Best Large Grants for Nonprofit Organizations in New York

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The Russell Sage Foundation's Visiting Scholars Program offers a prestigious opportunity for scholars in social sciences to conduct research and writing at their New York City headquarters. Annually, 15 to 17 fellowships are awarded to applicants at least two years post-Ph.D. Scholars engage in diverse projects related to vital social issues while benefiting from office space, resources, and financial support for their salary. This program emphasizes intellectual engagement and collaboration among scholars across disciplines.

Every Kindness is a Gift

Dollar Tree Gift Card Program 2026

Every Kindness is a Gift is a gift card grant program made possible through the generosity of Dollar Tree and managed by the team here at Gift Card Bank. We are a nonprofit organization that specializes in the distribution of gift cards and our mission is to improve well-being and build financial stability by supporting people through their time of need.

Through Every Kindness is a Gift, nonprofit organizations and Title I schools located in the 48 contiguous states may apply to receive a grant of Dollar Tree gift cards.

Gift cards received through these grants are meant to be distributed directly to individuals and families in need. A primary goal of the program is to give gift card recipients the dignity of choice by empowering them to shop for what they need themselves. By putting gift cards directly in the hands of our neighbors in need, we are able to increase access to essentials like food, school supplies, paper products, cleaning products, and hygiene items.

In 2026, there will be two rounds of grant distributions. In each round, we will award a number of grants between $2,500 and $10,000.

Round One is a summer distribution. Gift cards awarded in Round One will arrive in late June, while kids are on break and back-to-school is around the corner. Round Two is a holiday distribution. Gift cards awarded in Round Two will arrive in early November, as the end-of-year holidays approach.

We know that these are times of year when budgets are tight. Through these gift card grants, we hope to connect individuals and families directly to the essential resources they need during difficult months.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

The Goldman Sachs Community Development Grants Program aims to strengthen low- and moderate-income communities through funding for nonprofits. This initiative includes multi-year unrestricted grants and one-time grants for homeownership initiatives. Eligible organizations must focus on community development, particularly in New York City and parts of New Jersey and Utah. The program emphasizes affordable housing, small business development, and neighborhood revitalization, aligning with the urgent community needs identified through extensive partner consultations.

The Brower Youth Awards for Environmental Leadership honors young leaders aged 13 to 22 in North America who excel in environmental initiatives. Awardees receive a $3,000 cash prize, training, and networking opportunities to enhance their impact. This prestigious program fosters youth leadership and amplifies diverse voices within the environmental movement, encouraging innovative solutions to pressing ecological challenges. Over the past 25 years, the awards have celebrated over 100 emerging leaders dedicated to making a difference in their communities.

The Johnson Controls Foundation Grants support nonprofit organizations dedicated to creating smarter, healthier, and more sustainable communities. Since 1952, the Foundation has contributed over $77 million to U.S. charities, emphasizing initiatives in education, health, and environmental protection. Eligible organizations should align with the Foundation’s priorities and demonstrate community impact, particularly in areas with a strong Johnson Controls presence. Each year, approximately $7 million is distributed to support these vital programs.

The John Goddard Prize offers microgrants to empower youth-led environmental initiatives across the nation. This competitive cash prize supports ambitious young leaders seeking funding for innovative projects that promote environmental sustainability. Applications are welcomed from young people dedicated to making a positive impact on the planet. By fostering creativity and action, the prize aims to inspire the next generation of environmental stewards.

The AWWA Scholarship Program offers the GFT Forces of Change Scholarship, providing $5,000 to undergraduate or graduate engineering students passionate about advancing the water industry. This scholarship underscores AWWA's commitment to nurturing future professionals who will tackle critical infrastructure challenges. By investing in education, AWWA aims to empower the next generation to innovate and lead in water supply solutions. This initiative highlights the importance of skilled engineers in shaping a sustainable future.

About Us

The Youth Climate Justice Fund aims to support climate justice young leaders with trust-based funding, resources, and capacity strengthening, enabling them to amplify their voices and to keep their vision and influence alive.

Collectively, we have the power to ignite meaningful change and build equitable and sustainable futures. Despite the challenges posed by the current crisis, youth climate justice organizers remain determined to address current issues and explore new approaches.

