Best Unrestricted Grants for Nonprofits in Puerto Rico

The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) aims to create a secure, scalable cloud platform for genetic data related to Alzheimer’s disease. This initiative will enhance data accessibility, promote interoperability, and support rigorous research practices. By facilitating collaboration and providing robust analytical tools, the platform will maximize the scientific impact of AD/ADRD research, aligning with NIH goals for transparent and reproducible science, while addressing recommendations for broad access to high-value datasets.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5430 - Unlocking Value and Opportunities from Carbon Flows in Water Utilities

Grant Information

• Identify carbon flows across drinking water, stormwater, wastewater, and advanced treatment systems. Carbon flows may include source water, stormwater, process emissions, process inputs, residuals, and biogas.
• Identify the most relevant carbon recovery, capture, conversion, storage, and avoidance opportunities.
• Evaluate value creation pathways, including products, avoided costs, and environmental attributes, and mechanisms and partnerships needed to put them into practice.
• Assess how opportunities vary across system types and local contexts by focusing on more common scenarios for utilities.
• Provide practical, research-based insights to support identification, prioritization, evaluation, and advancement of carbon management opportunities under site-specific conditions and constraints.
• Evaluate implications for greenhouse gas (GHG) accounting, environmental attribute claims, and other potential benefits across pathways.

The LFF: Nature-Based Climate Action Grant aims to support initiatives that leverage natural systems to combat climate change. By funding projects focused on tree planting, prairie restoration, and carbon sequestration, the program seeks to engage communities and enhance understanding of climate challenges. Ideal applicants include rural organizations working to create measurable environmental impacts while fostering collaboration and policy change. This grant represents an opportunity for organizations ready to take significant strides in addressing the climate crisis.

The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.

Our Work:

The Citi Foundation commits $20 million to help nonprofit housing developers overcome financial and operational barriers to building and preserving affordable housing in the U.S.

Apply for Funding

Citi Foundation primarily provides funding through open Requests for Proposals (RFP). This model enables us to engage and support a broad range of organizations across the globe to tackle some of the most pressing social issues of our time. Each RFP launched is accompanied by detailed information on goals, selection criteria and relevant application deadlines.

Housing Affordability

Citi's Blueprint for Housing Opportunity

Recognized as the number one affordable housing lender in the U.S. by Affordable Housing Finance magazine, Citi knows increasing supply is essential to addressing housing affordability — one of the defining economic challenges of our time. That’s why we are putting our capital, community impact and expertise toward helping more Americans access housing they can truly afford.

The FY26 Military Burn Research Program (MBRP) Technology/Therapeutic Development Award (TTDA) aims to translate promising preclinical findings into burn products for clinical use in challenging environments. This award supports the development of both tangible products, like medical devices, and knowledge products that enhance health outcomes. A new Mentorship Option encourages collaboration between experienced researchers and junior scientists, fostering the next generation of leaders in military burn care research.

The National Swine Resource and Research Center (NSRRC) is a pivotal resource that enhances biomedical research by providing genetically modified models. This centralized facility reduces variability and costs for researchers, allowing them to focus on scientific discovery. NSRRC offers breeding, cryopreservation, and genotyping services, ensuring consistent access to high-quality models. By consolidating these resources, it promotes reproducibility and supports the development of innovative methodologies in research, ultimately advancing our understanding of human health and disease.

The CareQuest Institute for Oral Health® is inviting proposals for school-based and school-linked initiatives aimed at improving oral health access for high-risk children. This grant opportunity seeks to address systemic barriers to oral health through innovative programs that engage schools and communities. Ideal projects may include workforce development, community engagement strategies, policy advocacy, and the use of technology. Proposals should focus on creating equitable oral health solutions that enhance both health and academic success for children and their families.

The CERF: Artist Get Ready Grant offers up to $1,000 to craft artists for safeguarding their studios and preparing for emergencies. Priority is given to underrepresented artists, including BIPOC and folk/traditional artists. Eligible activities encompass studio safety upgrades and disaster readiness. Applicants must be 18 years or older, residing in the U.S. for two years, and not have received this grant in the previous year. Funds must be used within six months, with outcomes documented for CERF+.

The Field Initiated Projects Program aims to foster new research and develop solutions that enhance the inclusion and independence of individuals with disabilities. This initiative focuses on generating scientific knowledge and understanding critical issues faced by these populations, particularly those with significant support needs. With a total of 16 grants available over a 36-month period, this program encourages innovative approaches that support employment, living arrangements, and caregiver involvement.

The FY26 Reconstructive Transplant Research Program (RTRP) Investigator-Initiated Research Award supports innovative studies aimed at enhancing reconstructive transplant research and patient care. It emphasizes projects with military relevance, focusing on all research phases from basic to clinical. Essential components include rigorous study design, preliminary data, and the potential for significant short- and long-term impacts on patients and the reconstructive transplant field.

The Climate Smart Communities Initiative (CSCI) Grant supports US-based projects aimed at enhancing community resilience against climate change. With a budget of $1.5-2 million, grants typically range from $75,000 to $115,000. CSCI prioritizes projects that focus on historically disinvested populations facing climate vulnerabilities, emphasizing equity, nature-based solutions, and community capacity building. The initiative encourages collaboration between climate adaptation practitioners and local government entities to address climate impacts effectively.

