Best Operating Grants for Nonprofits in Kentucky

Pediatric Hidradenitis Suppurativa Challenge Grant

Hidradenitis suppurativa (HS) is a devastating chronic inflammatory disease that manifests as recurrent painful nodules under the skin in the intertriginous areas of the body. It is associated with significant impacts on quality of life, psychosocial well-being, and long-term health outcomes of patients as well as consequences for families and caregivers. HS is prevalent, affecting between 1 and 4% of the population beginning in adolescence and persisting into adulthood. Despite the impact of HS, it remains underdiagnosed, undertreated, and understudied particularly in the pediatric and adolescent populations. Contributing to this dynamic are unknowns related to a complex disease etiology, stigma associated with HS symptoms (e.g., sweating, itching, and scarring commonly in the genital region), and limited treatment options to date with even fewer available for children under the age of 12.

To address the needs of children and adolescents living with HS, the Pediatric Dermatology Research Alliance (PeDRA), HS Connect, and the HS Foundation are offering the 2026 Pediatric HS Challenge Grant to support an early-to-mid career investigator for a one-year project focused on a high-priority, patient-centric research topic.

Focus

Proposals should address one or more of the following high-priority research topics:

• Predicting treatment effectiveness and risk utilizing real world evidence and/or experience
• Early disease and factors involved in severe disease development
• Optimizing surgical and procedural approaches to minimize pain, shorten healing time, and reduce recurrence
• Improving recruitment of diverse and representative populations for clinical studies, trials and advanced therapeutics

Funding:

• Up to $50,000 to support one year of research
• One award anticipated for this funding cycle

Northern Piedmont Community Foundation

The Northern Piedmont Community Foundation (NPCF) began in December 2000 when nine concerned citizens from Virginia’s Piedmont region were searching for solutions to the charitable needs in Culpeper, Fauquier, Madison, and Rappahannock counties. With modest beginnings, our funds have grown to over $39 million in support of local charities, scholarships and community need in our northern Piedmont region.

Scholarships

Northern Piedmont Community Foundation manages the scholarship application process for dozens of scholarships for students in Culpeper, Fauquier, Madison, and Rappahannock counties (as well as a handful serving students from surrounding counties too). 

Fauquier County Chamber Of Commerce Max Tufts, Sr. Memorial

This scholarship was created in memory of Maximilian A. Tufts Sr. who was an energetic community volunteer. He was committed to many organizations including the Fauquier County Chamber of Commerce, Highland School, Fauquier Community Action Committee, Fauquier Human Relation Committee, Warrenton Rescue Squad, the Meadows Outdoors Foundation and the Airlie Foundation. Eligible students should be college or university bound graduating seniors from any Fauquier County public or private high school. Scholarship recipients should demonstrate involvement in both school and community. 

David Webb Memorial Scholarship

To provide financial support for graduates of Cheyenne-Eagle Butte, Faith, Dupree, Timber Lake, Mc Laughlin and McIntosh High School.

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

NCCF awards more than $530,000 in scholarships a year. 

Douglas and Janet Roberts Scholarship

Academic Focus:

• Unspecified

Award Average:

• $4,000-$8,000

Patrick J. Kiley / Houston AGC Scholarship

Benefiting employees, dependents of employees, and/or interns of AGC Houston member firms OR students involved in AGC Student Chapters.

Award Amounts

Multiple awards are given each year. Scholarship award amounts will vary for each selected scholarship recipient.

The Willson Center Research Seminar Program at the University of Georgia provides $2,000 for faculty-led interdisciplinary discussion groups on specific research topics. This grant is aimed at tenured or tenure-track faculty and is intended to facilitate the visit of external scholars to the campus. Applications are open for the upcoming academic year, focusing on fostering collaborative research initiatives among faculty.

The U.S. Department of Energy (DOE) plans to issue a Notice of Funding Opportunity (NOFO) titled "Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)." This initiative aims to support financial assistance applications from entities focusing on innovative chemical technologies that enhance supply chain resiliency and reduce costs. The program seeks to advance the production of chemicals from alternative and waste feedstocks, fostering domestic manufacturing and improving environmental safety.

The BJA FY 2025/2026 Project Safe Neighborhoods Formula Grant Program aims to enhance community safety by funding comprehensive violent crime reduction strategies across the U.S. This initiative, coordinated by U.S. Attorney’s Offices, unites law enforcement, prosecutors, and community partners to tackle issues like drug trafficking and human trafficking. Applications are due by August 27, 2026, emphasizing the DOJ's commitment to empowering communities against ongoing threats and fulfilling its core policy goals.

