Best Large Grants for Nonprofit Organizations in South Dakota

Nonprofit organizations, government entities, and fiscally sponsored groups in South Dakota can seek Community Innovation Grants to develop, test, and spread community-focused ideas. Grants from Bush Foundation help community services initiatives pilot solutions, support local leaders, and share successful approaches that can be replicated across the broader region.

South Dakota 501(c)(3) nonprofits working on economic and workforce advancement, affordable housing, or community arts and culture can access funding through the U.S. Bank Foundation’s Community Possible Grant Program. Organizations based in and serving U.S. Bank communities, especially those led by people of color and addressing multiple pillars of work, home, and play, may be prioritized.

South Dakota 501(c)(3) nonprofits with innovative approaches to social problems can seek funding to develop or expand human services and related programs. Focused on innovation, Creag Foundation invites organizations that have held 501(c)(3) status for at least one year and are testing new solutions to societal issues to submit a letter of inquiry.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

Nonprofit and nongovernmental organizations using technology to address major social challenges in crisis response, education access, or economic empowerment, including in South Dakota, can apply for Global Impact Cash Grants up to US $100,000. Cisco Systems Foundation supports innovative, early-stage, tech-enabled programs serving predominantly economically underserved communities worldwide.

South Dakota arts and cultural nonprofits with audited expenses over $2 million can access funding through the William Randolph Hearst Foundation for high-impact culture programs. U.S.-based 501(c)(3) institutions such as museums, theaters, ballets, symphonies, and arts schools may receive more than US $100,000 for program, capital, or limited general and endowment support.

South Dakota nonprofits providing direct social services that address chronic poverty and economic hardship can access funding through the William Randolph Hearst Foundation, with awards of more than US $100,000. Eligible U.S.-based 501(c)(3) organizations with audited expenses over $2 million may seek program, capital, or general support for scalable, proven initiatives.

Nonprofits and social enterprises in South Dakota working on education, children’s health, or family economic stability for urban low-income youth can apply for Michael & Susan Dell Foundation grants of more than US $50,000. Funding supports project costs or scaling efforts for programs based in the U.S., India, or South Africa that meet its mission and values.

The Oriental Trading Company Corporate Giving Program focuses on enhancing the lives of children through education, youth programming, healthcare, and human services. With a commitment to making the world a better place, they support organizations that are tax-exempt under Section 501(c)(3) or public educational institutions. Their initiatives aim to foster community partnerships and provide essential resources to youth in need, ensuring they have access to vital services and opportunities for growth.

Nonprofit organizations and accredited charities in South Dakota working on humanitarian, social, science education, community, environmental, or contemporary arts projects may be eligible for support that promotes sustainable development and community benefit. Focused on strategic philanthropy, Roche invites locally based programs to partner with its affiliate offices for impactful, high-quality initiatives.

Nonprofit and humanitarian organizations working on health, education, or disaster relief can seek support for marginalized communities worldwide, including South Dakota. Semnani Family Foundation provides funding for programs such as healthcare access, child and women’s health, hunger and homelessness services, disaster relief, and related human and social services initiatives.

The Sidney Stern Memorial Trust Grant supports charitable, scientific, medical, and educational organizations that are 501(c)(3) certified. This private funder emphasizes impactful service to diverse populations without discrimination. Grants must be utilized within the United States and cannot be awarded to individuals, political candidates, or lobbying efforts. The Trust is dedicated to enhancing the general welfare through soundly-managed initiatives that contribute significantly to community needs.

Nonprofits, NGOs, and institutions with proven, scalable solutions to urgent global challenges can seek large-scale, multi-year support through TED’s Audacious Project, including organizations based in South Dakota. This initiative backs bold, evidence-based ideas across areas like global health, climate, social justice, and education, helping experienced teams refine and launch high-impact plans.

Nonprofit 501(c)(3) organizations in South Dakota working on housing, jobs, hunger, or related community development needs can seek sponsorship support for programs and events. Bank of America Charitable Foundation also considers initiatives in arts and culture, environment, diversity and inclusion, and workforce development that strengthen low- and moderate-income communities.

Nonprofit organizations working on environment, justice and human rights, science, human services, arts, education, health, or community development can apply for the Zegar Family Foundation’s invitation-only grants, including those in South Dakota. Funding supports programs that create meaningful, tangible impact, so South Dakota nonprofits with strong, mission-driven initiatives may be considered when invited to submit proposals.

South Dakota 501(c)(3) nonprofits working on hunger relief, food access, waste reduction, health, youth development, or community strengthening can receive donations that may support large-scale efforts. Grants from Kroger Co. Foundation help organizations request cash, sponsorships, gift cards, or product donations that advance Zero Hunger | Zero Waste and related community programs.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

Southern U.S. 501(c)(3) organizations serving communities through education, poverty relief, health, disaster relief, animal welfare, veterans, or faith-based programs can access funding through Robinson Foundation for single-year projects. Eligible nonprofits must be over three years old, serve areas below the Mason-Dixon line, and seek support for programmatic, not capital, needs.

The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.

Nonprofit organizations serving LGBTQ+ communities in South Dakota and the wider upper Midwest can apply for Philanthrofund Foundation’s PRISM Fund to build capacity and connections for rural programs. Eligible applicants are 501(c)(3)s or fiscally sponsored groups primarily serving LGBTQ+ people in Iowa, Minnesota, North Dakota, South Dakota, Wisconsin, and Native Nations.

RBC Foundation – USA aims to enhance community quality of life by supporting non-profit organizations that promote diversity and positive change. In 2023, it awarded over $2.8 million in grants, prioritizing youth programs for ages 15-29, arts access for diverse populations, and mental well-being initiatives. The foundation encourages sustainable projects that foster economic independence, providing critical support for education, mental health, and cultural enrichment, thereby making a significant impact across various communities.

Environmental and animal-focused 501(c)(3) organizations in South Dakota can seek project funding that advances environmental sustainability, land and habitat conservation, or ornithology-related work. With a mission to improve quality of life through environmental, educational, arts, and cultural initiatives, the Schumann Foundation favors innovative projects that might not proceed without its support; national applicants are considered, with preference for East Coast regions.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

South Dakota nonprofit organizations with 501(c)(3) status can access funding through Chick Fil A Foundation’s True Inspiration Awards to support youth education, housing, hunger relief, and environmental stewardship programs. Grants range from US $30,000 - US $350,000 for initiatives serving underserved youth and families, including food access, community services, and community beautification projects.

Nonprofit organizations and fiscally sponsored groups developing or testing community-based ideas in South Dakota can seek US $5,000 - US $100,000 per year for projects that benefit local residents. South Dakota Community Foundation’s Beyond Idea Grants support planning, piloting, and spreading innovative approaches that strengthen communities, with emphasis on inclusive engagement and demonstrated community support.

Nonprofit organizations in South Dakota with strong, replicable community partnerships can apply for Mutual of America Foundation's national Community Partnership Award, recognizing collaborations that address significant social issues. U.S. nonprofits demonstrating measurable community impact and effective cross-sector partnerships may be honored through several annual awards highlighting leadership and scalable models.

Nonprofit organizations working on poverty alleviation, disability services, social justice, or humanitarian relief can seek large project or operating support, including in South Dakota. With a mission to help disadvantaged people become self-reliant, Gupta Family Foundation provides US $5,000 - US $250,000 grants to smaller 501(c)(3) entities and qualifying foreign organizations in selected countries.