Best Small Grants for Nonprofits in Puerto Rico

This funding opportunity aims to advance mechanistic research on precision probiotic therapies through a phased R61/R33 award mechanism. The initiative supports innovative studies identifying unique host characteristics that influence probiotic responses, addressing the variability in clinical outcomes. By focusing on person-specific features, the goal is to enhance the effectiveness of probiotics and overcome barriers to treatment success, ultimately leading to tailored probiotic interventions that better meet individual health needs.

The Research Scholar Grants (RSG) by the American Cancer Society support independent researchers engaged in cancer-related studies. Eligible applicants must be affiliated with US academic institutions and have been appointed as independent faculty for less than ten years. Grants provide funding up to $215,000 annually for direct costs and allow for 10% indirect costs, with project durations of up to four years, fostering innovative cancer research across various priority areas.

The ACS Professor Award, presented by the American Cancer Society, recognizes full professors who have significantly advanced cancer research. This honorific award aims to support innovative pursuits in cancer research with a budget of up to $80,000 per year for five years. Applicants are expected to demonstrate impactful contributions and leadership in the field, along with a commitment to mentorship and community engagement. The award highlights the importance of ongoing advocacy and research in improving cancer treatment and prevention.

The National Cancer Institute's PAIRS program aims to explore innovative cancer therapies by leveraging synthetic vulnerabilities that interact with tumor responses to radiation therapy. This initiative supports the development of targeted drug-radiation combinations, focusing on precision medicine to optimize treatment efficacy while minimizing harm to normal tissues. By consolidating prior funding opportunities, PAIRS encourages research that addresses context-dependent vulnerabilities, enhancing therapeutic strategies and aligning with NIH's scientific goals.

The NEI Center Core Grant for Vision Research aims to enhance research infrastructure and support collaborative studies among NEI R01-funded investigators. By combining multiple Resource and Service Cores, this grant promotes cost-effective research and productivity through shared facilities and resources. It is designed to bolster an institution's capabilities in vision research, encouraging innovative studies on the visual system and its disorders while adhering to the NEI's mission and Strategic Plan.

The Cancer Center Support Grants (CCSGs) aim to bolster NCI-Designated Cancer Centers by funding comprehensive, clinical, and basic cancer research. These grants facilitate the integration of diverse research capabilities, promoting innovative approaches to cancer prevention, diagnosis, and therapy. CCSGs encourage collaboration among researchers and the development of Shared Resources, ultimately enhancing the understanding of cancer and its treatment. This initiative supports the continuous discovery and dissemination of crucial research findings for community benefit.

The National Cancer Institute (NCI) invites research applications focused on early-onset cancers (ages 18-49), aiming to uncover their etiology and biological mechanisms. This funding opportunity supports studies that explore modifiable risk factors, biological responses, and improved identification of at-risk individuals. The initiative seeks to address the concerning rise in these cancers among young adults, facilitating essential prevention and control strategies. Applicants can choose between exploratory or research project formats, with project durations ranging from 2 to 5 years.

The National Cancer Institute's STRIPE program aims to advance cancer therapy by investigating the effects of radionuclide-emitted radiation. This initiative encourages multidisciplinary research to understand how radiation impacts normal tissues and tumor cells, ultimately improving therapeutic outcomes. By consolidating various funding mechanisms, STRIPE seeks to lower entry barriers for researchers, enhance the scientific foundation of radiopharmaceutical therapy, and foster innovative treatment strategies. Projects can be exploratory or research-focused, with flexible timelines for completion.

The National Institutes of Health (NIH) invites applications for clinical trials and ancillary studies within its funded research networks. This program supports multi-center trials, emphasizing collaborations and responsive projects. The UG3/UH3 cooperative agreement will fund an initial 2-year planning phase, with a potential 5-year implementation phase. This notice is to prepare applicants for future submissions, as applications are currently not being solicited. Prioritization will be given to studies aligned with network capabilities.

The Family-to-Family Health Information Centers (F2F HIC) program, funded by the US HHS: Health Resources & Services Administration (HRSA), aims to empower families of children and youth with special health care needs (CYSHCN). By providing crucial information, education, and peer support, the program helps families navigate complex health systems to access necessary services, ultimately enhancing the health and well-being of CYSHCN and their families.

Southern SARE offers Graduate Student Grants to support Master’s and PhD students engaged in sustainable agriculture research. This initiative encourages impactful research across various topics, including production, marketing, and social sciences. By providing funding opportunities, Southern SARE aims to foster the next generation of researchers committed to advancing sustainable agricultural practices throughout the Southern region.

