Best Grants for New Nonprofits in North Carolina

The Nature Awards for Inspiring Women in Science celebrate outstanding contributions by women in STEM fields. These awards recognize early-career female researchers who demonstrate exceptional achievements, face challenges, and inspire the next generation through outreach. Winners receive prizes totaling $50,000, mentorship opportunities, and invitations to prestigious ceremonies. This initiative promotes inclusivity and aims to enhance the representation of women in science, thereby supporting a diverse and equitable scientific community.

This funding opportunity invites applications for Testing Centers focused on evaluating somatic cell genome editing technologies for translational applications. These centers will provide essential resources and testing services to researchers, ensuring the efficacy and safety of novel genome editing methods. By developing innovative in vivo and in vitro models, the centers aim to enhance scientific rigor and reproducibility in biomedical research, ultimately supporting the advancement of therapeutics for human diseases.

The NIH Support for Conferences and Scientific Meetings (R13) grant aims to facilitate high-quality conferences that contribute to public health and the scientific missions of NIH Institutes and Centers. Key application deadlines range from April 2024 to January 2027, providing vital opportunities for researchers to gather and share knowledge. This grant is particularly focused on enhancing the impact of scientific dialogue in critical health areas.

The L’Oréal USA For Women in Science Fellowship empowers women postdoctoral scientists by providing annual grants to support their research in STEM fields. This initiative not only recognizes their contributions but also encourages them to serve as role models for future generations. With a long-standing partnership with the AAAS, the program has awarded over $5 million to 105 scientists, demonstrating a strong commitment to advancing women's roles in science and technology.

The NSF Core Research in Biological Sciences (BIO Core) program supports innovative research that enhances our understanding of biological systems, from molecular to biome scales. This funding opportunity encourages interdisciplinary proposals and can fund both single and multi-investigator projects. The awards will vary in scope and duration, accommodating exploratory projects and long-term commitments, depending on available funding and alignment with the program's objectives.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

The NIH Common Fund is planning to issue a NOFO to continue the Bridge2AI program, which aims to develop AI-ready datasets and best practices for biomedical research. This next stage will leverage these datasets to address significant health challenges and foster multidisciplinary collaboration. The initiative will support 3-5 Centers focused on trustworthy AI in biomedical research, creating frameworks for reproducibility, transparency, and advancing the AI workforce in health sciences.

The Nature Awards for Inspiring Women in Science, particularly in the Science Outreach category, honors initiatives that empower girls and young women in STEM fields. With a focus on engagement and retention, the awards aim to celebrate projects that encourage participation in natural sciences, technology, engineering, mathematics, and medicine. Winners will receive significant cash prizes and opportunities for mentorship, creating pathways for future generations of women in science.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

The Ashe County Community Foundation Grant supports local nonprofits through various funds, including those for education and children's programs. Established in 1995, ACCF aids community development via competitive grants, typically ranging from $500 to $2,000. Organizations eligible for funding must be 501(c)(3) public charities or local government units, promoting inclusivity without discrimination. This grant is vital for enhancing community assets and addressing local needs in Ashe County.

The Lenoir County Community Foundation Grant Program, established in 1993, supports local charitable initiatives through competitive grants. It primarily serves organizations that are tax-exempt under Section 501(c)(3) or local government units, including public schools. Grants typically range from $500 to $3,000 and are aimed at enhancing community life in Lenoir County. This program encourages diverse organizations to apply, excluding those that engage in political lobbying or faith-based exclusivity.

The Hanna H. Gray Fellows Program, funded by the Howard Hughes Medical Institute, aims to enhance diversity in the scientific community by supporting early-career researchers. The program provides funding for postdoctoral training and early faculty years, promoting an inclusive academic culture. Fellows receive an initial salary of $80,000 and a $20,000 annual expense allowance. This initiative helps develop future leaders in biological and biomedical sciences, ensuring equitable opportunities for all backgrounds.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The NIH Independent Scientist Award (K02) aims to support the development of independent scientists and enhance their research capabilities. This award offers salary support and protected time for three to five years, specifically for those leading independent clinical trials or feasibility studies. Applicants must demonstrate a need for focused research to advance their careers. Key deadlines for applications span from June 2024 to February 2027, catering to various submission types including standard and AIDS-related grants.

The Beazley Foundation Grants support educational, charitable, and religious initiatives, primarily awarding funds to 501(c)(3) organizations. While historically favoring projects in Portsmouth, the Foundation extends its reach throughout South Hampton Roads and beyond. Applicants must consult with the Foundation's president prior to submission, and grants are not available to individuals or for certain projects, including environmental and arts initiatives, unless deemed compelling by the Board.

The Kelley Foundation

The Kelley Foundation was established by Robert and Judy Kelley and their daughter Marla. The Kelleys are native Oklahomans and longtime residents of Southern Oklahoma.

The foundation is primarily focused on humanitarian projects in Oklahoma, with an emphasis on Southern Oklahoma. Our mission is to develop and strengthen our community, state, and nation by providing essential resources to those in need.

The Kelley Foundation Grant

The Kelley Foundation is a private, charitable foundation, incorporated under the laws of the State of Oklahoma and operated exclusively for providing support through its gifts and grants to religious, charitable, scientific, and educational institutions which are qualified under section 501(c)(3) and which are not private foundations within the meaning of section 509(a) of the Internal Revenue Service Code.

About the Hertz Foundation

Empowering the Nation’s Most EXCEPTIONAL Innovators

The Hertz Foundation identifies and empowers the nation’s most exceptional innovators in science and technology, fueling a lifelong community dedicated to solving our most pressing problems.

