Best Small Grants for Nonprofits in Puerto Rico

The FY26 Orthopaedic Research Program Clinical Research Award supports vital clinical research addressing orthopaedic-specific factors and interventions. It aims to generate evidence that optimizes patient outcomes and informs clinical care, benefiting Service Members, Veterans, and the public. Applications should focus on priority areas such as Ligamentous Trauma and Military Women’s Health, ensuring significant impact on patient care and mitigation of orthopaedic injuries.

The DoW Orthopaedic Applied Research Award supports innovative research aimed at improving treatment and functionality for individuals with combat-related orthopaedic injuries. Applicants are required to present preliminary data and focus on applied research that evaluates new solutions, including pharmacologic agents and rehabilitation techniques. This initiative emphasizes the importance of military relevance, aiming to benefit Service Members, their families, and Veterans, while clinical research proposals are not permitted.

The Limited Competition: Biomedical Research Environment & Sponsored Programs Administration Development (BRE-SPAD) Program aims to enhance the research capacity of resource-limited institutions. By focusing on essential areas like biomedical research environment and sponsored programs administration, this initiative seeks to foster rigorous and reproducible biomedical research. Eligible organizations are encouraged to submit proposals addressing their specific needs, thereby expanding the pool of qualified researchers and strengthening the settings for NIH-funded research.

The NIDCR is inviting applications for the continuation or revision of ongoing clinical trials through the UH3 Clinical Trial Required grant. This opportunity supports extensions for completing trials or longer follow-up periods, as well as revisions that are well justified. Key deadlines for submissions are set from March 2025 to January 2028, with optional Letters of Intent encouraged thirty days prior to application due dates. Ensure compliance with the outlined requirements to enhance your chances of funding.

The AAPD Foundation provides Access to Care Grants aimed at ensuring dental care is accessible for all children. As the largest dentist-led charity, it supports community programs that deliver essential dental services. With a focus on innovative ideas and effective grant utilization, the foundation works tirelessly to promote healthy smiles for every child. By partnering with pediatric dentists, it strives to make a meaningful impact in communities nationwide.

Bristol Myers Squibb Foundation Inc supports independent medical education to enhance healthcare professional competence and improve patient health outcomes. Their mission is to be a global leader in innovative medical education, focusing on evidence-based activities that address critical gaps in knowledge. By fostering excellence in healthcare, they aim to ensure measurable improvements in performance and patient outcomes across various disease areas.

The MPS Mathematical Sciences Research Programs (MPS MathSci) by the NSF supports diverse research initiatives in theoretical and applied mathematical sciences. Key areas include Algebra, Applied Mathematics, Combinatorics, and Mathematical Biology. The program encourages groundbreaking foundational research with flexible budgets and durations. Proposals do not need to promise immediate outcomes, allowing researchers to explore innovative concepts without the pressure of commercial viability.

PetSmart Charities' Adoption Prep Grants aim to support organizations that facilitate the adoption of homeless pets through in-store programs. Eligible partners must demonstrate a commitment to increasing adoptions, with grants reaching up to $75,000 in the U.S. and $40,000 in Canada. The funding can be utilized for vaccinations, spay/neuter services, staffing, and volunteer support. This initiative focuses on building sustainable adoption programs that break down barriers to pet adoption.

The National Foundation for the Centers for Disease Control and Prevention offers funding to support administrative expenses that bolster CDC's mission. This initiative enhances partnerships to address health threats both domestically and globally. Projects funded through this grant align with CDC's strategic goals, focusing on measurable outcomes such as program support and participation from various CDC Centers and Offices. Importantly, this grant only supports non-research activities.

The Infant-Toddler Court Program's National Resource Center (NRC) focuses on enhancing child welfare practices across the United States. By collaborating with courts, social services, and families, the NRC aims to improve the safety and healthy development of young children involved with the child welfare system. This initiative not only supports families but also fosters nurturing relationships essential for child growth and well-being, making it a crucial resource for communities.

The Raftelis Leadership Scholarship, offered by the American Water Works Association, supports undergraduate and graduate students pursuing a consulting career in water utilities. With a value of $5,000, this scholarship aims to foster relationships with diverse, promising students who demonstrate leadership and strong academic performance. Applicants from various academic backgrounds, including business and finance, are encouraged to apply, emphasizing initiative and a desire to contribute positively to the community.

The NIH Instrumentation Grant Program for Resource-Limited Institutions supports the acquisition of advanced scientific instruments. This initiative aims to bolster biomedical research capabilities and educational opportunities at institutions that typically receive limited NIH Research Project Grant funding. By facilitating access to modern technology, the program enhances research quality and fosters innovation in healthcare and related fields.

