Best Large Grants for Nonprofit Organizations in New York

The Louis Padovano Grants, awarded by The Lotos Foundation, support not-for-profit organizations in New York City that provide free arts and science programs to middle and high school students. These grants aim to nurture talented individuals across diverse fields such as dance, film, music, theater, visual arts, writing, and the sciences. Eligible organizations must be 501(c)(3) tax-exempt and have not received funding for the past three consecutive years.

The John Lenard Civil Engineering Scholarship, established in 2008 by John Lenard, P.E., F.ASCE, supports undergraduate students pursuing civil engineering with a focus on water supply or environmental engineering. The scholarship aims to assist deserving students in covering tuition expenses. Awarded annually, it is limited to two recipients who demonstrate commitment to their field. The American Society of Civil Engineers, founded in 1852, oversees this scholarship, fostering excellence in civil engineering education.

The WWT Foundation Grant aims to empower organizations aligned with the foundation's values, focusing on community service, employee engagement, and business impact. Key areas of support include career readiness, STEM education, human services, and health and wellness. Eligible organizations must be located in the U.S. and registered as 501(c)(3). Applications are accepted year-round, allowing for flexible engagement and support for impactful community initiatives.

The United Company Foundation, established in 1986, provides grants to support charitable organizations in Bristol, VA, Bristol, TN, and Southwest Virginia. This private non-profit focuses on areas such as food, shelter, education, the arts, health, and youth services, emphasizing fiscal responsibility and innovative approaches. By prioritizing accountability and measurable outcomes, the Foundation aims to foster long-term improvements in the community it serves.

The NIH R25 program aims to enhance inclusivity in research education by supporting activities that encourage individuals from diverse backgrounds to pursue careers in substance use and addiction sciences. This initiative focuses on skills development courses and research experiences, particularly targeting underrepresented groups in biomedical and behavioral sciences. Applications are due by 5:00 PM local time of the applicant organization, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline.

The Fehr Graham Scholarship provides financial support for students pursuing careers in engineering, landscape architecture, land surveying, geology, hydrogeology, assessment and remediation, and environmental health and safety. Applicants must reside within fifty miles of a Fehr Graham office and intend to enroll in their first year of post-secondary education. This scholarship is renewable for up to three years, contingent upon maintaining a 2.8 GPA. It aims to enhance educational opportunities in the communities served by Fehr Graham.

Avnet Cares Grants support nonprofit organizations in the U.S., Canada, and Mexico that focus on making a positive impact in their communities. Grants are available for initiatives in STEM, environmental sustainability, and assistance for communities in crisis. Eligible nonprofits must have been operational for at least three years. The program prioritizes organizations that serve areas where Avnet has significant operations, fostering community growth and development.

The SU-CASA Grant is a 3-month program placing local artists in Staten Island senior centers to engage older adults through creative workshops. Each residency concludes with a public event showcasing the participants' work. Artists receive a stipend of $6,000 and a $2,000 budget for materials. Funded by the NYC Council, this initiative fosters collaboration among various city departments and supports artists passionate about teaching and working with seniors.

The Rural Communities Opioid Response Program - Overdose Response aims to enhance healthcare access in rural areas by addressing urgent needs related to substance use disorder services. This initiative focuses on reducing overdose risks through targeted interventions and support, ensuring that rural communities receive necessary assistance. Funded by the Health Resources and Services Administration, this program is crucial for mitigating the opioid crisis in underserved regions, improving health outcomes, and promoting overall community well-being.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5409 - Smarter Water Governance with AMI: Conservation, Affordability, and Rate Design

Grant Information

• Evaluate how utilities are currently leveraging advanced metering infrastructure (AMI) data to inform pricing, conservation programs (including emergency curtailment practices), affordability programs, and plans for future implementation.
• Analyze AMI data and assess how the data can be leveraged to develop and/or enhance conservation programs, policies, rates, and affordability programs.
• Investigate the potential for advanced analytics, including machine learning, of AMIdatasets to support adaptive or dynamic rate structures, early detection of hardship or atrisk households, categorization of customer classes, dynamic tiering based on household size, and better targeting of affordability and conservation interventions.
• Identify the obstacles utilities and regulators face when balancing conservation, equity, and revenue stability, and how improved AMI data can clarify tradeoffs.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Rodney B. Janes Business, Vocational, or Technical Award

Purpose of Scholarship

This need-based scholarship provides educational assistance to young adult students up to age 30 who are residents of Monroe County, NY; have financial need; and are attending or entering post-secondary business, vocational, or technical schools or programs in Monroe County.