The Basil L. King Scholarship Foundation offers two-year scholarships to St. Lucie County residents pursuing careers in health sciences. Established in 1978, the Foundation supports students with financial needs and encourages local talent to return to the Treasure Coast after graduation. To qualify, applicants must maintain a GPA of 3.0 or higher and be accepted into a Health Science program. Awards are determined annually, ensuring support for future healthcare professionals.

The FY26 Community Policing Development (CPD) Accreditation Program aims to enhance law enforcement accreditation by supporting state, local, territorial, and Tribal agencies. Managed by the COPS Office, this initiative provides funding for technical assistance, accreditation cost support, and development of user-friendly policy templates. Applications must be submitted via JustGrants by September 3, 2026. This funding opportunity promotes community policing as a vital strategy for public safety.

The Cellular Senescence Network (SenNet) aims to establish a Data Coordination and Integration Center (DCIC) to enhance data management and accessibility within the NIH Common Fund. This initiative focuses on the submission, harmonization, and dissemination of SenNet-generated data, ensuring high-quality integration and usability. The DCIC will support both Stage 1 and Stage 2 outputs, fostering organizational outreach activities and promoting cross-study comparability through robust data infrastructure and tools.

Digital Promise

Digital Promise is a global nonprofit working to expand opportunity for every learner. Working with a wide range of partners and practitioners in the U.S. and around the world, our initiatives have impacted over 4.4 million students and 180,000 teachers across 173 districts and in 27 countries to date.

Digital Promise was authorized by Congress in 2008, signed into law by President George W. Bush, and formally launched by President Barack Obama in September 2011. Startup support came from the U.S. Department of Education, Carnegie Corporation of New York, William and Flora Hewlett Foundation, and Bill & Melinda Gates Foundation. Since then, Digital Promise has grown rapidly with support from both original and new funders.

AIMS EduData Initiative

The Advancing Innovative Math Solutions (AIMS) EduData Initiative, funded by the Gates Foundation, seeks to build sustainable and scalable research infrastructure to advance math learning. AIMS EduData especially encourages applications from graduate students and early career professionals, educators with research roles, such as those working in district research offices, and researchers located at minority serving institutions or Title I school districts. Successful applicants will conduct original research using datasets provided by leading digital learning platforms (DLPs) and participate in a growing community.

RightOn Education and Teachley Math RFP

For education researchers and practitioners

Benefits for successful applicants:

• Opportunity to investigate associations between features of a Digital Learning Platform and mechanisms supporting student learning, engagement, motivation, and instructional practice.
• Opportunity to contribute to the education R&D movement by expanding its capacity and skills, providing feedback to DLPs about the utility of their datasets and insights about their features, and demonstrating the affordances and value of conducting research through DLPs.
• Involvement in a dynamic, supportive community of digital learning providers and researchers
• Two proposals will be funded

This solicitation offers opportunities to run experiments in two DLPs. One enables research with Teachley Math, an intervention that includes interactive digital games and problem-solving modeling tools, lessons and formative assessment data for students in grades K-5. The second enables research with RightOn Education, an online digital learning platform for grades 7-10 that allows teachers to create or select math games, engage students in feedback and reflection on their thinking, and access real-time information about student misconceptions. 

Teachley Math

Teachley Math is particularly interested in research investigating:

• Through what mechanisms does feedback shape outcomes?
• What sequences of tool actions best predict eventual correctness?
• What are common error patterns and do they vary by grade level?
• Do process measures add predictive validity beyond final-answer accuracy?

Digital Promise

Digital Promise is a global nonprofit working to expand opportunity for every learner. Working with a wide range of partners and practitioners in the U.S. and around the world, our initiatives have impacted over 4.4 million students and 180,000 teachers across 173 districts and in 27 countries to date.

Digital Promise was authorized by Congress in 2008, signed into law by President George W. Bush, and formally launched by President Barack Obama in September 2011. Startup support came from the U.S. Department of Education, Carnegie Corporation of New York, William and Flora Hewlett Foundation, and Bill & Melinda Gates Foundation. Since then, Digital Promise has grown rapidly with support from both original and new funders.

