Best Large Grants for Nonprofit Organizations in New York

What We Do

At the North Carolina Community Foundation, we bring together generous people and connect them to causes and organizations they care about.

Our mission is to inspire North Carolinians to make lasting and meaningful contributions to their communities.

Our Philanthropic Network

We believe in the power of permanent philanthropy to strengthen our communities and people. By stewarding and growing donors’ gifts, our philanthropic network makes a powerful impact through robust grants and scholarships programs.

Geraldine Mayo Beveridge Scholarship Endowment

About Geraldine Mayo Beveridge

Geraldine “Gerry” Mayo Beveridge taught school in Carteret County for 40 years. She was a Home Economics teacher and thought of her students as her children; she and husband “Captain David” had none of their own. Gerry would discreetly provide classroom supplies and clothing items for students in need. She quietly contributed money toward college for capable students who couldn’t afford it.

Gerry’s concern for students continued after retirement. As a member of the Carteret County Retired School Personnel (CCRSP), Gerry convinced members of the importance of awarding a scholarship to a graduating senior in each high school – East Carteret, West Carteret, and later, Croatan. To raise money, she organized bake sales and brought plants and canned foods to sell to members. The scholarships, though small, were a great effort for members and were greatly appreciated by recipients.

Gerry left a considerable sum of money to CCRSP with the expectation that it be managed well and used for scholarships. Today, the Geraldine Mayo Beveridge Scholarship is awarded to qualifying graduating seniors who want to teach Vocational Education, now called Career and Technical Education.

Gerry’s passion for her students and her love of education continues through this scholarship. She was an amazing educator whose philanthropy will last in perpetuity.

The Elizabeth M. Pfriem Foundation, established in 2015 in Rye Brook, New York, is committed to enhancing the human condition through grants to 501(c)(3) public charities. Focusing primarily on the greater Bridgeport, Connecticut area, it supports initiatives in education, healthcare, food security, and housing. The foundation prioritizes organizations demonstrating fiscal responsibility and innovative programs with significant impact potential, ensuring sustainable support for vulnerable populations, especially children and families in need.

The Special Emphasis Limited Project Grant from the American Society of Colon and Rectal Surgeons aims to address health disparities in colorectal surgery. It focuses on improving care for racial/ethnic minorities, women, LGBTQ+ populations, and individuals with disabilities. Proposals should concentrate on patient-oriented interventions and may explore quality improvement, access to services, and enhancing workforce diversity. Funding of up to $20,000 is available for innovative projects that promote equity in colorectal healthcare.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5412 - Determinants of Workforce Retention in Public-Sector Water Utilities

Grant Information

• Quantify the relative influence of compensation, pension stability, mission alignment, schedule flexibility, leadership support, career development opportunities, and other factors on employee retention in public-sector water utilities.
• Identify and analyze key impediments to retaining talent, including structural, cultural, compensation-related, and organizational barriers.
• Identify and benchmark retention best practices from sectors outside the water industry to assess transferability and develop case studies of high-retention organizations to distill replicable strategies and measurable success factors.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The Comcast NBCUniversal Foundation offers Local Impact Grants to nonprofit organizations in 11 markets, providing $225,000 to support local programs addressing community issues. Eligible organizations must be 501(c)(3) nonprofits with a revenue exceeding $100,000 and must operate in one of the specified television markets. The grants aim to empower youth through education, promote diverse storytelling, and enhance community engagement. This initiative underscores Comcast's commitment to fostering inclusion and equitable opportunities for underserved communities.

The Michael R. Priddy Music Scholarship, offered by the Central Kentucky Community Foundation, aims to support graduating high school seniors from Hardin County Schools, specifically Elizabethtown and LaRue County High Schools. This scholarship is intended for students who have demonstrated involvement in classical orchestra or music performance, or who plan to pursue music studies, thereby fostering musical education in the community.

Overview

The Tower Foundation is a family foundation that helps children, adolescents, and young people affected by intellectual disabilities, learning disabilities, mental health issues, and/or substance use disorders. Our goal is to improve the lives of young people in our geographic footprint of Erie and Niagara Counties in Western New York, and Barnstable, Dukes, Essex, and Nantucket Counties in Eastern Massachusetts.

The Tower Foundation believes every young person should have the chance to achieve their personal goals, regardless of the challenges they face. Individuals who live with one or more of these issues may be overlooked or stigmatized, creating additional challenges. We also know that some young people face more challenges than others because of systemic inequalities. The convergence of our focus areas with racism, ableism, sexism, and other types of discrimination warrants the Foundation’s attention because as we know, people do not live single-issue lives.

The Tower Foundation sees its role as more than just a funder. These issues are near and dear to us because we have members of our family who live with one or more of the issues. These are individuals who are resilient—persevering despite the challenges they face— and who should be valued by our communities. The Tower Foundation envisions a future in which equitable communities include, accept and value these young people.

Strengthening Partner Capacity Grants

The Foundation seeks to fund requests that, “build and/or strengthen the systems, structures, cultures, skills, resources, and power that organizations need to serve their communities.” Strengthening Partner Capacity grants are available for board/leadership development; diversity, equity, inclusion; evaluation/evaluation design; organizational development; professional development; program design and planning (not service delivery); small capital projects/equipment purchases; staff mental wellness support; technology planning/purchasing; and other ideas that help organizations better serve their communities as described above. 

Native Forward awards are allocated based on the financial aid information provided by the institution’s Financial Aid Office. Awards can vary, ranging from $100 to $30,000 per academic year.

Native Forward Scholars Fund members of federally and state-recognized Tribes as well as first and second-generation descendants. However, Native Forward Scholars Fund scholarship opportunities have different Tribal eligibility requirements and can be determined by submitting a Tribal Eligibility Certificate.

