Best Health and Wellness Grants for Nonprofits in Pennsylvania

The FISA Foundation Grant supports initiatives aimed at improving the health and well-being of people with disabilities, particularly women and girls. Priorities include enhancing access to healthcare, addressing biases in the system, and preventing violence against vulnerable populations. The foundation emphasizes projects with clear outcomes and realistic evaluation plans, focusing on marginalized groups, especially those facing systemic barriers. Eligible organizations must operate within southwestern Pennsylvania and benefit women, girls, or people with disabilities.

The Gismondi Family Foundation Grant supports nonprofit organizations in the Pittsburgh region, focusing on essential needs such as food, shelter, education, and medical care. Founded by John P. Gismondi and Lisa, the foundation aims to foster vibrant communities by addressing basic human needs and encouraging collaboration among organizations. Interested applicants should submit a letter of inquiry, detailing their project purpose and impact measurement, to the foundation's office or via an online form.

The Henry L. Hillman Foundation Grant supports innovative projects aimed at improving the quality of life in Pittsburgh and southwestern Pennsylvania. With a focus on civic leadership, collaboration, and new models of economic development, the foundation prioritizes initiatives that leverage community assets and address pressing social needs. Grant recipients must be 501(c)(3) organizations, with the aim of fostering healthy neighborhoods, strengthening democracy, and promoting sustainable regional infrastructure.

The Mary Hillman Jennings Foundation Grant supports nonprofit organizations in southwestern Pennsylvania, focusing on community development, health, education, and the arts. Established in 1968, the Foundation aims to improve the quality of life for underserved populations, including at-risk youth and homeless individuals. It prioritizes direct services that promote economic and social welfare, while accepting applications from tax-exempt organizations. The grant cycle may take two to three months, reflecting the Foundation's commitment to thorough review.

The Richard King Mellon Foundation's Economic Mobility program is currently accepting grant applications through its General Application. While specific RFPs are no longer available, proposals that align with the Foundation's strategic goals for 2021-2030 are encouraged. The Foundation, established by visionary Richard King Mellon, has a history of supporting initiatives that enhance economic development and environmental stewardship in Southwestern Pennsylvania, with a commitment to awarding over $1.2 billion in the coming years.

The MTF Rolling Grants by Moses Taylor Foundation support projects under $40,000 throughout the year. Emphasizing collaboration, applicants must meet with Foundation staff before submission to ensure alignment with focus areas. The Foundation prioritizes health care access, older adult health, school-based health, and nonprofit effectiveness, aiming to enhance service delivery in Northeastern Pennsylvania. This initiative seeks innovative solutions to pressing community health challenges, fostering sustainable improvements in well-being.

The Richard King Mellon Foundation invites innovative proposals that align with their 2021-2030 Strategic Plan, aiming to invest over $1.2 billion to enhance opportunities in southwestern Pennsylvania. Their funding focuses on conservation, economic development, economic mobility, health and well-being, organizational effectiveness, and social-impact investments. The General Application offers flexibility without deadlines, allowing for a variety of support types, including project-specific and general operating funding, aimed at enriching community vitality and environmental stewardship.

The FirstBank Charitable Foundation (FBCF) is a 501(c)(3) nonprofit established in 2008, focused on supporting charitable organizations in New Jersey, Pennsylvania, and Florida. With over a million dollars awarded, FBCF aims to enhance community well-being through partnerships in health, housing, and education. Nonprofits aligning with FBCF's mission and demonstrating significant service impact are encouraged to apply for grants, fostering a stronger fabric within their neighborhoods.

The Birmingham Foundation Grant aims to support nonprofit organizations in South Pittsburgh focused on enhancing the lives of young children and their families. With three main focus areas—Maternal and Child Health, Early Care and Education, and Parent and Family Wellbeing—the grant seeks to promote health, educational readiness, and family stability. Eligible applicants must operate within specific Pittsburgh zip codes and hold a 501(c)(3) tax exemption status. This initiative fosters community growth and resilience.

The Staunton Farm Foundation Grant aims to enhance the lives of individuals facing mental health and substance use challenges in southwestern Pennsylvania. By supporting evidence-based practices and collaborations among stakeholders, the foundation seeks to eliminate stigma and improve treatment outcomes. Priority areas include innovation, advocacy, and public communication to foster understanding and acceptance of behavioral health issues. This initiative focuses on measurable impacts and sustainable community partnerships to drive positive change.