The Cellular Senescence Network (SenNet) aims to establish a Data Coordination and Integration Center (DCIC) to enhance data management and accessibility within the NIH Common Fund. This initiative focuses on the submission, harmonization, and dissemination of SenNet-generated data, ensuring high-quality integration and usability. The DCIC will support both Stage 1 and Stage 2 outputs, fostering organizational outreach activities and promoting cross-study comparability through robust data infrastructure and tools.

This Request for Information (RFI) seeks input on the urgent need for gigawatt-scale electricity generation and transmission due to rapid demand growth from data centers and advanced manufacturing. The U.S. electric grid faces significant challenges, including limited capacity and aging infrastructure, which could hinder timely interconnection of new energy sources. Stakeholders are invited to provide feedback on overcoming regulatory and operational barriers to meet this escalating demand.

The National Institutes of Health (NIH) is set to announce a Notice of Funding Opportunity (NOFO) for multi-site investigator-initiated clinical trials. This initiative aims to support a range of clinical trials addressing efficacy and implementation research. The funding mechanism includes a two-phase approach (UG3/UH3), with a total award duration of up to seven years. Investigators are encouraged to prepare proposals that demonstrate scientific rationale and operational plans for these important studies.

The Institute of Education Sciences (IES) supports state agencies in utilizing their longitudinal data systems to inform educational policies and program decisions. This grant aims to enhance access to high-quality education and improve academic performance among learners. By empowering local education agencies with data-driven insights, IES fosters evidence-based practices that can lead to significant advancements in educational outcomes. This initiative is essential for shaping effective education strategies across states.

The Wold Foundation Grant, established in 1985, aims to support charitable, scientific, literary, and educational projects primarily benefiting Wyoming citizens and youth. It prioritizes initiatives in education, human services, cultural activities, healthcare, and scientific endeavors that promote conservation and outdoor recreation. Eligible organizations must be 501(c)(3) classified and operate in the U.S. The foundation does not fund individuals or projects that discriminate based on sex, age, or religion.

The Institute of Education Sciences (IES) offers the Statistical and Research Methodology in Education grant (84.305D) to enhance education research through improved statistical methods and tools. This program invites applications focused on Core Grants for developing new methodologies or Toolkits for compiling existing research into user-friendly resources. The initiative aims to ensure these products are rigorously tested and disseminated widely to support effective education research practices.

The U.S. Department of Energy (DOE) plans to issue a Notice of Funding Opportunity (NOFO) titled "Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)." This initiative aims to support financial assistance applications from entities focusing on innovative chemical technologies that enhance supply chain resiliency and reduce costs. The program seeks to advance the production of chemicals from alternative and waste feedstocks, fostering domestic manufacturing and improving environmental safety.

Project Lead The Way Inc is offering a grant of $14,000 to schools looking to implement the PLTW Computer Science program for the first time. Schools must commit to offering PLTW Computer Science courses over the next three years, ensuring that at least one course is available in the first year. This funding will support program implementation costs, with awards distributed directly to PLTW accounts for eligible schools.

The Senior Chemists Mini Grant for Local Sections, offered by the American Chemical Society, is designed to support local events that engage senior members in innovative activities. Grants are available on a first-come, first-serve basis, and funding can be used for various events including recognition luncheons, mentoring for undergraduates, collaborative activities with younger chemists, and community support events such as science fairs.

The SESAPS Francis Slack Award, established by the Southeastern Section of the American Physical Society, honors individuals who have selflessly contributed to advancing physics in the Southeast. It recognizes efforts in enhancing research facilities, strengthening academic departments, and fostering regional physics organizations. Nominations remain active for three years, with a focus on encouraging women and minority candidates. This prestigious award commemorates the legacy of Francis G. Slack, a pivotal figure in the development of the Southeastern Section.

The MPS Materials Research Programs, funded by the National Science Foundation, aim to enhance the understanding of materials and their diverse applications. These programs cover areas such as biomaterials, ceramics, condensed matter physics, and electronic materials. With an emphasis on transformative research, NSF MPS encourages proposals that are innovative and foundational, without the necessity for immediate commercial outcomes, fostering long-term advancements in materials science.

The Alvah H. and Wyline P. Chapman Foundation offers grants to support charitable, educational, and community-focused initiatives, primarily in Florida and Georgia. Eligible applicants must be IRS-recognized 501(c)(3) organizations. The foundation prioritizes projects that address children's welfare, education, multicultural understanding, substance abuse prevention, and homelessness. Grants typically do not exceed $15,000, and proposals must be endorsed by a Foundation Director. Interested parties should submit a Letter of Inquiry for consideration.

The NSF National Innovation Corps (I-Corps) Teams program aims to bridge the gap between scientific research and marketable technologies. By providing NSF-funded researchers with entrepreneurial education, mentoring, and funding, it accelerates the transformation of foundational discoveries into viable products and services. Participants engage in hands-on customer discovery and business model assessments, leading to improved product-market fit and strategic partnerships. This initiative fosters collaboration between academia and industry, enhancing the commercialization of deep technologies.