Mission & Purpose

We work to strengthen existing organizing efforts and support emerging youth-led initiatives with a focus on bridging funders and organizers to enable flexible and impactful support. Through capacity strengthening and resource sharing, we empower and support young people to drive change and build a just and sustainable future.

How To Apply

The Youth Climate Justice Fund provides funding to emerging youth-led climate justice and socio-environmental groups through a participatory decision-making process.

The NYSCA Arts Bring Change (ABC) Grants support local cultural organizations and artists who collaborate with public schools to provide K-12 students with engaging artistic experiences. Funded by the New York State Council on the Arts, this program emphasizes art exploration and requires projects to include hands-on learning sessions. Applicants must demonstrate a partnership with schools and meet specific eligibility criteria, ensuring impactful and meaningful artistic education for students.

The Morris Animal Foundation invites research pre-proposals for the Wildlife Health (Reptile and Amphibian) - First Award, aimed at enhancing the health and welfare of amphibians and reptiles. This initiative focuses on impactful research, particularly in chytrid disease. Eligible applicants include early career researchers with appropriate qualifications and a clear understanding of animal health challenges. Projects should demonstrate collaboration with relevant stakeholders and provide direct benefits to wildlife populations, emphasizing conservation through an animal health perspective.

The Morris Animal Foundation is offering Pilot Study Awards focused on reptile and amphibian health and welfare, particularly for chytrid research. These awards aim to fund innovative, proof-of-concept studies that demonstrate a clear understanding of animal health issues and collaboration with stakeholders. Proposals must have a direct impact on wildlife populations and adhere to strict health study policies. The maximum funding is $20,000 for a duration of 12 months, ensuring significant contributions to wildlife health advancements.

The H. Hovnanian Family Foundation Grant supports the Armenian community in Armenia and the U.S., focusing on Monmouth and Ocean Counties, New Jersey. The Foundation prioritizes education, healthcare, arts, and youth development through grants to registered non-profits. Proposals should demonstrate sustainability and community impact, with favorable consideration given to projects that engage local stakeholders and foster collaboration. Applications are accepted year-round, with a maximum funding limit of $10,000 for operational expenses.

AmeriCorps Seniors RSVP Opportunity

About RSVP

Established in 1971 and now one of the largest senior volunteer programs in the nation, AmeriCorps Seniors RSVP engages people ages 55 and older in a diverse range of volunteer activities. AmeriCorps Seniors RSVP volunteers tutor children, help prepare simple taxes, assist victims of natural disasters, provide nutrition/food support, facilitate opioid and substance abuse education workshops, and serve in their communities in many other ways. AmeriCorps Seniors RSVP volunteers choose how, where, and how often they want to serve, with commitments ranging from a few hours to a maximum of 40 hours per week. While serving, AmeriCorps Seniors RSVP volunteers improve their own lives by staying active and civically engaged. 

Funding Priorities

AmeriCorps Seniors RSVP programming is designed to meet community needs. Applicants may propose activities intended to address community needs by thoroughly explaining the unmet need and activities to be completed by volunteers to address that need. In addition, AmeriCorps is interested in programming that addresses agency priorities. AmeriCorps Seniors RSVP priorities for this funding opportunity are:

• Supporting Older Adults and Caregivers: Provide respite, support groups, system navigation, care coordination, and resources for older adults, including custodial grandparents, and caregivers.
• Helping Older Adults Re-enter the Workforce: Offer job readiness, mentoring, training, and remove barriers to employment for older adults (volunteers provide services, not seek jobs).
• Building Strong Families: Support parents in helping children succeed, mentor parents, connect families to resources, and strengthen community partnerships.
• Preventing and Mitigating Fraud and Scams: Use digital navigators and other strategies to protect older adults from financial fraud and exploitation, including emerging AI-driven scams.
• Reducing Homelessness: Develop or renovate affordable housing, assist people experiencing homelessness in finding and maintaining permanent housing, and address housing needs for vulnerable populations.
• Supporting Behavioral Health Initiatives: Improve mental health, reduce isolation, prevent substance use, provide harm reduction tools (Naloxone, fentanyl test strips), peer support, and recovery services.

Award Funding Requirements

Applicants must construct the budget in the following manner. The federal share of the budget must not exceed $75,000 plus up to $350 for every unduplicated volunteer, whether or not they serve in an outcome-based work plan. 

