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Best Unrestricted Grants for Nonprofits in Puerto Rico

Find the perfect Unrestricted grants for nonprofits in Puerto Rico on Instrumentl. 9,000+ Unrestricted grants for nonprofits in Puerto Rico in the United States.

9,000+

Available grants

$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

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8,956 Results based on applied filters

DoW Joint Warfighter Medical, Military Medical Research and Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
US $1,400,000 - US $3,000,000
The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.
Military Operations

Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required) (353747)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Mentored Clinical Scientist Research Career Development Award (K08) supports individuals with clinical doctoral degrees to develop their research careers in biomedical and behavioral fields. This program emphasizes a structured mentoring approach, aiming to address the nation's health-related research needs. Key application deadlines include June 12, 2024, and October 12, 2024, among others, providing opportunities for both new and renewal submissions.
Medical Education & Professional Training Biology Health & Medicine

DoW Rare Cancers Idea Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $490,000
The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.
Cancer / Oncology

BURGER KING Scholars: Nancy McLamore Scholarship

Burger King Mclamore Foundation Inc
Private
Guam, Puerto Rico +1 more
US $1,000 - US $5,000
The BURGER KING Scholars: Nancy McLamore Scholarship offers $20,000 to deserving students, focusing on employees and their families. Administered by Scholarship America, it supports U.S. citizens graduating from high school or pursuing higher education. With over $64 million awarded to 55,000 students, the program emphasizes empowerment through education, reflecting the values of the Burger King Foundation. Eligible applicants must meet specific criteria, ensuring support for those committed to their educational journey.
Education - Higher Education Academic Scholarship Programs

Translational Centers Using Microphysiologic Systems for Infectious Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.
Infectious & Parasitic Diseases

External Collaborative Research Grants

Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) - BI Cares Foundation
Corporate
United States
Unspecified amount
The External Collaborative Research Grants by Boehringer Ingelheim support academic and clinical scientists in proposing research studies. These grants facilitate collaboration with Boehringer Ingelheim, which may provide intellectual and financial support. Applicants must assume full responsibility for their research while complying with regulatory standards. The funding should cover research costs, excluding salary support for the collaborative partner. Interested investigators must apply online for consideration.
Cancer / Oncology Diabetes Interstitial Lung Disease +2 more

Improving Linkage to Care for People with Opioid Use Disorder (U01)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $550,000
The CDC's NCIPC is seeking research proposals to tackle implementation challenges in providing linkage to care services for individuals with opioid use disorder (OUD). This initiative encourages partnerships with public health entities and local healthcare champions to create actionable, evidence-based strategies. The goal is to enhance care access and ensure comprehensive overdose prevention services are available in real-world healthcare settings, thereby improving outcomes for those at risk of opioid overdose.
Addiction & Substance Use Disorders Health Care Access & Delivery

National Meredith Willson Awards

The Meredith And Rosemary Willson Charitable Foundation (aka The Music Man Foundation)
Private
American Samoa, Guam +4 more
US $100,000 - US $1,000,000
The National Meredith Willson Awards provide multi-year operating support to organizations using music for systemic change. The Music Man Foundation will award grants of $50,000 to $500,000 to 5-10 selected organizations in 2026, focusing on their impact through music. Eligible organizations must have 501(c)(3) status, a history of music programming, and a commitment to systemic change. Applications will be evaluated on leadership, organizational capacity, and alignment with grant criteria.
Music Education

NIDCR Mentored Career Development Award to Promote Broad Participation in Research (K01 Independent Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $625,000
The NIDCR Mentored Career Development Award aims to enhance the dental, oral, and craniofacial research workforce by supporting postdoctoral fellows and early career faculty. This grant provides essential salary and research support for a sustained period, enabling intensive research career development under the mentorship of experienced professionals. Applicants should be aware of upcoming deadlines for both standard and renewal applications, which span from February 2025 to November 2027, ensuring ample opportunity for participation.
Dental Health Medical Education & Professional Training

BRAIN Initiative: Development and Validation of Novel Tools and New Approaches for Neuroscience Research

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.
Neuroscience

TIP Office International Programs to Combat Human Trafficking Annual Program Statement (362906)

US Department of State: Office to Monitor and Combat Trafficking in Persons
Federal Government
American Samoa, Guam +4 more
US $1,000,000 - US $10,000,000
The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.
Human Trafficking

TACF Small Grants Program

American Chestnut Foundation (TACF)
Private
United States
Up to US $10,000

About The American Chestnut Foundation:

Our mission is to return the iconic American chestnut to its native range.

Our vision is a robust eastern forest returned to its splendor.

Small Grants Program

Are you looking for funding to support your American chestnut research? External small grants offer recipients a variety of benefits such as professional development and an expanded network. Grant activities contribute to the continuous renewal and development of faculty and staff, to the education and motivation of students, and achievement of our mutual interest — restoration of the American chestnut. This is a small grants program. TACF does not ordinarily fund projects in excess of $10,000.