This funding opportunity invites applications for R01 grants focused on molecular imaging methods to explore cancer inflammation in vivo. It aims to enhance understanding of dynamic interactions between inflammation and cancer through innovative imaging techniques. The initiative encourages collaborations between cancer researchers and imaging scientists to leverage molecular imaging for identifying cellular physiology changes in response to treatment. Deadline dates for applications range from February 2025 to October 2027, emphasizing timely submission for prospective researchers.

The Laboratory Flexible Funding Model (LFFM) aims to enhance state food testing laboratories' capabilities, supporting an integrated food safety system. By prioritizing sample testing and food defense preparedness in microbiology, chemistry, and radiochemistry, this cooperative agreement facilitates method development and expands testing capacity, ensuring safer food for consumers.

The Traumatic Brain Injury Model Systems Centers aim to enhance TBI rehabilitation through evidence-based research. These centers focus on generating knowledge to improve health, community participation, and employment outcomes for TBI individuals. Funded by the US HHS Administration for Community Living, the grants support site-specific and collaborative research, contributing to a longitudinal database. Each center can receive varying funding amounts, depending on eligible database participants, with a project timeline of 60 months comprising five 12-month budget periods.

The BRAIN Initiative's BBQS Program aims to revolutionize the study of brain function by facilitating high-resolution tracking of complex behaviors alongside neural activity. This transformative research opportunity seeks to develop innovative tools for minimally intrusive measurements of various biobehavioral functions while accounting for environmental variables. Emphasizing transdisciplinary collaboration, it focuses on creating new analytical frameworks that model neurobehavioral function as dynamic systems influenced by an organism's surroundings, thereby advancing our understanding of behavior at the organismal level.

The ReFED Catalytic Grant Fund, managed by Refed Inc., supports innovative solutions to minimize food waste and reduce methane emissions, a cost-effective strategy for climate action. This fund prioritizes initiatives that enhance food recycling and improve supply chain efficiency in the beef and dairy sectors. By focusing on proven methods, the grant aims to accelerate impactful changes in the food system, ultimately fostering sustainable practices and collaborative efforts to combat food waste.

The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.

This funding opportunity aims to enhance the cancer surveillance workforce through education and support for certified Oncology Data Specialists. The initiative will improve the quality and completeness of cancer data collected by the National Program of Cancer Registries. By fostering collaboration and promoting the value of cancer surveillance data, this program seeks to empower public health actions, research, and policy-making, ensuring a robust response to current and future cancer-related challenges.

The National Network of STI Clinical Prevention Training Centers (NNPTC) aims to enhance the education and training of clinicians and disease intervention professionals in STI patient care. This initiative focuses on improving the ability of healthcare providers and systems to effectively diagnose, manage, and counsel individuals at risk for STIs, ultimately reducing morbidity and enhancing public health outcomes on both local and national levels.

The Autism Centers of Excellence (ACE) initiative, spearheaded by the Eunice Kennedy Shriver National Institute for Child Health and Human Development along with several other prominent institutes, aims to encourage innovative research projects. While applications are not currently open, potential applicants are urged to prepare collaborative proposals that leverage cutting-edge technologies. This funding opportunity, utilizing the P50 Research Program Projects and Centers activity code, seeks to build upon over two decades of research advancements.

The Autism Centers of Excellence R01 aims to advance research in autism through collaborative networks, enhancing the past 23 years of progress. This initiative encourages innovative methods and technologies, inviting experts to consider applying for future funding opportunities. Although applications are not currently solicited, potential applicants are urged to form meaningful collaborations. This funding opportunity reflects a commitment to improving research in autism, leveraging diverse scientific expertise to address critical challenges in the field.

The Albert G. and Olive H. Schlink Foundation, established in 1966, has significantly impacted Ohio's nonprofit sector by increasing its annual grant distribution from an initial $500 to over $1.4 million in 2023. The Foundation prioritizes organizations with ties to Erie and Huron Counties and emphasizes thoughtful evaluation of all grant applications. With a focus on community needs, it continues to honor the founders' legacy while adapting to the evolving demands of local nonprofits.

The Asian Cultural Council's New York Fellowship offers a transformative six-month program for artists, scholars, and arts professionals from Asia. Participants engage deeply with New York City's vibrant cultural landscape, attending performances, exhibitions, and workshops while building networks with local communities. This unique opportunity fosters peer-learning and individual artistic development, encouraging fellows to incorporate their experiences into their practices and contribute to their home cultures. The fellowship emphasizes exploration, exchange, and support, culminating in a rich cultural immersion.

The NIGMS Institutional Biomedical Undergraduate Research Training Program aims to enhance the training of undergraduate students in biomedical research. By supporting institutions with limited NIH funding, the program provides trainees with 2–3 years of full-time research training. This initiative fosters a skilled workforce prepared for advanced biomedical degrees, addressing national health-related research needs through comprehensive educational and developmental programs.

The Exploratory Grant Award aims to enhance workforce diversity in basic cancer research by supporting junior and Early Stage Investigators from underrepresented groups in the biomedical and social sciences. This initiative provides essential funding to bridge the gap for researchers completing their training, ensuring they have the resources needed to develop larger grant applications. Applications are due by 5:00 PM local time of the applicant organization, emphasizing the importance of timely submissions.

This grant aims to enhance cooperation and regulatory standards among animal food safety programs by funding national feed associations. It promotes inter-agency collaboration, strengthens state regulatory frameworks, and supports the Animal Feed Regulatory Program Standards (AFRPS). By leveraging resources and aligning with federal and state initiatives, the program seeks to improve animal food safety and ensure comprehensive surveillance and protection.