Best Operating Grants for Nonprofits in South Dakota

The National Breastfeeding Support Initiative aims to enhance maternity care quality by engaging diverse partners and providing training to healthcare organizations. It focuses on implementing evidence-based practices to support breastfeeding, ensuring safe and effective maternity care in hospitals across the U.S. and territories. By fostering collaboration and utilizing data for quality improvement, the initiative seeks to create a sustainable impact on maternal and infant health.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

The National Parks Business Plan Internship aims to enhance the operational health of national parks through a graduate-level program that trains students in business management and NPS operations. Participants will engage in substantive analysis, gain insights into park management, and promote federal careers in conservation. This initiative seeks to involve underrepresented graduate students from disciplines such as business administration and public policy, fostering a commitment to stewardship of public lands.

The Robert L. Johnson Memorial Research Grant, offered by the Midwest Aquatic Plant Management Society, supports graduate students in aquatic plant management with grants of up to $10,000. This initiative promotes research that advances the management of aquatic ecosystems and fosters educational opportunities. Recipients are required to present their findings at the annual conference, contributing to the society's mission of sustainable aquatic resource management and ecological preservation.

The Behavioral Health Integration Initiative aims to enhance the health of American Indian and Alaska Native individuals by expanding access to integrated behavioral health care. It supports Tribal and Urban Indian Organization health systems in providing culturally responsive and trauma-informed services. The initiative focuses on improving care coordination, promoting early identification of mental health issues, and integrating various health services to improve overall health outcomes and quality of life for AI/AN communities.

The Public Health Nursing initiative aims to enhance the health and wellness of American Indian and Alaska Native men by implementing a culturally sensitive case management model. Through this program, Public Health Nurses will provide preventive health services, facilitate access to care, and encourage healthy lifestyle choices. By promoting early identification and management of health issues, the initiative strives to improve overall community health outcomes through targeted, collaborative interventions.

The Native American/Native Hawaiian Museum Services (NANH) program, funded by the Institute of Museum and Library Services (IMLS), aims to support Native American Tribes, Alaska Native Villages, and organizations serving Native Hawaiians. It focuses on preserving heritage and culture through educational services, workforce development, capacity building, community engagement, and effective collections stewardship. This initiative is crucial for sustaining the rich cultural heritage of Native communities.

The Clinician Scholar Educator Award, funded by the Rheumatology Research Foundation, aims to enhance education in musculoskeletal and rheumatic diseases for future healthcare professionals. With an award amount of $210,000 over three years, this program supports rheumatology professionals dedicated to education and training, ensuring a well-prepared workforce to meet the growing needs of patients with rheumatic diseases.

The Mentored Nurse Practitioner/Physician Assistant Award for Workforce Expansion, funded by the Rheumatology Research Foundation, aims to increase the number of rheumatology healthcare providers across the U.S. This initiative addresses the growing demand for specialists, particularly in underserved areas. With an award amount of $25,000 for one year, it equips new NP/PAs with essential skills and knowledge needed for successful integration into rheumatology practices, enhancing patient access to quality care.

The DHQP Global NOFO aims to enhance the CDC's mission against antimicrobial resistance (AR) by integrating non-research implementation with focused research. This initiative addresses urgent global threats posed by various pathogens and healthcare-associated infections (HAIs). By leveraging existing CDC networks, the NOFO seeks to improve detection, surveillance, and infection control measures, ultimately reducing illness and mortality while protecting healthcare workers and patients, especially in low and middle-income countries.

The Steven Berkeley Marine Conservation Fellowship, established by the American Fisheries Society in 2007, honors a dedicated fisheries scientist. This $15,000 award supports graduate students engaged in thesis research on marine conservation topics. Applicants must be enrolled in a North American university's M.S. or Ph.D. program and be AFS members in good standing. The fellowship encourages innovative research addressing various conservation issues, not limited to fisheries.

The JA Community Foundation focuses on funding solutions that address the needs of the Japanese American and broader Asian American communities. They prioritize programs that enhance senior health, promote history, arts, culture, and support youth. Eligible applicants must be registered 501c3 organizations and can apply from all 50 states. However, organizations with open grants cannot submit new applications until their current grants are closed.

