Best Large Grants for Nonprofit Organizations in Tennessee

The John H. and Ruby M. Laurie Charitable Scholarship offers a $1,000 scholarship to graduating seniors from Camdenton High School with a minimum GPA of 3.5. This renewable scholarship supports students enrolled in accredited colleges or vocational schools, encouraging academic achievement. Preference is given to those pursuing a Business degree. This initiative aims to enhance community welfare through educational support and resource development, fostering future leaders in the region.

Cures Within Reach

Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.

Clinical Repurposing Research to Impact US Veterans/Military

This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals. 

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.

The Rural Communities Opioid Response Program - Evaluation aims to assess the effectiveness of behavioral health strategies in rural settings. By developing evaluation tools and resources, this initiative seeks to empower local communities in their health initiatives, ensuring that future programs are informed by comprehensive evaluations. Funded by the Health Resources and Services Administration, the program highlights the importance of tailored approaches to address opioid-related challenges in rural areas.

The AFNGA AusArt Scholarship, offered by the American Australian Association, supports Australian graduate students in fine arts or related fields for one year of artistic development in the US. With funding of US $30,000, recipients can cover travel, living, and tuition costs. Eligible applicants must be Australian citizens or permanent residents, emerging artists, and have a formal offer from an accredited US institution. This scholarship fosters cultural exchange and artistic growth between Australia and the US.

The Jeannett Slesnick Community Spirit Scholarship offers up to four years of college tuition assistance for graduating seniors from Coral Gables High School, Miami Senior High School, or ISPA. Applicants should demonstrate an interest in communications, journalism, leadership, or historic preservation, and must maintain a 3.0 GPA. Established in 2022 by Jeannett and Don Slesnick, this scholarship honors Jeannett's commitment to community service and education, supporting local high school graduates in their academic pursuits.

Community Foundation of the Fox River Valley

The Community Foundation of the Fox River Valley is a collection of individual funds and resources given by local citizens to enhance and support the quality of life in the Fox River Valley of Illinois.

We are a tax-exempt public charity that allows individuals, businesses, and non-profit organizations to establish permanent endowments and temporary funds within the confines of one large foundation.

Foundation funds are used to provide grants to non-profit organizations and scholarships to area students. The Foundation also hosts a Youth Engagement in Philanthropy (YEP) program, which helps high school students learn more about philanthropy and empowers them to make a difference in the community.

The Community Foundation of the Fox River Valley serves the City of Aurora, Kane County, and Kendall County within the State of Illinois.

Robert J. O’Connor Memorial Scholarship Fund

The Robert J. O’Connor Memorial Scholarship Fund was created as a way to honor his long-standing relationship with the Community Foundation and the passion he held for helping local students pursue their educational goals. Bob’s connection to the Community Foundation started when he was the recipient of a scholarship as a 1962 graduate of East Aurora High School. He would later serve nine years as a Foundation Board member.

Mission

To empower worthy nonprofits by providing critically needed, unrestricted funding that helps them fulfill their missions with confidence and sustainability.

How We Serve Nonprofits

AmFund partners with nearly 800 organizations annually—supporting causes related to health, education, the arts, human services, animal welfare, and more. We’re known for our:

• Signature silent and live auctions featuring once-in-a-lifetime travel experiences.
• National reach with personalized service at events in all 50 states.
• Comprehensive marketing toolkits, onsite staff support, and beautifully displayed materials
• No-cost platform development for virtual and hybrid fundraising
• In-house travel specialists who provide custom planning, extensions, insurance, and 24/7 emergency support.
• Ongoing educational resources, grants, and consulting support for nonprofit development.

Request Support

Our model is built on relationship, trust, and results. Every trip sold, every service provided, and every donor interaction is designed to maximize your fundraising impact—without adding burden to your team.

The National Cancer Institute (NCI) invites applications for studies on mechanisms by which bariatric surgery influences cancer risk. This funding opportunity encourages exploration beyond short-term outcomes like weight loss and diabetes. The goal is to support innovative proof of concept studies, emphasizing feasibility without prior development in the literature. Unpublished data is not allowed, but references from preprints with a DOI are acceptable. Deadlines for applications span from February 2025 to November 2027.

