Best Large Grants for Nonprofit Organizations in New York

The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) aims to support clinical trials that evaluate interventions for communication disorders. This funding opportunity encourages collaboration between NIDCD Project Scientists and investigators, focusing on trials that require FDA oversight, establish efficacy, or pose risks of harm. By fostering well-designed studies, the NIDCD seeks to advance treatment and prevention strategies in the field of communication disorders.

The William T. Grant Scholars Program provides crucial support for early-career researchers aiming to expand their expertise through innovative research and mentoring. This five-year program focuses on reducing inequality and improving the use of research evidence to benefit young people in the U.S. By emphasizing the development of new disciplines and methods, the program encourages applicants to take bold risks in their research trajectories, ultimately fostering a supportive academic community.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

The IAF Research Fellowship Program, administered by the Social Science Research Council, aims to support rigorous research on community-led development in Latin America and the Caribbean. The fellowship provides a $20,000 stipend for twelve months, fostering innovative solutions to pressing issues such as economic opportunity, migration, and social inclusion. Researchers are encouraged to explore how community-led models can create lasting impacts and respond to global trends, enhancing local resilience and development.

The PSEG Foundation provides funding for events and initiatives that enhance community safety and environmental stewardship in areas where they operate, such as New Jersey and New York. Organizations must be 501(c)(3) nonprofits that align with the foundation's focus areas, including sustainable neighborhoods and safety preparedness. The application process is rolling, with a response time of 8 to 12 weeks. Proposals must be submitted online between January 1 and October 31, at least eight weeks before the event.

James H Cummings Foundation

The James H. Cummings Foundation is a charitable, not-for-profit corporation organized in New York State in July, 1962 for the purpose of complying with certain provisions in the will of its founder and namesake. Admired for his unassuming manner, friendly demeanor, and quiet generosity, Cummings was dedicated to giving back to the communities he once called home.

The Foundation’s focus is on funding not-for-profits making strides in medical research, science and post-secondary education in Buffalo, Toronto, and Hendersonville, North Carolina. In addition, we focus on funding programming for vulnerable people of all ages—children to older adults—in Buffalo and Hendersonville.

James H Cummings Foundation Grants

Our Focus

The Foundation focuses on supporting 501 (c)(3) not-for-profit organizations whose missions and services align with our guidelines and mission:

• To advance medical research, science, and post-secondary medical education in Buffalo and Hendersonville, North Carolina.
• To provide services for vulnerable children and children with disabilities that will enhance high school graduation rates with a focus on the quality of out-of-school (before and after school and summer care) for school age children and early care and education programs and initiatives in Buffalo and Hendersonville, North Carolina.
• To assist older adults and vulnerable adults with services that help them maintain independent, healthy, and active lifestyles, remaining in their own homes when possible in Buffalo and Hendersonville, North Carolina.
• To advance medical research in Toronto.

James H Cummings Foundation

The James H. Cummings Foundation is a charitable, not-for-profit corporation organized in New York State in July, 1962 for the purpose of complying with certain provisions in the will of its founder and namesake. Admired for his unassuming manner, friendly demeanor, and quiet generosity, Cummings was dedicated to giving back to the communities he once called home.

The Foundation’s focus is on funding not-for-profits making strides in medical research, science and post-secondary education in Buffalo, Toronto, and Hendersonville, North Carolina. In addition, we focus on funding programming for vulnerable people of all ages—children to older adults—in Buffalo and Hendersonville.

James H Cummings Foundation Grants

Our Focus

The Foundation focuses on supporting 501 (c)(3) not-for-profit organizations whose missions and services align with our guidelines and mission:

• To advance medical research, science, and post-secondary medical education in Buffalo and Hendersonville, North Carolina.
• To provide services for vulnerable children and children with disabilities that will enhance high school graduation rates with a focus on the quality of out-of-school (before and after school and summer care) for school age children and early care and education programs and initiatives in Buffalo and Hendersonville, North Carolina.
• To assist older adults and vulnerable adults with services that help them maintain independent, healthy, and active lifestyles, remaining in their own homes when possible in Buffalo and Hendersonville, North Carolina.
• To advance medical research in Toronto.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

The Goldman Sachs Community Development Grants Program aims to strengthen low- and moderate-income communities through funding for nonprofits. This initiative includes multi-year unrestricted grants and one-time grants for homeownership initiatives. Eligible organizations must focus on community development, particularly in New York City and parts of New Jersey and Utah. The program emphasizes affordable housing, small business development, and neighborhood revitalization, aligning with the urgent community needs identified through extensive partner consultations.

