Best Large Grants for Nonprofit Organizations in Puerto Rico

Nonprofit 501(c)(3) organizations in Puerto Rico supporting children, education, or health and human services can seek monetary support for community programs. Costco Foundation supports these efforts by funding projects that demonstrate clear community need, measurable outcomes, collaboration, and a broad base of financial support, with applications typically reviewed within 4–6 weeks.

The Creag Foundation, established in 2009 in Woodinville, Washington, provides funding to innovative 501(c)(3) nonprofit organizations addressing social issues. Focused on smaller organizations, the foundation seeks to support those with unique approaches to improve the human condition. Eligible applicants must have held 501(c)(3) status for at least one year and present a new or previously unaddressed solution to societal challenges. Applications are by invitation only, encouraging creativity and passion in charitable work.

Early-stage nonprofit and impact-driven for-profit organizations tackling major social or environmental challenges can access up to US $300,000 from Draper Richards Kaplan Foundation to scale proven solutions. Grants from Draper Richards Kaplan Foundation help Puerto Rico and global social impact ventures grow capacity, refine models, and expand reach to underserved communities.

Nonprofit and nongovernmental organizations using technology to tackle education, crisis response, economic empowerment, or climate resilience can apply for Cisco Systems Foundation’s Global Impact Cash Grants, offering up to US $100,000. Puerto Rico organizations serving mostly economically underserved communities with innovative, scalable programs may be eligible and can submit letters of inquiry year-round.

Educational institutions, government programs, 501(c)(3) nonprofits, and 501(c)(4) volunteer fire companies in Puerto Rico can apply for community safety, education, and development funding from State Farm Companies Foundation. Grants support auto and home safety, disaster preparedness and recovery, affordable housing, financial literacy, food insecurity, workforce readiness, and K–12 and higher education initiatives across the U.S.

Nonprofit cultural institutions in Puerto Rico offering arts, arts education, or science programs for U.S. audiences can seek more than US $100,000 to support program, capital, or limited general support needs. With a mission to help people build healthy, productive lives, William Randolph Hearst Foundation prioritizes large, well-established organizations serving broad populations, especially in arts education, artist development, and STEAM initiatives.

Nonprofit organizations in Puerto Rico tackling chronic poverty and related social and economic challenges can apply for more than US $100,000 to support program, capital, or general operations. With a mission to strengthen social services, William Randolph Hearst Foundation prioritizes scalable efforts in areas like affordable housing, food access, job training, legal aid, reentry, and youth development.

Puerto Rico 501(c)(3) nonprofits focused on health, education, or community services can seek funding for programs like food pantries, healthcare access for underserved populations, STEM education, and preventive health initiatives. Focused on community well-being, Labcorp Charitable Foundation invites eligible organizations to apply during its March and September review cycles.

Nonprofits and social enterprises working on education, children’s health, or family economic stability projects can access funding of more than US $50,000 for project support or scaling in Puerto Rico and other eligible locations. Grants from Michael & Susan Dell Foundation prioritize initiatives serving urban low-income children and youth in the U.S., India, and South Africa.

Nonprofit organizations running humanitarian, social, education, or community programs in Puerto Rico or serving U.S. communities can seek charitable donations and sponsorships to support their initiatives. Amgen Foundation provides funding to eligible 501(c)(3) public charities, qualified Puerto Rico charities, and U.S.-based governmental entities for charitable and educational purposes.

Puerto Rico nonprofit organizations and public schools serving children and youth through education, healthcare, or human services programs can access funding through Oriental Trading Company. Eligible applicants must be 501(c)(3) organizations or public educational institutions focused on improving the lives, health, and academic success of children and youth, which may benefit local large-scale initiatives.

Accredited charities in Puerto Rico working on humanitarian, education, community, environmental, or contemporary arts projects can apply for Roche’s corporate donations program to support high-quality, sustainable initiatives. Projects should allow use of Roche expertise, engage local affiliates and employees, and be managed locally within Puerto Rico through the relevant Roche office.

Nonprofit organizations providing health, education, or humanitarian services to marginalized communities can apply for grants that support healthcare access, disaster relief, and social services. Grants from Semnani Family Foundation help Puerto Rico nonprofits and other international organizations deliver medical care, child and women’s health programs, literacy initiatives, and emergency relief where needs are greatest.