Hertz Community

Awards & Recognition

We’ve established several awards to recognize and support Hertz community members who are accelerating solutions to significant real-world challenges, either through their individual careers or volunteering to strengthen the Hertz Foundation’s work. In addition to providing financial and professional support at a critical time, we also hope to generate more awareness within the Hertz community and inspire collaborations that build on the momentum.

Hertz Thesis Prize

The Hertz Thesis Prize recognizes fellows who publish exemplary doctoral theses with applications to real-world problems. Winners receive a $5,000 honorarium.

Exemplary Graduate Work

Since 1981, more than 60 fellows have been recognized with the Hertz Thesis Prize. Much of their work has led to successful patents, the formation of influential companies and contributed solutions to some of our most pressing challenges.

The NIH Director's New Innovator Award supports creative early-stage investigators pursuing innovative research with transformative potential for science relevant to the NIH mission. Applications are encouraged across all NIH-related fields, enhancing support for emerging talent. This award is part of the NIH Common Fund's High-Risk, High-Reward Research Program, which aims to cultivate groundbreaking research and foster the next generation of scientists.

The Rea Charitable Trust, established in 2009 by Mrs. Isabel McClintic Rea, prioritizes support for charitable organizations that focus on the arts. Administered by Comerica Bank & Trust, the trust provides funding through structured application periods for organizations based on their names. Eligible applicants must be 501(c)(3) organizations, limited to one application per year. The trust aims to uphold Mrs. Rea's legacy by fostering artistic endeavors within the community.

The Zuckerman Postdoctoral Scholars Program fosters collaboration between leading scientific institutions in the U.S. and Israel by attracting top postdoctoral researchers. With a focus on STEM leadership, this program offers a unique two-year scholarship, allowing scholars to conduct research at participating Israeli universities and North American institutions. The initiative aims to strengthen academic ties, enhance research capabilities, and support the return of talented Israeli scholars to their home institutions, ultimately enriching the global scientific community.

The Japanese-Language Education Project Grant supports initiatives that enhance Japanese language education across various regions. Offered by the Japan Foundation, Los Angeles, this grant targets workshops, seminars, and original projects that connect language learning with Japan Studies. Eligible applicants include non-profit educational organizations in the U.S. Projects should benefit multiple programs, ensuring a broad impact on Japanese language education. The deadline for applications is two months before the project start date, which must be between April 1, 2025, and March 31, 2026.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Calvin H. & Elizabeth L. Topliff Scholarship

Georgia Mathews, mother to Marion Community Foundation board member, Spencer Mathews, created this endowed scholarship in 2023 in honor of her parents. The scholarship will be awarded to Marion County students who are pursuing a career in either education or engineering, with special consideration for students who will be attending Ohio Northern University, which is where Georgia’s parents met.

Betty Beatty Topliff was born in Pittsburgh but ended up in Marion after meeting Calvin at Ohio Northern and moving to his hometown of Marion. Betty (1928-2022) was a dedicated teacher for 30 years, most recently at Ridgedale High School. Calvin (1924-2009) was an Army veteran who served in Europe during WWII and was awarded the Bronze Star. Calvin retired from the marketing department of Ohio Edison Marion Division after 36 years of service.

Following retirement, Calvin and Betty were Florida snowbirds, but Betty returned to Marion after Calvin’s death to be with her beloved children, grandchildren, and great grandchildren.

The NIH Mentored Patient-Oriented Research Career Development Award (K23) aims to enhance the career development of clinical doctoral degree holders dedicated to patient-oriented research. It supports individuals in their commitment to focus their research efforts on improving patient outcomes. The award has multiple application deadlines, including June 12, 2024, and October 12, 2024, among others, catering to various grant types, including standard, renewal, and AIDS-related applications.

The Mary Duke Biddle Foundation's Arts Grant Program provides multiyear funding to arts nonprofits and PreK-12 education organizations in North Carolina's Triangle region. With grants ranging from $20,000 to $50,000 annually, the program focuses on supporting developing and established organizations, emphasizing artistic excellence and community engagement. Eligibility includes a commitment to diversity, equity, and inclusion. This initiative aims to strengthen the cultural sector, foster growth, and enhance the overall well-being of communities through arts programming.

The Paul Culberson Agricultural Development Fund, established in 1991, supports agricultural advancement in the Polk County community. This fund honors Paul Culberson's contributions and funds projects such as community gardens and farmers markets. Eligible applicants include 501(c)(3) nonprofits and public school systems serving Polk County. However, grants cannot support fundraising, political activities, or scholarships. Interested organizations should submit a Letter of Intent to confirm eligibility before applying.

The NSF Mid-scale Research Infrastructure-1 Program supports projects that enhance research capabilities in science and engineering. This program provides funding for both design and implementation of mid-scale research infrastructure, emphasizing the development of a diverse workforce. By addressing specific community needs and promoting competitive research environments, the program encourages innovative approaches to infrastructure development. Proposals may involve upgrades, new acquisitions, or design efforts aimed at successful implementation of vital research tools.

The H.S. Lopez Family Foundation Grant focuses on funding innovative projects that enhance the quality of life, primarily in Arizona. With an emphasis on health, education, and welfare, the foundation aims to support not-for-profit organizations that address critical community needs. Grants are awarded to initiatives that demonstrate potential for lasting impact and community benefit, encouraging sustainable support beyond the foundation's involvement.