Best Large Grants for Nonprofit Organizations in Tennessee

The In These Mountains: Infrastructure Grants, offered by South Arts, aim to preserve and promote the folk arts and traditional culture of Central Appalachia. This initiative supports non-profit organizations in Kentucky, North Carolina, and Tennessee, focusing on enhancing the resources necessary for sustaining and advancing traditional arts. Grants of up to $30,000 are available to address non-programming expenses, ensuring the continuity of cultural practices while prioritizing inclusivity and accessibility.

Alliance for Cancer Gene Therapy

Unlike surgery, chemotherapy and radiation, cell and gene therapies harness the power of your immune system to destroy cancer cells without harming healthy tissue. We fund the research that will make this vision a reality.

Collaborating with partners and funding research fellows, we are transforming cancer treatments today while bringing the world closer to a cure for all cancers tomorrow.

ACGT Investigator Award in Cell and Gene Therapy for SOLID TUMOR CANCERS 

Purpose

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds breakthrough research that is transforming cancer treatment through cell and gene therapy. This ACGT grant award is for those conducting translational cell and gene therapy research specifically in solid tumor cancers.

Research Objectives

Cell and gene therapy for solid tumors poses major challenges driven by antigen heterogeneity, physical exclusion, immunosuppressive microenvironments, genomic instability, and safety limitations. This RFA seeks innovative, translational cell and gene therapy strategies that directly address these barriers.

Proposed approaches should demonstrate the capacity to: (1) overcome antigen escape through multi-targeted designs that broaden patient populations and account for heterogeneity and resistance due to antigen loss; (2) enhance trafficking, infiltration, and persistence within solid tumor sites; (3) resist or reprogram the immunosuppressive tumor microenvironment; and (4) incorporate built-in safety and controllability mechanisms suitable for clinical translation. Successful proposals will integrate these elements to enable durable, precise, and scalable therapeutic impact in solid tumors.

Building on the priorities outlined above, this RFP encourages proposals spanning a broad range of cell and gene therapy (CGT) platforms and rational combinations, including but not limited to:

• Engineered T Cell Approaches
• Innate and Alternative Immune Cell Platforms
• Gene Editing & Synthetic Biology Strategies
• Microenvironment-Modulating Strategies
• Combinatorial Approaches

Proposals that integrate multiple strategies to overcome trafficking, suppression, antigen escape, and safety barriers in a coordinated manner are strongly encouraged. Preference will be given to approaches with clear mechanistic rationale and a credible path toward clinical translation in solid tumors.

The U.S.-Southeast Asia-Japan Collaboration and Exchange Initiative Grant, administered by the Japan Foundation, New York, aims to enhance Japanese Studies through collaborative research and academic exchanges. Targeting U.S. institutions with developing Japanese Studies programs, this initiative fosters meaningful connections between scholars in the U.S., Southeast Asia, and Japan, promoting interdisciplinary collaboration and resource sharing to strengthen academic networks across these regions.

The ISF Policy Scholarship Program offers financial assistance ranging from $3,000 to $5,000 for scholars dedicated to improving Muslim representation in media and government. Since 2009, ISF has awarded 747 scholarships to students in fields that influence public policy and opinion, such as political science and international relations. With a commitment to mentorship and real-world experience, ISF aims to foster positive narratives about American Muslims and encourage their involvement in the policymaking process.

The Martin Luther King Jr. (MLK) Corridor Community Grants, provided by Keep America Beautiful, aim to empower communities to revitalize and beautify MLK corridors across the U.S. These grants support various projects, including murals, community gardens, and cleanup efforts, contributing to the initiative's goal of beautifying 25,000 communities by 2026. Eligible applicants include nonprofits, local governments, and community organizations, with a focus on sustainable impacts and local engagement.

The Small Business Transition Grant for New Entrepreneurs supports new investigators transitioning into entrepreneurship, particularly in small business settings. This NIH initiative aims to bolster their development as Program Directors or Principal Investigators while fostering their research and entrepreneurial skills. By promoting training and mentorship, this grant encourages the growth of promising technologies that align with NIH's mission to enhance health and save lives. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The Snapdragon Book Foundation Grant aims to enhance school libraries for disadvantaged children by providing essential funding. Established in 2008, it supports public, private, and experimental schools in the U.S., including territories. The foundation emphasizes access to quality reading materials, aiming to address inequities caused by structural racism. Eligible libraries can apply for funding to acquire books, reference materials, and subscriptions, ensuring that all students have access to enriching literary resources.