The Francis Grants, established by Catholic Extension, offer funding for significant events in poor mission dioceses, such as the ordination of new Bishops, anniversaries, or papal visits. These grants also support educational endeavors for Bishops. Named in honor of Francis Clement Kelly, Francis Cardinal George OMI, and Pope Francis, the program aims to strengthen the Catholic faith across the U.S. Since 1905, Catholic Extension has invested over $500 million to assist communities in need.

The Fiscal Year 2027 Regional Nutrition Hubs initiative by the US HHS aims to enhance nutrition services across regional health centers. By providing targeted technical assistance, the program seeks to improve health outcomes through effective nutritional interventions. This initiative supports HRSA's mission to expand access to high-quality healthcare services, ultimately benefiting communities by addressing dietary needs and managing health conditions. With a focus on collaboration, the program is set to strengthen the health infrastructure at the local level.

The Building Capacity Grants by Catholic Extension aim to enhance the financial and operational capabilities of dioceses. This initiative focuses on funding projects that promote efficiency, financial stability, and effective fiscal management, ultimately fostering a self-sustaining community. Eligible programs include fundraising development initiatives and operational assessments, ensuring resources are utilized efficiently while supporting professional development for church leadership. This grant empowers dioceses to strengthen their foundations for future growth.

The Engaging Young Catholics Grants aim to support ministries that provide faith formation to children, teens, young adults, and families. By focusing on the pastoral needs of young Catholics, the program enhances community vibrancy and fosters new leadership within the church. Catholic Extension prioritizes operational support and seed funding for initiatives that develop youth and young adult ministries, ensuring that dioceses can effectively reach and engage younger generations in their faith.

The Building Leaders Grants by Catholic Extension aim to enhance the recruitment, education, and ongoing formation of church leaders. This initiative provides critical funding for the professional development of both ordained and lay leaders in mission dioceses. By fostering partnerships with various organizations, it addresses the need for trained ministers and supports various funding areas, including seminarian sponsorship and diaconate formation, ensuring a robust future for church leadership.

The Building Foundation Grants by Catholic Extension aim to support essential pastoral and administrative functions in under-resourced communities. These grants provide salary subsidies and operational funding to ordained, religious, and lay ministers, ensuring access to Catholic services. Prioritizing areas with significant financial need, this initiative seeks to sustain the church's presence where it is most critical, enabling continued ministry and outreach for those who may otherwise be underserved.

Catholic Extension provides essential funding to support the construction, expansion, or renovation of churches and community facilities. This initiative aims to meet the facility needs of under-resourced Catholic dioceses across the U.S. By focusing on active projects, Catholic Extension ensures that communities can enhance their worship spaces and support local ministries, ultimately fostering a stronger church community. Funding is available for both minor and major requests, with an emphasis on urgent needs and robust funding strategies.

The Mission Program Grants: New Worshiping Communities Seed Grant offers up to $10,000 to support the establishment of new worshiping communities connected to the Presbyterian Church (USA). These grants focus on covering initial operational costs for the first year, including salaries and educational materials. Eligible applicants must be newly formed communities established after July 2010, located in the U.S. or Puerto Rico. This initiative fosters community growth rather than expanding existing congregations.

The Michael Masser Scholarship, established by the late composer Michael Masser, supports talented students in music. It offers $3,000 to recipients for educational advancement, with nominations made by ASCAP representatives. Eligible nominees must demonstrate exceptional talent in music composition or performance and be entering a collegiate music program. This scholarship aims to foster the next generation of music creators and enrich the arts community through financial assistance.

The FY 2027 DURIP program invites universities to submit proposals for purchasing essential research equipment and instrumentation that aligns with the Department of War's research priorities. This initiative aims to enhance educational experiences through research in fields crucial to national defense, supported by agencies such as the Army Research Office, Office of Naval Research, and Air Force Office of Scientific Research. Proposals should demonstrate the potential impact on student education and research capabilities.

The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.

The CDC's initiative focuses on developing clinical decision support (CDS) tools for cancer screening and management, specifically for cervical, breast, and colorectal cancers. The project aims to enhance guideline-concordant screening and improve management processes through rigorous implementation and evaluation within large health systems. By integrating these tools into electronic health records, the initiative seeks to support clinicians in making evidence-based decisions at the point of care, ultimately improving patient outcomes in cancer care.

The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.

This research study, funded by the Bureau of Consular Affairs, aims to investigate the effects of international parental child abduction (IPCA) on both abducted children and their left-behind parents. Key objectives include identifying the psychological, developmental, and social impacts of IPCA, pinpointing supportive gaps in the U.S., and recommending effective solutions to enhance support for affected families.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.