The Kenneth A. Scott Charitable Trust offers grants aimed at enhancing the lives of animals in the Ohio/Great Lakes region. It prioritizes projects that foster animal adoption, behavior training, and humane education. Eligible organizations must be 501(c)(3) certified and demonstrate a commitment to animal welfare. The Trust seeks innovative, collaborative initiatives that significantly improve the well-being of animals, particularly in underserved communities, ensuring a high quality of life for both individual animals and larger populations.

The Social-Impact Investment Pitch Competition aims to enhance the vitality of Southwestern Pennsylvania, particularly in Pittsburgh, by fostering economic development, wildlife conservation, and community health. The Foundation invites nonprofits, public agencies, and socially-driven for-profit companies to apply for funding to implement innovative ideas that address societal challenges. Applications are open to U.S.-based organizations seeking capital and project support, with a focus on creating lasting positive change in the community.

The George and Margaret Mee Charitable Foundation Grant supports nonprofit organizations in Delaware County, NY; Cameron County, PA; and Broome County, NY. It funds educational, community, health, and cultural projects with a minimum award of $1,000. Eligible organizations must have 501(c)(3) status and demonstrate sustainability. The foundation does not fund individual awards or religious organizations, and applicants must complete prior grants before submitting new requests.

The Pittsburgh Foundation aims to foster a vibrant, equitable, and just community in the Pittsburgh region through its Foundation-Directed Grantmaking. Focus areas include Basic Needs, Equity and Social Justice, Arts and Culture, Economic Mobility, and Environmental Action. The Foundation prioritizes support for organizations serving low-income communities and those impacted by social injustices. By aligning grantmaking with community aspirations, they strive to ensure everyone can thrive and access essential resources and opportunities.

The Bayer Fund Health & Wellness Grant Program aims to support organizations that provide education and resources for patients and caregivers facing cancer and cardiovascular diseases. Grants focus on assisting communities, particularly the African American population, in managing these health issues. Funding covers educational services, disease awareness, and access to care, with all activities to commence post-funding decisions. Eligible organizations must hold a 501(c)(3) status and operate within 55 miles of Bayer sites.

The Wayne County Community Foundation provides grants to nonprofit organizations in Wayne County, PA, aiming to support community development in various sectors, including arts, education, and health. Grants are awarded biannually and prioritize projects that address critical community needs and have a proven impact. Eligible applicants include 501(c)(3) organizations serving local residents, while certain expenses like advertising and routine operating costs are not funded. The Foundation seeks to empower local agencies to become self-sustaining.

The Cigna Group Foundation is launching the Improving Youth Mental Health Grant, committing $9 million over three years to enhance mental health support for youth aged five to 18. This initiative targets post-pandemic challenges, offering resources to parents, caregivers, and youth service professionals. Nonprofits are encouraged to apply for funding between $100,000 and $150,000 to develop programs that promote social-emotional skills, enhance caregiver support, and improve access to mental health interventions in underserved communities.

The Snee-Reinhardt Charitable Foundation Grant supports transformative programs in Pittsburgh and surrounding areas, focusing on arts, education, environmental health, and human services. With an emphasis on tangible outcomes, the foundation values projects that serve large community segments. Eligibility requires organizations to have 501(c)(3) status for three years, while ineligible requests include fiscal sponsorships and general operating expenses. The foundation prioritizes local initiatives, particularly from Southwestern Pennsylvania and Northern West Virginia.

Staunton Farm Foundation

Working for mental wellness

Staunton Farm Foundation is dedicated to improving the lives of people who live with mental illness and/or substance use disorders. The Foundation works to enhance behavioral health treatment and support by advancing best practices through grant making to non-profit organizations in ten southwestern Pennsylvania counties: Allegheny, Armstrong, Beaver, Butler, Fayette, Greene, Indiana, Lawrence, Washington, Westmoreland.

Investing in a future where behavioral health is understood, supported, and accepted.

Purpose

Staunton Farm Foundation (SFF) recognizes that strong organizational capacity is essential to sustaining high-quality mental health and substance use services over time. Capacity-building investments strengthen nonprofit organizations’ internal systems, leadership, and infrastructure, enabling them to more effectively carry out their missions. By supporting capacity-building efforts, SFF seeks to empower organizations to innovate, adapt, and enhance programs and resources in response to evolving community needs, ultimately broadening and deepening positive impact for the individuals and communities they serve.