Community Foundation of the Fox River Valley

The Community Foundation of the Fox River Valley is a collection of individual funds and resources given by local citizens to enhance and support the quality of life in the Fox River Valley of Illinois.

We are a tax-exempt public charity that allows individuals, businesses, and non-profit organizations to establish permanent endowments and temporary funds within the confines of one large foundation.

Foundation funds are used to provide grants to non-profit organizations and scholarships to area students. The Foundation also hosts a Youth Engagement in Philanthropy (YEP) program, which helps high school students learn more about philanthropy and empowers them to make a difference in the community.

The Community Foundation of the Fox River Valley serves the City of Aurora, Kane County, and Kendall County within the State of Illinois.

John Masus Memorial Scholarship Fund

Originally the Masus Financial Group Scholarship Fund, the fund was renamed the John Masus Memorial Scholarship Fund as a memorial to John Masus at the time of his passing.

The Fund supports scholarships to graduating high school seniors who reside within the 60510 zip code in Kane County. 

The monetary value of each scholarship award varies depending upon the amount available in each individual scholarship fund. The most common scholarship award amount is $1,000 for a single year. Scholarships are designated as non-renewable one-year awards or renewable multi-year awards depending upon the scholarship fund criteria, as established by the donor of the scholarship fund.

The Celia C. Newcomb Memorial Scholarship, managed by the Crown Point Community Foundation, aims to enrich the lives of South Lake County residents. This scholarship supports Lake County, IN residents pursuing degrees in Education, including high school graduates and adult learners. Applicants must provide an additional essay and meet specific eligibility criteria. It embodies the foundation's mission to address community needs through charitable giving.

Armstrong County Community Foundation (The Community Foundation Serving the Heart of Western Pennsylvania)

In 1997 Merchants National Bank, an Armstrong County community bank, marked its 100th anniversary. The centennial celebration included a unique expression of gratitude to the community in the form of $100,000 to be used as a seed fund to initiate a community foundation for Armstrong County. The bank challenged the community to keep the principal balance of the endowed funds intact and spend only a portion of the interest earnings to ensure a lasting legacy.

The Armstrong County Community Foundation, a public nonprofit corporation,

• Gives grants, scholarships, and organizational support to address the needs of our community.
• Builds a permanent endowment to help our donors create a legacy through this endowment.
• Promotes informed philanthropy to increase and sustain charitable resources for the region.
• Provides leadership and builds partnerships to identify and solve community issues.

Kay Detrick Owen Scholarship

The Kay Detrick Owen Scholarship Fund was established in 2007 by The ARC Manor Foundation to support the education of students who plan to major in, or are currently studying for, a degree in human services.

A human services professional is a generic term for people who hold professional and paraprofessional jobs in diverse settings such as group homes, halfway houses, community mental health centers, programs concerned with drugs and alcohol, domestic violence, aging, correctional programs, programs for people with intellectual disabilities, social workers, and probation/parole officials. Human services is a field of study that assists individuals and communities to function as effectively as possible in major domains of living. Its objective is to meet human needs through an applied knowledge base, focusing on prevention as well as remediation of problems, and maintaining a commitment to improving the overall quality of life of service populations.

Suggested (but not limited to) acceptable examples of college majors and human services positions are psychology, sociology, social work, adult education, individual and family guidance counseling, behavioral management, criminal justice, probation officer, rehabilitation, mental health counselor, marriage and family therapist, substance abuse counselor, grief counselor, case manager, child advocate, child life specialist, etc. 

The Robert Glenn Rapp Foundation, established in 1951 in Oklahoma, aims to support charitable organizations across the U.S., with a focus on education and local initiatives. Grants are awarded to qualified 501(C)(3) organizations, prioritizing projects that align with the foundation's mission in areas such as education, health, arts, and literacy. Interested applicants must submit a Letter of Inquiry before applying for funding, ensuring alignment with the foundation's priorities.

The DARPA Tactical Technology Office (TTO) seeks innovative proposals to enhance national security through cutting-edge technology. This initiative focuses on Design/Build/Buy, Surge and Sustain, Long Range Effects, and Disruptive Innovation. By fostering rapid adaptation and sustainable force structures, TTO aims to demonstrate revolutionary systems that are not only effective but also affordable and responsive to emerging challenges.

