Best Large Grants for Nonprofit Organizations in Virginia

The Environmental Stewardship - Seed & Program Funding initiative by the Hampton Roads Community Foundation aims to foster conservation practices among youth in South Hampton Roads. It emphasizes education about local waterways and the effects of sea level rise, encouraging hands-on experiences and action plans for watershed preservation. By equipping students with knowledge and skills, the program seeks to enhance environmental stewardship and ensure a healthier future for the region's natural resources.

The Elizabeth Furber Scholarship honors the legacy of Elizabeth Furber by providing financial assistance to American Indian and Alaska Native female graduate students. This scholarship supports students pursuing full-time degrees in various fields, including fine arts, music, and creative writing. As a need-based award, it requires applicants to demonstrate Tribal affiliation through a Tribal Eligibility Certificate. This opportunity empowers eligible students to achieve their academic goals.

The Carl and Marilynn Thoma Foundation offers Special Project Funding to support innovative initiatives in the arts, particularly in under-resourced areas. This grant encourages collaborative projects that enhance community engagement and education, focusing on art exhibitions and scholarships in the greater Texas Panhandle. By fostering leadership and creativity, the Foundation aims to empower individuals and organizations to make a lasting impact in the fields of art and art history.

The OVW Fiscal Year 2026 Training and Services to End Violence and Abuse Against Individuals with Disabilities and Deaf People Program aims to empower states, local and Tribal governments, and nonprofit organizations to provide crucial training and resources. This initiative focuses on addressing domestic violence, stalking, sexual assault, and caregiver abuse against individuals with disabilities and Deaf individuals, enhancing direct services and support for these vulnerable populations.

The Rheumatology Scholarship supports undergraduate and post-baccalaureate students in attending ACR Convergence 2025, a premier event for rheumatology. Awardees gain exposure to innovative research and networking opportunities, enhancing their understanding of rheumatic diseases. The scholarship includes $2,000 for travel expenses and complimentary registration, encouraging future professionals to explore careers in this essential field. This initiative aims to strengthen the rheumatology workforce, ensuring better care for patients with musculoskeletal diseases.

The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Breast Cancer Screening & Prevention Initiative

The Breast Cancer Screening & Prevention Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to lifesaving breast cancer screening and prevention services for uninsured and medically underserved. Through this initiative, the NAFC will provide $30,000 grants to members to establish or strengthen breast cancer screening programs in alignment with evidence-based guidelines from the U.S. Preventive Services Task Force and the American Cancer Society. Funding will support activities such as improving patient identification and referral systems, increasing access to mammography services through partnerships or mobile units, strengthening staffing and technology capacity, and providing patient education and case management to ensure follow-through with recommended screenings. By enhancing early detection and preventive care, the initiative seeks to reduce barriers to care and improve health outcomes for women who might otherwise go without critical cancer screening services.

The Quality of Life Grants Program, managed by the Christopher & Dana Reeve Foundation, provides funding of up to $25,000 for projects that support individuals living with paralysis. This program emphasizes community engagement and health promotion in all U.S. states and territories. It focuses on funding initiatives that directly impact those affected by various conditions, such as spinal cord injuries and multiple sclerosis, fostering inclusion and well-being.

The NIHCM Journalism Grants support projects that enhance health reporting and education, targeting critical issues such as healthcare affordability, pharmaceutical pricing, provider market dynamics, and chronic disease management. This initiative emphasizes the importance of informing policymakers and the public on how to improve healthcare quality and access in the U.S. Proposals may also explore the role of artificial intelligence in healthcare delivery. Applications are welcome from journalists, nonprofits, and universities.

The Medical and Graduate Student Preceptorship provides a unique opportunity for students to engage in rheumatology through either clinical or research experiences lasting 4 to 8 weeks. Participants will observe practices in a shadowing role, gaining invaluable insights without direct patient management. The program supports students with financial awards of $2,000 or $4,000, depending on the duration of their preceptorship, and includes additional funds for travel expenses to attend professional conferences.

The Mathews CF Community Impact Grants support local nonprofits to enhance cultural vibrancy, economic prosperity, educational success, and health and wellness in Mathews County. Funded by generous donors, the program focuses on impactful projects that yield positive, lasting changes. Eligible organizations include 501(c)(3) charities, which may apply once a year. This initiative fosters collaboration with grantees to achieve essential community goals and adapt to evolving needs.

The WWT Foundation Grant aims to empower organizations aligned with the foundation's values, focusing on community service, employee engagement, and business impact. Key areas of support include career readiness, STEM education, human services, and health and wellness. Eligible organizations must be located in the U.S. and registered as 501(c)(3). Applications are accepted year-round, allowing for flexible engagement and support for impactful community initiatives.