The AHRQ Improving Diagnostic Safety in Ambulatory Care (R18) program invites proposals aimed at enhancing diagnostic safety in ambulatory settings. This initiative supports the development, testing, and evaluation of strategies and interventions that address diagnostic challenges in healthcare. The goal is to improve patient safety and quality of care through innovative solutions tailored to the diverse needs of ambulatory care environments.

The Rotary Works Foundation Grant supports charitable projects primarily focused on children, youth, and families, emphasizing active Rotarian involvement. Grants range from $500 to $5,000, awarded prior to events. Eligible applicants include 501(c)(3) or 501(c)(1) organizations. Preference is given to projects engaging Rotarians. The application deadline is the 2nd Wednesday of each month, and all grantees must report outcomes post-project.

The Breast Cancer Community Education Grants, funded by the Oncology Nursing Foundation through AstraZeneca HealthCare Foundation, aim to enhance breast cancer awareness through nurse-led community education programs. Grants of up to $1,000 are available to ONS Chapters in the U.S., enabling them to implement impactful educational initiatives. Eligible activities must focus on community outreach and education, fostering a broader understanding of breast cancer.

The National Cancer Institute (NCI) is seeking applications for studies that explore how bariatric surgery influences cancer risk, emphasizing the need for innovative research in this area. This funding opportunity encourages the participation of researchers who focus on the long-term impacts of bariatric surgery beyond weight loss and diabetes, addressing critical gaps in understanding the disease mechanisms involved. Key deadlines for application submissions span from February 2025 to October 2027.

The Clifford and Rubye Angleton Scholarship Fund, managed by the Central Kansas Community Foundation, supports graduating high school seniors and college students from Butler County, Kansas, pursuing higher education. Scholarships are based on available funds and applicants' merit. Recipients may renew their scholarships for up to three years with satisfactory academic progress. This initiative emphasizes the importance of rural philanthropy and aims to empower local students to achieve their educational goals.

The Robert L. Johnson Memorial Research Grant, offered by the Midwest Aquatic Plant Management Society, supports graduate students in aquatic plant management with grants of up to $10,000. This initiative promotes research that advances the management of aquatic ecosystems and fosters educational opportunities. Recipients are required to present their findings at the annual conference, contributing to the society's mission of sustainable aquatic resource management and ecological preservation.

The AISES RISE Scholarship offers $2,000 annually to support Indigenous students pursuing careers in STEM, particularly in the casino gaming industry. This initiative, powered by Aristocrat Gaming, aims to empower Indigenous talent through exposure, resources, and programming. Eligible applicants must be full-time students and current AISES members, demonstrating a commitment to their education and community. The scholarship seeks to enhance diversity in STEM fields by providing critical financial support to deserving students.

The Rod's Tire and Service Scholarship Fund, managed by the Central Kansas Community Foundation, offers $2,500 to assist graduating Marion County high school seniors pursuing higher education or vocational training. The foundation, established in 1994, focuses on enhancing community welfare through charitable giving and emphasizes support for students majoring in agricultural fields. This scholarship aims to empower local youth and strengthen the community by investing in their educational futures.

The OVW Fiscal Year 2026 Consolidated Grant Program aims to support community-based initiatives that assist children and youth impacted by domestic violence, dating violence, sexual assault, and stalking. It also focuses on engaging men and youth in prevention efforts. Eligible applicants can develop or expand strategies for prevention, intervention, and treatment, addressing the needs of affected individuals aged 0-24. Applications are due by September 10, 2026.

The Jennie K. Scaife Charitable Foundation Grant focuses on enhancing family support, women's and children's health, and animal welfare. It aims to fund programs that promote beneficial human-animal interactions and early intervention in addiction prevention. Eligible organizations must have a valid 501(c)(3) designation. Grants align with at least one of the foundation's focus areas, ensuring impactful contributions to community welfare and well-being.

The Indian Housing Block Grant Competitive Program (IHBG-COMP) for FY 2026 offers competitive grants to eligible recipients under NAHASDA. This program aims to support affordable housing initiatives benefiting low-income Tribal families, enhancing their living conditions and community well-being. Funded by the US HUD's Office of Public and Indian Housing, the IHBG-COMP encourages the development of sustainable housing solutions within Native American communities.