Proteus Fund

Proteus Fund partners with foundations, individual donors, activists, and other allies to work strategically towards racial, gender, queer, and disability justice and an inclusive, fully-representative democracy. We curate an ecosystem of mutually reinforcing, aligned donor collaboratives and fiscally sponsored projects that deploy a creative array of strategies and tactics to further this vision.

RISE Together Fund: Small Grants

Call For Application

RISE Together Fund (RTF), an initiative of Proteus Fund, is announcing an open call for inquiries for our 2026 Small Grants Fund for U.S. public charity organizations or fiscally sponsored projects of such organizations, that support Black, African, Arab, Middle Eastern, Muslim and South Asian (BAMEMSA) communities.

As part of RTF’s commitment to prioritizing the needs and sustainability of the fields we collectively support, RTF will provide organizations with general operating grants to allow for organizational flexibility when possible. 

About RTF's Small Grants Fund

BAMEMSA movements have a strong history of organizing and collaboration, and are well poised with the knowledge, learning and experience to build an inclusive, multiracial democratic future and respond to the current unconstitutional threats facing the country. Through this fund, RTF aims to resource community power building organizations that use a multiplicity of approaches to create change rooted in the strength and leadership of BAMEMSA movements.

RTF supports groups that build community power, strengthen movement bases, defend civil and human rights including freedom of protest, speech, religion, and association, end the criminalization and surveillance of our communities, and respond to the rise in xenophobia, Islamophobia, and hate. RTF values groups that are intersectional in their approach and have or are developing sustainable long-term strategies to support BAMEMSA communities and movements.

Priority Issue Areas

• Protecting and advancing the rights of immigrant and refugee BAMEMSA communities by responding to harmful policies and practices, and strengthening community-led advocacy at the local, state, or federal level.

• Mobilizing BAMEMSA communities for nonpartisan civic engagement and election protection by increasing nonpartisan voter participation, combating voter suppression, and building sustained civic infrastructure ahead of, during, and between elections.

• Advocating for U.S. policy changes that end violence in Gaza and the West Bank by elevating Palestinian voices, influencing public discourse, and engaging in advocacy that shifts U.S. political, diplomatic, or funding decisions.

• Challenging harmful national security frameworks and their impacts on BAMEMSA communities by documenting, exposing, and organizing against surveillance, Islamophobia, and policies rooted in the War on Terror, particularly in the context of 9/11’s 25-year legacy.

• Responding to emerging opportunities and threats affecting BAMESMA communities such as influencing policy developments, addressing civic issues in the U.S., or developing narratives to change public discourse. This includes work addressing weaponizing issues around bodily autonomy and LGBTQ+ identity to fracture movements and communities.

Priority Strategies

RTF values organizations that take an intersectional approach and are intentionally building long-term community power. We prioritize support for groups that strengthen movement ecosystems, deepen their base, and defend the rights of BAMEMSA communities through the following strategies:

• Convening, Collaboration, and Movement Coordination: Bringing together organizations, leaders, and coalitions to align shared goals, coordinate strategies to advance shared visions, and reduce fragmentation across the field. This includes facilitating strategic convenings, developing platforms for collaboration, building cross-issue or cross-regional partnerships, developing shared agendas or issue campaigns, and strengthening trust and alignment among movement actors.
• Community Power-Building, Base Building, Civic Engagement, and Organizing: Expanding and activating a grassroots base within BAMEMSA communities to drive collective action and policy change. This includes community leadership development, public education campaigns, community organizing, nonpartisan voter engagement and election protection, and ongoing nonpartisan civic participation efforts that build sustained community power.
• Legal and Policy Advocacy Infrastructure: Advancing legal strategies and policy advocacy that expand and protect the rights of BAMEMSA communities. This includes impact litigation, legal advocacy, know-your-rights efforts, policy development, and advocacy at a local, state, or federal level.
• Communications and Narrative Strategy: Shaping public discourse and advancing narratives that reflect the experiences, dignity, and demands of BAMEMSA communities. This includes developing messaging strategies, producing and amplifying media, countering harmful or divisive narratives (including those targeting immigrants, religious minorities, LGBTQ+ communities, and reproductive rights), and increasing the voice share of BAMEMSA community members.
• Bolstering Movement Infrastructure: Strengthening the internal capacity and long-term sustainability of organizations and the broader movement ecosystem. This includes organizations supporting leadership development and pipelines, data and technology infrastructure, security and safety, and other core functions that enable groups to operate effectively and respond to evolving challenges.