Scholarships are available to graduating high school seniors. Applications are accepted from mid-November until mid-March. Scholarship award recipients will be announced at the high school awards ceremony. 

Van Cott Family Memorial Scholarship

Established in memory of Kermit Van Cott and his son Forrest to provide tuition assistance to a graduating Senior from one of the High Schools in Susquehanna County, with priority given to Blue Ridge, who will major in Landscape Architecture, Environmental Science, Environmental Engineering, Horticulture, Botany, Forestry, or Agriculture and who will matriculate at college or a post-secondary degree program.

The Empathy Building Initiative, led by Acton Family Giving, seeks to foster partnerships with organizations aligned with its mission. While currently not expanding its portfolio, it invites inquiries from potential partners. Eligible organizations must hold 501(c)3 status and align with specific giving areas. The initiative focuses on a national or broad reach and evaluates grant applications based on alignment and conversation. For more details, potential partners are encouraged to review the grants list available on their website.

The Yocha Dehe Community Fund, established by the Yocha Dehe Wintun Nation in 2000, supports initiatives that strengthen communities throughout Yolo County and beyond. With nearly $40 million in grants, the Fund prioritizes projects in health, education, Native arts, and environmental protection. The Tribe's commitment involves active participation in the grant process, ensuring impactful partnerships with various organizations. New applicants must register on the grant portal and submit a letter of inquiry to be considered for funding.

The John Lenard Civil Engineering Scholarship, established in 2008 by John Lenard, P.E., F.ASCE, supports undergraduate students pursuing civil engineering with a focus on water supply or environmental engineering. The scholarship aims to assist deserving students in covering tuition expenses. Awarded annually, it is limited to two recipients who demonstrate commitment to their field. The American Society of Civil Engineers, founded in 1852, oversees this scholarship, fostering excellence in civil engineering education.

BioMarin offers funding through its donation program focused on improving healthcare and patient advocacy, particularly for rare diseases. Organizations eligible for support include hospitals, accredited providers, and patient advocacy groups. BioMarin prioritizes innovative therapeutic solutions for rare genetic conditions. The company is dedicated to enhancing patient care and education, and it reviews funding requests year-round, although specific deadlines apply for year-end funding. This initiative reflects BioMarin's commitment to addressing unmet medical needs.

Young Health Programme

The Young Health Programme (YHP) is a global disease prevention initiative, aiming to provide education for young people to feel empowered to make informed choices about their health and catalyse a global, youth-led advocacy movement.

The programme operates in over 40 countries and partners with more than 60 non-profit organisations, including UNICEF and Plan International. The YHP combines community programmes, research, advocacy, and the development of young leaders, with a focus on underserved communities.

Since its launch in 2010, the YHP has directly reached over 23 million young people, trained over 1 million, and engaged more than 23,000 AstraZeneca employees, who have volunteered their time with more than 140,000 hours.

The YHP aims to prevent the most common non-communicable diseases (NCDs), including cancer, diabetes, heart disease and respiratory disease, by addressing five main risk factors: tobacco use, unhealthy diet, physical inactivity, harmful use of alcohol, and air pollution. Additionally, the programme tackles climate-health impacts to build healthier communities, recognising, as projected in the IPCC Sixth Assessment Report, that children born after 2010 will be the first generation to enter adulthood in a world where the average temperature will reach 1.5°C above pre-industrial levels, and are expected to experience a +2°C rise within their lifetime.1

AstraZeneca Young Health Programme Impact Fellowship 2026

AstraZeneca is looking for passionate, driven young leaders to join their 2026 Young Health Programme (YHP) Impact Fellowship. The Fellowship supports young advocates to create actionable change to: 

• Advance health equity – with a focus on acting early to prevent non-communicable diseases among young people, or supporting young people living with rare diseases.
• Take action on climate and nature – advocating for the mitigation of the harmful effects of climate change on the health and well-being of young people.
• Build health systems resilience – contributing to stronger health systems that prioritise earlier intervention to meet today’s needs and mitigate tomorrow’s disease burden.

Benefits

The selected Fellows will gain access to networks, funding and development opportunities, enabling them to drive a global health movement led by and for young people:

A fully-funded scholarship to attend the 2026 One Young World Summit in Cape Town, South Africa (3–6 November 2026) as well as access to the One Young World Ambassador Network and the Young Health Programme (YHP) Alumni group of other young changemakers working to improve youth health.

Structured learning and development offerings to enable them to scale their impact, including both self-directed and live learning. This includes access to the One Young World Academy, an award-winning mini-MBA programme, mentorship from AstraZeneca colleagues and professional training.