Guidelines for Use of Funds

Capacity-building grants may be used to support activities that strengthen an organization’s infrastructure, systems, leadership, and long-term sustainability. Funds may be used to contract for technical assistance, training, evaluation, planning, technology upgrades, and other expenses necessary to achieve the goals of the proposed project. Specific grant terms will be outlined with successful applicants.

Allowable uses include, but are not limited to, the following:

• Organizational Infrastructure & Systems
  • Strategic planning, sustainability planning, or business model development
  • Data collection, evaluation, or outcomes measurement systems
  • Technology upgrades that support service delivery, coordination, or reporting (e.g., EHR enhancements, client tracking systems, cybersecurity improvements)
• Workforce & Leadership Development
  • Staff training and professional development related to behavioral health or substance use services
  • Leadership development or succession planning
  • Workforce initiatives aimed at improving retention
• Program & Operational Effectiveness
  • Program design or redesign to improve quality, accessibility, or cultural responsiveness
  • Implementation support for evidence-based or promising practices
  • Quality improvement initiatives
  • Policy, procedure, or compliance development related to licensure, accreditation, or best practices
• External Expertise & Technical Assistance
  • Consultants or technical assistance providers with relevant expertise (e.g., finance, evaluation, clinical quality, operations, or technology)
  • Compliance support related to organizational operations (excluding litigation)

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

Enterprise Community Partners

Enterprise Community Partners is a national nonprofit that exists to make a good home possible for the millions of families without one. Home is where life happens, where plans are made, and futures begin. It is the foundation for dignity, health, education, wealth, and community. Yet rents keep going up, paychecks don’t keep pace, and good homes in strong neighborhoods are increasingly out of reach.

The system doesn’t work. It must be changed, and it must be changed by us.

Enterprise has the breadth, scale, and expertise to do it. We support community development organizations on the ground. We aggregate and invest billions to improve housing and strengthen communities across the U.S. We advance housing policy at every level of government. We build and manage communities ourselves. Everything we do is informed by the residents we serve.

Together with our partners, we focus on the greatest need — the massive shortage of affordable rental homes — to achieve three goals:

• Increase the supply of affordable homes
• Advance racial equity after decades of systematic racism in housing
• Support residents and strengthen communities to be resilient to the unpredictable, and make upward mobility possible

Since 1982, we have invested $92.0 billion and created 1.1 million homes across all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. We do all this to make home and community places of pride, power, and belonging.

National Housing Innovation Grant Competition

Home is foundational. It’s where we plant roots, raise and care for our families, and build community bonds. Yet in every corner of the country, millions of people of all ages and backgrounds need a home they can afford.

Wells Fargo is meeting this moment with a powerful grant opportunity. Together with Enterprise, Wells Fargo has launched the third iteration of the Housing Affordability Breakthrough Challenge. The 2026 cycle of the housing innovation competition will identify and propel proven, ready-to-scale solutions that transform current practices and increase housing choice and access.

Eligible applicants will compete for five individual grants of $2 million to advance their innovation and drive meaningful, systems-level change in the housing and adjacent industries. Winners will gain access to mentorship and coaching from industry leaders and experts and join a powerful network of Breakthrough Challenge innovators.

Focus Areas

This third cycle of the Housing Affordability Breakthrough Challenge aims to meet the nation’s affordable housing challenges across all types of communities: Native, rural, suburban, tribal, and urban.

Proposals must encompass one or more of three focus areas:

• Design and Construction
• Finance
• Service Delivery and Programs

Applicants will be asked to show how their proof of concept or pilot program has achieved clear outcomes and success, and provide a clear pathway to expanding the innovation’s reach and impact

Round 1: Criteria and Scoring

Your innovation must meet the criteria below to advance to the official scoring stage.

Type of Community

Innovations can serve all types of communities:

• Rural
• Urban
• Suburban
• Tribal

Location

Priority scoring will be given to applications from entities that are based in – or whose innovations are designed for – one or more of these 28 states, plus D.C.:

• Alaska, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Iowa, Maryland, Massachusetts, Minnesota, Montana, Nevada, New Jersey, New Mexico, New York, North Carolina, North Dakota, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Washington D.C.

