mission reflects its commitment to impactful charitable causes that resonate personally with the founders.

The ARISE Grants, offered by the Appalachian Regional Commission, aim to drive regional economic transformation across 13 Appalachian states. With funding of up to $63.5 million for implementation grants and $10 million maximum awards, the initiative supports collaborative projects that enhance community capacity and economic growth. The program encourages innovative partnerships to strengthen local economies and achieve socioeconomic parity, benefiting over 26 million residents in the Appalachian Region.

The Frankenthaler Climate Initiative offers implementation grants aimed at enhancing energy efficiency in visual arts museums, addressing climate change through innovative projects. With deadlines extended for those affected by the LA Fires, eligible institutions can apply for funding ranging from $50,000 to $100,000. This initiative supports museums of all sizes, helping them reduce emissions and operational costs while promoting sustainable practices in the arts sector.

The Corridors Neighborhood Enhancement Match Grant, funded by the Lexington-Fayette Urban County Government, aims to enhance the aesthetic and functional qualities of community corridors in Lexington. This program promotes collaboration with local neighborhoods and organizations, focusing on public benefit activities. Eligible projects include landscaping, public art, and corridor cleanup efforts. With a 2:1 matching grant requirement, this initiative encourages community engagement and supports the beautification and improvement of vital urban spaces.

The Frankenthaler Climate Initiative provides funding for energy efficiency projects in visual arts museums, addressing climate change through innovative cultural leadership. Grants up to $25,000 support institutions in evaluating energy mitigation opportunities, enhancing efficiency, and reducing emissions. Eligible applicants include museums and visual arts schools across the U.S. The initiative encourages sustainable practices while assisting organizations in understanding their energy needs and planning for effective interventions within a project timeline of 18 months.

About NIF

Advancing Equality for All Israelis

The New Israel Fund (NIF) helps Israel live up to its founders’ vision of a society that ensures complete equality to all its inhabitants. Our aim is to advance liberal democracy, including freedom of speech and minority rights, and to fight the inequality, injustice and extremism that diminish Israel.

From Israel’s first rape crisis centers, to fighting discrimination, NIF-funded organizations have driven positive social change and furthered justice and equality. NIF has provided over $350 million to more than 950 organizations since our inception in 1979.

Naomi Chazan Global Activism Fellowship

Want to travel to Israel/Palestine while advancing equality, democracy, and peace for all?

The New Israel Fund’s Naomi Chazan Global Activism Fellowship offers a one-of-a-kind opportunity to visit Israel/Palestine, meet frontline Israeli and Palestinian activists, and learn about issues of war, peace, and inequality by seeing the reality on the ground. 

Fellows will visit Israel/Palestine on November 3-10, 2026.

This trip is a great opportunity to learn alongside peers and friends (ages 21 – 35). NIF is based on the simple idea that those of us who share a commitment to Israel/Palestine and to progressive values can join together to work for equality, freedom, and human rights. You will join a cohort of participants from the U.S. and Canada building relationships across borders to be sustained for years to come.

Following the trip, participants are expected to organize at least two NIF events in their home communities, with support from NIF staff. These events could look like a report-back highlighting the participants’ learnings from the trip, educational programs featuring NIF grantees/partners, or something else entirely that is tailored to the intellectual, emotional, and spiritual needs of the fellow’s communities.

The program is subsidized by generous donors in the NIF community. All “on-the-ground” costs—your hotel accommodation and almost all meals—will be covered by NIF. Participants are responsible for purchasing their own airfare and travel/health insurance. If the cost of airfare is a barrier for you, please apply anyway. Limited airfare subsidies may be available.

The Louder Than Words Grant Program, supported by the Finish Line Youth Foundation, focuses on empowering diverse and underserved communities in Indianapolis and beyond. With grant cycles addressing areas like health, workforce development, and safe communities, organizations can request up to $10,000 to support impactful programming. Eligible applicants must be 501(c)(3) organizations dedicated to fostering positive change, particularly for communities of color, ensuring equitable access to resources and opportunities.

About BHOF

For 40 years, the Bone Health & Osteoporosis Foundation (BHOF) has been committed to preventing osteoporosis and promoting awareness about bone health. Learn more about our organization.

Awards

Robert F. Gagel, M.D. Community Leadership Award

The Robert F. Gagel, M.D. Community Leadership Award recognizes a healthcare professional who has made outstanding contributions to improving osteoporosis care and increasing community awareness about bone health. This award will be presented annually to a healthcare professional residing and working in the United States or its territories.

The Executive Committee of the Bone Health and Osteoporosis Foundation’s (BHOF’s) Board of Trustees will review nominations and select the recipient.

The award winner will be notified and announced in May, in recognition of Osteoporosis Awareness and Prevention Month. The recipient will receive a plaque and a financial award (currently $1,000) to support community service efforts initiatives related to osteoporosis and bone health.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) aim to bridge the funding gap that often hinders the commercialization of medical biotechnology products. This initiative encourages partnerships between NINDS awardees and third-party investors to advance projects requiring federal regulatory approval. By supporting the next milestones necessary for product development, this opportunity fosters the transition of innovative research tools to market, ultimately enhancing public health outcomes.

Driving University Impact: Expanding the Public Exchange Network Grant

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

The AAAE Diversity, Equity & Inclusion Scholarship, provided by the AAAE Foundation, supports ethnic diversity students pursuing aviation studies in the U.S. or Canada. With two awards of $5,000 each, recipients are chosen based on their academic achievements, financial need, and community involvement. Eligible applicants include college juniors, seniors, or graduate students with a minimum GPA of 3.0. This scholarship aims to foster future leaders in the aviation industry, enhancing diversity and inclusion.