The Ella B. Cleveland Trust Grant supports charitable medical research organizations focusing on leukemia, muscular dystrophy, and cerebral palsy. Established in memory of Ella B. Cleveland, the trust prioritizes 501(c)(3) entities and has no geographic limitations, though it often funds organizations in Georgia. Applications are accepted year-round, with an average grant size of $5,000, and total annual giving ranging from $10,000 to $15,000.

Morris Animal Foundation invites Established Investigators to submit pre-proposals for research focused on reptile and amphibian health. This initiative emphasizes the importance of animal health and welfare while facilitating impactful conservation efforts. Proposals must demonstrate clear animal health needs, collaborative strategies, and potential benefits to wildlife populations. Funding for these projects is anticipated to average around $100,000 over a maximum duration of 36 months, fostering innovative solutions for pressing health challenges in these species.

The Down Syndrome – Aim High Scholarship, offered by The Community Foundation for the Greater Capital Region, empowers students pursuing careers in special education or therapy for individuals with Down Syndrome. This scholarship supports dedicated individuals committed to improving the lives of others through education and professional development. Since 1968, the foundation has focused on enhancing community well-being, making this scholarship a vital resource for aspiring professionals in the field.

The Elizabeth Furber Scholarship honors the legacy of Elizabeth Furber by providing financial assistance to American Indian and Alaska Native female graduate students. This scholarship supports students pursuing full-time degrees in various fields, including fine arts, music, and creative writing. As a need-based award, it requires applicants to demonstrate Tribal affiliation through a Tribal Eligibility Certificate. This opportunity empowers eligible students to achieve their academic goals.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

The Sustainable Forests and Communities Grant aims to foster environmentally and economically sustainable forest communities in the U.S., particularly where the Weyerhaeuser Family has interests. It prioritizes projects enhancing the environment, economy, and community through sustainable practices. Eligible organizations must be 501(c)(3) tax-exempt entities operating in forested areas, focusing on integrated approaches that value forest ecosystem services. This initiative encourages local job creation, sustainable economic activities, and innovative partnerships to achieve sustainability goals.

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting the Centers for Structural Biology of HIV and other Infectious Diseases. This solicitation will support multidisciplinary groups of scientists to determine the 3-dimensional structures of molecules and molecular complexes involved in priority infectious diseases. The effort focuses on exploring biomolecular complexes that can be targeted to make new medicines and tests to prevent or treat infections and improve human health. The centers will drive cutting-edge research and development of structural biology technologies, including high-resolution 3D structural analyses, computational molecular dynamics, functional and mechanistic characterization at the molecular and cellular level, visualization at the atomic level of molecular complexes in cells and tissues, and advanced structure-guided design of molecules to combat infectious diseases. The centers will maximize use of common resources, establish broad collaborations, and mentor future structural biology researchers. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

The Quality of Life Grants Program, managed by the Christopher & Dana Reeve Foundation, provides funding of up to $25,000 for projects that support individuals living with paralysis. This program emphasizes community engagement and health promotion in all U.S. states and territories. It focuses on funding initiatives that directly impact those affected by various conditions, such as spinal cord injuries and multiple sclerosis, fostering inclusion and well-being.

The FY26 Tick-Borne Disease Research Program (TBDRP) Idea Development Award aims to fund innovative research that enhances understanding and treatment of Lyme disease and other tick-borne diseases. The program encourages creative approaches that challenge existing paradigms and fosters impactful discoveries. A special career development option is available for early-career investigators, offering mentorship and a tailored review process to support significant research advancements.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

Nassau County has launched the Septic Environmental Program to Improve Cleanliness (SEPTIC) Grant, aimed at replacing outdated septic systems with innovative nitrogen-reducing technologies. Grants of up to $20,000 are available for eligible homeowners and small businesses, addressing nitrogen pollution—an urgent concern for Long Island's water quality. This initiative supports public health and environmental sustainability, significantly reducing nitrogen discharge while ensuring effective wastewater treatment.

The Hope APFED/AAAAI Grant Award aims to support innovative research projects related to Eosinophilic Disorders, excluding asthma, rhinitis, and eczema. This initiative encourages collaboration between the American Academy of Allergy, Asthma & Immunology and the American Partnership for Eosinophilic Disorders, providing a platform for independent researchers to secure future funding. Applicants must be AAAAI members and hold relevant academic positions, ensuring a commitment to advancing knowledge in allergy and immunology.