Affordability

Innovations must serve residents at these income levels:

• Rental: 80% AMI or below
• Homeownership: 120% AMI or below
• Workforce housing: 120% AMI or below

Pennsylvania Department of Community and Economic Development

The Department of Community and Economic Development (DCED) works every day to ensure Pennsylvania is a premier state to do business, where we adopt and innovate the next generation of breakthroughs in a diverse mix of industry clusters, where we cultivate a resilient economy, and where we invest in our people and our communities to build a stronger Pennsylvania that works for all the residents, workers, businesses, and entrepreneurs that call our Commonwealth home.

Neighborhood Assistance Program (NAP)

Tax credit program to encourage businesses to invest in projects which improve distressed areas.

Statement of Purpose

The goals of NAP are to provide resources to assist low-income and distressed neighborhoods and communities, encourage positive health outcomes, and address the safety and welfare of their residents. As a result, NAP encourages communities to pursue and achieve fiscal well-being and self-sufficiency.

These Programs are intended to benefit low-income populations. Applicant’s proposed projects must not result in the displacement or forced relocation of low-income individuals or households.

The goals of the Programs are to promote community participation and collaborations among the residents, nonprofits and businesses while producing outcomes by assisting a distressed area or the low-income population in a neighborhood. Eligible neighborhood nonprofits (“Applicants”) apply for tax credits based on pending contributions from for-profit companies (“Contributors”).

Project Priorities

In FY2026-27, the Department will prioritize applications that align with the vision and goals of newly developed Commonwealth’s Housing Action Plan & Economic Development Strategy in addition to childcare. These priorities include:

• Affordable Housing Development
• Affordable Housing Support Services
• Access to Affordable and Reliable Childcare

The Universal Leaf Foundation Grants support 501(c)(3) nonprofit organizations primarily in areas where Universal Leaf Tobacco Company operates. Focus areas include education for at-risk individuals, higher education, civic/community arts, and environmental initiatives. The Foundation emphasizes good corporate citizenship and community engagement through financial support and employee volunteerism. Organizations must operate within designated geographic areas and cannot be involved in political advocacy or restrict services based on demographics. Grants aim to enhance community well-being and educational opportunities.

About FCFP

Change Agents for the community

We’re on mission to improve North Central PA through the power of philanthropy.

Founded in 1916, First Community Foundation Partnership is the leading resource for philanthropists in North Central PA.

Drawing from a deep well of experience, we can help anyone who wants to make a difference make it happen. Whether through a modest donation or a substantial endowment, we help donors grow their contributions and reinvest the gains back into our region.

Our partnerships are as diverse as the public we serve. We oversee projects ranging from small, donor-directed funds to Raise the Region, our area’s largest and most celebrated charitable event. And the initiatives we sustain support causes from scholarships and fine arts to healthcare and food security.

We’re determined to broaden our reach and deepen our impact in the counties we serve. We’re committed to driving positive social change for another hundred years—and ensuring everyone who shares our vision can get involved.

To improve quality of life in north central Pennsylvania through community leadership, the promotion of philanthropy, the strengthening of nonprofit impact and the perpetual stewardship of charitable assets

To create powerful communities through passionate giving.

2026 FCFP Birthday Grants for Lycoming County

Competitive grant program that supports nonprofit organizations with missions relating to arts and culture, education, health and human service, youth, environment, and economic development in Lycoming County.

The Greater Harrisburg Foundation Upstream Grant aims to foster community improvement by funding innovative projects that address systemic issues at their source. This grant supports nonprofit organizations in Cumberland, Dauphin, Franklin, Lebanon, and Perry Counties, allowing them to implement creative solutions in areas such as education, health, and environmental stewardship. By focusing on upstream interventions, the foundation encourages a proactive approach to social change, ultimately enhancing community resilience and well-being.

The United Way of Southwestern Pennsylvania is launching its Multi-Year Grants program, with applications opening in January 2026 for funding starting in July 2026. This initiative aims to support nonprofit organizations addressing critical community needs across five counties. Key investment priorities include meeting basic needs, promoting financial stability, and enhancing educational success for youth. Interested applicants can attend information sessions from October to November 2025 to learn more about the grant process.