The Harry Sudakoff Foundation Grant supports qualified charities in Sarasota, Florida, focusing on arts, community, education for youth, environment, human services, and science. Established by builder Harry Sudakoff, the foundation prioritizes organizations with a history of support. Grants are restricted to 501(c)(3) entities, excluding individuals and certain funding types like endowments and operating expenses. A commitment to impactful contributions is central to the foundation's mission.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5413 - Comparison of PFAS Contributions to Agricultural Systems

Grant Information

• Report per- and polyfluoroalkyl substance (PFAS) concentrations from a variety of agricultural inputs, including animal manures, fertilizers, pesticides, composts, soil amendments, seed coatings, and biosolids-based products.
• Compare the impact of the various agricultural inputs on PFAS concentration in the soil profile over varying timeframes.
• Evaluate the fate and transport of different inputs to PFAS contributions in agricultural systems at field-scale.
• Determine the relative contributions from biosolids-based products and other inputs to help develop and prioritize risk management strategies.

The Health Professional Online Education Grant, offered by the Rheumatology Research Foundation, aims to enhance the skills of non-physician rheumatology professionals. By covering registration costs for the Advanced Rheumatology Course, this grant addresses the growing need for knowledgeable healthcare providers in rheumatology, ensuring better patient care for those with rheumatic diseases. This initiative supports the Foundation's mission to cultivate a robust workforce and improve health outcomes for patients.

The OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use program aims to provide high-quality mentoring services to youth affected by substance use. This funding opportunity supports various mentoring formats, including one-on-one, group, and peer mentoring, to assist those currently using substances or at risk due to familial influences. The initiative seeks to enhance the well-being of these youth through supportive relationships and guidance.

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

National Community Care Corps Grant

Community Care Corps encourages organizations across the country to apply for 18-month grants ($30,000–$200,000) to develop and scale innovative volunteer programs that provide nonmedical assistance to older adults, adults age 18 and older with disabilities and family caregivers.

Projects funded through this initiative will increase the number of community-based volunteer programs available to provide nonmedical assistance while decreasing the number of older adults, adults with disabilities, and family caregivers who need assistance in maintaining independence in the community but are unable to obtain help. In doing so, the initiative will strengthen community-based supports that help people maintain independence, reduce unmet needs, and improve overall well-being.

Focus Areas

Proposals must include one or more of the following focus areas:

• Integrate principles of the National Strategy to Support Family Caregivers
• Support grandparent/kinship-led households
• Use off-the-shelf materials. Off-the-shelf materials are products, components, or resources that are readily available for purchase and immediate use, without the need for custom development, modification, or special ordering
• Engage college students/interns for intergenerational connections
• Expand virtual or low-tech access
• Provide volunteer chaperone programs for non-emergency medical appointments
• Increase access to respite programs
• Build opportunities for volunteer skill-building

Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease

The Challenge

Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).

The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.

This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.

The Career Development Bridge Funding Award from the Rheumatology Research Foundation aims to support early and mid-career researchers facing funding challenges. This program provides $200,000 over two years to help investigators refine their NIH or equivalent grant applications while pursuing innovative research in rheumatic diseases. By fostering the next generation of rheumatologists, the foundation seeks to enhance patient care and advance treatment options for those affected by these conditions.

The Pediatric Rheumatology Fellow Research Award, offered by the Rheumatology Research Foundation, recognizes exemplary scientific abstracts from pediatric rheumatology fellows at ACR Convergence. With a $1,500 award and an additional $1,000 for travel expenses, this initiative aims to promote innovative research and enhance educational opportunities for future rheumatologists. The program underscores the importance of developing a skilled workforce to improve access to specialized care for patients with rheumatic diseases.

Patagonia supports environmental organisations with bold, direct-action agendas and a commitment to long-term change.

We support innovative work that addresses the root causes of the environmental crisis and seeks to protect both the environment and affected communities. We focus on places where we’ve built connections through outdoor recreation and through our network of retail stores, nationally and internationally.

