Best Small Grants for Nonprofits in Puerto Rico

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Charles and Melva T. Owen Memorial Scholarships

First established by Charles Owen in loving memory of his blind wife, these two awards are now endowed to honor the memory of both. In founding these scholarships, Charles Owen wrote: "There shall be no limitation as to field of study, except that it shall be directed toward attaining financial independence.”

This funding opportunity invites applications for investigator-initiated clinical trials that deliver complementary and integrative health interventions remotely or via mobile health technologies. Emphasizing no in-person contact, the trials should demonstrate feasibility, safety, and potential clinical benefits. A Plan for Enhancing Diverse Perspectives is required for submission, and applicants are encouraged to consult with NCCIH contacts before applying. Deadlines for submissions range from February 2025 to October 2026.

The Institutional Training Programs to Advance Translational Research on Alzheimer's Disease and AD-Related Dementias aim to cultivate a diverse workforce skilled in translational research. This initiative supports predoctoral and postdoctoral researchers from various educational backgrounds, including data science and clinical research. By fostering interdisciplinary training, the program equips trainees with essential knowledge in disease biology and drug discovery, ultimately enhancing the research capabilities for Alzheimer's and related dementias.

The Howard Fellowships, administered by the George A. and Eliza Gardner Howard Foundation, support early mid-career artists and scholars with $40,000 awards for independent projects in selected fields. This unrestricted, non-residency fellowship encourages significant creative development and public visibility through exhibitions or publications. Applicants should demonstrate a promising program of work and must currently reside in the U.S. or its territories. Ten fellowships are awarded annually, promoting artistic and intellectual advancement.

The Bill Kane Undergraduate Scholarship, awarded by SHAPE America, provides $1,000 annually to undergraduate students majoring in school-based health education at accredited institutions in the U.S. or territories. Eligible candidates must be full-time students with a GPA of at least 3.25. Alongside the scholarship, recipients receive a complimentary one-year membership with SHAPE America, promoting professional development in health and physical education.

This funding opportunity invites applications for investigator-initiated clinical trials focused on complementary and integrative health interventions delivered remotely or via mobile health technologies. The trials must be fully powered, with no in-person contact, and require justification for this approach. Preliminary data on feasibility and safety must be provided, alongside evidence of clinical benefit. A Plan for Enhancing Diverse Perspectives is mandatory for submission. Key deadlines range from February 2024 to June 2026.

The NIH grant focuses on elucidating the role of transporters in key perinatal barriers such as the placenta and blood-brain barrier. By establishing a multi-barrier transport network, the initiative aims to enhance understanding of maternal and infant health regarding nutrient and medication transport. This research will create essential resources and standards, fostering future studies on perinatal exposure and intervention strategies. Ultimately, it aims to advance knowledge in pediatric pharmacology and neurodevelopment.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) invites applications for mid-phase clinical trials involving natural products like botanicals and dietary supplements. The goal is to advance clinical testing through robust preliminary data, ensuring these products demonstrate measurable impacts on target engagement. Submission deadlines span from March 2024 to October 2026. Applications must focus on optimizing doses and identifying patient responders to inform future efficacy trials, aligning with NCCIH's research priorities.

The BRAIN Initiative invites proposals for innovative devices aimed at recording and modulating the human central nervous system. This program supports efforts in developing therapeutic and diagnostic devices through clinical prototype implementation, safety testing, and small clinical studies. The goal is to gather critical data on device functionality and design, which may not be achievable through traditional non-clinical studies. This initiative requires NIH collaboration in project planning and progress monitoring.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Hershey Heartwarming Young Heroes GYSD Grant supports youth-led projects for Youth Service Month and Global Youth Service Day. Open to U.S. and Canadian youth aged 5-25, grants of $250 or $500 are available, depending on volunteer engagement. Projects should address community needs and foster inclusivity among diverse youth volunteers. Successful applications will partner with local organizations and focus on relationship-building. A total of $50,000 in grants will be awarded, encouraging meaningful community service.

The NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) promotes innovative clinical trials on natural products, such as botanicals and dietary supplements. This funding opportunity supports studies that demonstrate significant scientific rationale and preliminary evidence for efficacy. Applications can explore various delivery methods and combinations with existing treatments to enhance outcomes. Funding is available for up to three years, aimed at bridging basic science discoveries into practical clinical applications.

The Express Health Information Outreach Awards aim to enhance public health by increasing access to biomedical information for U.S. health professionals and the general public. These awards support projects that improve health information literacy among consumers and caregivers, ensuring they can effectively find and utilize health information. Focused on partnerships and outreach to underrepresented communities, the initiative seeks to promote healthy behaviors, prevent illness, and improve health outcomes through informed decision-making.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award supports investigator-initiated clinical trials of natural products, including botanicals and dietary supplements. This funding opportunity aims to validate the pharmacokinetics and bioavailability of these products over three years in a phased approach. Successful trials will provide crucial data for further development and clinical application, emphasizing the importance of scientifically driven research in natural product efficacy.