Every Kindness is a Gift

Dollar Tree Gift Card Program 2026

Every Kindness is a Gift is a gift card grant program made possible through the generosity of Dollar Tree and managed by the team here at Gift Card Bank. We are a nonprofit organization that specializes in the distribution of gift cards and our mission is to improve well-being and build financial stability by supporting people through their time of need.

Through Every Kindness is a Gift, nonprofit organizations and Title I schools located in the 48 contiguous states may apply to receive a grant of Dollar Tree gift cards.

Gift cards received through these grants are meant to be distributed directly to individuals and families in need. A primary goal of the program is to give gift card recipients the dignity of choice by empowering them to shop for what they need themselves. By putting gift cards directly in the hands of our neighbors in need, we are able to increase access to essentials like food, school supplies, paper products, cleaning products, and hygiene items.

In 2026, there will be two rounds of grant distributions. In each round, we will award a number of grants between $2,500 and $10,000.

Round One is a summer distribution. Gift cards awarded in Round One will arrive in late June, while kids are on break and back-to-school is around the corner. Round Two is a holiday distribution. Gift cards awarded in Round Two will arrive in early November, as the end-of-year holidays approach.

We know that these are times of year when budgets are tight. Through these gift card grants, we hope to connect individuals and families directly to the essential resources they need during difficult months.

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The 2026 Vilcek Prizes for Creative Promise in Biomedical Science will award three $50,000 prizes to exceptional young immigrant scientists in the U.S. This prestigious prize recognizes innovative research contributions in biomedical science. Eligible candidates must be under 38 years old, hold a doctoral degree, and have made significant achievements in their field. The Vilcek Foundation aims to highlight the impact of immigrant scientists on the advancement of biomedical research, fostering diversity and excellence.

The Iroquois Community Grant Program, established in 2007, aims to enhance the quality of life in communities hosting Iroquois facilities through funding initiatives focused on environmental preservation, passive recreation, historic preservation, and arts and culture. Grants range from $2,500 to $10,000 and are available to local governments and nonprofit organizations. The program prioritizes projects that demonstrate community involvement and alignment with grant objectives, fostering sustainable benefits for the communities served.

About Us

Our team is working tirelessly to heal the planet and ensure that a just and livable future prevails.

With three decades of clean energy industry experience, our leadership team draws upon a long track record of environmental stewardship and meaningful throughput to confidently navigate today's unprecedented challenges.

We are teaming up with local philanthropists, nonprofit organizations, advocates and elected officials to implement effective solutions towards stopping the climate crisis.

Solar Moonshot Program Grant

The Solar Moonshot Program is helping nonprofit organizations across the United States afford the switch to clean energy.

Grants up to $25,000 are typically awarded, with grant amounts dependent on various factors, including the organization’s need for funding. 

In addition to grants given through the program, we also offer short-term, low-interest recoverable grants to help cover the project costs offset by the Investment Tax Credit.

Grants for 2026 are made possible by the BQuest Foundation and two anonymous donors, and the program is managed by Hammond Climate Solutions Foundation. Learn more about the program's status and participants below! 

The Russell Sage Foundation's Visiting Scholars Program offers a prestigious opportunity for scholars in social sciences to conduct research and writing at their New York City headquarters. Annually, 15 to 17 fellowships are awarded to applicants at least two years post-Ph.D. Scholars engage in diverse projects related to vital social issues while benefiting from office space, resources, and financial support for their salary. This program emphasizes intellectual engagement and collaboration among scholars across disciplines.

The AWWA Scholarship Program offers the GFT Forces of Change Scholarship, providing $5,000 to undergraduate or graduate engineering students passionate about advancing the water industry. This scholarship underscores AWWA's commitment to nurturing future professionals who will tackle critical infrastructure challenges. By investing in education, AWWA aims to empower the next generation to innovate and lead in water supply solutions. This initiative highlights the importance of skilled engineers in shaping a sustainable future.

The NYSCA Arts Bring Change (ABC) Grants support local cultural organizations and artists who collaborate with public schools to provide K-12 students with engaging artistic experiences. Funded by the New York State Council on the Arts, this program emphasizes art exploration and requires projects to include hands-on learning sessions. Applicants must demonstrate a partnership with schools and meet specific eligibility criteria, ensuring impactful and meaningful artistic education for students.

