Best Operating Grants for Nonprofits in South Dakota

The Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional) invites applications that address urgent research needs in substance use epidemiology and health services. This funding opportunity encourages pilot studies focusing on emerging drug issues, unexpected prescription drug abuse trends, and timely medical system challenges. Letters of Intent are recommended 30 days before the proposal deadline, emphasizing the necessity for rapid review and funding to address pressing scientific questions.

The Congenital Sucrase-Isomaltase Deficiency Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from this genetic disorder. By providing assistance with prescription drugs and treatment costs, the fund ensures that vital medications are accessible, allowing patients to manage their condition effectively. In 2024, the Foundation is expected to award over $1.2 billion in grants, showcasing its commitment to enhancing healthcare access for those in need.

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Implementation Grants

Implementation Grants fund projects and strategies identified in an Action Plan that address roadway safety problems. Implementation Grants may also fund supplemental planning and demonstration activities, as well as project-level planning, design, and development activities for projects and strategies identified in an Action Plan (e.g., project-level 21 National Environmental Policy Act (NEPA) compliance, associated environmental review activities, permits and approvals, construction design, etc.). 

• Expected number of awards: 40 to 70

The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.

The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.

The Imagine Learning Foundation's Signature Grant Program aims to enhance the well-being of learners by supporting social and emotional learning (SEL) initiatives. By bridging classroom and community efforts, it fosters healthier environments for youth, families, and educators. The program prioritizes funding for organizations addressing critical issues like chronic absenteeism and housing insecurity. In 2024, the foundation will allocate over $400,000 to impactful projects, furthering its mission to cultivate supportive learning experiences both in and out of the classroom.

The Chronic Lymphocytic Leukemia Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients battling chronic lymphocytic leukemia (CLL). This fund provides essential support for prescription copays and premiums, ensuring that patients can access necessary treatments without the stress of financial constraints. Since its inception, the foundation has awarded over $1.2 billion in grants, helping more than 1.1 million patients. The initiative emphasizes the importance of accessible healthcare and aims to improve the quality of life for those affected by this condition.

Michael Dean Guilliams Memorial Scholarship Fund

Fund provides scholarship assistance to deserving students who are pursuing further educational studies in a career and technical field.

Amount

$1,500+

The Zendesk Tech for Good Impact Awards support nonprofits by providing them with essential software, grants, and pro bono assistance to enhance their impact on vulnerable populations. The program aims to foster community connections, promote resilience during crises, and create career pathways in technology. Eligible organizations must demonstrate a commitment to utilizing technology in their services, enhancing their ability to support beneficiaries effectively. This initiative empowers nonprofits to leverage technology for greater social good.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers in quantitative science and engineering to focus on NIH-relevant health research. This award provides protected time for supervised study and research, allowing professionals from fields like mathematics, statistics, and engineering to integrate their expertise into health-related studies. The K25 is specifically for lead investigators of independent clinical trials or related studies, fostering innovation in clinical research and career development.

The NCMA Education and Research Foundation Grant aims to support the concrete masonry and hardscape industry through research and educational initiatives. With over $2 million invested, the Foundation invites proposals from qualified professionals, emphasizing national and regional benefits. Eligible projects should focus on workforce development, educational opportunities for students, and collaborative efforts with other organizations. Notably, certain entities, such as those involved in political campaigns or proprietary projects, are ineligible for funding.

The Koerner Family Foundation Scholarship, offered by the Four County Community Foundation, supports high school seniors and recent graduates from Almont, Dryden, and Romeo High Schools. Eligible students must plan to major in business, engineering, IT, medical health fields, natural sciences, or vocational training, with a minimum GPA of 2.50. Award recipients will be honored at a Scholarship Celebration in May and at their respective high school awards events.

The Research Experiences for Undergraduates (REU) program, funded by the National Science Foundation (NSF), promotes active research participation among undergraduate students across various research areas. It supports two mechanisms: REU Sites, which engage multiple students in ongoing research, and REU Supplements, which enhance existing NSF-funded projects. Participants must be U.S. citizens, nationals, or permanent residents, and each REU opportunity has its unique application process.

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Life Needs Support

Life Needs Support provides need-based financial assistance to students and young adults from the Greater Milan area who face barriers that may prevent them from completing a degree or skilled trades training program. 

Requests are reviewed on a case-by-case basis. We recognize that unexpected hardships can disrupt educational progress, including expenses related to books and supplies, medical care, transportation, childcare, trade tools.

