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Best Large Grants for Nonprofit Organizations in Tennessee

Find the perfect Large Grants for Nonprofit Organizations in Tennessee on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in Tennessee in the United States.

9,000+

Available grants

$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

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9,430 Results based on applied filters

Southern NM Down Syndrome Families Scholarship Fund Endowment

The Community Foundation Of Southern New Mexico
Private
United States
Unspecified amount
The Southern NM Down Syndrome Families Scholarship Fund Endowment aims to provide financial support for individuals with Down syndrome pursuing post-secondary education or life skills training at accredited institutions. Managed by the Community Foundation of Southern New Mexico, this scholarship embodies the mission of improving quality of life and fostering educational opportunities for diverse communities. It encourages applicants from various backgrounds, including those with disabilities, to achieve their academic and personal goals.
Education - Higher Education Down Syndrome Vocational & Trade Education +2 more

Best Buy Teen Tech Center - Mini Tech Skills Workshop Grant

Best Buy Foundation
Private
Alameda County, California, Albemarle County, Virginia +47 more
Up to US $24,999
The Best Buy Teen Tech Center is offering a Mini Tech Skills Workshop Grant to support local and national non-profits in providing STEAM skills workshops for youth aged 13-19. These workshops, which include topics such as coding, filmmaking, and robotics, aim to enhance technical skills and career exploration. Funding can reach up to $24,999, with a focus on hands-on, facilitator-led experiences, and additional programming opportunities may be considered.
After School / Summer Educational Programs Youth Services Workforce Preparation & Job Readiness +2 more

Presbyterian Church (U.S.A.): Undergraduate Scholarships

Presbyterian Mission Agency
Private
United States
Up to US $6,000
The Presbyterian Church (U.S.A.) offers financial support through undergraduate scholarships for up to 100 eligible college students each year. Applicants must be members of PC(USA) pursuing their first associates or bachelor's degree at an accredited institution in the U.S. during the 2025-2026 academic year. This initiative aims to assist students in overcoming financial barriers to education while fostering a commitment to service within their communities.
Academic Scholarship Programs Presbyterianism Black American Services +2 more

TMCity Foundation: Research Grant

TMCity Foundation
Private
United States
US $25,000 - US $250,000
The TMCity Foundation Grant supports innovative research in neurocognitive healthcare, with funding ranging from $25,000 to $250,000. This grant aims to address critical challenges in mental health by fostering cutting-edge research and transformative technologies. Applicants, preferably 501(c)(3) organizations, can submit letters of inquiry on a rolling basis, with a focus on projects based in Southern California and the Greater Boston area. The Foundation is committed to catalyzing advancements in understanding the brain and delivering effective treatments.
Brain Injuries Cognitive Science Neuroscience +3 more

Health & Wellness Agency Grant

Jack And Jill Of America Foundation Inc
Private
United States
Up to US $10,000
The Health & Wellness Agency Grant, offered by the Jack and Jill of America Foundation, aims to empower disadvantaged communities by providing access to heart and mental health education. This grant supports 501(c)(3) organizations that align with the foundation's mission to enhance the well-being of African American children and families. Eligible applicants can receive funding to implement impactful health initiatives, while ineligible expenses include scholarships and operational costs.
Mental Health & Psychiatric Diseases Heart Disease Community Health Education +1 more

AHRQ Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01) (349962)

US Department of Health and Human Services: Agency for Healthcare Research and Quality (AHRQ)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.
Patient Care & Services Home Health Care Health Care Access & Delivery +1 more

Cohort Studies of HIV/AIDS and Substance Use (U01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.
HIV / AIDS Addiction & Substance Use Disorders

PNC Foundation: Grow Up Great Grant

PNC Foundation
Private
Accomack County, Virginia, Adams County, Colorado +667 more
Unspecified amount
The PNC Foundation's Grow Up Great Grant is a significant initiative aimed at enhancing educational opportunities for children from birth to age 5. With a commitment of $500 million, this program focuses on improving school readiness through support in vocabulary development, social-emotional learning, and the arts. By partnering with community-based nonprofits, PNC aims to foster stronger, smarter, and healthier communities, ensuring a brighter future for the next generation.
Education - Preschool / Early Learning Teacher Development & Training Parental Involvement in Education +4 more

Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed) (358087)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Central America +6 more
Unspecified amount
This funding opportunity aims to address health disparities in non-communicable and chronic diseases in Latin America. The initiative encourages collaborative research that evaluates public health policies and improves health outcomes among U.S. Hispanics/Latinos. Applications are welcomed from multi-disciplinary teams, with a requirement for collaboration with Latin American institutions. Key deadlines for submission are outlined, with a focus on innovative approaches to tackling critical health issues across the region.
Health Care Access & Delivery Health Policy & Advocacy Health Disparities & Social Determinants of Health +4 more

Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional) (357817)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The U.S. Department of Health & Human Services, through the NIH, invites applications for the U01 grant aimed at advancing gene-based therapies for ultra-rare neurological and neuromuscular disorders. This initiative focuses on IND-enabling studies and supports the development of innovative therapeutics with proven biological rationale. Applications must include robust data and compelling justification for the proposed clinical candidates, targeting a specific patient population to facilitate IND filing and subsequent clinical trials.
Neurological Diseases & Disorders Rare Diseases Genetics & Genomics +2 more

NCAA Postgraduate Scholarship - Fall Sports

National Collegiate Athletic Association
Private
Canada, Puerto Rico +2 more
US $7,000
The NCAA Postgraduate Scholarship for Fall Sports offers up to 126 scholarships annually, valued at $10,000 each, to student-athletes who excel academically and athletically. Eligible candidates must be in their final year of intercollegiate competition and maintain a minimum GPA of 3.20. Scholarships are awarded three times a year, with 21 available for men and 21 for women across various sports. This initiative promotes graduate education and recognizes the achievements of outstanding student-athletes.
Sports & Athletics Equestrian Sports Duathlons & Triathlons +2 more

Indigo Oak Fund: Grant for Women & Children's Issues

Vance R and Colleen H Andrus Family Foundation
Private
United States
Unspecified amount
The Indigo Oak Fund, a Colorado-based private foundation, focuses on empowering women and children through various initiatives. By funding organizations that address issues such as domestic abuse, food insecurity, and gender equity, the Fund aims to improve lives and foster lifelong learning. Their mission emphasizes recognizing individual potential and ensuring equal opportunity for all, making a significant impact in communities across Colorado and the Bay Area.
Women & Girl Services Women's Rights & Equality Women's Health +4 more

Limited Competition: CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $450,000
This funding opportunity aims to enhance understanding of chemical-induced skin injuries, particularly those recognized as public health threats. The initiative encourages research focused on identifying commonalities in these injuries and exploring shared signaling pathways. By investigating therapeutic targets, this program seeks to develop effective medical countermeasures. Multiple application deadlines are set from 2025 to 2027, supporting diverse research proposals in this crucial area.
Environmental Chemistry & Toxicology Wounds & Injuries Burn Care

Research Experiences and/or Mentoring Networks through Research Education to Enhance Clinician-Scientists' Participation in NIDCDs Research (R25 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,250,000
The NIH R25 program enhances clinician-scientists' involvement in research by supporting educational activities aimed at recruiting individuals from diverse backgrounds into biomedical, behavioral, and clinical sciences. This initiative promotes the development of research experiences and mentoring networks to foster a robust research workforce. Applications are due by 5:00 PM local time of the applicant's organization, providing an opportunity for engaging with the NIH's mission.
Medical Education & Professional Training Hearing Disorders & Audiology Hearing Impairment Care & Services +1 more

Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional) invites applications that address urgent research needs in substance use epidemiology and health services. This funding opportunity encourages pilot studies focusing on emerging drug issues, unexpected prescription drug abuse trends, and timely medical system challenges. Letters of Intent are recommended 30 days before the proposal deadline, emphasizing the necessity for rapid review and funding to address pressing scientific questions.
Addiction & Substance Use Disorders Drug Use Disorder

