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Best Santa Cruz County Grants for Nonprofits in Arizona

Looking for grants for 501(c)(3) nonprofit organizations working in Santa Cruz County, Arizona? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

Available grants

$2.71B

Total funding

$5K

Median grant

9,000+ grants
$2.71B total
$5K median

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9,216 Results based on applied filters

Workforce Innovation and Opportunity Act (WIOA), Governor’s Discretionary Fund

State of Arizona Governor’s Office of Youth, Faith, and Family
State/Local Government
Arizona
Unspecified amount

Workforce Innovation and Opportunity Act (WIOA), Governor’s Discretionary Fund

Through the Workforce Innovation and Opportunity Act (WIOA), the Governor’s Discretionary Fund awarded by the Arizona Department of Economic Security (DES), the GOYFF works with organizations to implement best practices that provide opportunities for Arizonans to access employment, education, training, and support services to succeed in desired careers and match employers with the skilled workers necessary to create thriving economic communities across the state.

Funding supports programs in Arizona's urban, rural, and tribal communities that serve the following target populations:

  • Currently and formerly incarcerated individuals.
  • Currently or formerly involved with the foster care system.
  • Disconnected youth.
  • Veterans.
  • High school students preparing for college or a career.
  • Unemployed and underemployed individuals
  • Individuals with disabilities.
  • Individuals who have experienced trauma.
Workforce Preparation & Job Readiness

F26AS00030 Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $14,162,000
The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.
Wildlife Management Land / Habitat Conservation Wildlife Health

Somatic Mosaicism across Human Tissues (SMaHT) Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of biological processes driven by somatic mutations in human tissues through innovative technology development. Since its inception in 2023, the program has produced multi-omic datasets from human tissues representing all germ layers. The NIH is now advancing to Stage 2, focusing on collaborative efforts to refine and implement validated technologies for somatic mutation detection and functional interpretation, promoting rigorous and cost-effective methodologies.
Biology Genetics & Genomics Computer Science & Engineering +1 more

Cancer Prevention and Control Programs for State, Territorial, and Tribal Organizations (363855)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The Cancer Prevention and Control Programs aim to eliminate cancer through collaborative efforts among state, territorial, and tribal organizations. Funded by the CDC, this program supports initiatives such as breast and cervical cancer screening, cancer control planning, and cancer surveillance. By fostering partnerships and community involvement, the program seeks to improve health outcomes and achieve the mission of 'All People Free of Cancer.' This comprehensive approach ensures that resources are effectively coordinated to address the cancer burden in communities.
Cancer / Oncology Epidemiology & Public Health Health Care Access & Delivery +2 more

Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $100,000 - US $500,000
This funding opportunity from the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to advance mechanistic research on metal exposure and its effects on human health. Studies should focus on biological processes altered by metals, including their absorption, transport, and immune interactions. Innovative methodologies and human biospecimens are encouraged to explore how metals might impact immune homeostasis and cross biological barriers, providing insights into health risks associated with metal exposure.
Biology Environmental Contamination & Pollution Neurological Diseases & Disorders +1 more

Limited Competition: Tribal Undergraduate and Graduate Research Training and Leadership Experiences (TURTLE) Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.
Education - Higher Education Workforce Preparation & Job Readiness Native American Services +1 more

Limited Competition: Tribal Institutional Review Board Establishment and Enhancement (TIRBEE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The TIRBEE funding opportunity supports federally-recognized Tribes and Tribal Entities in establishing or enhancing Institutional Review Boards. This initiative aims to strengthen the capacity for biomedical research involving human participants within these communities by improving review and oversight capabilities. Eligible organizations are invited to apply, with applications subject to NIH's standard peer-review process to ensure only the most meritorious proposals are considered.
Epidemiology & Public Health Native American Services Health Disparities & Social Determinants of Health +1 more

Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (R24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of somatic mutations and their impact on human biology and disease. This initiative will establish a Tissue Procurement Center (TPC) to collect and provide clinically relevant tissue samples from a diverse set of healthy donors. The TPC will support ongoing research by ensuring high-quality, well-characterized specimens are available for functional analyses, advancing the field of somatic mosaicism.
Biology Genetics & Genomics