Limited funding may be available for requests above $25,000.

The Edward M. Nagel Endowed Scholarship, provided by the United Negro College Fund, supports undergraduate students pursuing business-related studies. With a focus on academic excellence and leadership, applicants must maintain a GPA of 3.0 or higher and demonstrate financial need. This scholarship plays a vital role in promoting education for future leaders, reflecting UNCF's mission to empower minority students for over seventy years.

The ENF Community Investments Program - Beacon Grants offers a unique opportunity for Elks Lodges to initiate and lead charitable projects in their local communities. This program encourages Lodges to develop sustainable initiatives, allowing them to address community needs effectively. By fostering collaboration and providing resources, the Beacon Grants enhance the quality of life for residents, including veterans and families. In 2025-26, all Lodges will have the chance to participate, promoting a culture of giving back.

At the Community Foundation for Muskegon County, we work with donors, grantees, and advisors to address key community issues.

Ken and Clara Kolberg Family Scholarship

This scholarship has been made possible by the generosity of Ken Kolberg and family, who established the Ken and Clara Kolberg Family Scholarship of the Community Foundation for Muskegon County. Teaching is the family business of the Kolberg Family. Ken started teaching in Muskegon Public Schools after WWII and did so for thirty-seven years. Ken and Clara raised five children, of whom four became teachers - two working in Muskegon. Through the establishment of this Fund, the family is assured of having an impact on students far into the future. This Fund will support Muskegon students pursuing careers in education, especially minority students so greatly needed as teachers in our school systems.

The Blueprint MedTech Translator program aims to support the advancement of therapeutic and diagnostic devices for nervous and neuromuscular disorders. This initiative encourages clinical feasibility studies and the implementation of clinical prototype devices, along with safety and efficacy testing. Participants will receive funding to conduct research in their own labs, collaborate with NIH consultants, and access contract research organizations for specialized testing, ensuring a comprehensive approach to device development.

The Mifflin Memorial Fund Grant supports nonprofit organizations in human services and education, particularly those serving low-income and minority populations. This private fund also contributes to environmental and conservation initiatives, and occasionally cultural organizations for specific projects. Eligible applicants must be tax-exempt nonprofits, ensuring that grants are directed towards impactful community services and educational opportunities.

The Progressive Multiplier Grants support U.S. based nonprofits and subsidiaries focused on generating independent revenue through innovative projects. These grants aim to empower organizations working towards democracy, justice, and environmental restoration, fostering civic engagement and equality. By funding campaigns and civic mobilization, the program seeks to build sustained progressive power, avoiding direct service or public education initiatives. Interested parties can submit letters of inquiry on a rolling basis when funding aligns with grant criteria.

The Northeast Asia Council Japan Studies Grants provide funding for small scholarly conferences on Japanese studies in the U.S. These grants, up to $5,000, support events that foster collaboration among scholars, focusing on cutting-edge research. Eligible applicants must be U.S. citizens or Japanese nationals and current AAS members. Priority is given to those securing matching funds and for projects not previously funded by NEAC. Ineligible costs include stipends for organizers and travel to unrelated seminars.

The Michigan Health Endowment Fund offers Scholarships for Conferences and Professional Development to support health-related events. These scholarships, up to $2,500 per person and $5,000 per organization, are available for current or past grantees and partners. Applications are accepted on a rolling basis, with a requirement to submit at least four weeks before the event. Priority is given to organizations that haven't received funding in the previous year, ensuring equitable access to professional development opportunities.

The Foist Family Perseverance Scholarship Fund, established by the Berkshire Taconic Community Foundation, aims to support adult learners and graduating high school seniors from Berkshire County pursuing careers in healthcare and sciences. With a focus on clinical and research fields such as nursing and occupational therapy, this fund seeks to empower individuals in their educational and professional journeys, promoting economic mobility and high quality of life in the community.

Leadership through Scholarship Fellowship

The yearlong Leadership through Scholarship Fellowship offers training and mentorship for early-career and mid-career faculty with a focus on developing scholarly writing skills for academic advancement and leadership.