Each selected Fellow will receive a grant of either USD $10,000 or USD $50,000 (if selected as the Lead2030 winner** for Sustainable Development Goal 3, for which applicants will be automatically considered) from AstraZeneca, through their non-profit organisation. Fellows are expected to use the grant to implement a project focused on either (1) advancing health equity (2) taking action on climate and nature (3) building health systems resilience.

The Erie Insurance Giving Network Grant supports organizations focused on community building, safety, and environmental responsibility. Grants under $10,000 can be submitted at any time, while larger requests follow specific deadlines. Priority is given to organizations with community representation in their governing bodies. Eligible entities include nonprofit organizations, accredited educational institutions, and municipalities. The initiative emphasizes a commitment to diversity and inclusion, aligning with ERIE's corporate values.

The United Company Foundation, established in 1986, provides grants to support charitable organizations in Bristol, VA, Bristol, TN, and Southwest Virginia. This private non-profit focuses on areas such as food, shelter, education, the arts, health, and youth services, emphasizing fiscal responsibility and innovative approaches. By prioritizing accountability and measurable outcomes, the Foundation aims to foster long-term improvements in the community it serves.

The NIH R25 program aims to enhance inclusivity in research education by supporting activities that encourage individuals from diverse backgrounds to pursue careers in substance use and addiction sciences. This initiative focuses on skills development courses and research experiences, particularly targeting underrepresented groups in biomedical and behavioral sciences. Applications are due by 5:00 PM local time of the applicant organization, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline.

Avnet Cares Grants support nonprofit organizations in the U.S., Canada, and Mexico that focus on making a positive impact in their communities. Grants are available for initiatives in STEM, environmental sustainability, and assistance for communities in crisis. Eligible nonprofits must have been operational for at least three years. The program prioritizes organizations that serve areas where Avnet has significant operations, fostering community growth and development.

The Fehr Graham Scholarship provides financial support for students pursuing careers in engineering, landscape architecture, land surveying, geology, hydrogeology, assessment and remediation, and environmental health and safety. Applicants must reside within fifty miles of a Fehr Graham office and intend to enroll in their first year of post-secondary education. This scholarship is renewable for up to three years, contingent upon maintaining a 2.8 GPA. It aims to enhance educational opportunities in the communities served by Fehr Graham.

MGM National Harbor Charitable Grant

We believe that corporations have the responsibility and the resources to affect the world’s most pressing economic, social and environmental issues. The growth and success of our company depends on the business decisions that we make, and the ways in which we harness our influence for good. Through our monetary, in-kind and volunteerism support, we invest in charitable organizations that focus on five critical issues.

• Education: K-12 public education, public colleges and universities, community colleges
• Fighting Hunger: Programs that provide access and nutritious meals for food-insecure individuals and families within the community.
• Health and Wellness: Programs that encourage a healthy lifestyle and improve one’s well-being while reducing social and health challenges.
• Workforce Development: Educational and training programs that align with our business and prepare individuals for sustainable career opportunities.
• Environmental Sustainability: Programs that improve the quality of our environment and promote sustainability through education, stewardship of community ecosystems, conservation and beautification.

*Before submitting a request for support, please see our eligibility requirements below. Incomplete forms and those with missing documentation will not be considered. Each request must be submitted no later than 45 days prior to your sponsorship deadline. Please, no phone calls or emails.

We fund work that:

• Has a clear strategy
• Can be effectively measuredto evaluate success
• Approaches challenges witha commitment to long-term change
• Builds an inclusive anddiverse community
• Uses innovation to addressa social issue

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

Headstream Accelerator 2026

Accelerator Application Cohort VI

The Headstream Accelerator supports entrepreneurs from all backgrounds in scaling digital solutions that improve the mental well-being of teens at risk, with a focus on the education and healthcare sectors. Our four-month, virtual-first program is designed for early-stage innovators, helping them strengthen their business models, refine their value propositions, and build the foundation for sustainable growth and meaningful impact.

Benefits:

• $30,000 non-dilutive stipend 
• Partnership with youth from Headsteam’s Youth Co-Creator Club to gain insights on cultural relevance, age-appropriateness, and user experience, ensuring your solutions resonate deeply and effectively with the next generation 
• Access to a network of expert advisors, connect with a community of founders, and engage with potential investors and capital providers 
• Access to one-on-one and group coaching sessions with our partner, FounderWell

Participant Expectations:

• Attend all activities, including virtual cohort and youth co-creation sessions, advisor calls, and an in-person kickoff event from July 28–30, 2026
• Commit 2–5 hours weekly during the program, including virtual sessions, advisor network office hours, guide calls, and more
• Embed youth voices throughout your product development