Best Grants for 501(c)(3) in Pennsylvania

The Imagine Learning Foundation's Signature Grant Program aims to enhance the well-being of learners by supporting social and emotional learning (SEL) initiatives. By bridging classroom and community efforts, it fosters healthier environments for youth, families, and educators. The program prioritizes funding for organizations addressing critical issues like chronic absenteeism and housing insecurity. In 2024, the foundation will allocate over $400,000 to impactful projects, furthering its mission to cultivate supportive learning experiences both in and out of the classroom.

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

The Building Hope: Future Forward Schools Prize & Fellowship Program aims to enhance career exploration for middle and high school students. This initiative, launched by Building Hope in partnership with American Student Assistance, recognizes schools that excel in career-connected learning. Awardees receive funding, mentorship, and resources to empower students from diverse backgrounds, ensuring they develop essential skills for future success. With $50,000 available for five schools, this program fosters innovation and prepares students for a changing economy.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000

The Dr. Alice M. Hudder- Richard T. Molder Post-Secondary Scholarship Fund, established by Richard Molder, supports Erie County high school seniors pursuing post-secondary education. In 2023, the Erie Community Foundation awarded over $800,000 in scholarships to deserving students. Two awards will be granted: one for students focusing on science, math, or business, and another for those studying art or music, emphasizing financial need and a strong work ethic.

The Avant Garde Award supports innovative research on HIV and substance use disorders, encouraging creative scientists to explore high-risk, high-reward approaches. While applications are not currently being accepted, this initiative by the National Institute on Drug Abuse (NIDA) aims to stimulate collaborations and impactful research. Early-stage investigators are particularly encouraged to consider this opportunity as they develop their proposals for future funding. The program uses the DP1 activity code, fostering transformative advancements in biomedical and behavioral science.

Home

The Middle Run Foundation is a family-governed foundation based in Newark, Delaware. The Board of the foundation is chaired by Sarah Ives Gore, its founder, and includes her children, grandchildren, and non-family members who bring experience and expertise to our work.

About

Purpose:

The purpose of the foundation is to fund and support non-profit programs which focus on building healthy, self-sufficient families.

Apply

The Middle Run Foundation makes grants up to $500,000 annually with individual grants ranging from $5,000 to $50,000.

The NCAA Postgraduate Scholarship for Fall Sports offers up to 126 scholarships annually, valued at $10,000 each, to student-athletes who excel academically and athletically. Eligible candidates must be in their final year of intercollegiate competition and maintain a minimum GPA of 3.20. Scholarships are awarded three times a year, with 21 available for men and 21 for women across various sports. This initiative promotes graduate education and recognizes the achievements of outstanding student-athletes.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

The Agriculture and Food Research Initiative (AFRI) focuses on enhancing education and workforce development in food and agricultural sciences. It invites applications for various grants aimed at professional development, non-formal education for youth, community college training, and fellowships for both predoctoral and postdoctoral candidates. The program, managed by the USDA's National Institute of Food and Agriculture, emphasizes the cultivation of skills necessary for the future workforce in agriculture, with multiple deadlines for submissions.

The THRIVE Grants program, formerly known as Community Grants, offers funding of up to $10,000 to support initiatives that promote economic mobility for low-income individuals in York County. Managed by the York County Community Foundation, these grants prioritize career development, child and youth development, health, housing, and transportation. Eligible applicants include nonprofit organizations and government agencies dedicated to transforming lives and communities through impactful programs.

Our Mission

Empower Students to Thrive in an Evolving World

STEM and CTE Grants for Your School

PLTW provides STEM and CTE-aligned curriculum grants for elementary schools, middle schools, and high schools to implement or expand PLTW Launch, PLTW Gateway, PLTW Computer Science, PLTW Engineering, and PLTW Biomedical Science STEM programs.

We work with companies and foundations across the U.S. to make these grants possible.

PLTW Gateway

Caterpillar Foundation understands the importance of equipping individuals and communities with the skills, resources and services they need to thrive in our changing world. Investments in workforce readiness and STEM aim to create human infrastructure through an empowered, prepared and skilled workforce. 

Caterpillar Foundation has worked with PLTW to expand access to STEM education. Through this collaboration, Caterpillar Foundation is supporting PLTW grants to schools interested in starting and expanding PLTW programs beginning in the 2027-2028 academic year.