Mid-Career Fellows

Mid-career fellows will benefit from tailored mentorship and guidance to reach the next milestone in their careers, including:

• Receive 1:1 mentorship specific to their challenges or roadblocks to promotion or leadership
• Participate in a detailed CV review to determine edits for promotion
• Work as a group with mentor faculty on challenges in scholarship to move forward with stuck projects
• Learn how to navigate mid-career leadership challenges

The tuition cost for fellows is $1200. A limited number of scholarships are available to cover the fellowship tuition due to a generous gift from Drs Marjorie Bowman and Robert Choplin.

Benefits of the Fellowship

The Research on Research Security Program, funded by the National Science Foundation, aims to foster collaboration between STEM researchers and research security practitioners. It encourages interdisciplinary approaches to enhance evidence-based research on security issues. Proposals can include conferences, workshops, and planning grants, as well as international partnerships, to address U.S. concerns in research security. This initiative is vital for developing a robust community in this emerging field.

The Schilling Scholarship, offered by the Community Foundation of the Ozarks, provides six $3,000 scholarships to graduating high school seniors from select schools. Renewable for up to three years, recipients must maintain a 3.0 GPA, enroll in 12 credit hours, and major in Agriculture. An essay submission is required, and applicants must demonstrate financial need by submitting their FAFSA-SAI. This scholarship aims to support students pursuing degrees in various Agriculture fields.

About Boeing

A leading global aerospace company and top U.S. exporter, Boeing develops, manufactures and services commercial airplanes, defense products and space systems for customers in more than 150 countries. Our U.S. and global workforce and supplier base drive innovation, economic opportunity, sustainability and community impact. Boeing is committed to fostering a culture based on our core values of safety, quality and integrity.

The Employees Community Fund (ECF) of The Boeing Company

One of the largest employee-managed funds of its kind in the world, the Employees Community Fund (ECF) of The Boeing Company has empowered employees to make a greater impact by pooling their tax-deductible donations for more than 60 years. Employee-led grantmaking committees at 20 Boeing sites provide combined employee donations to nonprofits in their communities through ECF grants.

Charitable or educational organizations can apply for grants from the Employees Community Fund (ECF) of The Boeing Company.

Puget Sound Chapter

The Employees Community Fund (ECF) of Boeing Puget Sound is a pooled fund consisting of recurring payroll contributions from generous Boeing employees. It funds local nonprofits that help thousands of families and individuals in the Puget Sound region where Boeing employees live and work.

ECF focus areas

ECF makes grants to 501(c)(3) Health & Human Service nonprofits such as food banks, job-training programs, shelters, transitional housing, mental health services, and low-income medical clinics. ECF seeks the direct client benefit of each grant to ensure that our employees’ contributions directly help those in need.

ECF funding criteria

ECF has two distinct grant categories – Supporting Grants and Capital Campaign Grants.

ECF of Boeing Company: Puget Sound Chapter Supporting Grants

Consideration is given to nonprofits/agencies that are performing well and are seeking to upgrade, replace or modify elements of their infrastructure.

• Supporting grants cannot exceed $50,000. The requested amount cannot be more than 10% of an agency’s gross annual revenue.
• Supporting grants will be considered only for agencies benefiting residents in the Puget Sound Region.
• Supporting grants help agencies continue to effectively provide services through enhanced direct client benefit by aiding them in procuring and/or paying for items such as:
  • Equipment (ex. office, kitchen, industrial, furniture, etc.)
  • Vehicles used to support clients and/or transport food and/or goods (cost of vehicle and accommodations, tax, and licensing only; operating expenses, such as insurance, fuel, etc. is not allowed)
  • Phone systems
  • Cell phones for direct client use
  • Remodels and/or renovations (must hold at least a 10-year lease or own the building)
  • Purchase or construction of new buildings
  • Computers or tablets for direct client benefit and/or use
  • Software for direct client benefit and/or use (ex. Augmentative and alternative communication (AAC) device)
  • Information Technology expenses, without which procured tools would not work
  • External improvements for client safety (i.e. security system, exterior lighting, improved ADA accessibility, new or refinished pavement or concrete)
• Supporting grants which are accepted must be spent as approved within nine (9) months.

The Rev. Robert L. Browning Memorial Scholarship, managed by the Decatur County Community Foundation, supports students from Decatur County pursuing careers in ministry or social services, as well as those planning to attend Anderson University. This scholarship is renewable for up to three years and is aimed at graduating high school seniors residing in Decatur County, IN. Preference is given to applicants who attend the Church of God.