Hillman Barnett Adkins Endowed Fund Scholarship

The Hillman Barnett Adkins Endowed Fund is provided in honor of members of the Hillman, Barnett, and Adkins families. The purpose of the Hillman Barnett Adkins Endowed Fund is to provide financial assistance to eligible American Indian and Alaska Native vocational, undergraduate, and graduate students enrolled at an accredited not-for-profit college/university, vocational school, or Tribally controlled college or university (TCU) and pursuing degrees with a focus in Fine Arts (studio arts), Performing Arts (music, drama, musical theater, dance), Creative Writing, Art History, Visual Communication, Photography, Culinary Arts, Film (Cinematography, Screenwriting), or Fashion Design & Jewelry Design.

This opportunity is a merit-based award.

The Rheum for Kids: Pediatric Skin and Joint Grant, offered by the Arthritis National Research Foundation, is aimed at early-career researchers focused on pediatric joint and skin diseases. This grant provides funding of up to $50,000 for one year to support innovative research projects. It encourages applications from diverse fields to advance the understanding and treatment of rheumatic diseases in children, fostering new insights and potential breakthroughs in pediatric healthcare.

The Helpful Harvest Grant, offered by the Community Foundation of Herkimer and Oneida Counties, aims to combat food insecurity in the region, especially during the winter and holiday seasons. This grant prioritizes food pantries, soup kitchens, and shelters, providing funding for food products, care packages, and necessary equipment like refrigeration. By supporting these crucial organizations, the grant helps ensure that local residents have access to essential food resources, fostering community resilience and collaboration.

The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.

The Spencer T. and Ann W. Olin Foundation Wetlands and Waterfowl Research Fellowship supports graduate students in North America conducting research on waterfowl or wetland biology. The fellowship, offering up to $9,500 annually, emphasizes applicant qualifications, research proposal soundness, originality, and potential contributions to conservation efforts. This competitive opportunity is renewable for up to two additional years for PhD students and once for Masters students, pending satisfactory progress reports.

The AWWA Scholarship Program, administered by the American Water Works Association, offers a $5,000 scholarship to graduate-level students pursuing careers in the water industry. Recognizing the vital role of future professionals, AWWA aims to support education in water supply and wastewater management through this scholarship initiative. Founded in 1886, American Water is the largest U.S. investor-owned water utility, emphasizing the importance of investing in education for sustainable water solutions.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

HIV, AIDS, and prevention

Help with healthcare costs for HIV, AIDS, and prevention

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

HIV, also known as human immunodeficiency virus or acquired immunodeficiency syndrome, is a virus that attacks the immune system. When left untreated, it can develop into AIDS. HIV is a chronic disease that affects the immune system.

The Keith Haring Foundation offers grants primarily to support non-profit organizations that provide educational opportunities for underprivileged youth and those affected by HIV/AIDS. Established by the artist Keith Haring in 1989, the foundation focuses on initiatives that foster self-sufficiency among vulnerable populations in New York City and the Southeastern US. It invites applications from organizations dedicated to promoting Haring's legacy through arts and culture, ensuring impactful, evidence-based programming.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Young Investigator

$100,000 over 3 years

• PI must hold an academic appointment at the instructor level or higher
• PI must be within 5 years of completing a training fellowship in Pediatric Hematology/Oncology or a closely related discipline that has direct clinical contact with pediatric cancer patients
• Research must be within 2-3 years to translation to a clinical trial or already associated with a clinical trial

• Evidence of Mentor's commitment to the PI's career development plan
• Translational potential

The SCALE initiative aims to combat injury, violence, overdose, and suicide, the leading causes of morbidity and mortality among individuals aged 0-44. By enhancing implementation and outreach, this funding opportunity seeks to empower organizations to implement effective prevention strategies, especially in underserved communities, including tribal areas. The program encourages collaboration and continuous improvement to achieve sustainable reductions in these critical public health issues.

The Kars4Kids Small Grant Program aims to support educational initiatives globally, impacting the lives of children. This program welcomes applications from IRS-recognized nonprofit organizations focused on youth development, mentorship, and education. Grants typically range from $500 to $2,000, depending on mission alignment and available funds. Kars4Kids, a national Jewish nonprofit, is dedicated to nurturing productive community members through educational and mentoring opportunities.

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Skilled Trades Scholarship

The Greater Milan Area Community Fund is proud to support students pursuing skilled trades and hands-on career pathways that build practical skills, open doors to stable employment, and strengthen our local community.

Scholarship awards are typically paid directly to the accredited trade program or educational institution and are generally non-taxable.

Applications are evaluated two times each year for awarding in the six months after application and selection.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) supports innovative, hypothesis-driven clinical studies with a focus on diseases relevant to NIDDK. This initiative facilitates early peer review and assessment of study designs while providing essential support for operational documents. Applicants are encouraged to consult with NIDDK staff before submission to enhance the chances of success.

The Basil O'Connor Starter Scholar Research Awards, offered by March of Dimes, support emerging researchers in maternal and child health. With a $150,000 grant over two years, the program prioritizes projects addressing preterm birth and health equity. Eligible applicants must be within four to nine years of completing their clinical training or terminal degree, holding a tenure-track position. This initiative aims to foster impactful research that enhances clinical treatments for serious maternal and newborn health conditions.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

The Comis Foundation Grant aims to provide equitable opportunities for children to thrive through education and community engagement. It supports innovative programs that enhance educational outcomes, focusing on areas such as capacity building and pilot projects. With funding ranging from $5,000 to $75,000, the foundation prioritizes nonprofit organizations that foster inclusive environments. By emphasizing trust and collaboration, Comis Foundation strives to create lasting impacts in the communities it serves.

The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.

The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.