Best Large Grants for Nonprofit Organizations in New York

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Ted Kohler Music Scholarship

The Ted Kohler Music Scholarship benefits Calistoga students who are committed to music and wish to advance their musical development. The scholarship can be used to pay for activities such as music lessons or summer camp, or for college tuition (where the student demonstrates their desire to continue their musical education). The Ted Kohler Scholarship was established in 1997 to promote musical participation and aspirations in honor of Ted, who upon retirement from San Francisco State University, became a full-time musician and leader of the Napa Valley Jazz Band. He encouraged people of all ages to express themselves musically.

Herold and Retta Reuss Public Safety Scholarship

Applicants must demonstrate the drive and ability to be successful in pursuing a college education and/or a certification process in the fields aforementioned. Financial information is requested, but not necessarily a determining factor. Students who receive this scholarship may apply for further support in subsequent years.

The DHQP Global NOFO aims to enhance the CDC's mission against antimicrobial resistance (AR) by integrating non-research implementation with focused research. This initiative addresses urgent global threats posed by various pathogens and healthcare-associated infections (HAIs). By leveraging existing CDC networks, the NOFO seeks to improve detection, surveillance, and infection control measures, ultimately reducing illness and mortality while protecting healthcare workers and patients, especially in low and middle-income countries.

The Solon E. Summerfield Foundation Grant focuses on empowering youth in the NYC-Metro area by fostering partnerships with nonprofit organizations. The foundation aims to transform systems and pathways of opportunity, ensuring that young people facing social and economic injustices can lead choice-filled lives. Priorities include promoting mental health, addressing climate change, and enhancing youth participation in civic engagement. Through flexible, multiyear grants, the foundation supports initiatives that advance equity and create lasting impact.

The Public Health Nursing initiative aims to enhance the health and wellness of American Indian and Alaska Native men by implementing a culturally sensitive case management model. Through this program, Public Health Nurses will provide preventive health services, facilitate access to care, and encourage healthy lifestyle choices. By promoting early identification and management of health issues, the initiative strives to improve overall community health outcomes through targeted, collaborative interventions.

The Ralph C. Wilson, Jr. Legacy Funds: Design and Access Grant aims to enhance community access to spaces and programs supporting healthy living in Western New York. Managed by the Community Foundation for Greater Buffalo, this grant focuses on projects that improve walkability, bikeability, and the overall recreational landscape. Eligible 501(c)(3) nonprofits can apply for funding to support pre-planning, development, or construction costs, fostering sustainable community enhancements.

The Daland Fellowships in Clinical Investigation, awarded by the American Philosophical Society, support research in clinical medicine across various fields, including internal medicine and psychiatry. Each fellowship provides $40,000 annually for up to two years, contingent on satisfactory progress. Eligible candidates include those with recent M.D. or Ph.D. degrees, and applicants must conduct research under a scientific advisor in the U.S. Preference is given to those with limited postdoctoral training.

The Council of Independent Colleges

Founded in 1956, the Council of Independent Colleges (CIC) is an association of nonprofit independent colleges and universities, state-based councils, and higher education affiliates that works to support college and university leadership, advance institutional excellence, and enhance public understanding of independent higher education’s contributions to society.

CIC is the major national organization that focuses on providing services to leaders of independent colleges and universities and state-based councils. CIC offers conferences, seminars, publications, and other programs and services that help institutions improve educational quality, administrative and financial performance, student outcomes, and institutional visibility.

NetVUE Vocation across the Academy Grants

​One major purpose of an undergraduate education in the liberal arts is to help students shape a philosophy of life. At the same time, undergraduates today are increasingly preoccupied with postgraduate employment. The purpose of this grant program is to help colleges and universities develop more effective ways to strengthen the link between these two purposes of undergraduate education. It is designed to support institutions in their efforts to expand vocational exploration and discernment programs across the curriculum and co-curricular programs, with the following goals:

• to help students develop more effective links between developing a philosophy of life and preparing for a career;
• to include more faculty and students in the work of vocational exploration and discernment; and, in some cases,
• to build connections with community partners, such as local businesses, nonprofits, and other community organizations.