AIMS EduData Initiative

The Advancing Innovative Math Solutions (AIMS) EduData Initiative, funded by the Gates Foundation, seeks to build sustainable and scalable research infrastructure to advance math learning. AIMS EduData especially encourages applications from graduate students and early career professionals, educators with research roles, such as those working in district research offices, and researchers located at minority serving institutions or Title I school districts. Successful applicants will conduct original research using datasets provided by leading digital learning platforms (DLPs) and participate in a growing community.

RightOn Education and Teachley Math RFP

For education researchers and practitioners

Benefits for successful applicants:

• Opportunity to investigate associations between features of a Digital Learning Platform and mechanisms supporting student learning, engagement, motivation, and instructional practice.
• Opportunity to contribute to the education R&D movement by expanding its capacity and skills, providing feedback to DLPs about the utility of their datasets and insights about their features, and demonstrating the affordances and value of conducting research through DLPs.
• Involvement in a dynamic, supportive community of digital learning providers and researchers
• Two proposals will be funded

This solicitation offers opportunities to run experiments in two DLPs. One enables research with Teachley Math, an intervention that includes interactive digital games and problem-solving modeling tools, lessons and formative assessment data for students in grades K-5. The second enables research with RightOn Education, an online digital learning platform for grades 7-10 that allows teachers to create or select math games, engage students in feedback and reflection on their thinking, and access real-time information about student misconceptions. 

RightOn Education

RightOn Education is particularly interested in research investigating questions related to the following areas (illustrative research questions are provided below):

• Student confidence and math self-efficacy: How do patterns of student confidence differ across correct and incorrect responses, and how do they vary by question or Common Core standard?
• Productive struggle, metacognition, and learning from misconceptions: How do different types of reflection prompts (e.g., self-directed vs. peer-directed explanations) affect the likelihood of optional hint submission and the length of student-generated hints?
• Student motivation and engagement: How do different incentive conditions influence student participation in optional activities, and how are they associated with student correctness and confidence?

The Honoring the Best in the Construction Community initiative celebrates outstanding individuals in the construction field, such as Craft Instructor of the Year, who exemplify creativity and dedication to education. Award recipients gain national recognition and a $10,000 cash prize, promoting construction as a rewarding career while emphasizing safety and lifelong learning. This prestigious award is part of the ABC Construction Workforce Awards, which highlights the importance of quality instruction in the industry.

The ASNT Foundation offers the Engineering Undergraduate Scholarship, a $3,000 cash award aimed at encouraging undergraduate students in U.S. universities to specialize in nondestructive testing (NDT/NDE). This initiative supports students committed to advancing their education in engineering programs and demonstrates a strong interest in the NDT field. The foundation aims to enhance workforce development through scholarships and educational grants, thereby fostering a skilled workforce in nondestructive testing.

The Dynamics, Control and Systems Diagnostics (DCSD) program focuses on advancing dynamic systems engineering to tackle critical societal challenges. It encourages innovative research proposals that enhance understanding and applications in areas such as climate change, infrastructure resilience, and healthcare. The program emphasizes both scientific merit and broader societal impacts, promoting inclusivity and evidence-based approaches. Proposals should align with NSF's Merit Review Principles and seek adequate funding to successfully achieve project goals.

The National Institutes of Health (NIH) is set to announce a Notice of Funding Opportunity (NOFO) for multi-site investigator-initiated clinical trials. This initiative aims to support a range of clinical trials addressing efficacy and implementation research. The funding mechanism includes a two-phase approach (UG3/UH3), with a total award duration of up to seven years. Investigators are encouraged to prepare proposals that demonstrate scientific rationale and operational plans for these important studies.

The ACLS Leading Edge Fellowships provide recent humanities PhDs with the opportunity to work with nonprofit organizations focused on social justice. Over 24 months, fellows receive a stipend of $70,000 in the first year and $72,000 in the second, along with relocation funds and health insurance. The program emphasizes diversity and inclusion, encouraging applications from all eligible scholars to enhance their professional skills in meaningful roles.

The Basil L. King Scholarship Foundation offers four-year scholarships to St. Lucie County residents pursuing careers in Health Sciences. Applicants must maintain a GPA of 3.00 or higher, although those with a GPA of 2.5 may be considered under special circumstances. The scholarship is renewable for up to three years with continued eligibility. Preference is given to students who intend to return to the Treasure Coast after graduation, ensuring support for local talent.