Number and Size of Awards

One award of $2,000; award may not exceed cost of tuition/program/course. Award paid in one lump sum.

Donor Information

A former trust established this fund to benefit secondary school students and students pursuing training at business, vocational, or technical schools.

Quest Diagnostics Foundation

Established as a 501(c)(3) nonprofit organization, the Quest Diagnostics Foundation is committed to addressing the systemic root causes of health disparities. By combining corporate resources with trusted community leadership, we fund and scale evidence-based initiatives that promote wellness, prevent chronic disease, and empower individuals.

We focus our resources on three critical, interconnected clinical and social interventions to build sustainable health improvement:

• Strengthening the community health workforce
• Addressing social drivers of health (SDoH)
• Promoting the prevention, early detection, monitoring, and treatment of disease through diagnostic testing

About Quest for Healthy Communities Champions

The Quest for Healthy Communities Champion award was created to honor, uplift, and support outstanding organizations across the United States that are actively living our core purpose:

Working together to create a healthier world, one life at a time.

Whether you are expanding access to life-saving screenings, supporting maternal and family wellness, or addressing critical social drivers of health, your dedication is moving us closer to an equitable healthcare future. We want to recognize and celebrate your impact.

What we celebrate: Our core impact pillars

The Champions we look to honor are community-first organizations and coalitions tackling critical disparities head-on. We are especially excited to spotlight work that advances health, addresses social drivers of health, fosters community-clinical linkages and develops the community workforce. Examples of this work could include: 

• Programs actively dismantling clinical barriers to ensure every individual—regardless of zip code, background, or income—has access to high-quality care
• Innovators providing creative solutions for food security, transportation, health education, and maternal-child support networks
• Organizations bringing critical care directly to those in need through mobile clinics, community health workers, and localized diagnostic screenings
• Organizations finding creative ways to engage the communities they serve directly into the solutions they are delivering

The award: Selected organization champions will receive a $10,000 grant.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Elvira Caroselli Creative Spirit Award

Purpose of Scholarship

The Elvira Caroselli Creative Spirit Award will provide small awards to encourage the creative spirit and endeavors of junior and senior high school students.

Number and Size of Awards

Number of recipients and award amounts vary; paid in one lump sum in the Summer. Maximum award $1,500.

Donor Information

Mrs. Caroselli loved creating, designing, and experimenting. This remarkable woman dropped out of school in the eighth grade to help support her family. Despite a lack of formal education, she sold an invention to a major manufacturer when she was 70 years old.

The Carl & Marilynn Thoma Foundation offers Collections-Related Grants for Nonprofits, aimed at enhancing public interest in art through innovative projects. Grants support exhibitions, academic convenings, research, and catalog publication, focusing on art from the Spanish Americas, digital media, and more. The foundation prioritizes proposals from 501(c)(3) organizations in the U.S., particularly from New Mexico, Oklahoma, and Texas, fostering partnerships that advance art scholarship and cultural engagement.

The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.

The FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN) grant program aims to enhance transportation through the deployment of innovative technologies. It focuses on improving safety, mobility, and efficiency while fostering economic competitiveness. Projects funded will prioritize core infrastructure improvements and address roadway congestion, aligning with the Trump Administration's goals. The program emphasizes economic opportunities and community benefits, ensuring that selected projects contribute positively to families and communities, ultimately enhancing their quality of life.

The Oriental Trading Company Corporate Giving Program focuses on enhancing the lives of children through education, youth programming, healthcare, and human services. With a commitment to making the world a better place, they support organizations that are tax-exempt under Section 501(c)(3) or public educational institutions. Their initiatives aim to foster community partnerships and provide essential resources to youth in need, ensuring they have access to vital services and opportunities for growth.

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.

About Us

Our Mission

We create lasting impact through asset development, nonprofit capacity building, and community leadership. 