The Master's Degree Scholarship Program for Under-Represented Minority Students, offered by the Environmental Engineering and Science Foundation, provides three scholarships of $2,500 each. These scholarships aim to support students from diverse backgrounds who are pursuing a Master's Degree in Environmental Engineering or a related field. Applicants must demonstrate academic excellence with a minimum GPA of 3.0 and must identify as part of specific under-represented groups.

Hogg Foundation for Mental Health

The Hogg Foundation for Mental Health was established in 1940 at The University of Texas at Austin by the children of Texas Governor James Hogg. For over a quarter of a century, the Hogg Foundation was guided by the passion and insight of the Governor’s daughter, Miss Ima Hogg, who actively promoted the foundation and encouraged its staff to pursue a bold, new vision. Today the Hogg Foundation is based at The University of Texas at Austin Steve Hicks School of Social Work and is funded through an endowment created by gifts from the Hogg family and managed by The University of Texas/Texas A&M Investment Management Company.

The Hogg Foundation is inspired by Ima Hogg’s vision for a Texas that supports and promotes mental health, resilience, and well-being. Miss Ima was ahead of her time in believing that mental health was just as important as physical health. She believed all people should have access to community-based resources to support mental well-being and live fulfilling lives, and she championed supports in everyday environments like schools, workplaces, places of worship, and homes.

Stephany June Bryan: Bold Spirit of Achievement Scholarship

The Hogg Foundation for Mental Health is offering ten $5,000 scholarships in honor of Stephany June Bryan to individuals facing personal and financial barriers to achieving their educational or career goals due to the impact of living with a mental health challenge and/or supporting a loved one with a mental health challenge.

You do not need to be enrolled in a program at the time you submit your application. However, you will need to provide enrollment verification and/or a certificate of completion when/if it is awarded.

The Seymour Siegel Youth Achievement Award, offered by the Jewish Community Foundation, provides financial support for high school students pursuing post-secondary education or vocational training. Open to applicants of the Jewish faith, this award prioritizes those from single-parent households, orphans, or foster children. Interested candidates must submit a personal narrative detailing their qualifications. The foundation, established in 1979, is a leading community resource in South Jersey, managing over $35 million in assets.

The Graham Foundation for Advanced Studies in the Fine Arts offers grants to organizations focused on architecture and its role in society. Established in 1956, the Foundation promotes innovative projects that encourage public dialogue, raise awareness, and foster experimentation in the field. Grants, not exceeding $30,000, support diverse practitioners and initiatives, enhancing discourse in architecture, design, visual arts, and related fields. The Foundation encourages projects that demonstrate originality, feasibility, and potential for meaningful impact.

The Graham Foundation for Advanced Studies in the Fine Arts, established in 1956, supports innovative projects that explore architecture's role in society and culture. It offers grants to individuals for production and presentation, as well as research and development, focusing on diverse ideas that provoke critical dialogue. The foundation prioritizes first-time applicants and seeks to amplify underrepresented perspectives while fostering collaboration across various disciplines in the arts and education.

The Environmental Engineering and Science Foundation offers six Master's Degree scholarships of $2,500 each for students pursuing advanced studies in Environmental Engineering or related fields. Eligible candidates must be U.S. citizens or permanent residents, have a strong academic record with a minimum GPA of 3.0, and be accepted into an accredited graduate program. This initiative aims to support future leaders in environmental engineering and science.

The Fair Housing Initiatives Program (FHIP) aims to combat discriminatory housing practices through funding provided to various organizations. Established by Congress in 1988 and made permanent in 1992, FHIP supports entities that educate the public and enforce fair housing rights. The program offers competitive grants across four initiatives, including the Private Enforcement Initiative, which enables national non-profit organizations to investigate violations and uphold fair housing laws effectively.

The EMF EMRA Resident Research Grant, funded by the Society for Academic Emergency Medicine Foundation, aims to enhance research in emergency medicine by providing up to $10,000 for residents in accredited programs. This grant promotes the development of future researchers, improves patient care, and supports effective health policy through rigorous scientific inquiry. Eligible applicants must be ACGME-approved residents and secure a faculty preceptor's support, ensuring a robust educational experience in research methodologies.