Dementia CAReS Grants for American Indian and Alaska Native Communities

US Dept. of Health & Human Services: Indian Health Service
Federal Government
United States
US $750,000
The Dementia CAReS Grants aim to enhance the lives of American Indian and Alaska Native communities affected by dementia. By providing funding, training, and support, this initiative focuses on developing actionable strategies within Tribal and Urban Indian settings. Key activities include establishing a network of dementia champions and promoting local best practices. The goal is to empower communities to improve dementia care and outcomes through collaborative efforts and innovative approaches.
Indigenous Health Systems Native American Services Indigenous Services +1 more

AWWA Scholarship Program - Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship

American Water Works Association (AWWA)
Association/Society
North America
US $5,000
The AWWA Scholarship Program, specifically the Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship, offers a $5000 award to undergraduate students pursuing careers in the water sector. Established by the American Water Works Association, this scholarship honors the mentorship of Vernon D. Lucy III and aims to support the next generation of water industry professionals. Eligible candidates must demonstrate interest in water-related fields, underscoring AWWA's commitment to fostering future leaders.
Water Resource Management Academic Scholarship Programs

AWWA Scholarships Program - Mueller Water Products Continuing Education Scholarship

American Water Works Association (AWWA)
Association/Society
North America
US $5,000
The AWWA Scholarships Program, led by the American Water Works Association, aims to support the future of the water industry by investing in students. The Mueller Water Products Continuing Education Scholarship awards $5,000 to an undergraduate student employed by a water utility, emphasizing the importance of practical experience in education. This scholarship not only aids financial needs but also encourages students to pursue careers in water supply, fostering growth in this vital sector.
Water Resource Management Academic Scholarship Programs

See, Test & Treat Grant - Multiyear Funding

College Of American Pathologists Foundation
Private
United States
Up to US $50,000
The See, Test & Treat Grant offers vital funding for cancer screening and health education programs targeting medically underserved communities. This pathologist-led initiative aims to reduce healthcare barriers, empower preventive care, and connect patients with local resources. Eligible organizations can apply for up to $50,000 over three years, fostering sustainable health improvements. The program emphasizes same-day results for screenings and culturally appropriate education, ensuring equitable access to essential healthcare services.
Reproductive Health Breast Cancer Reproductive Education +1 more

Walking Classroom Grant Program

Alliance For A Healthier Generation
Private
United States
Unspecified amount in in-kind support
The Walking Classroom Grant Program, offered by the Alliance for a Healthier Generation, enables classroom teachers in public schools to receive donated materials for their students. This innovative program promotes physical activity while maintaining instructional time through engaging podcasts. Ideal for grades 3-8, it enhances cognitive function and retention. Schools with the greatest need, both socioeconomically and academically, are prioritized, ensuring that all students can benefit from this unique educational approach.
Academic Success & Enrichment Education - Middle School Education - Elementary School +2 more

Indigenous Scholarships: Arts Fund (AUS to USA and USA to AUS)

American Australian Association
Private
Australia, United States
US $10,000
The Indigenous Scholarships: Arts Fund facilitates artistic development for Aboriginal Australian, Torres Strait Islander, Native American, Alaskan Native, and Native Hawaiian artists. Offering up to $5,000, it supports projects in each other's countries, with applications due in March and September. Since 2002, over $1 million has been awarded to more than 500 artists, fostering cultural exchange and growth in the arts between Australia and the USA.
Writing & Literature Performing Arts Media Arts +5 more

NEA Federal Rescue Implementation Network Grant

National Education Association Staff Organization
Private
United States
Up to US $100,000
The NEA Federal Rescue Implementation Network Grant provides up to $100,000 per year for two years to state affiliates for hiring a coordinator to implement the American Rescue Plan in support of public education. This funding is specifically for backfilling a position that must remain filled for at least ninety days, ensuring effective oversight of federal recovery initiatives within the affiliate.
Education - K through 12 Teacher Development & Training After School / Summer Educational Programs +3 more