Our Vision

To enrich the lives of Wabash County residents by fostering opportunity, inspiring generosity, and building a thriving connected community. 

Our Scholarships

For High School Seniors & Non Traditional Students who are beginning college more than one year after high school.

The Community Foundation of Wabash County offers a wide variety of post-secondary education scholarships to traditional, non-traditional, and graduate students. With nearly 70 different scholarship endowments created through the generosity of our donors, many students are eligible to apply.    

Jennie Wade Scholarship Endowment

More than one hundred years ago, Jennie Wade created a scholarship in her words “to benefit mankind.” This scholarship is made to help young men and women continue their education after high school. Wabash County residents under the age of 21 are selected from among applicants who have done as much as possible in helping themselves obtain an education and whose families are unable to provide an education.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34) aims to support high-risk, multi-center clinical studies by facilitating early peer review and assessment of study designs. This program helps in the development of necessary operational documents and essential elements for conducting hypothesis-driven studies focused on diseases relevant to NIDDK. Applications are due by 5:00 PM local time, and consulting with NIDDK staff is strongly encouraged.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5432 - Validating Reverse Osmosis Conductivity Profiling for Pathogen Log Reduction Value Credit

Grant Information

• Validate conductivity profiling against pathogen removal by establishing the relationship between conductivity-profile response and MS2 bacteriophage removal under intact and controlled membrane integrity-defect conditions.
• Demonstrate the robustness and applicability of conductivity profiling across representative reverse osmosis conditions, including new and aged membranes, different defect types and severities, operating conditions, variations in feedwater quality/composition/salinity, and temperature.
• Develop a validation implementation framework that defines testing procedures, log removal value calculation methods, sensitivity and performance criteria, continuous monitoring, alarm/response thresholds, and operational requirements needed to support regulatory pathogen log removal values credit for reverse osmosis.

The Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPN) Grant, offered by the Patient Advocate Foundation, provides crucial financial assistance to patients facing this cancer type. It covers out-of-pocket healthcare costs, including medication copays and insurance premiums, ensuring those affected can access necessary treatments. With a focus on personalized case management, the foundation has supported millions in navigating their healthcare needs, emphasizing the importance of timely and affordable care for patients diagnosed with MPN.

The Core State Injury Prevention Program (Core SIPP) aims to enhance public health infrastructure and partnerships to prevent unintentional injuries through data-driven strategies. Focusing on key areas such as traumatic brain injury, falls among older adults, and drowning, it seeks to improve community safety by strengthening data use and fostering collaborations. This initiative supports states in identifying local injury concerns, thus promoting evidence-based prevention approaches and increasing the capacity for sustained public health actions.

The 2026 National Urban and Community Forestry Challenge Cost Share Grant Program aims to tackle economic, health, and environmental issues in communities through innovative tree resource utilization. By transforming wood from various sources into valuable products like lumber and biochar, this initiative promotes local economies and enhances community resilience. Projects should align with community forestry plans, adhere to safety standards, and provide job creation opportunities, ultimately fostering sustainable urban forest management and utilization.

This funding opportunity invites Small Business Technology Transfer (STTR) grant applications aimed at developing FDA-regulated medical products for patients with opioid and stimulant use disorders. Projects may focus on pharmacotherapeutics or diagnostic devices, including software. The initiative seeks to address the ongoing opioid crisis by supporting innovations that enhance treatment options for individuals and communities affected by these disorders.

The Lilah Hilliard Fisher Foundation Grant offers year-round funding for initiatives focused on regenerative agriculture and nutrition education, particularly in New York City and Litchfield County, Connecticut. Emphasizing support for human trafficking survivors, youth development, and social justice, the Foundation seeks projects that align with these priorities. Eligible organizations must be 501(c)(3) tax-exempt entities, with some multi-year grants available. Notably, proposals outside the specified areas are by invitation only.

The Park Foundation Grants: Media support public interest media that raises awareness of critical environmental and social issues. They prioritize funding for investigative journalism, media policy, public broadcasting, and documentary films to promote a better-informed citizenry. Eligible organizations must be 501(c)(3) certified, and funding is aimed at projects that ensure diverse perspectives and community engagement. The foundation is committed to fostering a robust democracy and independent media, reflecting its mission to advance a just and sustainable society.