Dorothy and Marshall M. Reisman Foundation Grant

The Reisman foundation is pro-active in seeking grant proposals from qualifying 501(c)(3) organizations as well as accepting unsolicited proposals.

Mission

The Dorothy and Marshall M. Reisman Foundation is a private foundation dedicated to the stewardship of the funds entrusted to its care. The Foundation is committed to using its resources to enhance the quality of life through support of organizations located primarily in the Central New York community.

About Us

The Youth Climate Justice Fund aims to support climate justice young leaders with trust-based funding, resources, and capacity strengthening, enabling them to amplify their voices and to keep their vision and influence alive.

Collectively, we have the power to ignite meaningful change and build equitable and sustainable futures. Despite the challenges posed by the current crisis, youth climate justice organizers remain determined to address current issues and explore new approaches.

Mission & Purpose

We work to strengthen existing organizing efforts and support emerging youth-led initiatives with a focus on bridging funders and organizers to enable flexible and impactful support. Through capacity strengthening and resource sharing, we empower and support young people to drive change and build a just and sustainable future.

How To Apply

The Youth Climate Justice Fund provides funding to emerging youth-led climate justice and socio-environmental groups through a participatory decision-making process.

The Brower Youth Awards for Environmental Leadership honors young leaders aged 13 to 22 in North America who excel in environmental initiatives. Awardees receive a $3,000 cash prize, training, and networking opportunities to enhance their impact. This prestigious program fosters youth leadership and amplifies diverse voices within the environmental movement, encouraging innovative solutions to pressing ecological challenges. Over the past 25 years, the awards have celebrated over 100 emerging leaders dedicated to making a difference in their communities.

About Foam Recycling

The process to recycle foam is like that of other recyclables. In the case of foam products, a special compactor – called a “densifier” – may be used in the processing of the material. Foam products are over 90% air, so densifying it allows the material to be transported more cost-effectively. To give you an example, a 48-foot truckload of baled foam polystyrene weighs only around 16,000 pounds, whereas a truckload of densified foam polystyrene weighs 40,000 pounds.

Innovative alternatives are being developed and deployed that are categorized as chemical recycling (vs. mechanical recycling). This will take the plastic resin back to its base state – in the case of foam PS, back to a styrene monomer. With chemical recycling, increased organic contamination will only impact the amount of foam for recovery (yield), but will not impact the recyclability of the plastic.

Foam Recycling Coalition Grant Program

Funding Source: Funding for the grant program comes from contributions from members of the Foam Recycling Coalition, a special interest group of the Foodservice Packaging Institute.

Grant Amounts: Funding amounts will be made on a case-by-case basis and will be dependent on equipment needs. The maximum amount per grant is $50,000.

Cash Match: No cash match is required, but additional costs by the grantee may be incurred for related items such as site preparation, provision of conveying system and electrical infrastructure, freight, and other installation costs.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

The Recycling Partnership offers grants for community recycling programs, providing nearly $50 million to support 370 communities since 2014. Their mission is to create a robust and accessible recycling system that benefits people and the environment. Eligible applicants include publicly, privately, and non-profit owned MRFs in the U.S. This initiative aims to enhance curbside, drop-off, and multifamily recycling, ensuring that everyone can participate in sustainable practices.

About Us

The Recycling Partnership is a team of experts, practitioners, and thought leaders who are deeply invested in protecting our natural resources, creating more sustainable communities, and delivering on our mission of building a better recycling system. We work alongside communities, companies, and policymakers to enact meaningful change across the entire recycling industry.

We firmly believe that if you want to recycle, you should be able to recycle. A robust and accessible recycling system is how we achieve this goal. A better system will deliver the true economic and environmental benefits that our people, our communities, and our entire recycling industry deserve.

This is our mission. This is our purpose. This is who we are. 

Grants for Processors/Materials Recovery Facilities (MRF)

Designed to help equipment manufacturers and MRFs boost throughput and increase capacity. 

The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.

The FY26 Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award aims to foster innovative therapeutic and diagnostic research for Lyme disease and other tick-borne conditions. This award supports early-stage drug discovery and evaluation studies, as well as novel diagnostic methods that can be seamlessly implemented in clinical environments, ultimately enhancing patient care and quality of life.

The FY26 Tick-Borne Disease Research Program (TBDRP) Idea Development Award aims to fund innovative research that enhances understanding and treatment of Lyme disease and other tick-borne diseases. The program encourages creative approaches that challenge existing paradigms and fosters impactful discoveries. A special career development option is available for early-career investigators, offering mentorship and a tailored review process to support significant research advancements.