The Leukemia & Lymphoma Society's Equity in Access Research Grants aim to enhance equitable access to care for blood cancer patients and survivors. This program funds research to identify effective interventions that increase participation in clinical trials among underrepresented groups. Projects can receive up to $500,000 annually for a maximum of five years, with a total budget cap of $2.5 million. The initiative seeks to address systemic barriers that hinder clinical trial enrollment and improve healthcare access.

The STEM + Families Science Festival, sponsored by Bayer Fund, is designed for elementary schools, providing $1,500 in funding to 40 selected PTAs. This initiative encourages hands-on STEM experiences for students and their families, fostering engagement and exploration in science. To qualify, PTAs must conduct in-person events within a 55-mile radius of designated regions. This program emphasizes the importance of connecting families through fun and educational STEM activities.

The BRAIN Initiative aims to support clinical studies that advance next-generation devices for recording and modulation in the human central nervous system. This initiative encourages small clinical trials to gather crucial data for developing devices that address central nervous system disorders. Investigators are invited to explore both Non-Significant and Significant Risk studies to enhance understanding of brain function, paving the way for future clinical trials and market approval.

The Innovation Grants to Nurture Initial Translational Efforts (IGNITE) support the development of assays and screening processes to identify potential therapeutic agents for neurological disorders and non-opioid analgesics. Sponsored by the NIH, this initiative seeks to foster collaborations and projects that utilize innovative methodologies. Although applications are not currently being solicited, interested parties are encouraged to prepare meaningful proposals that align with the goals of the NIH Helping to End Addiction Long Term initiative.

The NIA Academic Leadership Career Award (K07) provides funding for established investigators to strengthen research capacity in aging and Alzheimer's Disease. The program supports the development of educational infrastructure, mentorship, and career development activities. Key deadlines for applications include February 12, June 12, and October 12 from 2025 to 2027. This award is specifically for research not involving independent clinical trials, allowing applicants to gain experience in trials led by others.

The Rooted Pathways Program, initiated by First Peoples Fund, offers essential support to Native-led arts organizations, fostering their growth and stability. This funding empowers these organizations to thrive in their missions, providing unrestricted operating support and participation in a Learning Cohort. Eligible applicants include Native nonprofits and collectives with budgets under $500,000, and the program aims to uplift artists from U.S. federally recognized tribes. This initiative is part of the Wallace Foundation's broader commitment to enhancing well-being in the arts.

The RFA-FD-23-001 funding opportunity aims to support clinical trials for orphan products targeting rare diseases. It focuses on evaluating the efficacy and safety of treatments to address unmet medical needs. By promoting innovative and collaborative trial designs, the FDA seeks to enhance the approval rates of effective therapies for rare conditions, ultimately benefiting patients and advancing drug development in this critical area.

The FY26 Reconstructive Transplant Research Program Concept Award encourages innovative research addressing critical issues in reconstructive transplantation. It supports groundbreaking concepts and untested theories, emphasizing creativity and relevance to specific focus areas. Notably, preliminary data presentation is prohibited, yet applications must demonstrate potential for interpretable results. Early-career investigators are particularly encouraged to apply, fostering new talent in this vital research field.

The NIDCD Research Fellowship for Audiologists provides clinical audiologists enrolled in Ph.D. programs with essential research training. This initiative encourages the integration of clinical and translational research, fostering strong research foundations vital for advancing audiology and hearing healthcare. Although applications are not currently being solicited, the program aims to prepare potential candidates for meaningful collaborations and impactful research projects in the biomedical, behavioral, or clinical sciences.

The NIDCD Mentored Career Development Award for Postdoctorate Au.D./Ph.D. Audiologists (K01) aims to foster the development of promising audiologists through comprehensive postdoctoral research experiences. This funding opportunity supports individuals in biomedical, behavioral, or clinical sciences, helping them become independent researchers. The deadlines for applications span from June 2024 to May 2027, ensuring ample time for preparation and submission.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

Gabby's Dream Scholarship honors the memory of Gabriella Garven, who tragically passed away but chose to be an organ donor, saving five lives. This scholarship aims to support Muskingum County high school seniors pursuing higher education. Applicants must maintain a GPA of 3.5 or higher and demonstrate involvement in extracurricular activities. By providing financial assistance, this scholarship helps students achieve their dreams, reflecting Gabby's spirit of kindness and generosity, and empowering them to make a positive impact in their communities.