The Goldman Sachs Group, Inc

Since its founding in 1869, Goldman Sachs has been a dominant force in the financial world. Built from the foundation of our renowned investment banking business, the firm has evolved its culture and expanded its offerings over time - but its commitment to client service and excellence endures.

The Goldman Sachs culture values teamwork, client service, and giving back to the communities we serve. It has been described as the foundation of the firm's success. Moreover, the people of Goldman Sachs have long valued their opportunity to give back through public service and volunteerism, humanitarian efforts, and programs that foster economic progress in communities around the world.

Goldman Sachs Community Development Grant

The Community Development Grants program aims to address critical funding gaps in low- and moderate-income (LMI) communities across New York City, New Jersey, and Salt Lake City. The program provides financial support to high-impact organizations dedicated to advancing economic opportunity and community stability. 

The Change Makers Initiative

The Change Makers Initiative: Provides organizations with a one-time, general operating grant (e.g., for programmatic or staffing needs). Key themes in this cohort included:

• Access to Housing: Expediting access to affordable apartments for homeless New Yorkers with housing vouchers.
• Embracing AI: Leading AI adoption initiatives, ensuring LMI communities aren't left behind in the digital economy through literacy training and organizational transformation.
• Empowering Parents: Providing free, high-quality childcare, enabling parents to work towards financial autonomy and security.
• Building Financial Futures: Offering financial coaching and debt relief services that open doors to homeownership and economic stability.

Syndax Pharmaceuticals, Inc.

At Syndax, we are determined to realize a future in which people with cancer live longer and better than ever before. We believe that it takes a community to build a great medicine, and that is why we are working to set the new standard for developing medicines in the field of oncology – one that revolves around collaboration, shared learning, and excellence.

Syndax’s mission is to obtain regulatory approval and commercialize drugs that extend and improve the lives of cancer patients by drawing on the newest scientific research and advances, collaborating with determined problem solvers, and identifying value in overlooked aspects of science.

Educational Funding

At Syndax, we are committed to the goal of supporting objective, balanced and scientifically rigorous education that furthers improvements in science, medicine, and patient care. We accomplish this goal, in part, by providing grants for independent medical education (IME) programs. These can include live, online, and/or enduring programs that educate healthcare providers (HCPs), patients, or caregivers. Programs that are funded via Syndax medical education grants must be primarily dedicated, in both effort and time, to medical, health or scientific topics that are objective, balanced, unbiased, and scientifically rigorous. Medical education grants must never be made with the intent to directly or indirectly reward, influence or encourage the recipient to prescribe, purchase, sell or arrange for any Syndax product.

Danny Did Foundation

The Danny Did Foundation is a not-for-profit corporation organized in the state of Illinois and recognized by the Internal Revenue Service as a 501©(3) tax-exempt organization. 

Founded by Chicagoans Mike and Mariann Stanton in January 2010 after the death of their four-year-old son Danny, the Danny Did Foundation works toward its mission to prevent deaths caused by seizures with these main goals in mind: advancing public awareness of Sudden Unexpected Death in Epilepsy (SUDEP), enhancing SUDEP education and disclosure between medical professionals and families afflicted by seizures, and the mainstreaming of seizure detection and prediction devices that may assist in preventing seizure-related deaths.

Danny Did Foundation Hardship Grant

The Danny Did Foundation (“Foundation”) strives to assist individuals and families living with seizures. With an approved Request for Funding, the Foundation will provide monetary funding to the Grantee so they may gain access to a particular device or technology (“Device”) that the Grantee, in collaboration with the Grantee’s medical providers and professionals, independently deem appropriate. This money shall be defined as “Funds” and the spending of any Funds shall be at the sole discretion of the Grantee. The Foundation does not direct, limit, participate, or manage the decision-making or purchase of any specific Device.

While no Device has been proven to prevent epilepsy-related mortality (including SUDEP), the Danny Did Foundation is devoted to seeking out resources that may assist families living with epilepsy.

Hardship Grant: I am unable to make a purchase for the epilepsy related resource I seek therefore I am requesting a hardship grant. If I am approved for funding, I agree to provide a receipt for the resource I purchase to the Danny Did Foundation within 14 days of receiving the grant check, or I will return the funds to the Danny Did Foundation. 