Hearst Foundation: Health Grant

William Randolph Hearst Foundation
Private
United States
More than US $100,000
The Hearst Foundation's Health Grant aims to support nonprofits that enhance healthcare access for underserved populations in the U.S. Focused on improving skills and increasing healthcare practitioners, the grant also emphasizes public health and medical research. With a history of funding significant projects, the foundation prioritizes programs that address the complex needs of low-income, rural, and elderly communities. This commitment ensures a sustainable impact on national health outcomes while supporting innovative healthcare delivery systems.
Health Care Access & Delivery Health Facilities & Clinics Epidemiology & Public Health +3 more

Pediatric Scientist Development Program

March Of Dimes Inc
Private
Canada, United States
Up to US $250,000
The Pediatric Scientist Development Program (PSDP) supports early-career pediatricians committed to research. It emphasizes flexible research proposals, fostering scientific inquiry in pediatrics, particularly in areas like prematurity and health equity. Funded by March of Dimes and other organizations, the program aids scholars in gaining vital training and mentorship while contributing to advancing pediatric health outcomes. Applicants must have completed pediatric residency in the USA or Canada and demonstrate a strong commitment to medical research.
Obstetrics & Neonatal Care Children’s Health & Pediatrics

Reproductive Scientist Development Program

March Of Dimes Inc
Private
United States
Up to US $250,000
The Reproductive Scientist Development Program (RSDP) aims to enhance maternal and infant health by supporting early-career researchers in obstetrics and gynecology. This program encourages applicants committed to advancing their careers in academic research. With a focus on health equity and the training of scholars, RSDP seeks to foster impactful research proposals that address critical issues such as prematurity and maternal morbidity. Funded by the March of Dimes and other organizations, it empowers diverse talent in the field.
Reproductive Health Obstetrics & Neonatal Care

PERF: Career Development Grants - CNS Elterman Research Grant

Pediatric Epilepsy Research Foundation
Private
Canada, United States
US $150,000
The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.
Children’s Health & Pediatrics Epilepsy Neurological Diseases & Disorders +1 more

PERF: Career Development Grants - CNS Shields Research Grant

Pediatric Epilepsy Research Foundation
Private
Canada, United States
US $150,000
The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.
Neuroscience Neurological Diseases & Disorders Children’s Health & Pediatrics +1 more

Large Grants for Nonprofit Organizations in Tennessee Highlights

Looking for large grants for nonprofit organizations in Tennessee?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Tennessee recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Tennessee

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Large Grants for Nonprofit Organizations in Tennessee grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

36 Large Grants for Nonprofit Organizations in Tennessee over $25K in average grant size

24 Large Grants for Nonprofit Organizations in Tennessee over $50K in average grant size

22 Large Grants for Nonprofit Organizations in Tennessee supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in Tennessee supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Tennessee?

Most grants are due in the first quarter.

Q1
32.2%
Q2
21.7%
Q3
26.3%
Q4
19.7%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Tennessee?

Grants are most commonly $12,250.

$500 $500 Min.
$12,250 $12.3 K Median
$72,415 $72.4 K Average
$2,300,000 $2.3 M Max.

Average Grant Size

What's the typical amount funded for Tennessee?

Grants are most commonly $122,522.

$122,522

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Tennessee year over year?

In 2024, funders in Tennessee awarded a total of 44,541 grants.

2022 39,759

2023 39,873

2024 44,541

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Tennessee given out in Tennessee, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Tennessee changing over time?

Funding has increased by 25.17%.

2022 $3,809,568,961

2023 $4,350,973,827
14.21%

2024 $5,446,107,598
25.17%

Tennessee Counties That Receive the Most Funding

How does grant funding vary by county?

Shelby County, Davidson County, and Knox County receive the most funding.

County Total Grant Funding in 2024
Shelby County $2,664,074,547
Davidson County $1,298,691,246
Knox County $294,292,803
Hamilton County $283,062,013
Henderson County $215,691,648