The DOE Computational Science Graduate Fellowship (CSGF) supports U.S. citizens and permanent residents pursuing Ph.D. degrees in high-performance computing fields. Established in 1991, this fellowship offers financial aid, professional development, and practical research experiences. It aims to cultivate a diverse community of scientists who contribute to national workforce needs and encourages students to engage in impactful research at DOE laboratories and institutions. Eligible candidates can focus on computational sciences, applied mathematics, and related disciplines.

Unlikely Collaborators Inc

We exist to help people RESOLVE CONFLICT. What kind of conflict are we talking about? The inside kind.

It's our perspective that most of the EXTERNAL conflict in the world is the result of unconscious, unresolved INTERNAL conflict in each and every one of us.

Unlikely Collaborators is an organization that exists to help people resolve conflict by making them aware of and helping them work with their Perception Box.

RFP To Fund Transformative Projects Rooted in the Perception Box™ Framework

This RFP is designed for organizations creating meaningful shifts in how people interpret their experiences, beliefs, and perspectives.

All requests must be project-specific and aligned with the Perception Box framework.

At Unlikely Collaborators, we support people and organizations who are helping others see something about themselves they couldn’t see before. Our work is grounded in the Perception Box, a framework developed by our founder, Elizabeth R. Koch.

The Perception Box is the internal lens through which each of us experiences the world. It is shaped by our beliefs, our past experiences, our identity, and the stories we carry, often without realizing it.

Most of the time, we don’t see this lens. We experience our perspective as reality. But when people begin to notice it, something shifts. There is often more curiosity, less certainty, and more openness to others and new possibilities.

We are not a fit for projects focused primarily on advocacy, external blame, or telling people what to think. We support work that helps people examine how they think.

What this looks like in practice

We are most interested in projects where participants are actively engaged in noticing and questioning their own assumptions. This might include:

• Structured experiences where people reflect on their beliefs and how those beliefs were formed
• Encounters with perspectives that challenge their existing worldview
• Moments of realization where someone recognizes their interpretation may not be the only one
• Practices that build curiosity, self-awareness, and the ability to stay open in the face of difference

Before you get started on your RFP grant application, here’s what to expect:

• At Unlikely Collaborators, we support people and organizations that create meaningful shifts in how individuals see themselves.
• We are not looking for surface-level awareness. We are looking for work that leads to a real moment of recognition, when someone begins to question their own assumptions, reconsider their perspective, or see others differently.
• We prioritize leaders working from lived experience, not distance—people who understand the challenge from the inside and are translating that insight into something others can directly experience.
• The strongest projects are designed to create these moments of reflection in a tangible way. They bring people together in environments that are thoughtful, human, and often unexpected, where insight is felt, not just discussed.

The Emil Buehler Perpetual Trust Grant supports U.S. public charities dedicated to advancing aviation science and technology through research and development of improved aircraft. Established in 1984 by Emil Buehler, a visionary in aeronautical science, the trust perpetuates his passion for flight. Proposals should align with the foundation's mission to enhance the aviation field. Deadlines for submissions are June 1 for September meetings and December 1 for April meetings.

The Center of Excellence for Alternative Jet Fuels and Environment, co-led by Washington State University and MIT, focuses on advancing aviation technology through research. Supported by the FAA, NASA, and other federal entities, ASCENT collaborates with 16 top U.S. universities and over 60 stakeholders to enhance the safety and sustainability of aviation. This initiative aims to foster innovative solutions in alternative jet fuels while addressing environmental impacts in the aviation sector.

The Next Generation of the Clinical and Translational Science Awards Program Trial Innovation Network aims to tackle significant challenges in multi-center clinical trials. By enhancing trial efficiency and safety through innovative solutions, the initiative seeks to improve the design and execution of these studies. Key areas of focus include safety monitoring tools, trial leader mentorship, and advancements in digital health technologies. This program invites eligible organizations to apply for funding to promote groundbreaking clinical research.

The NIH Instrumentation Grant Program for Resource-Limited Institutions supports the acquisition of advanced scientific instruments. This initiative aims to bolster biomedical research capabilities and educational opportunities at institutions that typically receive limited NIH Research Project Grant funding. By facilitating access to modern technology, the program enhances research quality and fosters innovation in healthcare and related fields.

The Just Tech Fellowship, supported by the Social Science Research Council, aims to empower diverse researchers and practitioners to address injustices arising from new technologies. With a two-year award of $100,000 annually, this fellowship fosters collaboration and community engagement, promoting equitable tech futures. It focuses on the intersection of technology and social justice, encouraging insights from historically marginalized groups to inform structural change and create a more just society.

The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.