Danny Did Foundation

The Danny Did Foundation is a not-for-profit corporation organized in the state of Illinois and recognized by the Internal Revenue Service as a 501©(3) tax-exempt organization. 

Founded by Chicagoans Mike and Mariann Stanton in January 2010 after the death of their four-year-old son Danny, the Danny Did Foundation works toward its mission to prevent deaths caused by seizures with these main goals in mind: advancing public awareness of Sudden Unexpected Death in Epilepsy (SUDEP), enhancing SUDEP education and disclosure between medical professionals and families afflicted by seizures, and the mainstreaming of seizure detection and prediction devices that may assist in preventing seizure-related deaths.

Danny Did Foundation Reimbursement Grant

The Danny Did Foundation (“Foundation”) strives to assist individuals and families living with seizures. With an approved Request for Funding, the Foundation will provide monetary funding to the Grantee so they may gain access to a particular device or technology (“Device”) that the Grantee, in collaboration with the Grantee’s medical providers and professionals, independently deem appropriate. This money shall be defined as “Funds” and the spending of any Funds shall be at the sole discretion of the Grantee. The Foundation does not direct, limit, participate, or manage the decision-making or purchase of any specific Device.

While no Device has been proven to prevent epilepsy-related mortality (including SUDEP), the Danny Did Foundation is devoted to seeking out resources that may assist families living with epilepsy.

Reimbursement Grant: Danny Did will consider partial reimbursement for device purchases made in the last 30 days. I have already purchased the epilepsy device. I am seeking reimbursement and will provide receipt of purchase to the Danny Did Foundation to be considered for funding.

The Bank of Greene County Charitable Foundation Grant supports local communities through funding for non-profit organizations. Established in 1998, the foundation has contributed over $2.5 million to various sectors, including education, health, and the arts. Grants of up to $2,500 are awarded annually, with a focus on specific funding requests. Eligibility requires a 501(c)(3) status letter, while individuals and political candidates are ineligible for support.

The LEGO Foundation Fellowship

Advancing the science and practice of supporting children to thrive

The LEGO Foundation Fellowship is a global initiative supporting researchers working to deepen our understanding of how children thrive. Spanning disciplines from education and psychology to public health, data science, and humanitarian studies, the fellowship brings together early- and mid-career scholars whose work has the potential to generate evidence that matters for children’s lives.

Fellows receive three years of flexible support to pursue rigorous, practically relevant research, and join a cohort of peers working across the fellowship’s themes. In addition to funding research, the program fosters a community of scholars engaged in meaningful exchange with one another and with research, policy, and practice audiences.

The LEGO Foundation Fellowship is developed in partnership with the LEGO Foundation, and administered by SSRC as part of its commitment to supporting scholars whose work bridges research and real-world impact.

Research themes

The LEGO Foundation Fellowship welcomes research proposals that advance understanding of children’s thriving through one of the following three themes: the youngest children in crisis and conflict settings; inclusion and wellbeing of neurodivergent children; and children’s learning and development in an AI-enabled world. Applicants may explore the role of play where it is relevant to the research question. The consideration of play is optional and not a condition of eligibility.

The Hypercholesterolemia Grant by the Patient Advocate Foundation offers financial assistance to individuals diagnosed with hypercholesterolemia, helping cover out-of-pocket healthcare costs such as medication copays and insurance premiums. This nonprofit aims to improve patient access to necessary care while supporting over 3.8 million patients since its inception. Eligible applicants must have health insurance and meet specific income requirements to receive assistance in managing their healthcare expenses effectively.

The Hyperkalemia Grant, provided by the Patient Advocate Foundation, offers crucial financial assistance to patients struggling with hyperkalemia. This grant covers out-of-pocket healthcare costs, including medication copays and health insurance premiums. Eligible applicants must have a confirmed diagnosis and meet specific income and residency requirements. Since its inception, the foundation has supported millions of patients, ensuring they can access the necessary treatment and resources for their health needs.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

The Fair Housing Initiatives Program (FHIP) aims to combat discriminatory housing practices through funding provided to various organizations. Established by Congress in 1988 and made permanent in 1992, FHIP supports entities that educate the public and enforce fair housing rights. The program offers competitive grants across four initiatives, including the Private Enforcement Initiative, which enables national non-profit organizations to investigate violations and uphold fair housing laws effectively.