U.S.-based 501(c)(3) organizations conducting charitable, scientific, medical, or educational work can apply for the Sidney Stern Memorial Trust’s national funding; awards support projects carried out within the U.S. Puerto Rico nonprofits that meet these criteria and operate qualifying programs may be eligible for this broadly focused support.

Nonprofits, NGOs, and institutions with annual budgets of at least $2M in Puerto Rico can apply for TED’s Audacious Project to scale bold, proven solutions to urgent global challenges. Eligible changemakers may receive multi-year philanthropic support, strategic idea shaping, and visibility for initiatives in areas like health, climate, social justice, and education.

The Zegar Family Foundation Grant, established in 2007, focuses on improving lives through impactful charitable donations. The foundation prioritizes areas such as environment, justice, human rights, science, education, and community development. While unsolicited proposals are not accepted, the foundation remains open to innovative ideas that align with its mission. Through targeted support, it aims to create lasting positive change in communities and promote social equity.

The Journey For Good Grant aims to combat poverty by supporting charitable organizations in North America focused on food security, housing, education, and workforce development. The grant prioritizes initiatives that provide nutritional wellness, combat homelessness, and support veterans and their families. By fostering partnerships among nonprofits, government, and business, the foundation addresses the interconnected challenges faced by economically vulnerable individuals, creating sustainable solutions for community empowerment.

Puerto Rico 501(c)(3) nonprofits and aligned for-profit organizations can access funding to tell impactful stories about their work through the Storytelling Grant, which supports projects across preservation, education, and wellness. Large grants of more than US $50,000 from Jesse W Couch Charitable Foundation may benefit wildlife conservation and related initiatives.

Southern U.S. 501(c)(3) public charities with at least three years of activity can seek single-year program funding for humanitarian, family, education, health, and related services from the Robinson Foundation. Organizations in Puerto Rico working in areas like poverty relief, disaster response, children and families, or medical assistance may be eligible if they meet the regional and mission criteria.

Nonprofit 501(c)(3) organizations near TJX locations that support basic needs, at-risk youth, or domestic violence services in Puerto Rico and beyond can seek grants for program support. With a mission to help vulnerable families and children build better futures, TJX Foundation provides funding for basic needs, education and training, patient care, and empowering women.

Puerto Rico 501(c)(3) nonprofits developing multifamily permanent supportive housing for low-income veterans can access funding through THDF for new construction or rehabilitation hard costs. Grants of US $100,000 - US $500,000 support projects where at least 20% of units are reserved for veterans and long-term veteran occupancy is contractually ensured.

U.S.-based 501(c)(3) nonprofits, schools, religious organizations, government agencies, and qualifying civic, youth, and veterans groups in Puerto Rico can apply for J.B. Hunt Transport Services’ Company Giving to support health care, veterans’ services, education, or crisis management projects. Organizations must demonstrate at least two years of community-focused programming and responsible financial practices.

The Robert F. Schumann Foundation Grant supports organizations dedicated to environmental sustainability, education, and the arts. Founded by Robert F. Schumann, an environmentalist, the foundation aims to enhance the quality of life for both humans and animals. It prioritizes projects that would not have been pursued without its assistance, particularly in ornithology and open space habitats. Organizations must be 501(c)(3) exempt to apply, ensuring a focus on impactful community initiatives.

Nonprofit 501(c)(3) organizations serving underserved communities in Puerto Rico with programs in economic stability, workforce development, health and social services, or disaster relief may be eligible for project, operating, or capital support. With a mission to improve quality of life, O'Reilly Automotive Foundation provides funding in communities where O’Reilly Auto Parts has a business presence.

Nonprofit 501(c)(3) organizations in Puerto Rico working on youth education, food security, housing, or environmental stewardship can receive US $30,000 - US $350,000 in program support. Chick Fil A Foundation’s True Inspiration Awards back initiatives for underserved youth and their families, including leadership development, hunger relief, family services, and community or environmental projects.

Consultants and evaluation firms in Puerto Rico can apply for Enterprise Community Partners’ RFP to provide program evaluation and related services, including quantitative and qualitative analysis, training, and reporting support. Those with experience in equitable and affordable housing, community development, or data systems may be especially competitive for this national, as-needed contract opportunity.