PLTW Gateway

New Program

The Pottstown Area Health & Wellness Foundation offers a Capacity Building Award aimed at strengthening nonprofits in its service area. This grant supports enhancing organizational infrastructure, governance, and sustainability through investments in training, technology upgrades, and strategic planning. By fostering robust nonprofit capabilities, the foundation ensures lasting community impact and addresses critical issues like health and education equity. Eligible applicants include 501(c)(3) organizations and public/private K-12 schools within the designated region.

Our Mission

Empower Students to Thrive in an Evolving World

STEM and CTE Grants for Your School

PLTW provides STEM and CTE-aligned curriculum grants for elementary schools, middle schools, and high schools to implement or expand PLTW Launch, PLTW Gateway, PLTW Computer Science, PLTW Engineering, and PLTW Biomedical Science STEM programs.

We work with companies and foundations across the U.S. to make these grants possible.

PLTW Gateway

Caterpillar Foundation understands the importance of equipping individuals and communities with the skills, resources and services they need to thrive in our changing world. Investments in workforce readiness and STEM aim to create human infrastructure through an empowered, prepared and skilled workforce. 

Caterpillar Foundation has worked with PLTW to expand access to STEM education. Through this collaboration, Caterpillar Foundation is supporting PLTW grants to schools interested in starting and expanding PLTW programs beginning in the 2027-2028 academic year.

PLTW Gateway

Program Expansion

Who We Are - CAP Foundation

Mission

Our mission is to improve people’s health by:

• Developing tomorrow’s pathology leaders through awards for advanced training, research, and education.
• Mobilizing pathologists to expand health equity in medically underserved communities within the US and globally.

Vision

Our vision is that pathologists are equipped to bridge health disparities and enhance outcomes globally.

CAP Foundation History

For over 50 years, the CAP Foundation has granted millions of dollars to support pathology education, research, training, and travel grants, with the purpose to:

• Enhance the role of the pathologist in the provision of medical care.
• Advance pathology through the education of the medical community.
• Encourage the clinical application of research developments.

Our Core Values

• Advancement: We are committed to pushing the boundaries of pathology and patient care through scholarships, grants, and educational programs.
• Collaboration: Through effective partnerships, we significantly enhance our capacity to fulfill our mission.
• Excellence: We are dedicated to achieving the highest standards in pathology education, research, and community service.
• Service: Service reflects our core mission of improving health equity by providing access to healthcare and pathology expertise, particularly in underserved communities.

Presidential Pathology Scholarship

This scholarship allows the sitting CAP President to personally support educational creativity, expand awareness of pathology, and connect communities through the CAP Foundation’s mission to develop tomorrow’s pathology leaders. This scholarship is established in honor of each sitting CAP President, as a commitment to the CAP Foundation’s efforts to advance the specialty by supporting creative projects that encourage interest in or expand the reach of pathology. Up to two scholarships will be supported each year. Ranging from $500-$1,500 per awardee, to be used toward the selected project(s).

Each year the sitting CAP President will select a focus area to support based on at least one of the CAP Foundation’s Five (5) Pillars. CAP Foundation Five Pillars:

• Global: Expands global pathology access, capacity, training, and equity.
• Future Leaders: Builds pipeline through learning, leadership, mentorship, and awards.
• Ethics, Research, Innovation: Advances ethical practice, discovery, innovation, and diagnostic excellence.
• Advanced Training: Delivers specialized skills through grants, workshops, and roundtables.
• Community Engagement: Increases visibility and connection with patients, partners, and the public.

The Congenital Sucrase-Isomaltase Deficiency Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from this genetic disorder. By providing assistance with prescription drugs and treatment costs, the fund ensures that vital medications are accessible, allowing patients to manage their condition effectively. In 2024, the Foundation is expected to award over $1.2 billion in grants, showcasing its commitment to enhancing healthcare access for those in need.

The Chronic Lymphocytic Leukemia Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients battling chronic lymphocytic leukemia (CLL). This fund provides essential support for prescription copays and premiums, ensuring that patients can access necessary treatments without the stress of financial constraints. Since its inception, the foundation has awarded over $1.2 billion in grants, helping more than 1.1 million patients. The initiative emphasizes the importance of accessible healthcare and aims to improve the quality of life for those affected by this condition.