Somatic Mosaicism across Human Tissues (SMaHT) Program: National Somatic Mosaicism Commons Data Analysis & Organizational Center (UM1 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.
Genetics & Genomics Computer Science & Engineering Emerging Technology Development

Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed) (363858)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to uncover biological processes and disease mechanisms influenced by somatic mutations. Since its inception in 2023, it has produced valuable multi-omic datasets from diverse human tissues. The upcoming Stage 2 Genome Characterization Centers will focus on understanding the impact of these mutations in both healthy and clinically significant samples, enhancing our knowledge of somatic mosaicism's role in human health and disease.
Biology Genetics & Genomics

A Year of STEM

American Library Association (ALA)
Association/Society
United States
US $5,000

In collaboration with Cummins Inc., the American Library Association (ALA) invites applications from U.S. public libraries to participate in A Year of STEM, 12 months of curated STEM programming to foster curiosity and STEM-mindedness in early childhood learners across the country. 

Twenty-five libraries will be chosen to participate in A Year of STEM, receiving professional development to prepare them for the project, copies of a newly created A Year of STEM programming guide developed by librarian advisors, a $5,000 programming stipend, four STEM kits (to be delivered quarterly), and support from ALA’s Public Programs Office staff throughout the project implementation period.

STEM / STEAM Education Library Services

The Penn Play Award

LR Penn
Corporate
United States
Unspecified amount

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

Theater

The DOE Quantum Genesis Q Competition

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $200,000,000
The DOE Quantum Genesis Q Competition aims to accelerate the development of fault-tolerant quantum computing capabilities essential for scientific research. This initiative invites proposals from domestic entities to create viable plans for the Quantum Genesis program, aligning with national scientific goals. The competition serves as a foundational effort to scale quantum technologies and enhance scientific workflows, fostering innovation and collaboration as the nation progresses into a new era of computational power.
Engineering Science Physics +2 more

Technology Development Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.
Engineering Science Emerging Technology Development

Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $190,000 - US $500,000
The R21 Clinical Trial Not Allowed funding opportunity invites innovative research to develop and enhance research models and biological materials vital for studying human health and diseases. It emphasizes the need for new approach methodologies (NAMs) to improve the identification of confounding factors in biomedical research. Projects should have broad applicability across multiple NIH Institutes, focusing on various body systems and disease categories, ensuring relevance to a wide range of health issues.
Biology Health & Medicine Emerging Technology Development

Broad Street Children's Foundation Grant

Broad Street Childrens Foundation
Private
United States
Unspecified amount

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

Child Welfare Services Vocational & Trade Education Child Abuse & Neglect +2 more

Easement Restoration and Stewardship

USDA: Natural Resources Conservation Service (NRCS)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $5,000,000
The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.
Habitat & Ecosystem Restoration Freshwater Conservation Land / Habitat Conservation +1 more

OJP FY 2026 Special Attorneys Program Round 9

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The OJP FY 2026 Special Attorneys Program provides funding for state, local, Tribal, and territorial prosecuting agencies to hire qualified prosecutors and support staff. These professionals will work under the National Fraud Enforcement Division to investigate and prosecute crimes committed by criminal aliens, as well as drug and human trafficking cases. This initiative aims to enhance law enforcement capabilities, improve intergovernmental coordination, and strengthen the prosecution of fraud and other serious crimes.
Crime & Justice Community / Public Safety Legal Services +1 more

FY 2027 Notice of Funding Opportunity: Infrastructure Investment and Jobs Act (IIJA) FAA Contract Tower (FCT) Competitive Grant Program

Airport Improvement Program Discretionary Grants
Federal Government
American Samoa, Guam +4 more
US $25,000 - US $55,000,000
The FY 2027 Notice of Funding Opportunity for the Infrastructure Investment and Jobs Act (IIJA) FAA Contract Tower Competitive Grant Program offers up to $100 million for airport traffic control tower projects. This initiative aims to support airports in modernizing and repairing aging infrastructure, ensuring safety and efficiency in air traffic management. Eligible projects may involve construction, rehabilitation, or installation of essential air traffic control equipment, enhancing the operational capabilities of the nation's airports.
Aerospace Engineering Community / Public Safety Emerging Technology Development +1 more