Confederated Tribes of Siletz Indians

The Confederated Tribes of Siletz Indians is a sovereign nation and has three main branches of government – Judicial, Executive, and Legislative. One of our most important resources is our people.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

Cathern Tufts Memorial Scholarship

Cathern Tufts, affectionately known as “Cat” in the offices of the CTSI administrative offices and Tribal elder woodcuts, was the Tribal Attorney for fourteen and a half years until she passed in 2018 following a short illness. She was a Siletz Tribal member who graduated from Arizona State University School of Law. She served an internship in Washington D.C. prior to going to work as an attorney. Her parents and friends wished to honor her life and achievements through this memorial scholarship. This scholarship is for students in pre-law, law, or in a natural resource field.

The Alfred P. Sloan Foundation Research Fellowship supports innovative and fundamental research by early-career scientists across various fields. This prestigious two-year fellowship offers $75,000 in a lump sum, allowing recipients to allocate funds towards research-related expenses. Eligible candidates must hold a Ph.D. and be tenure-track faculty at U.S. or Canadian institutions. The fellowship aims to nurture the next generation of leaders in research and academia.

Don and Bern Holcomb Memorial Scholarship

This scholarship was created in memory of Don and Bern Holcomb and is for high school students from any school in Cattaraugus or Allegany county who plans to attend an accredited post-secondary institution, with a preference for a student majoring in an agricultural or conservation-related field or a female pursuing an engineering degree.

The Armando "Frank" Quaglia Veteran's Scholarship, offered by the Grand Rapids Community Foundation, supports full-time graduate or upper-level undergraduate students from Kent or Ionia County pursuing healthcare or engineering degrees. With a minimum 3.0 GPA, preference is given to veterans and their families. This scholarship aims to eliminate barriers to education, fostering academic success and connecting students to opportunities in West Michigan's inclusive community.

About Us

Marshfield Area Community Foundation, Inc. is a public, 501-C-3 charity. There are 30 community foundations in Wisconsin and more than 750 in the nation. The purpose of all community foundations is to accumulate charitable dollars that impact a specific geographic region in areas such as education, the arts, economic development, recreation, environmental protection, health care, and social services. They may be relatively small, as we are (assets of $14 million), or very large, as is the Greater Milwaukee Foundation (assets over $400 million).

Most people are familiar with private foundations, established by individuals, families, or corporations. Typically, in order to establish a private foundation, one has to have considerable wealth. You could say Community Foundations are much more democratic. We are, in a sense, an umbrella foundation containing many small foundations. We call those small foundations “funds.”

Marshfield Area Community Foundation Scholarships

The mission of the Marshfield Area Community Foundation is “Connecting people who care with causes that matter to enrich the quality of life in the Marshfield area”. Education is a valuable tool and a cause that matters to all of us. Through assisting students with financial support to receive an education, not only do students and the families of those students benefit, but also our community benefits, which further allows us to achieve our mission of enriching the quality of life in the Marshfield area.

Sophia Smrz Memorial Scholarship (2025)

The Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) award aims to assist federally recognized AI/AN Tribes, Tribal colleges and universities, and Tribal health organizations in creating or enhancing Institutional Review Boards (IRBs). This initiative is crucial for ensuring ethical research practices within Tribal communities, fostering cultural sensitivity in research, and protecting the rights of AI/AN participants. Applications must be submitted by 5:00 PM local time of the applicant organization.

The Judith Halama Ebert Scholarship aims to support graduating seniors from Ashland County high schools with a GPA of 3.0 or higher, pursuing Education, particularly in Special Education. Established by Judy Ebert, a passionate advocate for education, the scholarship reflects her commitment to assist students demonstrating leadership and community engagement. This initiative not only honors Judy's educational legacy but also fosters future educators who will positively impact the community.

The ScotiaRISE initiative by Scotiabank aims to foster economic resilience among disadvantaged groups over ten years, with a budget of $500 million. By focusing on enhancing educational opportunities, facilitating employment for newcomers, and removing barriers to career advancement, ScotiaRISE seeks to create a more inclusive society. This program highlights the importance of collective efforts in supporting individuals and communities to thrive, ensuring everyone has the chance to rise above challenges and contribute positively to their environments.

The Stanford Children's Health Center for IBD and Celiac Disease offers Intramural Seed Grants to promote innovative research in pediatric diseases. This program supports high-risk, high-reward projects, encouraging multi-PI collaborations across disciplines. Awards of up to $100,000 per year for two years are available, aimed at generating preliminary data for future funding applications. Eligible applicants include Stanford faculty holding specific university positions. Proposals should focus on advancing understanding of pediatric IBD and celiac disease through various research approaches.

About Levitt

The Levitt Family Foundation exists to strengthen the social fabric of America. We partner with communities to activate underused outdoor spaces, creating welcoming, inclusive destinations where the power of free, live music brings people together and invigorates community life.

Festival Grants

The Levitt Foundation is offering grants of up to $5,000 to U.S.-based 501(c)(3) nonprofits presenting free outdoor music festivals in 2026. 

The Stanford Medicine Children’s Health Center for IBD and Celiac Disease offers funding for postdoctoral fellows and instructors to conduct innovative research focused on pediatric IBD and celiac disease. This initiative aims to nurture future researchers and prepare them for independent funding opportunities. Eligible research includes basic, clinical, epidemiological, and health policy studies related to maternal and child health. Funding supports substantial salary and benefits, ensuring commitment to impactful research in this critical area.