Applications are evaluated two times each year for awarding in the six months after application and selection.

The Safe Arborist Techniques Fund Grant Program, established by the Tree Research and Education Endowment Fund and the International Society of Arboriculture, aims to enhance worker safety in arboriculture through research and development. Grants focus on biomechanics and tree failure mechanisms, supporting innovative practices that protect both workers and the community. Proposals are evaluated on their potential impact, scientific rigor, and the experience of the investigative team, ensuring they align with the mission of the TREE Fund.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers with quantitative science backgrounds to NIH-relevant studies. It provides support and protected time for professionals to integrate their expertise in areas like mathematics and statistics with health research. Notably, it does not support independent clinical trials, focusing instead on collaborative experiences under mentorship. The application process involves specific deadlines for submissions, including standard, renewal, and AIDS-related grants, encouraging diverse participation in significant health research.

The Zone VI Fellowship in Urban Forestry, funded by the Garden Club of America, aims to promote urban forestry education among U.S. graduate and advanced undergraduate students. Established in 2006, this fellowship awards $7,500 annually to support students studying urban forestry and related fields. Recipients can reapply for additional funding, fostering ongoing research and engagement with the urban forest ecosystem. This initiative highlights the importance of healthy urban forests and their impact on communities.

The Yéigo Action Grant, provided by the First Peoples Fund, offers financial support ranging from $100 to $2,500 for Native artists and culture bearers facing hardships that affect their creative practices. This grant aims to assist artists with specific professional opportunities, such as workshops or emergencies. By honoring the spirit of encouragement embodied in the Diné word 'yéigo', the grant helps ensure that artists can continue their vital work within their communities.

The AAO-HNSF Bobby R. Alford Endowed Research Grant offers $30,000 for one year to support innovative research in otolaryngology. This grant aims to facilitate the career development of young investigators and promote research that may lead to significant advancements in understanding diseases of the head and neck. Eligible projects should have direct clinical significance for patients and can include basic, translational, and clinical research.

Our Mission

UNCF envisions a nation where all Americans have equal access to a college education that prepares them for rich intellectual lives, competitive and fulfilling careers, engaged citizenship and service to our nation.

UNCF’s mission is to build a robust and nationally-recognized pipeline of under-represented students who, because of UNCF support, become highly-qualified college graduates and to ensure that our network of member institutions is a respected model of best practice in moving students to and through college.

UNCF’s North Star is to increase the total annual number of African American college graduates by focusing on activities that ensure more students are college-ready, enroll in college and persist to graduation. This is done through a three-pillar strategy. Positioning member institutions as a viable college option for students and investing in institutional capacity to improve student outcomes; creating transformational support programs to ensure students are enrolling and persisting through college completion; building awareness of educational attainment and cultivating college-going behaviors within the African American community.

About the UNCF Lighted Pathways Program

Increasing the number of Black investment management professionals one opportunity at a time

According to The American College and the CFP Board, African Americans only make up 5% of financial advisors and 2% of certified financial planners (CFP), even though African Americans represent 13.4% of the U.S. population.

The UNCF Lighted Pathways programs meets the disparity and lack of Black talent in asset management through the UNCF Lighted Pathways initiative which provides scholarships and internships to African American undergraduate students interested in the investment management industry. Through this initiative, UNCF Lighted Pathways aims to create a career pathway to attract, develop, and retain Black talent for the asset management industry.

The UNCF Lighted Pathways Program excites, educates, and empowers young people by supporting personal and professional development, driving company performance, and providing the asset management industry the talent they need to meet today’s challenges and tomorrow’s opportunities. This program offers students a glimpse inside the dynamic, global asset management industries and the career opportunities, potential and rewards within them.

Students are afforded the opportunity to receive $5,000 in scholarships and/or participate in internships in the financial industry provided by the program’s partners.

About Us

As the community foundation for Eastern Washington and North Idaho, we partner with people who want to improve their communities and make the world better. We work together to identify and respond to our region’s greatest opportunities, help those in need, and leave a lasting impact.

Scholarship

Each year, Innovia awards over $500,000 in scholarships to deserving students like you who are college-bound or pursuing vocational or technical training. Single scholarship awards range between $500 and $10,000.