Plant Pathology Forestry Plant Genetics & Physiology +2 more

Emergency Community Water Assistance Grants in Puerto Rico

USDA: Rural Development (RD)
Federal Government
Puerto Rico
Up to US $1,000,000
The Emergency Community Water Assistance Grants in Puerto Rico aim to assist eligible communities in preparing for or recovering from emergencies that threaten safe drinking water. Events qualifying as emergencies include droughts, floods, and chemical spills. The grants can be used for constructing water sources or repairing existing water distribution lines, with funding up to $1 million. This program is vital for ensuring access to clean water in rural areas following disasters.
Sanitation & Clean Drinking Water

Limited Competition: Supporting Programs to Advance Research Knowledge in Environmental Health Sciences (SPARK-EHS) (UE5/T32 - Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $20,000
The SPARK-EHS initiative aims to broaden the reach of NIEHS training by launching innovative environmental health programs for predoctoral trainees at institutions without recent NIEHS T32 funding. This initiative focuses on research regarding the impact of the environment on biological systems and seeks to translate findings into practical health solutions. Eligible institutions will receive support for developing and implementing these targeted training programs, fostering advancements in environmental health research.
Environmental Health

DoW Rare Cancers Resource and Community Development Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $1,120,000
The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.
Cancer / Oncology

NIOSH Centers of Excellence for Total Worker Health® (U19) (363369)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $1,400,000
The NIOSH Centers of Excellence for Total Worker Health® (U19) aims to enhance worker well-being by funding research and translation activities that address harmful exposures and improve working conditions. Priority areas include high-risk occupations, young workers, and chronic diseases. The initiative emphasizes strong project coordination, scientific rigor, and economic evaluations. Projects must utilize the NIOSH Worker Well-Being Questionnaire and share findings with the HERO Clearinghouse, fostering innovative solutions for employers and workers.
Occupational Health & Safety Workers’ Rights

Asian Cultural Council: Graduate Fellowship

Asian Cultural Council Inc
Private
United States
US $15,000
The Asian Cultural Council's Graduate Fellowship provides financial support for travel and living expenses to graduate students from Asia studying in the U.S. It offers $15,000 for one academic year, potentially renewable for another year, covering essential costs while pursuing full-time coursework. This initiative fosters international cultural exchange and enhances academic training in the arts. Eligible applicants must be enrolled full-time in accredited graduate programs and commit to at least two consecutive semesters of study.
Art Conservation Archaeology Museums & Cultural Institutions +9 more

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
US $25,000,000
The National Cancer Institute (NCI) is inviting applications for the Specialized Programs of Research Excellence (SPOREs) in Human Cancers for 2027-2029. This funding opportunity supports innovative translational research aimed at improving prevention, detection, and treatment of organ-specific cancers. Eligible projects may address related cancer types from the same organ system or focus on common biological mechanisms. The program emphasizes research that translates findings into clinical applications, with the goal of achieving a human endpoint during the grant period.
Cancer / Oncology

MPS Astronomical Sciences Research Programs (MPS Astro)

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The MPS Astronomical Sciences Research Programs, funded by the National Science Foundation, support innovative research in astronomical sciences. These initiatives aim to enhance our understanding of the universe through core research, technological advancements, and instrumentation. Topics include solar storm prediction, the discovery of exoplanets, and the study of black holes. Proposals should reflect ambitious, transformative ideas that may not require immediate practical outcomes, fostering long-term scientific exploration.
Astronomy & Astrophysics Astrobiology

Fiscal Year 2027 Defense University Research Instrumentation Program (DURIP)

US DOD: Dept. of the Air Force, Materiel Command
Federal Government
American Samoa, Guam +4 more
US $50,000 - US $3,000,000
The Fiscal Year 2027 Defense University Research Instrumentation Program (DURIP) by the Department of Defense aims to enhance research capabilities at U.S. higher education institutions. It provides funding for the acquisition of essential research equipment to support education in fields critical to national defense. This initiative specifically excludes for-profit organizations, ensuring that the resources are directed towards accredited educational institutions committed to advancing scientific knowledge and engineering expertise.
International Security

Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) (357568)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $375,000
The Research Enhancement Award Program (REAP) aims to boost basic and clinical research at health professional and graduate schools that have historically received limited NIH funding. By supporting small-scale research projects led by faculty, REAP fosters student engagement in significant research endeavors, enhancing their educational experience. Eligible institutions must grant advanced degrees in health professions and have received under $6 million in NIH support in four of the last seven years, promoting broader participation in the nation's biomedical research efforts.
Medical Education & Professional Training Biology Health & Medicine

Fiscal Year (FY) 2027 Department of War (DoW) Defense University Research Instrumentation Program (DURIP)

US DOD: U.S. Army Materiel Command
Federal Government
American Samoa, Guam +4 more
US $50,000 - US $3,000,000
The Fiscal Year 2027 Department of War Defense University Research Instrumentation Program (DURIP) aims to enhance the capabilities of U.S. higher education institutions by providing funding for essential research equipment. This initiative supports the education of scientists and engineers in fields critical to national defense. However, for-profit organizations are not eligible for participation, ensuring that funds are directed towards accredited educational institutions.
International Security

Fiscal Year (FY) 2027 Department of War (DoW) Defense University Research Instrumentation Program (DURIP) (363378)