DOJ FY 2026 Assisting Neighborhoods and Governments with Enforcement of Laws (ANGEL) Grant Program

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $500,000
The DOJ FY 2026 ANGEL Grant Program aims to enhance public safety by funding state, local, and tribal government initiatives to combat violent crime committed by criminal illegal aliens. This program supports hiring law enforcement personnel, retaining critical staff, and acquiring advanced technology. The objective is to prevent harm to American citizens and support Homeland Security Task Force operations. Applications must be submitted by October 27, 2026, to qualify for funding.
Crime & Justice Community / Public Safety Violence Prevention

Deployed Warfighter Protection FY27

US DOD: Office of the Secretary of Defense
Federal Government
American Samoa, Guam +4 more
US $20,000 - US $1,100,000
The Deployed Warfighter Protection FY27 program aims to safeguard military personnel from disease-carrying arthropods, including ticks and mosquitoes. It seeks innovative research to develop new insecticides, improve existing formulations, and enhance personal protection technologies. The initiative also focuses on effective pesticide application equipment, addressing both current and emerging arthropod threats. This program is crucial for maintaining the health and safety of deployed military forces.
Infectious & Parasitic Diseases Occupational Health & Safety Preventative Healthcare +1 more

The Role of the Innate Immune System in the Pathogenesis of Type 1 Diabetes

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.
Genetics & Genomics Diabetes Immune System Diseases

Collaborative Centers in Children’s Environmental Health Research and Translation (P2C Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $750,000
The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.
Epidemiology & Public Health Environmental Health Children’s Health & Pediatrics

Immune Drivers of Autoimmune Disease

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Immune Drivers of Autoimmune Disease (IDAD) network, supported by NIAID, aims to uncover early triggers and mechanisms of autoimmunity to prevent disease. Key initiatives include developing predictive tools and biomarkers, fostering preclinical cohorts, and utilizing AI and big data. The network will leverage shared infrastructure for collaborative research, managed by the IDAD Network Coordinating Center, which ensures coordination and resource sharing among awardees. This initiative is crucial for advancing understanding and prevention of autoimmune diseases.
Immune System Diseases Preventative Healthcare Emerging Technology Development

NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) (363939)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $80,000
The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.
Health & Medicine Epidemiology & Public Health

LeverAging StraTegies to Maximize ImpLementation and Effectiveness for HIV (LAST MILE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.
Epidemiology & Public Health Infectious & Parasitic Diseases Health Care Access & Delivery +1 more

Continuation of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.
Biology Genetics & Genomics Emerging Technology Development

Santa Cruz County Grants for Nonprofits Highlights

Looking for Santa Cruz County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Santa Cruz County grants recommended for your specific programs in Arizona.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in Arizona

Average Grant Size

What's the typical amount funded for Arizona?

Grants are most commonly $116,794.

$116,794

Total Number of Grants

What's the total number of grants in Santa Cruz County Grants for Nonprofits year over year?

In 2024, funders in Arizona awarded a total of 32,255 grants.

2022 28,693

2023 30,847

2024 32,255

Top Grant Focus Areas

Among all the Santa Cruz County Grants for Nonprofits given out in Arizona, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Santa Cruz County Grants for Nonprofits changing over time?

Funding has increased by 18.51%.

2022 $3,028,974,870

2023 $3,163,785,616
4.45%

2024 $3,749,331,047
18.51%

Arizona Counties That Receive the Most Funding

How does grant funding vary by county?

Maricopa County, Pima County, and Coconino County receive the most funding.

County Total Grant Funding in 2024
Maricopa County $2,601,929,541
Pima County $787,444,349
Coconino County $236,303,583
Yavapai County $81,123,787
Gila County $64,666,331