Diversity in Advertising Scholarship

The scholarship is open to Black, Indigenous, and other People of Color of all ages in Innovia's 20 county service region. The scholarship is intended for students studying Marketing, Advertising or Design with a career focus of Digital Marketing, Advertising, Design and/or Computer Science at any accredited institution. Applicants must demonstrate academic achievement.

Special consideration will be given to those active in school activities, community service, and work experience. Previous recipients of this award are eligible to reapply.

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.

The Velma Shotwell Griffin Memorial Scholarship Fund

The Velma Shotwell Griffin Memorial Scholarship Fund was established to assist graduates of Conotton Valley or Carrollton High Schools planning to enroll, or currently enrolled, at an accredited college or university to pursue further education in the following fields: History, Writing (not limited to, English, Journalism, Language Arts, Communications and programs in Mass Media), Graphic Arts, Music (which shall include but not limited to, vocal music, instrumental music, music history, music education, and music performance) and any other program or field of study approved by the Selection Committee. 

Amount:

• Varies. Minimum $500.

Renewable:

• Yes

The Fred J. Brunner Foundation Grant supports organizations that aid vulnerable populations, particularly the young and elderly, through education, shelter, and hunger initiatives. Established in 1956 by Fred J., the foundation distributes grants annually in the fall, focusing primarily on recipients in the greater Chicago area, although exceptions are made. The foundation operates without regard to race, creed, or ethnicity, allowing all recipients to reapply each year.

T7 Social Impact GrantsThe T.D. Jakes Foundation (TDJF), in partnership with Wells Fargo, is proud to launch the Social Impact Grant Challenge, a transformative funding opportunity designed to identify, support, and amplify nonprofit organizations creating meaningful change in communities across the United States.

Designed around the T.D. Jakes Foundation's pillars of service (Educational Access & Workforce Readiness, financial inclusion, and community transformation and well-being), the Challenge seeks innovative nonprofit organizations that are addressing critical social issues through impactful, scalable, and sustainable solutions.

Finalists selected through this process will have the opportunity to showcase their organization through a live presentation at the inaugural Thriving Seven (T7) Summit, taking place November 12 –14 in Atlanta, Georgia. In addition to competing for grant funding, finalists will gain national visibility for their work and connect with nonprofit leaders, funders, and changemakers from across the country.Grant Funding: A total of $1,500,000 in grant funding is anticipated to be awarded: 

• One (1) - $500,000 grant
• One (1) - $250,000 grant
• Two (2) - $100,000 grant
• Eleven (11) - $50,000 grant

The West Michigan Nursery and Landscape Association Scholarship, established in 2001, supports students from Ottawa, Oceana, Newaygo, Muskegon, or Allegan County pursuing careers in horticulture or the green industry. Administered by the Grand Haven Area Community Foundation, awards consider financial need and academic achievement. Applicants, including high school seniors and college students, must submit transcripts and additional required documents. This scholarship aims to foster education and partnerships within West Michigan's green industry.

About All Points North Foundation

All Points North Foundation is dedicated to navigating communities upward.

All Points North Foundation was founded in 2011 by a family who believes passionately that everyone has a “true North” – a place of achievement – and that everyone should have equal opportunity and access to realize their goals.

Our Vision

We envision a nation where the middle school years are seen as an important, vital time in the lives of youth, and where the public middle school education experience in underserved communities measurably improves

We also envision a nation where the integration of solar benefits families, local economies and the environment.

Our Priorities

All Points North Foundation funds grantees in two areas – public middle school education (grades 6-8) and solar – that have the power to help communities nationwide navigate upward.

Grant Making

All Points North Foundation seeks collaborative partnerships with grantees in our two priority areas.

Solar Energy

All Points North Foundation is focused on finding ways to significantly advance the penetration of solar through education, job training and use of solar electric technologies in the United States.

All Points North Foundation has three priority areas:

Providing solar and workforce development training for Tribal communities to expand and diversify the solar job pipeline.

Working with small- to medium-sized science centers to engage students, families and local communities on the benefits and science behind solar.

Providing solar installations to nonprofit organizations that build high-quality, safe and affordable residential housing, offsetting energy costs and enabling cost savings for households.

The cost of solar has dropped dramatically over the last decade, however the upfront cost of going solar remains a hurdle for most families, communities and nonprofits.

All Points North Foundation does consider funding solar projects outside of these focal areas, but the programs must demonstrate how solar will have a broader impact on local communities (e.g., economic, social or environmental), as well as showcase the potential for replication across the nation.