Homecare Assistance Grant

MS Focus understands the daily needs and challenges that must be met by both those with MS and their caregivers. In order to meet these needs in the most timely and efficient way possible, our Homecare Assistance Grant connects you to the best available local services. Should resources within your community not be available, direct support may be provided on a temporary basis.

Available Services include:

• Home Care - Personal hygiene services, light housekeeping, grocery shopping, meal preparation, and transportation to and from appointments are all services that can be provided for a limited time.
• Therapy Visits - Based upon individual need, an appointment with an occupational, physical, or speech therapist can be arranged. Through education and training, these therapists can help to foster independence, self-esteem, and better quality of life for the person living with MS.
• Respite Care - Respite allows primary caregivers the opportunity to tend to themselves, or other family business, with the assurance that their loved one is being cared for by a properly trained individual. This service is provided on a short-term basis for a scheduled period of time. 
• Coming Home - Returning home from a stay at the hospital can be a difficult time of transition. We offer a four-hour visit from an aide who will meet the patient at the hospital, provide transportation home, and then get the patient settled comfortably at home.

The Limited Competition: Clinical and Translational Science Award (CTSA) Program's Collaborative and Innovative Acceleration Award aims to enhance translational research by fostering collaboration in developing and implementing innovative solutions. This funding opportunity invites applications focused on new approaches and technologies that will improve research impact across various diseases and expedite treatment availability. Eligible applicants include organizations with active CTSA hub prime or partnering awards.

The Behavioral Health Integration Initiative aims to enhance the health of American Indian and Alaska Native individuals by expanding access to integrated behavioral health care. It supports Tribal and Urban Indian Organization health systems in providing culturally responsive and trauma-informed services. The initiative focuses on improving care coordination, promoting early identification of mental health issues, and integrating various health services to improve overall health outcomes and quality of life for AI/AN communities.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

About Us

Midlands Community Foundation (MCF) is here to serve and add value to donors’ philanthropic needs by providing them an opportunity to “invest in the power of community.” It is our goal to identify current and emerging issues, channel resources to address community needs, and help prepare for the future.

MCF Mission

The mission of Midlands Community Foundation is to be a catalyst for lasting impact in Sarpy and Cass counties and to give opportunities to organizations and individuals to pursue their charitable goals.

Scholarships Through MCF

Midlands Community Foundation is committed to the futures of communities in Sarpy and Cass Counties, and across the country. Supporting higher education of students is a direct investment in the futures of these communities.

Sarpy County Bar Association Scholarship Application Guidelines

The Sarpy County Bar Association Scholarship Fund makes this scholarship available to students studying criminal justice, criminology, sociology, psychology, or pre-law

The Fund shall annually distribute two (2) scholarships in the total amount of $1,500, split evenly per semester (i.e., $750 Fall Semester, and $750 Spring/Semester).

The NCAA Postgraduate Scholarship for Winter Sports awards up to 126 scholarships of $10,000 annually to outstanding student-athletes who excel both academically and athletically. Eligible candidates are in their final year of NCAA competition and must have a minimum GPA of 3.2. The scholarships are available for men and women in various winter sports and are intended for use in accredited graduate programs, emphasizing the importance of academic achievement and community involvement.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Armenian Scholarship Fund in memory of Charles J. Churukian

Purpose of Scholarship

To provide financial assistance to graduating seniors pursuing careers in medicine, science, or music.

Number and Size of Awards

One award of $4,000; paid as $1,000 per year for up to four consecutive years of undergraduate study. Award paid in the Fall and divided equally between the Fall and Spring semesters.

The U.S. Hillman Prize for Broadcast Journalism, awarded by the Sidney Hillman Foundation, recognizes outstanding journalism that serves the common good. Open to global journalists, the contest honors work accessible to U.S. audiences, with no entry limits per outlet. Winners receive a $5,000 honorarium and a certificate at a ceremony in New York City. This prestigious award highlights impactful stories across various media platforms, emphasizing the importance of journalism in addressing social issues.