We believe local battles to protect a specific stand of forest, a stretch of river, an indigenous wild species or a community from a polluting refinery build public support and confront larger, more complex issues like climate change, biodiversity loss and environmental justice.

We encourage work that brings underrepresented communities to the forefront of the environmental movement and defends communities whose health and livelihoods are threatened by environmental exploitation.

We support multipronged campaigns that push for greater environmental protections and force the government to abide by its own laws.

We fund work that:

• builds an equitable, inclusive and diverse environmental movement
• confronts systemic bias, discrimination and injustice in environmental policy or outdoor spaces
• is action-oriented
• focuses on root causes
• has a clear strategy
• identifies specific goals and objectives that can be effectively measured to evaluate success
• builds public involvement and civic engagement

Patagonia believes that the most direct path to real change is through building grassroots momentum.

Our funding focuses on organisations that have or can create a strong base of support. Because we’re a privately held company, we have the freedom to fund risk-taking, off-the-beaten-track groups, and that’s where we believe our small grants are most effective.

Mission

The Fish Family Foundation of Maine is a faith based charitable organization located in Bangor, Maine. Founded in 2007, our mission is to provide resources for many initiatives including, but not limited to, missions, education scholarships, ministries, medical research, and employment creation. The Fish Family Foundation of Maine is primarily funded by the family. However, contributions from like minded individuals and organizations is appreciated. The Fish Family Foundation of Maine has a balanced strategy of making funds available for immediate needs, while also investing to build a perpetual earning endowment ensuring the Foundation's successful future.

Missions:

We support needs of missionary organizations including sponsorships for young people who wish to attend youth group sponsored mission trips. We ordinarily make one time contributions but on occasion have made up to a three year commitment. 

Education/Scholarships:

The Foundation makes scholarships available to Colleges, Universities, and other Schools for student enrollment and expenses. We also consider new construction, existing renovation, equipment, and support material contributions.

Independent Churches and Ministries:

We accept a wide variety of requests, including, but not limited to: materials, equipment, new construction, renovations, programs, and services. 

Medical Research:

We support medical research opportunities close to our hearts and organizations that our family and friends have experienced. 

Job Creation:

We Support organizations that fund entrepreneurs in impoverished areas to start small businesses providing services and employment to the community.

Requests are considered by the trustees the first week of each month. Foundation payments are made by paper check in US dollars and are reported to the appropriate tax agencies. While we certainly wish that we could contribute to all the applications that meet our funding criteria, there are times when when available funding is limited and we are not able to contribute to some very worthy causes. If we are not in a position to help in the timeline requested, we will keep the information on file for possible consideration in the future. 

The Rural Communities Opioid Response Program - Evaluation aims to assess the effectiveness of behavioral health strategies in rural settings. By developing evaluation tools and resources, this initiative seeks to empower local communities in their health initiatives, ensuring that future programs are informed by comprehensive evaluations. Funded by the Health Resources and Services Administration, the program highlights the importance of tailored approaches to address opioid-related challenges in rural areas.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Veterans Food Assistance Program

It is our goal to ensure that no veteran goes hungry by providing essential food assistance and household support, fostering stability and well-being in the lives of our veterans and their families.

The Veterans Food Assistance Program (VFAP) is designed to provide a one-time grant of essential food and household support to veterans and their families, ensuring no veteran goes hungry. With the rising cost of living, especially food prices due to inflation, this program offers a much-needed lifeline to those who have served our country. Once approved, the DVNF program team will handle the shopping for you.

The Veterans Food Assistance Program provides a one-time grant per household to support different family sizes, given the rising cost of food:

• Married Veterans Grant Allowance
  • Married - No Children up to $250
  • Married - 1 Child up to $300
  • Married - 2 Children up to $450
  • Married - 3+ Children up to $500
• Single Veterans Grant Allowance
  • Single - No Children up to $200
  • Single - 1 Child up to $300
  • Single - 2 Children up to $350
  • Single - 3+ Children up to $450

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.