Our Mission

Empower Students to Thrive in an Evolving World

STEM and CTE Grants for Your School

PLTW provides STEM and CTE-aligned curriculum grants for elementary schools, middle schools, and high schools to implement or expand PLTW Launch, PLTW Gateway, PLTW Computer Science, PLTW Engineering, and PLTW Biomedical Science STEM programs.

We work with companies and foundations across the U.S. to make these grants possible.

PLTW Launch

Caterpillar Foundation understands the importance of equipping individuals and communities with the skills, resources and services they need to thrive in our changing world. Investments in workforce readiness and STEM aim to create human infrastructure through an empowered, prepared and skilled workforce. 

Caterpillar Foundation has worked with PLTW to expand access to STEM education. Through this collaboration, Caterpillar Foundation is supporting PLTW grants to schools interested in starting and expanding PLTW programs beginning in the 2027-2028 academic year.

: PLTW Launch

: New Program

The Michigan Professional Insurance Agents Scholarship (MIPIA) is offered by the Four County Community Foundation to seniors and recent graduates in Michigan planning to major in Insurance/Risk Management. This scholarship provides up to four awards and aims to foster education in the insurance field. Award recipients will be honored at the Foundation Scholarship Celebration in May, ensuring recognition of their achievements and contributions to the community.

The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.

Our Mission

Empower Students to Thrive in an Evolving World

STEM and CTE Grants for Your School

PLTW provides STEM and CTE-aligned curriculum grants for elementary schools, middle schools, and high schools to implement or expand PLTW Launch, PLTW Gateway, PLTW Computer Science, PLTW Engineering, and PLTW Biomedical Science STEM programs.

We work with companies and foundations across the U.S. to make these grants possible.

PLTW Launch

Caterpillar Foundation understands the importance of equipping individuals and communities with the skills, resources and services they need to thrive in our changing world. Investments in workforce readiness and STEM aim to create human infrastructure through an empowered, prepared and skilled workforce. 

Caterpillar Foundation has worked with PLTW to expand access to STEM education. Through this collaboration, Caterpillar Foundation is supporting PLTW grants to schools interested in starting and expanding PLTW programs beginning in the 2027-2028 academic year.

PLTW Launch

Program Expansion

The Partners in Arts Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors from Smith County who have engaged in performing or visual arts and plan to pursue a related major in college. This scholarship highlights the importance of arts education and aims to empower students to achieve their academic goals. Eligible applicants must demonstrate a commitment to the arts and meet specific criteria, ensuring that funding is awarded to deserving candidates.

The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.

The Gospel Fest Music Arts Scholarship, established by Vicki Hill of WTLZ-FM, aims to support Saginaw County students pursuing degrees in Musical Arts. This initiative is part of a larger effort by the Saginaw Community Foundation to enhance local education through scholarships and grants. The annual Gospel Fest, attracting up to 2,000 attendees, serves as a vibrant community event promoting peace and cultural unity through music, showcasing both local and national talent.

The CDC's National Center for Injury Prevention and Control invites research proposals aimed at reducing suicide and interpersonal violence among youth aged 10 to 24. This funding opportunity encourages the evaluation of pre-existing primary prevention strategies that have not yet been rigorously assessed. Proposed approaches may include community programs and policies designed to enhance social connectedness, mitigate harmful online behaviors, and address technology-facilitated interpersonal violence.

The Juliette Low’s Amazing Girls Scholarship, established in 2011 by the East Texas Communities Foundation, is aimed at female graduating seniors from Smith County who have been active in Girl Scouts. This scholarship supports educational pursuits for students attending any college in the U.S. Applicants must demonstrate financial need and have a minimum GPA of 3.00. The award amount is $1,000, and preference is given to recipients of the Girl Scout Gold Award. Reapplication is encouraged.

The Reproductive Scientist Development Program (RSDP) aims to enhance maternal and infant health by supporting early-career researchers in obstetrics and gynecology. This program encourages applicants committed to advancing their careers in academic research. With a focus on health equity and the training of scholars, RSDP seeks to foster impactful research proposals that address critical issues such as prematurity and maternal morbidity. Funded by the March of Dimes and other organizations, it empowers diverse talent in the field.