US DOD: Dept. of the Navy, Office of the Chief of Naval Research
Federal Government
American Samoa, Guam +4 more
US $50,000 - US $3,000,000
The FY 2027 DURIP program invites universities to submit proposals for purchasing essential research equipment and instrumentation that aligns with the Department of War's research priorities. This initiative aims to enhance educational experiences through research in fields crucial to national defense, supported by agencies such as the Army Research Office, Office of Naval Research, and Air Force Office of Scientific Research. Proposals should demonstrate the potential impact on student education and research capabilities.
International Security

Elks National Foundation: Legacy Awards

Elks National Foundation Inc
Private
Panama, Philippines +2 more
US $4,000
The Elks National Foundation's Legacy Awards provide $4,000 scholarships for children and grandchildren of Elks members. Eligible applicants must be high school seniors and can apply online. The program supports educational pursuits at accredited U.S. institutions, ensuring that the legacy of community service and support continues. With criteria focusing on family connections to the Elks and a commitment to education, these awards promote opportunities for future generations to thrive and contribute to society.
Academic Scholarship Programs Education - Higher Education

Fiscal Year 2027 Regional Nutrition Hubs

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The Fiscal Year 2027 Regional Nutrition Hubs initiative by the US HHS aims to enhance nutrition services across regional health centers. By providing targeted technical assistance, the program seeks to improve health outcomes through effective nutritional interventions. This initiative supports HRSA's mission to expand access to high-quality healthcare services, ultimately benefiting communities by addressing dietary needs and managing health conditions. With a focus on collaboration, the program is set to strengthen the health infrastructure at the local level.
Nutrition & Healthy Eating

Family-to-Family Health Information Centers (F2F HIC)

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $96,750
The Family-to-Family Health Information Centers (F2F HIC) program, funded by the US HHS: Health Resources & Services Administration (HRSA), aims to empower families of children and youth with special health care needs (CYSHCN). By providing crucial information, education, and peer support, the program helps families navigate complex health systems to access necessary services, ultimately enhancing the health and well-being of CYSHCN and their families.
Disability Care & Services Family Services

Sammy Cahn Award

Ascap Foundation
Private
District of Columbia, Puerto Rico +1 more
US $5,000
The Sammy Cahn Award, presented by The ASCAP Foundation, honors exceptional lyric-writing talent among songwriters of original songs. Established in 1995 to commemorate Sammy Cahn's legacy, the award offers a $5,000 prize to recipients. Eligible entrants include ASCAP writer members in good standing or independent songwriters. Submissions are judged anonymously based on lyric quality and overall craft, ensuring the recognition of artistic excellence within the songwriting community.
Music

Unrestricted Grants for Nonprofits in Puerto Rico Highlights

Looking for unrestricted grants for nonprofits in Puerto Rico?


Read more about each grant below or start your 14-day free trial to see all unrestricted grants for nonprofits in Puerto Rico recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Unrestricted Grants for Nonprofits in Puerto Rico

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

800+ Unrestricted grants for nonprofits in Puerto Rico grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

500+ Unrestricted grants for nonprofits in Puerto Rico over $25K in average grant size

400+ Unrestricted grants for nonprofits in Puerto Rico over $50K in average grant size

16 Unrestricted grants for nonprofits in Puerto Rico supporting general operating expenses

500+ Unrestricted grants for nonprofits in Puerto Rico supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Unrestricted grants for Nonprofits in Puerto Rico?

Most grants are due in the first quarter.

Q1
31.5%
Q2
23.7%
Q3
19.8%
Q4
25.0%

Typical Funding Amounts

What's the typical grant amount funded for Unrestricted Grants for Nonprofits in Puerto Rico?

Grants are most commonly $318,750.

$375 $375 Min.
$318,750 $318.8 K Median
$1,385,019 $1.4 M Average
$80,000,000 $80 M Max.

Average Grant Size

What's the typical amount funded for Puerto Rico?

Grants are most commonly $104,638.

$104,638

Total Number of Grants

What's the total number of grants in Unrestricted Grants for Nonprofits in Puerto Rico year over year?

In 2024, funders in Puerto Rico awarded a total of 1,758 grants.

2022 1,942

2023 1,805

2024 1,758

Top Grant Focus Areas

Among all the Unrestricted Grants for Nonprofits in Puerto Rico given out in Puerto Rico, the most popular focus areas that receive funding are Education, Human Services, and Human Service Organizations.

1. Education

2. Human Services

3. Human Service Organizations

Funding Over Time

How is funding for Unrestricted Grants for Nonprofits in Puerto Rico changing over time?

Funding has increased by 15.38%.

2022 $135,836,997

2023 $159,254,276
17.24%

2024 $183,744,801
15.38%

Puerto Rico Counties That Receive the Most Funding

How does grant funding vary by county?

San Juan County, Dorado County, and Loiza County receive the most funding.

County Total Grant Funding in 2024
San Juan County $85,833,046
Dorado County $27,296,199
Loiza County $11,736,039
Bayamon County $11,338,985
Vega Alta County $9,404,211